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    Degraded dna

    Degraded DNA indicates a reduced quality of a DNA polymer. DNA can be degraded in many ways including direct damage to the bases, breaks between nucleotides, or fractures to the DNA backbone.

    Webinars

    • MAR 26, 2024 | 8:00 AM
      Improve WES library prep from low input and degraded FFPE samples
      Improve WES library prep from low input and degraded FFPE samples
      DNA fragmentation is a critical step in preparing DNA libraries for short read-based protocols. The two primary methods are mechanical shearing (using acoustic technology like Covaris) and e...
      Speaker: Nripesh Prasad, Ph.D. , Eugenio Daviso, Ph.D.
      Sponsored By: Covaris
      12
      OCT 13, 2021 | 10:00 AM
      Overcoming sequence artifacts to fuel clinically relevant NGS applications
      Overcoming sequence artifacts to fuel clinically relevant NGS...
      Date: October 13, 2021 Time: 10:00am (PDT), 01:00pm (EDT) Clinically-relevant applications, such as somatic variant detection, continue to push the bounds...
      Speaker: Zane Jaafar, Ph.D
      Sponsored By: Watchmaker Genomics
      27
      JUL 22, 2021 | 2:45 PM
      Targeted DNA integration without double-strand breaks using CRISPR RNA-guided transposons
      Targeted DNA integration without double-strand breaks using CRISPR...
      Learning Objectives: 1. CRISPR-Cas systems are naturally repurposes for non-canonical functions other than cleaving RNA and DNA 2. CRISPR RNA-guided transposases integrate donor DNA without...
      Speaker: Sam Sternberg, PhD
      Presented at: GenScript Gene & Cell Engineering Virtual Summit
      4
      MAY 05, 2021 | 7:30 AM
      Keynote Presentation: Forensic Genetic Genealogy, a Revolutionary New Tool for Solving Cold Cases
      Keynote Presentation: Forensic Genetic Genealogy, a Revolutionary...
      Genealogist have long supported the legal system through probate work, heir searching, and by identifying next-of-kin of servicemen. Even though DNA was first introduced to genealogists over...
      Speaker: Colleen Fitzpatrick, PhD
      Presented at: Forensic Sciences Virtual Event Series 2021
      3
      MAY 05, 2021 | 12:00 AM
      Leveraging Bioinformatic Resources to Better Tackle Challenging Biological Substrates and DNA Profiles
      Leveraging Bioinformatic Resources to Better Tackle Challenging...
      Short tandem repeats (STRs) are gold-standard genetic loci used for source attribution of evidentiary material in legal matters. Their power lies in their high heterozygosity and large allel...
      Speaker: Frank Wendt, PhD
      Presented at: Forensic Sciences Virtual Event Series 2021
      1
      SEP 10, 2020 | 10:00 AM
      Keynote Presentation: Squeezing out understanding from sequences: Genome to Phenome Connections in Viruses of Microbes
      Keynote Presentation: Squeezing out understanding from sequences:...
      Enigmatic and often vilified, viruses are now known to play important and possibly indispensable roles in the biology and ecology of cellular organisms. Evidence of viral impacts are everywh...
      Speaker: K. Eric Wommack
      Presented at: Microbiology Week Virtual Event Series 2020
      1
      SEP 10, 2020 | 7:30 AM
      Keynote Presentation: Discovery of a gene-microbiome interaction in lung cancer: lessons learned and future directions
      Keynote Presentation: Discovery of a gene-microbiome interaction...
      The selective pressure placed on the resident microbiota by local changes in the host environment – DNA damage, chronic inflammation, metabolic shifts, barrier damage, reduced immunosu...
      Speaker: K. Leigh Greathouse, PhD, MPH, MS, RD
      Presented at: Microbiology Week Virtual Event Series 2020
      3
      JUL 23, 2020 | 8:00 AM
      Characterizing Viruses: From deadly pathogens to the workhorses of gene therapy
      Characterizing Viruses: From deadly pathogens to the workhorses...
      DATE: July 23, 2020 TIME: 10:00am PT Human mesenchymal stromal or stem cells (MSCs)-based immunomodulation treatment has been proposed as a suitable therapeutic approach for many diseases, s...
      Speaker: Akash Bhattacharya, PhD
      Sponsored By: Beckman Coulter Life Sciences
      27 3
      JUL 02, 2020 | 12:45 PM
      Strategies to normalize miRNA expression in serum and plasma
      Strategies to normalize miRNA expression in serum and plasma
      MicroRNA(miRNA) are short non-coding single stranded RNA molecules that regulate gene expression at the post transcriptional level. They are known to play a critical role in multiple biologi...
      Speaker: Emily Zeringer , Harita Veereshlingam, PhD
      Presented at: APJ Virtual Genetic Solutions Tour 2020
      2
      MAY 07, 2020 | 7:00 AM
      A complete workflow for analysis of cfDNA: from plasma to variants
      A complete workflow for analysis of cfDNA: from plasma to variants
      DATE: May 7, 2020 TIME: 7:00am PT As cost of sequencing continues to drop, the throughput and complexity of NGS assays have risen precipitously. At the same time, the types of samples being...
      Speaker: Shilpa Parakh , Nicole Roseman
      Sponsored By: Beckman Coulter Life Sciences, IDT
      13 10
      MAY 06, 2020 | 1:00 PM
      Estimating the age of biological evidence recovered from a crime scene by assessing RNA degradation in the sample
      Estimating the age of biological evidence recovered from a crime...
      The forensic investigation of crime involves answering four basic questions: who, what, where, and when. Tools exist to answer questions of who, what and where, but the question when is ofte...
      Speaker: Robert W. Allen, PhD
      Presented at: Forensic Sciences Virtual Event Series 2020
      5
      MAY 06, 2020 | 12:00 AM
      Probabilistic genotyping and the power of modern DNA technology: A case study in overturning a wrongful conviction for murder in Texas
      Probabilistic genotyping and the power of modern DNA technology:...
      In late 2019, nearly a decade into a life sentence, Lydell Grant was released from a Texas prison after being convicted of a murder that he did not commit. The victim, Aaron Scheerhorn, was...
      Speaker: Angie Ambers, PhD
      Presented at: Forensic Sciences Virtual Event Series 2020
      3
      DEC 11, 2019 | 7:00 AM
      A Sensitive and Robust Plasmid Analysis Method by Capillary Electrophoresis with Laser-Induced Fluorescence Detection
      A Sensitive and Robust Plasmid Analysis Method by Capillary Electrophoresis...
      DATE: December 11, 2019TIME: 7:00am PST, 10:00am EST An important part of the biopharma industry, Plasmid DNA is used as a gene-delivery vehicle for DNA vaccination and as a key...
      Speaker: Colleen Reed
      Sponsored By: SCIEX
      7
      MAR 05, 2019 | 9:00 AM
      Strategies to normalize miRNA expression in serum and plasma.
      Strategies to normalize miRNA expression in serum and plasma.
      DATE:  March 5, 2019TIME:  09:00am PST, 12:00pm EST MicroRNA(miRNA) are short non-coding single stranded RNA molecules that regulate gene expression at the post tran...
      Speaker: Emily Zeringer , Harita Veereshlingam, PhD
      Sponsored By: Thermo Fisher Scientific - Applied Biosystems
      7
      OCT 11, 2018 | 9:00 AM
      Destabilization and Degradation of MYC: More Ways Than One
      Destabilization and Degradation of MYC: More Ways Than One
      The oncogenic transcription factor c-MYC (MYC) is deregulated, and often overexpressed, in more than 50% of cancers. MYC deregulation is associated with poor prognosis and aggressive disease,...
      Speaker: Jason De Melo, PhD
      Presented at: Cancer Research & Oncology Week Virtual Event Series 2018
      1
      MAY 10, 2018 | 6:00 AM
      C.E. CREDITS
      Multiplexed Precision Genome Editing with Trackable Genome-Integrated Barcodes in Yeast
      Multiplexed Precision Genome Editing with Trackable Genome-Integrated...
      Our understanding of how genotype controls phenotype is limited by the scale at which we can precisely alter the genome and assess the phenotypic consequences of each perturbation. In this pr...
      Speaker: Kevin Roy, PhD
      Presented at: Genetics and Genomics Virtual Event Series 2018
      1
      NOV 07, 2017 | 8:00 AM
      WEBINAR: The power of multiplexing and applications of the QuantiGene Plex Assay in oncology research and diagnostics
      WEBINAR: The power of multiplexing and applications of the QuantiGene...
      Cancer research diagnostic services in pathology laboratories worldwide have been negatively impacted by a lack of fresh-frozen tissue samples, the degradation of DNA and RNA in archival tiss...
      Speaker: Godfrey Grech, PhD
      Presented at: Protein and Cell Analysis Education Series
      Sponsored By: Thermo Fisher Scientific
      2 1
      MAY 10, 2017 | 7:30 AM
      C.E. CREDITS
      Enrichment of cffDNA and ctDNA via size selection for reduced diagnostic assay costs
      Enrichment of cffDNA and ctDNA via size selection for reduced...
      Cell free DNA (cfDNA) analysis for the purpose of diagnostics is currently practiced for non-invasive prenatal screening of cell free fetal DNA (cffDNA), and is anticipated to be leveraged fo...
      Speaker: Matthew Nesbitt, MSc
      Presented at: Genetics and Genomics Virtual Event Series 2017
      1
      MAY 10, 2017 | 6:00 AM
      C.E. CREDITS
      CATS - a novel library preparation method for ultrasensitive deep sequencing of extracellular circulating RNA and DNA
      CATS - a novel library preparation method for ultrasensitive deep...
      Massive parallel sequencing (MPS) technologies have paved the way into new areas of research including individualized medicine. However, sequencing of trace amounts of nucleic acids still rem...
      Speaker: Andrey Turchinovich, PhD
      Presented at: Genetics and Genomics Virtual Event Series 2017
      Sponsored By: Diagenode
      4
      JUN 22, 2016 | 9:00 AM
      Mapping nuclear-exosome targeted poly(A) tails with 3´-RNA seq
      Mapping nuclear-exosome targeted poly(A) tails with 3´-RNA seq
      DATE: June 22, 2016 TIME: 9am Pacific time, 12pm Eastern time, 6pm Central European time A large fraction of the RNA transcribed in eukaryotic cells is rapidly degraded in the nucleus. A ...
      Speaker: Kevin Roy, PhD
      Sponsored By: Lexogen, Lexogen
      10
    MAR 26, 2024 | 8:00 AM
    Improve WES library prep from low input and degraded FFPE samples
    Improve WES library prep from low input and degraded FFPE samples
    DNA fragmentation is a critical step in preparing DNA libraries for short read-based protocols. The two primary methods are mechanical shearing (using acoustic technology like Covaris) and e...
    Speaker: Nripesh Prasad, Ph.D. , Eugenio Daviso, Ph.D.
    Sponsored By: Covaris
    12
    OCT 13, 2021 | 10:00 AM
    Overcoming sequence artifacts to fuel clinically relevant NGS applications
    Overcoming sequence artifacts to fuel clinically relevant NGS...
    Date: October 13, 2021 Time: 10:00am (PDT), 01:00pm (EDT) Clinically-relevant applications, such as somatic variant detection, continue to push the bounds...
    Speaker: Zane Jaafar, Ph.D
    Sponsored By: Watchmaker Genomics
    27
    JUL 22, 2021 | 2:45 PM
    Targeted DNA integration without double-strand breaks using CRISPR RNA-guided transposons
    Targeted DNA integration without double-strand breaks using CRISPR...
    Learning Objectives: 1. CRISPR-Cas systems are naturally repurposes for non-canonical functions other than cleaving RNA and DNA 2. CRISPR RNA-guided transposases integrate donor DNA without...
    Speaker: Sam Sternberg, PhD
    Presented at: GenScript Gene & Cell Engineering Virtual Summit
    4
    MAY 05, 2021 | 7:30 AM
    Keynote Presentation: Forensic Genetic Genealogy, a Revolutionary New Tool for Solving Cold Cases
    Keynote Presentation: Forensic Genetic Genealogy, a Revolutionary...
    Genealogist have long supported the legal system through probate work, heir searching, and by identifying next-of-kin of servicemen. Even though DNA was first introduced to genealogists over...
    Speaker: Colleen Fitzpatrick, PhD
    Presented at: Forensic Sciences Virtual Event Series 2021
    3
    MAY 05, 2021 | 12:00 AM
    Leveraging Bioinformatic Resources to Better Tackle Challenging Biological Substrates and DNA Profiles
    Leveraging Bioinformatic Resources to Better Tackle Challenging...
    Short tandem repeats (STRs) are gold-standard genetic loci used for source attribution of evidentiary material in legal matters. Their power lies in their high heterozygosity and large allel...
    Speaker: Frank Wendt, PhD
    Presented at: Forensic Sciences Virtual Event Series 2021
    1
     
     
  • SEP 10, 2020 | 10:00 AM
    Keynote Presentation: Squeezing out understanding from sequences: Genome to Phenome Connections in Viruses of Microbes
    Keynote Presentation: Squeezing out understanding from sequences:...
    Enigmatic and often vilified, viruses are now known to play important and possibly indispensable roles in the biology and ecology of cellular organisms. Evidence of viral impacts are everywh...
    Speaker: K. Eric Wommack
    Presented at: Microbiology Week Virtual Event Series 2020
    1
    SEP 10, 2020 | 7:30 AM
    Keynote Presentation: Discovery of a gene-microbiome interaction in lung cancer: lessons learned and future directions
    Keynote Presentation: Discovery of a gene-microbiome interaction...
    The selective pressure placed on the resident microbiota by local changes in the host environment – DNA damage, chronic inflammation, metabolic shifts, barrier damage, reduced immunosu...
    Speaker: K. Leigh Greathouse, PhD, MPH, MS, RD
    Presented at: Microbiology Week Virtual Event Series 2020
    3
    JUL 23, 2020 | 8:00 AM
    Characterizing Viruses: From deadly pathogens to the workhorses of gene therapy
    Characterizing Viruses: From deadly pathogens to the workhorses...
    DATE: July 23, 2020 TIME: 10:00am PT Human mesenchymal stromal or stem cells (MSCs)-based immunomodulation treatment has been proposed as a suitable therapeutic approach for many diseases, s...
    Speaker: Akash Bhattacharya, PhD
    Sponsored By: Beckman Coulter Life Sciences
    27 3
    JUL 02, 2020 | 12:45 PM
    Strategies to normalize miRNA expression in serum and plasma
    Strategies to normalize miRNA expression in serum and plasma
    MicroRNA(miRNA) are short non-coding single stranded RNA molecules that regulate gene expression at the post transcriptional level. They are known to play a critical role in multiple biologi...
    Speaker: Emily Zeringer , Harita Veereshlingam, PhD
    Presented at: APJ Virtual Genetic Solutions Tour 2020
    2
    MAY 07, 2020 | 7:00 AM
    A complete workflow for analysis of cfDNA: from plasma to variants
    A complete workflow for analysis of cfDNA: from plasma to variants
    DATE: May 7, 2020 TIME: 7:00am PT As cost of sequencing continues to drop, the throughput and complexity of NGS assays have risen precipitously. At the same time, the types of samples being...
    Speaker: Shilpa Parakh , Nicole Roseman
    Sponsored By: Beckman Coulter Life Sciences, IDT
    13 10
     
     
  • MAY 06, 2020 | 1:00 PM
    Estimating the age of biological evidence recovered from a crime scene by assessing RNA degradation in the sample
    Estimating the age of biological evidence recovered from a crime...
    The forensic investigation of crime involves answering four basic questions: who, what, where, and when. Tools exist to answer questions of who, what and where, but the question when is ofte...
    Speaker: Robert W. Allen, PhD
    Presented at: Forensic Sciences Virtual Event Series 2020
    5
    MAY 06, 2020 | 12:00 AM
    Probabilistic genotyping and the power of modern DNA technology: A case study in overturning a wrongful conviction for murder in Texas
    Probabilistic genotyping and the power of modern DNA technology:...
    In late 2019, nearly a decade into a life sentence, Lydell Grant was released from a Texas prison after being convicted of a murder that he did not commit. The victim, Aaron Scheerhorn, was...
    Speaker: Angie Ambers, PhD
    Presented at: Forensic Sciences Virtual Event Series 2020
    3
    DEC 11, 2019 | 7:00 AM
    A Sensitive and Robust Plasmid Analysis Method by Capillary Electrophoresis with Laser-Induced Fluorescence Detection
    A Sensitive and Robust Plasmid Analysis Method by Capillary Electrophoresis...
    DATE: December 11, 2019TIME: 7:00am PST, 10:00am EST An important part of the biopharma industry, Plasmid DNA is used as a gene-delivery vehicle for DNA vaccination and as a key...
    Speaker: Colleen Reed
    Sponsored By: SCIEX
    7
    MAR 05, 2019 | 9:00 AM
    Strategies to normalize miRNA expression in serum and plasma.
    Strategies to normalize miRNA expression in serum and plasma.
    DATE:  March 5, 2019TIME:  09:00am PST, 12:00pm EST MicroRNA(miRNA) are short non-coding single stranded RNA molecules that regulate gene expression at the post tran...
    Speaker: Emily Zeringer , Harita Veereshlingam, PhD
    Sponsored By: Thermo Fisher Scientific - Applied Biosystems
    7
    OCT 11, 2018 | 9:00 AM
    Destabilization and Degradation of MYC: More Ways Than One
    Destabilization and Degradation of MYC: More Ways Than One
    The oncogenic transcription factor c-MYC (MYC) is deregulated, and often overexpressed, in more than 50% of cancers. MYC deregulation is associated with poor prognosis and aggressive disease,...
    Speaker: Jason De Melo, PhD
    Presented at: Cancer Research & Oncology Week Virtual Event Series 2018
    1
     
     
  • MAY 10, 2018 | 6:00 AM
    C.E. CREDITS
    Multiplexed Precision Genome Editing with Trackable Genome-Integrated Barcodes in Yeast
    Multiplexed Precision Genome Editing with Trackable Genome-Integrated...
    Our understanding of how genotype controls phenotype is limited by the scale at which we can precisely alter the genome and assess the phenotypic consequences of each perturbation. In this pr...
    Speaker: Kevin Roy, PhD
    Presented at: Genetics and Genomics Virtual Event Series 2018
    1
    NOV 07, 2017 | 8:00 AM
    WEBINAR: The power of multiplexing and applications of the QuantiGene Plex Assay in oncology research and diagnostics
    WEBINAR: The power of multiplexing and applications of the QuantiGene...
    Cancer research diagnostic services in pathology laboratories worldwide have been negatively impacted by a lack of fresh-frozen tissue samples, the degradation of DNA and RNA in archival tiss...
    Speaker: Godfrey Grech, PhD
    Presented at: Protein and Cell Analysis Education Series
    Sponsored By: Thermo Fisher Scientific
    2 1
    MAY 10, 2017 | 7:30 AM
    C.E. CREDITS
    Enrichment of cffDNA and ctDNA via size selection for reduced diagnostic assay costs
    Enrichment of cffDNA and ctDNA via size selection for reduced...
    Cell free DNA (cfDNA) analysis for the purpose of diagnostics is currently practiced for non-invasive prenatal screening of cell free fetal DNA (cffDNA), and is anticipated to be leveraged fo...
    Speaker: Matthew Nesbitt, MSc
    Presented at: Genetics and Genomics Virtual Event Series 2017
    1
    MAY 10, 2017 | 6:00 AM
    C.E. CREDITS
    CATS - a novel library preparation method for ultrasensitive deep sequencing of extracellular circulating RNA and DNA
    CATS - a novel library preparation method for ultrasensitive deep...
    Massive parallel sequencing (MPS) technologies have paved the way into new areas of research including individualized medicine. However, sequencing of trace amounts of nucleic acids still rem...
    Speaker: Andrey Turchinovich, PhD
    Presented at: Genetics and Genomics Virtual Event Series 2017
    Sponsored By: Diagenode
    4
    JUN 22, 2016 | 9:00 AM
    Mapping nuclear-exosome targeted poly(A) tails with 3´-RNA seq
    Mapping nuclear-exosome targeted poly(A) tails with 3´-RNA seq
    DATE: June 22, 2016 TIME: 9am Pacific time, 12pm Eastern time, 6pm Central European time A large fraction of the RNA transcribed in eukaryotic cells is rapidly degraded in the nucleus. A ...
    Speaker: Kevin Roy, PhD
    Sponsored By: Lexogen, Lexogen
    10
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