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    Post-Translational Modification

    Post-Translational Modification are crucial for controlling protein stability, localization, and conformation. It refers to the chemical changes that occur after a protein has been produced and is a key step in protein biosynthesis.

    Webinars

    • OCT 24, 2023 | 10:00 AM
      An epic advance in epigenomics: Automated CUT&RUN enables chromatin profiling for scaled research & drug discovery applications
      An epic advance in epigenomics: Automated CUT&RUN enables chromatin...
      Dynamic changes in chromatin drive gene expression programs during cellular development and contribute to pathological changes underlying disease. To date, efforts to characterize chromatin...
      Speaker: Andrea Johnstone, Ph.D. , Lori Euler
      Sponsored By: Beckman Coulter Life Sciences
      30
      JUL 26, 2023 | 2:30 PM
      Serine-129 phosphorylation of α-synuclein is an activity-dependent trigger for physiologic protein-protein interactions and synaptic function
      Serine-129 phosphorylation of α-synuclein is an activity-dependent...
      Phosphorylation of α-synuclein at the Serine-129 site (α-syn Ser129P) is an established pathologic hallmark of synucleinopathies and a therapeutic target. In physiologic states,...
      Speaker: Dr. Leonardo Parra-Rivas
      Presented at: GenScript 3rd Annual Gene and Cell Engineering Summit
      4
      APR 25, 2023 | 10:00 AM
      Alpha-synuclein, a Coat of Many Colors
      Alpha-synuclein, a Coat of Many Colors
      Date: April 25, 2023 Time: 10:00am (PDT), 1:00pm (EDT), 7:00pm (CEST) The presynaptic protein alpha-synuclein (α-syn) is associated with Parkinson’s disease and Lewy body dementi...
      Speaker: Prof. Poul Henning Jensen, M.D., Dr. Med. Sci.
      Sponsored By: BioLegend
      19
      APR 13, 2023 | 8:00 AM
      Novel subunit analysis for biotherapeutic development: increased coverage from a single injection
      Novel subunit analysis for biotherapeutic development: increased...
      Date: April 13, 2023 Time: 8:00am (PDT), 11:00am (EDT), 5:00pm (CEST) It is important to confirm the sequences and post-translational modifications (PTMs) of protein therapeutics to ensure d...
      Speaker: Haichuan Liu
      Sponsored By: SCIEX
      6
      OCT 20, 2022 | 8:00 AM
      Producing Recombinant Proteins with the Baculovirus Expression Vector System (BEVS)
      Producing Recombinant Proteins with the Baculovirus Expression...
      Date: October 20, 2022 Time: 8:00am (PDT), 11:00am (EDT), 5:00pm (CEST) Over the past three decades, baculovirus expression vector system (BEVS) has become one of the most powerful and robus...
      Speaker: Xuejiao Zhang
      Sponsored By: Sino Biological
      10
      JUL 26, 2022 | 9:00 AM
      Applications in Cancer Research: RNA Isolation from Organoids and Spheroids
      Applications in Cancer Research: RNA Isolation from Organoids...
      Date: July 26, 2022 Time: 9:00am (PDT), 12:00pm (EDT), 6:00pm (CEST) Organoids and spheroids are increasingly being used in many research applications, including drug discovery, toxicology,...
      Speaker: Laura Chapman , Anupriya Gupta , Jay Bhandari
      Sponsored By: Thermo Fisher Scientific
      24
      MAY 17, 2022 | 9:00 AM
      On the way towards personalized medicine: Gene therapy AAV characterization by capillary electrophoresis (CE) and liquid chromatography mass spectrometry (LC-MS)
      On the way towards personalized medicine: Gene therapy AAV characterization...
      Date: May 17, 2022 Time: 9:00am (PDT), 12:00pm (EDT), 8:00pm (CEST) Gene therapeutics have great potential to treat many severe diseases in an unprecedented, targeted manner. The biopharmace...
      Speaker: Kerstin Pohl , Jane Luo, PhD
      Sponsored By: SCIEX
      11
      DEC 09, 2021 | 6:00 AM
      Assessment of quality attributes of biotherapeutics leveraging a novel fragmentation technique
      Assessment of quality attributes of biotherapeutics leveraging...
      Date: December 9, 2021 Time: 6:00am (PDT), 9:00 am (EDT) As the number of biotherapeutic candidates in development is increasing, the requirements of analytical tools to understand the molec...
      Speaker: Armelle Martelet
      Sponsored By: SCIEX
      5
      OCT 27, 2021 | 6:00 AM
      Comprehensive characterization of Etanercept using the ZenoTOF 7600 system
      Comprehensive characterization of Etanercept using the ZenoTOF...
      Date: October 27, 2021 Time: 6:00 AM PDT, 9:00 AM EDT Etanercept is a recombinant Fc fusion protein therapeutic that has a complex distribution of post-translation modifications (PTM), such...
      Speaker: Xuezhi Bi, PhD
      Sponsored By: SCIEX
      5
      JUL 29, 2020 | 1:00 PM
      Using quantitative imaging microscopy to explore and target the molecular origins of cancer
      Using quantitative imaging microscopy to explore and target the...
      The identification of novel drug targets and the development of next generation therapeutic strategies remain elusive goals for cancer researchers. We believe that the aberrant molecular eve...
      Speaker: Kirk McManus, PhD
      Presented at: Immuno-Oncology & Cancer Biology Virtual Conference
      1
      JUN 17, 2020 | 11:00 AM
      Breaking the Bonds, Not the Bank: New Possibilities with e-MSion's ExD Cell
      Breaking the Bonds, Not the Bank: New Possibilities with e-MSion's...
      The ExD Option, available for both new and existing Agilent instruments, offers superior electron fragmentation in combination with collision induced dissociation (CID) compared to other exi...
      Speaker: Christian Klein, PhD , Joe Beckman, PhD
      Presented at: Agilent's Virtual Mass Spectacular!
      1
      JUN 03, 2020 | 2:00 AM
      A Mitotic Error Code
      A Mitotic Error Code
      Similar to the “histone code” hypothesis in which epigenetic marks on histone tails expand the information potential of the genetic code, different tubulin isoforms, combined wit...
      Speaker: KEYNOTE: Helder Maiato, PhD
      Presented at: Cell & Developmental Biology Virtual Meeting
      3
      APR 29, 2020 | 6:00 AM
      High-Throughput assessment of ChIP-grade capability with Luminex xMAP technology
      High-Throughput assessment of ChIP-grade capability with Luminex...
      Histone post-translational modifications (PTMs) play pivotal roles in chromatin dynamics and function, with alterations in the healthy profile associated with diverse human pathologies. The...
      Speaker: Michael-Christopher Keogh, PhD
      Presented at: xMAP® Connect Virtual Conference (On-Demand)
      1
      OCT 30, 2018 | 10:00 AM
      Post-translational Modifications and Data-Independent Acquisitions - Challenges and Opportunities
      Post-translational Modifications and Data-Independent Acquisitions...
      DATE: October 30, 2018TIME: 10:00am PT, 1:00pm ET Identification and quantification of post-translational modifications (PTM) presents a unique challenge to proteomic studies...
      Speaker: Birgit Schilling, PhD , Matthew Stokes, PhD
      Sponsored By: Cell Signaling Technology
      5
      OCT 11, 2018 | 9:00 AM
      Destabilization and Degradation of MYC: More Ways Than One
      Destabilization and Degradation of MYC: More Ways Than One
      The oncogenic transcription factor c-MYC (MYC) is deregulated, and often overexpressed, in more than 50% of cancers. MYC deregulation is associated with poor prognosis and aggressive disease,...
      Speaker: Jason De Melo, PhD
      Presented at: Cancer Research & Oncology Week Virtual Event Series 2018
      1
      MAR 27, 2018 | 9:00 AM
      Proteomics profiling of post-translational modifications in early drug discovery
      Proteomics profiling of post-translational modifications in early...
      DATE: March 27, 2018TIME: 09:00am PST, 12:00pm EST...
      Speaker: Matthew Stokes, PhD , Lilian Phu , Don Kirkpatrick, PhD
      Sponsored By: Cell Signaling Technology
      8 3
      DEC 11, 2017 | 9:00 AM
      WEBINAR: Responsible Science: Can you trust your antibody?
      WEBINAR: Responsible Science: Can you trust your antibody?
      DATE: December 11, 2017TIME: 09:00am PST, 12:00pm ESTReproducibility is an important and ongoing topic of discussion within the scientific community. Although the reasons underlying the...
      Speaker: Anthony Couvillon, PhD , Randall Wetzel, PhD
      Sponsored By: Cell Signaling Technology
      6
      AUG 29, 2017 | 9:00 AM
      Automated Optimization of IgG Production in CHO Cells
      Automated Optimization of IgG Production in CHO Cells
      DATE: August 29th, 2017TIME:  9:00am PT, 12:00pm ET Antibodies are frequently produced from a cell line that has been screened to ensure the protein is expressed with th...
      Speaker: Mike Kowalski, Ph.D. , David Apiyo
      Sponsored By: Biologics by Danaher, Biologics by Danaher
      4
      APR 14, 2017 | 10:00 AM
      WEBINAR: Comparative Analysis of Plasma Lipid Alterations Associated with Age and Dietary Restriction using Targeted MS and Untargeted LC-MS Lipidomics Approaches
      WEBINAR: Comparative Analysis of Plasma Lipid Alterations Associated...
      DATE: April 14, 2017TIME: 10:00AM PST, 1:00PM ET The study presented will represent the most comprehensive characterization of lipid changes in the context of aging and DR to d...
      Speaker: Kévin Contrepois , PhD
      Sponsored By: SCIEX
      6 3
      NOV 17, 2016 | 8:30 AM
      Simultaneous, single-cell visualization of RNA and Protein
      Simultaneous, single-cell visualization of RNA and Protein
      DATE: November 17, 2016 TIME: 8:30am PT, 11:30am ET The complex interactions between transcription, translation, and post-translational modifications are hidden from view in typ...
      Speaker: Sara Becker-Catania, PhD
      Sponsored By: eBioscience Business Unit, Thermo Fisher Scientific, eBioscience Business Unit, Thermo Fisher Scientific
      4
      OCT 27, 2016 | 9:00 AM
      Achieving Reproducibility: Don't Let Antibodies be a Variable in Your Experiment
      Achieving Reproducibility: Don't Let Antibodies be a Variable...
      DATE:  October 27, 2016 TIME:  9:00am PT, 12:00pm ET The importance of antibodies as tools in scientific research studies cannot be understated, yet these reagents have increasi...
      Speaker: Anthony Couvillon, PhD
      Sponsored By: Cell Signaling Technology, Cell Signaling Technology
      10
      SEP 22, 2016 | 4:00 AM
      Cross-validation of Antibodies Using DigiWest
      Cross-validation of Antibodies Using DigiWest
      DATE: September 22, 2016 TIME:  4:00am PT, 7:00am ET, 11:00am GMT Here, we present a novel approach that combines the principles of the western blot (protein separation by SDS-PAGE; ...
      Speaker: Anthony Couvillon, PhD , Markus Templin, PhD
      Sponsored By: Cell Signaling Technology, Cell Signaling Technology
      3 2
      JUN 30, 2016 | 7:30 AM
      Proteome centric precision medicine:  embracing pathological diversity
      Proteome centric precision medicine: embracing pathological diversity
      Precision medicine requires success in two intertwined aspects: precision therapy and personalized medicine. Precision therapy is being able to effectively treat the right disease; to have th...
      Speaker: Jennifer Van Eyk, PhD
      Presented at: Beckman Coulter Life Sciences Virtual Trade Show
      Sponsored By: Beckman Coulter Life Sciences, Beckman Coulter Life Sciences
      8
      JUN 15, 2016 | 8:00 AM
      Novel  PET radiochemistries: Improving understanding and detection of disease
      Novel PET radiochemistries: Improving understanding and detection...
      DATE: June 15, 2016TIME:  08:00AM PDT, 11:00AM EDT, 3:00PM GMT Positron Emission Tomography (PET) is a 3-dimensional, quantitative imaging technology that has robust clinical trans...
      Speaker: Timothy DeGrado, PhD , Roger Schibli, PhD
      Sponsored By: Revvity
      32 1
    OCT 24, 2023 | 10:00 AM
    An epic advance in epigenomics: Automated CUT&RUN enables chromatin profiling for scaled research & drug discovery applications
    An epic advance in epigenomics: Automated CUT&RUN enables chromatin...
    Dynamic changes in chromatin drive gene expression programs during cellular development and contribute to pathological changes underlying disease. To date, efforts to characterize chromatin...
    Speaker: Andrea Johnstone, Ph.D. , Lori Euler
    Sponsored By: Beckman Coulter Life Sciences
    30
    JUL 26, 2023 | 2:30 PM
    Serine-129 phosphorylation of α-synuclein is an activity-dependent trigger for physiologic protein-protein interactions and synaptic function
    Serine-129 phosphorylation of α-synuclein is an activity-dependent...
    Phosphorylation of α-synuclein at the Serine-129 site (α-syn Ser129P) is an established pathologic hallmark of synucleinopathies and a therapeutic target. In physiologic states,...
    Speaker: Dr. Leonardo Parra-Rivas
    Presented at: GenScript 3rd Annual Gene and Cell Engineering Summit
    4
    APR 25, 2023 | 10:00 AM
    Alpha-synuclein, a Coat of Many Colors
    Alpha-synuclein, a Coat of Many Colors
    Date: April 25, 2023 Time: 10:00am (PDT), 1:00pm (EDT), 7:00pm (CEST) The presynaptic protein alpha-synuclein (α-syn) is associated with Parkinson’s disease and Lewy body dementi...
    Speaker: Prof. Poul Henning Jensen, M.D., Dr. Med. Sci.
    Sponsored By: BioLegend
    19
    APR 13, 2023 | 8:00 AM
    Novel subunit analysis for biotherapeutic development: increased coverage from a single injection
    Novel subunit analysis for biotherapeutic development: increased...
    Date: April 13, 2023 Time: 8:00am (PDT), 11:00am (EDT), 5:00pm (CEST) It is important to confirm the sequences and post-translational modifications (PTMs) of protein therapeutics to ensure d...
    Speaker: Haichuan Liu
    Sponsored By: SCIEX
    6
    OCT 20, 2022 | 8:00 AM
    Producing Recombinant Proteins with the Baculovirus Expression Vector System (BEVS)
    Producing Recombinant Proteins with the Baculovirus Expression...
    Date: October 20, 2022 Time: 8:00am (PDT), 11:00am (EDT), 5:00pm (CEST) Over the past three decades, baculovirus expression vector system (BEVS) has become one of the most powerful and robus...
    Speaker: Xuejiao Zhang
    Sponsored By: Sino Biological
    10
     
     
  • JUL 26, 2022 | 9:00 AM
    Applications in Cancer Research: RNA Isolation from Organoids and Spheroids
    Applications in Cancer Research: RNA Isolation from Organoids...
    Date: July 26, 2022 Time: 9:00am (PDT), 12:00pm (EDT), 6:00pm (CEST) Organoids and spheroids are increasingly being used in many research applications, including drug discovery, toxicology,...
    Speaker: Laura Chapman , Anupriya Gupta , Jay Bhandari
    Sponsored By: Thermo Fisher Scientific
    24
    MAY 17, 2022 | 9:00 AM
    On the way towards personalized medicine: Gene therapy AAV characterization by capillary electrophoresis (CE) and liquid chromatography mass spectrometry (LC-MS)
    On the way towards personalized medicine: Gene therapy AAV characterization...
    Date: May 17, 2022 Time: 9:00am (PDT), 12:00pm (EDT), 8:00pm (CEST) Gene therapeutics have great potential to treat many severe diseases in an unprecedented, targeted manner. The biopharmace...
    Speaker: Kerstin Pohl , Jane Luo, PhD
    Sponsored By: SCIEX
    11
    DEC 09, 2021 | 6:00 AM
    Assessment of quality attributes of biotherapeutics leveraging a novel fragmentation technique
    Assessment of quality attributes of biotherapeutics leveraging...
    Date: December 9, 2021 Time: 6:00am (PDT), 9:00 am (EDT) As the number of biotherapeutic candidates in development is increasing, the requirements of analytical tools to understand the molec...
    Speaker: Armelle Martelet
    Sponsored By: SCIEX
    5
    OCT 27, 2021 | 6:00 AM
    Comprehensive characterization of Etanercept using the ZenoTOF 7600 system
    Comprehensive characterization of Etanercept using the ZenoTOF...
    Date: October 27, 2021 Time: 6:00 AM PDT, 9:00 AM EDT Etanercept is a recombinant Fc fusion protein therapeutic that has a complex distribution of post-translation modifications (PTM), such...
    Speaker: Xuezhi Bi, PhD
    Sponsored By: SCIEX
    5
    JUL 29, 2020 | 1:00 PM
    Using quantitative imaging microscopy to explore and target the molecular origins of cancer
    Using quantitative imaging microscopy to explore and target the...
    The identification of novel drug targets and the development of next generation therapeutic strategies remain elusive goals for cancer researchers. We believe that the aberrant molecular eve...
    Speaker: Kirk McManus, PhD
    Presented at: Immuno-Oncology & Cancer Biology Virtual Conference
    1
     
     
  • JUN 17, 2020 | 11:00 AM
    Breaking the Bonds, Not the Bank: New Possibilities with e-MSion's ExD Cell
    Breaking the Bonds, Not the Bank: New Possibilities with e-MSion's...
    The ExD Option, available for both new and existing Agilent instruments, offers superior electron fragmentation in combination with collision induced dissociation (CID) compared to other exi...
    Speaker: Christian Klein, PhD , Joe Beckman, PhD
    Presented at: Agilent's Virtual Mass Spectacular!
    1
    JUN 03, 2020 | 2:00 AM
    A Mitotic Error Code
    A Mitotic Error Code
    Similar to the “histone code” hypothesis in which epigenetic marks on histone tails expand the information potential of the genetic code, different tubulin isoforms, combined wit...
    Speaker: KEYNOTE: Helder Maiato, PhD
    Presented at: Cell & Developmental Biology Virtual Meeting
    3
    APR 29, 2020 | 6:00 AM
    High-Throughput assessment of ChIP-grade capability with Luminex xMAP technology
    High-Throughput assessment of ChIP-grade capability with Luminex...
    Histone post-translational modifications (PTMs) play pivotal roles in chromatin dynamics and function, with alterations in the healthy profile associated with diverse human pathologies. The...
    Speaker: Michael-Christopher Keogh, PhD
    Presented at: xMAP® Connect Virtual Conference (On-Demand)
    1
    OCT 30, 2018 | 10:00 AM
    Post-translational Modifications and Data-Independent Acquisitions - Challenges and Opportunities
    Post-translational Modifications and Data-Independent Acquisitions...
    DATE: October 30, 2018TIME: 10:00am PT, 1:00pm ET Identification and quantification of post-translational modifications (PTM) presents a unique challenge to proteomic studies...
    Speaker: Birgit Schilling, PhD , Matthew Stokes, PhD
    Sponsored By: Cell Signaling Technology
    5
    OCT 11, 2018 | 9:00 AM
    Destabilization and Degradation of MYC: More Ways Than One
    Destabilization and Degradation of MYC: More Ways Than One
    The oncogenic transcription factor c-MYC (MYC) is deregulated, and often overexpressed, in more than 50% of cancers. MYC deregulation is associated with poor prognosis and aggressive disease,...
    Speaker: Jason De Melo, PhD
    Presented at: Cancer Research & Oncology Week Virtual Event Series 2018
    1
     
     
  • MAR 27, 2018 | 9:00 AM
    Proteomics profiling of post-translational modifications in early drug discovery
    Proteomics profiling of post-translational modifications in early...
    DATE: March 27, 2018TIME: 09:00am PST, 12:00pm EST...
    Speaker: Matthew Stokes, PhD , Lilian Phu , Don Kirkpatrick, PhD
    Sponsored By: Cell Signaling Technology
    8 3
    DEC 11, 2017 | 9:00 AM
    WEBINAR: Responsible Science: Can you trust your antibody?
    WEBINAR: Responsible Science: Can you trust your antibody?
    DATE: December 11, 2017TIME: 09:00am PST, 12:00pm ESTReproducibility is an important and ongoing topic of discussion within the scientific community. Although the reasons underlying the...
    Speaker: Anthony Couvillon, PhD , Randall Wetzel, PhD
    Sponsored By: Cell Signaling Technology
    6
    AUG 29, 2017 | 9:00 AM
    Automated Optimization of IgG Production in CHO Cells
    Automated Optimization of IgG Production in CHO Cells
    DATE: August 29th, 2017TIME:  9:00am PT, 12:00pm ET Antibodies are frequently produced from a cell line that has been screened to ensure the protein is expressed with th...
    Speaker: Mike Kowalski, Ph.D. , David Apiyo
    Sponsored By: Biologics by Danaher, Biologics by Danaher
    4
    APR 14, 2017 | 10:00 AM
    WEBINAR: Comparative Analysis of Plasma Lipid Alterations Associated with Age and Dietary Restriction using Targeted MS and Untargeted LC-MS Lipidomics Approaches
    WEBINAR: Comparative Analysis of Plasma Lipid Alterations Associated...
    DATE: April 14, 2017TIME: 10:00AM PST, 1:00PM ET The study presented will represent the most comprehensive characterization of lipid changes in the context of aging and DR to d...
    Speaker: Kévin Contrepois , PhD
    Sponsored By: SCIEX
    6 3
    NOV 17, 2016 | 8:30 AM
    Simultaneous, single-cell visualization of RNA and Protein
    Simultaneous, single-cell visualization of RNA and Protein
    DATE: November 17, 2016 TIME: 8:30am PT, 11:30am ET The complex interactions between transcription, translation, and post-translational modifications are hidden from view in typ...
    Speaker: Sara Becker-Catania, PhD
    Sponsored By: eBioscience Business Unit, Thermo Fisher Scientific, eBioscience Business Unit, Thermo Fisher Scientific
    4
     
     
  • OCT 27, 2016 | 9:00 AM
    Achieving Reproducibility: Don't Let Antibodies be a Variable in Your Experiment
    Achieving Reproducibility: Don't Let Antibodies be a Variable...
    DATE:  October 27, 2016 TIME:  9:00am PT, 12:00pm ET The importance of antibodies as tools in scientific research studies cannot be understated, yet these reagents have increasi...
    Speaker: Anthony Couvillon, PhD
    Sponsored By: Cell Signaling Technology, Cell Signaling Technology
    10
    SEP 22, 2016 | 4:00 AM
    Cross-validation of Antibodies Using DigiWest
    Cross-validation of Antibodies Using DigiWest
    DATE: September 22, 2016 TIME:  4:00am PT, 7:00am ET, 11:00am GMT Here, we present a novel approach that combines the principles of the western blot (protein separation by SDS-PAGE; ...
    Speaker: Anthony Couvillon, PhD , Markus Templin, PhD
    Sponsored By: Cell Signaling Technology, Cell Signaling Technology
    3 2
    JUN 30, 2016 | 7:30 AM
    Proteome centric precision medicine:  embracing pathological diversity
    Proteome centric precision medicine: embracing pathological diversity
    Precision medicine requires success in two intertwined aspects: precision therapy and personalized medicine. Precision therapy is being able to effectively treat the right disease; to have th...
    Speaker: Jennifer Van Eyk, PhD
    Presented at: Beckman Coulter Life Sciences Virtual Trade Show
    Sponsored By: Beckman Coulter Life Sciences, Beckman Coulter Life Sciences
    8
    JUN 15, 2016 | 8:00 AM
    Novel  PET radiochemistries: Improving understanding and detection of disease
    Novel PET radiochemistries: Improving understanding and detection...
    DATE: June 15, 2016TIME:  08:00AM PDT, 11:00AM EDT, 3:00PM GMT Positron Emission Tomography (PET) is a 3-dimensional, quantitative imaging technology that has robust clinical trans...
    Speaker: Timothy DeGrado, PhD , Roger Schibli, PhD
    Sponsored By: Revvity
    32 1
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