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Metabolomics: An Evolving Approach to Cannabis Breeding

C.E. Credits: P.A.C.E. CE Florida CE
Speaker
  • Front Range Biosciences, Director of Process Development and Implementation
    Biography
      Caleb King directs analytical testing and phytochemical method development at Front Range Biosciences. Currently, Caleb works closely with a multi-disciplinary team working to understand the biogeochemistry and metabolomics of high-value crops. Caleb received his Master of Science in marine sciences from the University of North Carolina at Chapel Hill and his Bachelor of Science from the University of Mount Union. He has over 10 years of combined experience in paleoclimate research, environmental chemistry, veterinary medicine, and cannabis science. Caleb directed cannabis regulatory testing operations, scaled production testing capabilities, and developed numerous analytical chemistry methodologies while at Steep Hill Hawaii and Steep Hill Labs in Berkeley, California. Caleb enjoys wilderness hiking and shipwreck diving.

    Abstract

    Household produce varieties such as ‘Red Delicious,’ ‘Campari,’ and ‘Earlidew’ have been selectively bred and have been enhanced for flavor since the 1990’s because of small molecule profiling in conjunction with genomic and transcriptomic approaches. Metabolomics has also been utilized for selective breeding of Cannabis cultivars, but limited to a small number of cannabinoids, such as THC and CBD. Equally important are the over 500 natural compounds that have been identified in Cannabis, many of which are unknown or understudied. This situation results in a poor understanding of metabolic systems critical to the plant’s flowering, resistance to disease/pests, and nutrient uptake. The advancements in analytical instrumentation and statistical methods allow for high-throughput screening of Cannabis cultivars that will contain superior agronomic traits and augmented therapeutic potentials.

    Learning Objectives:
    1. Attendees will become familiar with analytical and statistical techniques commonly employed in metabolomics approaches.
    2. Viewers will learn about the interaction of biochemical pathways in Cannabis cultivars and the importance of these interactions for selective and rapid breeding.


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