High throughput cell biology is the use of automation equipment with classical cell biology techniques to address biological questions that are otherwise unattainable using conventional methods. It may incorporate techniques from optics, chemistry, biology or image analysis to permit rapid, highly parallel research into how cells function, interact with each other and how pathogens exploit them in disease. High-throughput biology serves as one facet of what has also been called "omics research" - the interface between large scale biology (genome, proteome, transcriptome), technology and researchers. High throughput cell biology has a definite focus on the cell, and methods accessing the cell such as imaging, gene expression microarrays, or genome wide screening. The basic idea is to take methods normally performed on their own and do a very large number of them without impacting their quality.
CRISPR-based genome editing has accelerated biological research and holds great potential for studying and treating human diseases. The CRISPR-Cas9 system requires a Cas9 nuclease and a guid...
Genome editing with an expanded CRISPR-Cas tool set increases the opportunity to make intentional, targeted changes in the genome. Furthermore, improved specificity of genome editing and abi...
The adenosine analogue remdesivir has emerged as a front-line antiviral treatment for SARS-CoV-2, with preliminary evidence that it reduces the duration and severity of illness. Prior clinic...
Combinatorial inhibition of effector and feedback pathways is a promising treatment strategy for KRAS mutant cancers. However, the particular pathways that should be targeted to optimize the...
Suspension by day, imaging by night: how to efficiently manage your system and optimize utilization Presented By: Jared K. Burks, PhD Mass cytometry, be it suspension or imaging, opens the d...
Date: Time: Over the last couple of years, it has become apparent that affinity-tuned CAR T cells display enhanced expansion and prolonged persistence in patients and that this strategy can...
Learning Objectives: 1. Understand methods of isolating and enriching exosomes along with their pros/cons of the different techniques 2. What do we mean when we talk about subtyping, and wha...
Richard Hughes: New immunogenicity strategies to meet the needs of a developing pandemic Shortly after the COVID-19 pandemic began, the subject of serological testing for anti-viral antibodi...
There are an urgent need for antivirals to treat the newly emerged SARS-CoV-2. We set out to develop cell-based screens to repurpose existing drugs for use against SARS-CoV-2. Our goal was t...
Date: September 16, 2020 Time: 9:00am PTD, 12:00pm EDT Harnessing the power of the host immune system to treat diseases has been transformational in patient care. Physiologically relevant ce...
Microbial biofilms form on all aquatic surfaces and can harbor pathogenic bacteria. In the aquaculture industry, Flavobacteria species can cause serious diseases and lead to high mortality....
Human chromosome 19q13.4 contains genes encoding killer-cell immunoglobulin-like receptors (KIR). The region has certain properties such as single nucleotide variation, structural variation,...
The receptor binding domain (RBD) of the SARS-CoV-2 spike glycoprotein mediates viral attachment to ACE2 receptor, and is a major determinant of host range and a dominant target of neutraliz...
Background: Haemophilus influenzae is the causative agent of multiple human disease conditions among multiple sites in the human body. Underlying genetic mechanisms are elusive, particularly...
Date: September 4, 2020 Time: 8:00am (PTD), 11:00am (ETD) Direct detection of viral RNA in human or other animal cells by RNA in situ hybridization (ISH) is a powerful tool to establish the...
DATE: September 3, 2020 TIME: 09:00am PT, 12:00pm ET xxx Learning Objectives: xxx Webinars will be available for unlimited on-demand viewing after live event. LabRoots is approved as a provi...
DATE: September 2, 2020 TIME: 03:00pm PDT, 6:00pm EDT Spatial omics is an expanding collection of methods to examine biological molecules in their geographical context. By retaining the prec...
DATE: August 27, 2020 TIME: 7:00am PT Novel anti-viral medications, including biologics and small molecule inhibitors, as well as serologic diagnostic tool sets are in urgent demand to fight...
SARS-CoV-2 has created significant challenges for laboratories, requiring the development, validation, and scale up of testing in a very short time period--often this was done for multiple m...
Recent advances in super-resolution fluorescence microscopy based on single-molecule imaging have led to ~10 nm spatial resolution and exciting science. We are developing new approaches to a...
Unique physical, chemical, and optical phenomena arise when materials are confined to the nanoscale. We are accustomed to making observations for the behavior of living systems on a macrosco...
Over the last decade the cancer research field has seen a number of advances aimed at increasing the efficacy of treatments, reducing toxic side effects, and decreasing attrition rates of dr...
The use of three‐dimensional (3D) culture models is rapidly expanding due to their recognition as representing more structurally and physiologically relevant models of in vivo biology. 3D ce...
CRISPR-based genome editing has accelerated biological research and holds great potential for studying and treating human diseases. The CRISPR-Cas9 system requires a Cas9 nuclease and a guid...
Genome editing with an expanded CRISPR-Cas tool set increases the opportunity to make intentional, targeted changes in the genome. Furthermore, improved specificity of genome editing and abi...
The adenosine analogue remdesivir has emerged as a front-line antiviral treatment for SARS-CoV-2, with preliminary evidence that it reduces the duration and severity of illness. Prior clinic...
Combinatorial inhibition of effector and feedback pathways is a promising treatment strategy for KRAS mutant cancers. However, the particular pathways that should be targeted to optimize the...
Suspension by day, imaging by night: how to efficiently manage your system and optimize utilization Presented By: Jared K. Burks, PhD Mass cytometry, be it suspension or imaging, opens the d...
Date: Time: Over the last couple of years, it has become apparent that affinity-tuned CAR T cells display enhanced expansion and prolonged persistence in patients and that this strategy can...
Learning Objectives: 1. Understand methods of isolating and enriching exosomes along with their pros/cons of the different techniques 2. What do we mean when we talk about subtyping, and wha...
Richard Hughes: New immunogenicity strategies to meet the needs of a developing pandemic Shortly after the COVID-19 pandemic began, the subject of serological testing for anti-viral antibodi...
There are an urgent need for antivirals to treat the newly emerged SARS-CoV-2. We set out to develop cell-based screens to repurpose existing drugs for use against SARS-CoV-2. Our goal was t...
Date: September 16, 2020 Time: 9:00am PTD, 12:00pm EDT Harnessing the power of the host immune system to treat diseases has been transformational in patient care. Physiologically relevant ce...
Microbial biofilms form on all aquatic surfaces and can harbor pathogenic bacteria. In the aquaculture industry, Flavobacteria species can cause serious diseases and lead to high mortality....
Human chromosome 19q13.4 contains genes encoding killer-cell immunoglobulin-like receptors (KIR). The region has certain properties such as single nucleotide variation, structural variation,...
The receptor binding domain (RBD) of the SARS-CoV-2 spike glycoprotein mediates viral attachment to ACE2 receptor, and is a major determinant of host range and a dominant target of neutraliz...
Background: Haemophilus influenzae is the causative agent of multiple human disease conditions among multiple sites in the human body. Underlying genetic mechanisms are elusive, particularly...
Date: September 4, 2020 Time: 8:00am (PTD), 11:00am (ETD) Direct detection of viral RNA in human or other animal cells by RNA in situ hybridization (ISH) is a powerful tool to establish the...
DATE: September 3, 2020 TIME: 09:00am PT, 12:00pm ET xxx Learning Objectives: xxx Webinars will be available for unlimited on-demand viewing after live event. LabRoots is approved as a provi...
DATE: September 2, 2020 TIME: 03:00pm PDT, 6:00pm EDT Spatial omics is an expanding collection of methods to examine biological molecules in their geographical context. By retaining the prec...
DATE: August 27, 2020 TIME: 7:00am PT Novel anti-viral medications, including biologics and small molecule inhibitors, as well as serologic diagnostic tool sets are in urgent demand to fight...
SARS-CoV-2 has created significant challenges for laboratories, requiring the development, validation, and scale up of testing in a very short time period--often this was done for multiple m...
Recent advances in super-resolution fluorescence microscopy based on single-molecule imaging have led to ~10 nm spatial resolution and exciting science. We are developing new approaches to a...
Unique physical, chemical, and optical phenomena arise when materials are confined to the nanoscale. We are accustomed to making observations for the behavior of living systems on a macrosco...
Over the last decade the cancer research field has seen a number of advances aimed at increasing the efficacy of treatments, reducing toxic side effects, and decreasing attrition rates of dr...
The use of three‐dimensional (3D) culture models is rapidly expanding due to their recognition as representing more structurally and physiologically relevant models of in vivo biology. 3D ce...
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