Human health and disease refers to understanding what contributes to human health (the staste of mental, social, and physical being) and what factors may deter health (such as disease, infection, etc.)
Among many surprising insights, the genomic revolution has helped us to realize that we're never alone and, in fact, barely human. For most of our lives, we share our bodies with some ten ti...
Date: June 16, 2015Time: 8:00AM Pacific time, 11:00AM Eastern TimeGroup 2 innate lymphoid cells (ILC2s) are recently described innate immune cells that contribute to type 2 inflammation, tiss...
Asthma is heritable, influenced by the environment, and is modified by in utero exposures and aging; all of these features are also common to epigenetic regulation. Furthermore, genetic varia...
I will discuss the use of genomic technologies - mostly ultrahigh-throughput DNA sequencing - to study normal human biology and to determine what goes wrong when we have disease. First I wil...
There is tremendous sexual dimorphism in human genetic disease susceptibility, progression, and drug response. It is thus alarming that most genome-wide association studies exclude the most s...
Genome Wide Association Studies (GWAS) and eQTL analyses are producing huge numbers of associations and show no signs of slowing. There are now more than 8,500 SNPs associated with more than...
Advanced sequencing technologies have made population scale whole genome sequencing a possibility. However, current strategies for analysis of this data rely upon parallelization approaches t...
Every major scientific and technological revolution in history has been driven by one thing: access to data. Today, the availability of Big Data from a wide variety of sources is transforming...
Cancers exhibit abnormal molecular signatures associated with disease initiation and progression. Molecular signatures could improve cancer screening, detection, drug development and selectio...
The NIH BRAIN initiative, informed by the report from the scientific community (BRAIN 2025) is underway. The major funded efforts at this time fit into 3 main categories; 1) defining the comp...
Since the discovery and maturing of in vitro techniques that characterized neurotransmitter receptor systems in animal and human brain and subsequent development of in vitro and in vivo autor...
Impulsivity can be defined as the tendency to act prematurely without foresight. Behavioural and neurobiological analysis of this construct, based on evidence from both animal and human studi...
Recent advances in noninvasive neuroimaging have set the stage for the systematic exploration of human brain circuits in health and disease. The Human Connectome Project (HCP) is systematical...
The hippocampal formation is one of the most extensively studied regions of the brain, with well described anatomy and basic physiology; moreover, aspects of human memory mediated by hippocam...
Single-cell analysis is one of the most rapidly growing fields in biomedical research that is significantly expanding our understanding on the biologic characteristics of various diseases. F...
The era of omics has ushered in the hope for personalized medicine. Proteomic and genomic strategies that allow unbiased identification of genes and proteins and their post-transcriptional a...
Obesity is associated with an aggressive subtype of breast cancer called basal-like breast cancer (BBC). Using C3(1)-TAg mice, a genetically engineered mouse model that resembles human BBC, w...
The comprehensive, multidimensional molecular characterization of tumors and the individuals in which they have developed is transforming cancer definition, diagnosis, treatment, and preventi...
The effective implementation of personalised cancer therapeutic regimens depends on the successful identification and translation of informative biomarkers to aid clinical decision-making. An...
The ever-quickening pace of breathtaking advances in our understanding of disease biology has implicitly promised a profusion of drugs that will dramatically improve human health and well-bei...
The ever-quickening pace of breathtaking advances in our understanding of disease biology has implicitly promised a profusion of drugs that will dramatically improve human health and well-bei...
When whole genome and whole exome sequencing are introduced into health care, and offered directly to consumers in commercial settings, the landscape of genetic testing will drastically chang...
The comprehensive, multidimensional molecular characterization of tumors and the individuals in which they have developed is transforming cancer definition, diagnosis, treatment, and preventi...
Medical applications of genetics and genomics have been advancing dramatically since completion of the sequencing of the human genome. The cost of DNA sequencing has plummeted, leading to the...
Among many surprising insights, the genomic revolution has helped us to realize that we're never alone and, in fact, barely human. For most of our lives, we share our bodies with some ten ti...
Date: June 16, 2015Time: 8:00AM Pacific time, 11:00AM Eastern TimeGroup 2 innate lymphoid cells (ILC2s) are recently described innate immune cells that contribute to type 2 inflammation, tiss...
Asthma is heritable, influenced by the environment, and is modified by in utero exposures and aging; all of these features are also common to epigenetic regulation. Furthermore, genetic varia...
I will discuss the use of genomic technologies - mostly ultrahigh-throughput DNA sequencing - to study normal human biology and to determine what goes wrong when we have disease. First I wil...
There is tremendous sexual dimorphism in human genetic disease susceptibility, progression, and drug response. It is thus alarming that most genome-wide association studies exclude the most s...
Genome Wide Association Studies (GWAS) and eQTL analyses are producing huge numbers of associations and show no signs of slowing. There are now more than 8,500 SNPs associated with more than...
Advanced sequencing technologies have made population scale whole genome sequencing a possibility. However, current strategies for analysis of this data rely upon parallelization approaches t...
Every major scientific and technological revolution in history has been driven by one thing: access to data. Today, the availability of Big Data from a wide variety of sources is transforming...
Cancers exhibit abnormal molecular signatures associated with disease initiation and progression. Molecular signatures could improve cancer screening, detection, drug development and selectio...
The NIH BRAIN initiative, informed by the report from the scientific community (BRAIN 2025) is underway. The major funded efforts at this time fit into 3 main categories; 1) defining the comp...
Since the discovery and maturing of in vitro techniques that characterized neurotransmitter receptor systems in animal and human brain and subsequent development of in vitro and in vivo autor...
Impulsivity can be defined as the tendency to act prematurely without foresight. Behavioural and neurobiological analysis of this construct, based on evidence from both animal and human studi...
Recent advances in noninvasive neuroimaging have set the stage for the systematic exploration of human brain circuits in health and disease. The Human Connectome Project (HCP) is systematical...
The hippocampal formation is one of the most extensively studied regions of the brain, with well described anatomy and basic physiology; moreover, aspects of human memory mediated by hippocam...
Single-cell analysis is one of the most rapidly growing fields in biomedical research that is significantly expanding our understanding on the biologic characteristics of various diseases. F...
The era of omics has ushered in the hope for personalized medicine. Proteomic and genomic strategies that allow unbiased identification of genes and proteins and their post-transcriptional a...
Obesity is associated with an aggressive subtype of breast cancer called basal-like breast cancer (BBC). Using C3(1)-TAg mice, a genetically engineered mouse model that resembles human BBC, w...
The comprehensive, multidimensional molecular characterization of tumors and the individuals in which they have developed is transforming cancer definition, diagnosis, treatment, and preventi...
The effective implementation of personalised cancer therapeutic regimens depends on the successful identification and translation of informative biomarkers to aid clinical decision-making. An...
The ever-quickening pace of breathtaking advances in our understanding of disease biology has implicitly promised a profusion of drugs that will dramatically improve human health and well-bei...
The ever-quickening pace of breathtaking advances in our understanding of disease biology has implicitly promised a profusion of drugs that will dramatically improve human health and well-bei...
When whole genome and whole exome sequencing are introduced into health care, and offered directly to consumers in commercial settings, the landscape of genetic testing will drastically chang...
The comprehensive, multidimensional molecular characterization of tumors and the individuals in which they have developed is transforming cancer definition, diagnosis, treatment, and preventi...
Medical applications of genetics and genomics have been advancing dramatically since completion of the sequencing of the human genome. The cost of DNA sequencing has plummeted, leading to the...
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