Monoclonal proteins, also called M proteins, are elevated in the blood and urine of patients with multiple myeloma or monoclonal gammopathy of undetermined significance (MGUS), a condition which is highly correlated to bone marrow and blood cancers. Monoclonal proteins are antibodies produced in the bone marrow by the cancerous cells.
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Most FDA-approved therapeutic drugs target transmembrane proteins, yet the development of monoclonal antibodies for multi-transmembrane protein targets has been limited. Despite the abundanc...
There is a great variability in testing for monoclonal gammopathies. During his presentation, Dr. David F. Keren, MD, Clinical Professor of Pathology at University of Michigan Health, descri...
Date: April 13, 2023 Time: 8:00am (PDT), 11:00am (EDT), 5:00pm (CEST) It is important to confirm the sequences and post-translational modifications (PTMs) of protein therapeutics to ensure d...
FEB 22, 2023 | 10:30 AM
C.E. CREDITS
Immunogens with native conformation and a high-throughput IgG cloning platform are two of the most important key components for high quality lead antibody molecules discovery. DIMABIO’...
FEB 09, 2023 | 9:00 AM
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Date: February 09, 2023 Time: 9:00am (PST), 12:00pm (EST), 6:00pm (CET) Monoclonal gammopathies (MGs) comprise a broad set of diseases involving the abnormal clonal proliferation of plasma c...
Date: June 22, 2022 Time: 10:00am (PDT), 1:00pm (EDT), 7:00pm (CEST) Rabbits have a robust and unique immune system that enables the generated antibodies with superior specificity, affinity,...
Date: June 01, 2022 Time: 9:00am (PDT), 12:00pm (EDT), 6:00pm (CEST) The manufacturing process for cell and gene therapies is complex and can contain process-related impurities from multiple...
APR 06, 2022 | 9:00 AM
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There is growing interest in the development of integrated continuous bioprocesses for the production of important biotherapeutics due to the potential for enhanced productivity, greater fle...
APR 06, 2022 | 5:30 AM
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In the last decades, the upstream processing in biopharma industry has been revolutionized regarding the production of bioactive materials such as monoclonal antibodies, proteins and biother...
Date: March 1, 2022 Time: 9:00am (PST), 12:00pm (EST) Dr. David F Keren currently serves as a Professor of Pathology at the University of Michigan (Michigan Medicine). Dr. Keren received his...
Cancer is a leading cause of morbidity and mortality in developed countries including the United States. Early detection of various cancers, before they spread and become incurable, has been...