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    T cell repertoire

    T cell receptors (TCRs) are proteins on the surface of T cells which recognize foreign antigen attached to major histocompatibility complex (MHC) molecules and initiating a immune response. TCRs undergo genetic rearrangements allowing each to recognize a single antigen and the unique genetic combinations are called the T cell repertoire. The more unique TCRs present in a system, the more robust the immune potential.

    Webinars

    • OCT 13, 2021 | 11:55 PM
      Low-Dose mRNA-1273 COVID-19 Vaccine Generates Durable Memory Enhanced by Cross-reactive T Cells
      Low-Dose mRNA-1273 COVID-19 Vaccine Generates Durable Memory Enhanced...
      Vaccination and infection are two different paths to immunity. Understanding human immune responses to SARS-CoV-2 RNA vaccines is of interest for a panoply of reasons. mRNA vaccines have dem...
      Speaker: Daniela Weiskopf, PhD
      Presented at: Coronavirus Series
      1
      OCT 07, 2021 | 11:55 PM
      Neoantigen Vaccines for Personalized Immunotherapy
      Neoantigen Vaccines for Personalized Immunotherapy
      Summary: Cancer neoantigens are highly specific to the tumor, potently immunogenic and can be targeted by both vaccines and engineered cellular therapies. This talk will introduce the defini...
      Speaker: Yan Asmann, PhD
      Presented at: Cancer Research & Oncology Week Virtual Event Series 2021
      1
      SEP 09, 2021 | 12:00 AM
      RNA Viruses Reshape the RNA Modification Landscape in the Cell
      RNA Viruses Reshape the RNA Modification Landscape in the Cell
      Ribonucleic acid (RNA) has a breathtaking variety of biological functions, which far exceeds its classical role as a carrier of genetic information. The repertoire of this versatile molecule...
      Speaker: Cara T. Pager, PhD
      Presented at: Microbiology Week Virtual Event Series 2021
      1
      JUN 02, 2021 | 3:00 PM
      Functional Evaluation of Unique Anti-PDL1 Antibodies Generated through Single Plasma B Cell Cloning on the Beacon® Platform Versus a Standard Hybridoma Approach
      Functional Evaluation of Unique Anti-PDL1 Antibodies Generated...
      PD-L1 is a key inhibitor of T cell activation that is often over-expressed in cancer to escape immune surveillance and promote tumor progression. Blocking antibodies against PD-L1 or its rec...
      Speaker: Neha Yevalekar
      Presented at: Immuno-Oncology Virtual Event Series 2021
      Sponsored By: ChemPartner
      2
      SEP 17, 2020 | 4:30 PM
      COVID-19 T-Cell Data: Mapping Out SARS-CoV-2 Antigen & T-Cell Repertoires
      COVID-19 T-Cell Data: Mapping Out SARS-CoV-2 Antigen & T-Cell...
      T cells are the adaptive immune system’s first responders to any virus, circulating in the blood to detect and quickly multiply to attack the virus, and also support the development of...
      Speaker: Sean Nolan , Patrick Raber, PhD , Thomas Snyder, PhD
      Presented at: Coronavirus Series
      Sponsored By: Adaptive Biotechnologies
      6
      SEP 09, 2020 | 12:00 AM
      Leveraging SMRT sequencing to resolve complex immune loci
      Leveraging SMRT sequencing to resolve complex immune loci
      The regions of our genome responsible for encoding the genes that regulate our immune response are some of the most complex and polymorphic known. This complexity encompasses multiple types...
      Speaker: Melissa L. Smith, PhD
      Presented at: Microbiology Week Virtual Event Series 2020
      1
      MAY 14, 2020 | 7:05 PM
      Haemato-Oncology Applications of BCR Immune Repertoire Sequencing
      Haemato-Oncology Applications of BCR Immune Repertoire Sequencing
      B-cell lymphomas and leukemias originate from the malignant transformation and proliferation of one or a small number of B cells. Since each B-cell expresses distinct B-cell receptors (BCRs)...
      Speaker: Timothy Looney, PhD
      Presented at: OncomineWorld 2022: A Virtual NGS Education Meeting
      8
      MAY 14, 2020 | 7:05 PM
      Haemato-Oncology Applications of BCR Immune Repertoire Sequencing
      Haemato-Oncology Applications of BCR Immune Repertoire Sequencing
      B-cell lymphomas and leukemias originate from the malignant transformation and proliferation of one or a small number of B cells. Since each B-cell expresses distinct B-cell receptors (BCRs)...
      Speaker: Timothy Looney, PhD
      Presented at: OncomineWorld Autumn: A virtual NGS education meeting
      1
      APR 23, 2020 | 6:00 AM
      Latest Applications of PacBio Sequencing for Clinical Research
      Latest Applications of PacBio Sequencing for Clinical Research
      Resolving the genetics of underlying Mendelian diseases as well as host immune responses to infectious diseases is an important prerequisite for understanding their biology and for ultimate...
      Speaker: Jonas Korlach, PhD
      Presented at: Genetics Week Virtual Event Series 2020
      Sponsored By: PacBio
      1
      SEP 10, 2019 | 8:00 AM
      Next Generation Sequencing of the Immune System: From Single Cell to Bulk RNA
      Next Generation Sequencing of the Immune System: From Single Cell...
      DATE: September 10, 2019TIME: 8:00am PTNext generation sequencing of the immune repertoire allows detailed, sequence-specific insight into the immune system’s adaptive response...
      Speaker: Miranda Byrne-Steele, Ph.D.
      Sponsored By: Beckman Coulter Life Sciences
      8 1
      MAY 21, 2019 | 7:00 AM
      Genome-wide CRISPR Screens in Primary Human T Cells Reveal Key Regulators of Immune Function
      Genome-wide CRISPR Screens in Primary Human T Cells Reveal Key...
      DATE: May 21, 2019TIMEL 7:00am PT, 10:00am ET Human T cells are central effectors of immunity and cancer immunotherapy. CRISPR-based functional studies in T cells could prioriti...
      Speaker: Eric Shifrut, PhD
      Sponsored By: Thermo Fisher Scientific
      10 1
      NOV 01, 2018 | 12:00 AM
      Glycosylation and stabilization of programmed death ligand-1 suppresses T-cell activity
      Glycosylation and stabilization of programmed death ligand-1 suppresses...
      The success of immune checkpoint blockade adds a new therapeutic category to the cancer therapy repertoire. Despite efforts made on cancer cell and immune cell interaction, how cancer cells i...
      Speaker: Chia-Wei Li, PhD
      Presented at: Dimension of Time: From Culture to Assay
      1
      OCT 10, 2018 | 6:00 AM
      Precise Detection of T-Cell Receptors Using RNAseq With Unique Molecular Indexing
      Precise Detection of T-Cell Receptors Using RNAseq With Unique...
      Understanding the immune repertoire is an important aspect of immuno-oncology research, which can be used to gather insights into the function and overall status of the immune system. We have...
      Speaker: Samuel Rulli, PhD
      Presented at: Cancer Research & Oncology Week Virtual Event Series 2018
      Sponsored By: QIAGEN
      1
      SEP 12, 2018 | 8:00 AM
      Advancing precision immunotherapy through next generation sequencing of T-cell receptors: Part II
      Advancing precision immunotherapy through next generation sequencing...
      DATE:  September 12, 2018 TIME:  08:00am PDT, 11:00am EDT In the last presentation of this webinar series, we will continue our discussions on recent advancements i...
      Speaker: Timothy Looney, PhD
      Sponsored By: Thermo Fisher Scientific - Ion Torrent
      9
      AUG 16, 2018 | 8:00 AM
      Advancing precision immunotherapy through next-generation sequencing of T cell receptors: Part I
      Advancing precision immunotherapy through next-generation sequencing...
      DATE: August, 16, 2018TIME: 08:00AM PDTThis webinar will review recent advancements in the application of next-generation sequencing of T cell receptor beta (TCRB) chain repertoires towards...
      Speaker: Timothy Looney, PhD
      Sponsored By: Thermo Fisher Scientific - Ion Torrent
      7
      SEP 27, 2017 | 12:00 PM
      Enhancing Checkpoint Blockade in Lymphoma with In Situ Vaccination
      Enhancing Checkpoint Blockade in Lymphoma with In Situ Vaccination
      Checkpoint blockade therapy for cancer has had tremendous impact on clinical outcomes, yet only a subset of patients respond. Recent studies show that response to checkpoint blockade does not...
      Speaker: Joshua Brody, MD
      Presented at: Cell Biology Virtual Event Series 2017
      2
      SEP 07, 2017 | 9:00 AM
      WEBINAR: Glycosylation and stabilization of programmed death ligand-1 suppresses T-cell activity
      WEBINAR: Glycosylation and stabilization of programmed death ligand-1...
      DATE: September 7, 2017TIME: 9:00AM PT, 12:00PM ETThe success of immune checkpoint blockade adds a new therapeutic category to the cancer therapy repertoire. Despite efforts made on can...
      Speaker: Chia-Wei Li, PhD
      Sponsored By: Essen BioScience
      5
      APR 11, 2017 | 8:00 AM
      WEBINAR: Enhancing Checkpoint Blockade in Lymphoma with In Situ Vaccination
      WEBINAR: Enhancing Checkpoint Blockade in Lymphoma with In Situ...
      DATE: April 11, 2017TIME: 8:00 AM PT, 11:00 AM ET Checkpoint blockade therapy for cancer has had tremendous impact on clinical outcomes, yet only a subset of patients respond....
      Speaker: Joshua Brody, MD , Michelle Poulin, PhD
      Sponsored By: Standard BioTools
      7 1
      MAY 14, 2015 | 7:30 AM
      Keynote: Using genomics to understand human health and disease
      Keynote: Using genomics to understand human health and disease
      I will discuss the use of genomic technologies - mostly ultrahigh-throughput DNA sequencing - to study normal human biology and to determine what goes wrong when we have disease. First I wil...
      Speaker: Richard Myers, PhD
      Presented at: Genetics and Genomics Virtual Event Series 2015
      6
    OCT 13, 2021 | 11:55 PM
    Low-Dose mRNA-1273 COVID-19 Vaccine Generates Durable Memory Enhanced by Cross-reactive T Cells
    Low-Dose mRNA-1273 COVID-19 Vaccine Generates Durable Memory Enhanced...
    Vaccination and infection are two different paths to immunity. Understanding human immune responses to SARS-CoV-2 RNA vaccines is of interest for a panoply of reasons. mRNA vaccines have dem...
    Speaker: Daniela Weiskopf, PhD
    Presented at: Coronavirus Series
    1
    OCT 07, 2021 | 11:55 PM
    Neoantigen Vaccines for Personalized Immunotherapy
    Neoantigen Vaccines for Personalized Immunotherapy
    Summary: Cancer neoantigens are highly specific to the tumor, potently immunogenic and can be targeted by both vaccines and engineered cellular therapies. This talk will introduce the defini...
    Speaker: Yan Asmann, PhD
    Presented at: Cancer Research & Oncology Week Virtual Event Series 2021
    1
    SEP 09, 2021 | 12:00 AM
    RNA Viruses Reshape the RNA Modification Landscape in the Cell
    RNA Viruses Reshape the RNA Modification Landscape in the Cell
    Ribonucleic acid (RNA) has a breathtaking variety of biological functions, which far exceeds its classical role as a carrier of genetic information. The repertoire of this versatile molecule...
    Speaker: Cara T. Pager, PhD
    Presented at: Microbiology Week Virtual Event Series 2021
    1
    JUN 02, 2021 | 3:00 PM
    Functional Evaluation of Unique Anti-PDL1 Antibodies Generated through Single Plasma B Cell Cloning on the Beacon® Platform Versus a Standard Hybridoma Approach
    Functional Evaluation of Unique Anti-PDL1 Antibodies Generated...
    PD-L1 is a key inhibitor of T cell activation that is often over-expressed in cancer to escape immune surveillance and promote tumor progression. Blocking antibodies against PD-L1 or its rec...
    Speaker: Neha Yevalekar
    Presented at: Immuno-Oncology Virtual Event Series 2021
    Sponsored By: ChemPartner
    2
    SEP 17, 2020 | 4:30 PM
    COVID-19 T-Cell Data: Mapping Out SARS-CoV-2 Antigen & T-Cell Repertoires
    COVID-19 T-Cell Data: Mapping Out SARS-CoV-2 Antigen & T-Cell...
    T cells are the adaptive immune system’s first responders to any virus, circulating in the blood to detect and quickly multiply to attack the virus, and also support the development of...
    Speaker: Sean Nolan , Patrick Raber, PhD , Thomas Snyder, PhD
    Presented at: Coronavirus Series
    Sponsored By: Adaptive Biotechnologies
    6
     
     
  • SEP 09, 2020 | 12:00 AM
    Leveraging SMRT sequencing to resolve complex immune loci
    Leveraging SMRT sequencing to resolve complex immune loci
    The regions of our genome responsible for encoding the genes that regulate our immune response are some of the most complex and polymorphic known. This complexity encompasses multiple types...
    Speaker: Melissa L. Smith, PhD
    Presented at: Microbiology Week Virtual Event Series 2020
    1
    MAY 14, 2020 | 7:05 PM
    Haemato-Oncology Applications of BCR Immune Repertoire Sequencing
    Haemato-Oncology Applications of BCR Immune Repertoire Sequencing
    B-cell lymphomas and leukemias originate from the malignant transformation and proliferation of one or a small number of B cells. Since each B-cell expresses distinct B-cell receptors (BCRs)...
    Speaker: Timothy Looney, PhD
    Presented at: OncomineWorld 2022: A Virtual NGS Education Meeting
    8
    MAY 14, 2020 | 7:05 PM
    Haemato-Oncology Applications of BCR Immune Repertoire Sequencing
    Haemato-Oncology Applications of BCR Immune Repertoire Sequencing
    B-cell lymphomas and leukemias originate from the malignant transformation and proliferation of one or a small number of B cells. Since each B-cell expresses distinct B-cell receptors (BCRs)...
    Speaker: Timothy Looney, PhD
    Presented at: OncomineWorld Autumn: A virtual NGS education meeting
    1
    APR 23, 2020 | 6:00 AM
    Latest Applications of PacBio Sequencing for Clinical Research
    Latest Applications of PacBio Sequencing for Clinical Research
    Resolving the genetics of underlying Mendelian diseases as well as host immune responses to infectious diseases is an important prerequisite for understanding their biology and for ultimate...
    Speaker: Jonas Korlach, PhD
    Presented at: Genetics Week Virtual Event Series 2020
    Sponsored By: PacBio
    1
    SEP 10, 2019 | 8:00 AM
    Next Generation Sequencing of the Immune System: From Single Cell to Bulk RNA
    Next Generation Sequencing of the Immune System: From Single Cell...
    DATE: September 10, 2019TIME: 8:00am PTNext generation sequencing of the immune repertoire allows detailed, sequence-specific insight into the immune system’s adaptive response...
    Speaker: Miranda Byrne-Steele, Ph.D.
    Sponsored By: Beckman Coulter Life Sciences
    8 1
     
     
  • MAY 21, 2019 | 7:00 AM
    Genome-wide CRISPR Screens in Primary Human T Cells Reveal Key Regulators of Immune Function
    Genome-wide CRISPR Screens in Primary Human T Cells Reveal Key...
    DATE: May 21, 2019TIMEL 7:00am PT, 10:00am ET Human T cells are central effectors of immunity and cancer immunotherapy. CRISPR-based functional studies in T cells could prioriti...
    Speaker: Eric Shifrut, PhD
    Sponsored By: Thermo Fisher Scientific
    10 1
    NOV 01, 2018 | 12:00 AM
    Glycosylation and stabilization of programmed death ligand-1 suppresses T-cell activity
    Glycosylation and stabilization of programmed death ligand-1 suppresses...
    The success of immune checkpoint blockade adds a new therapeutic category to the cancer therapy repertoire. Despite efforts made on cancer cell and immune cell interaction, how cancer cells i...
    Speaker: Chia-Wei Li, PhD
    Presented at: Dimension of Time: From Culture to Assay
    1
    OCT 10, 2018 | 6:00 AM
    Precise Detection of T-Cell Receptors Using RNAseq With Unique Molecular Indexing
    Precise Detection of T-Cell Receptors Using RNAseq With Unique...
    Understanding the immune repertoire is an important aspect of immuno-oncology research, which can be used to gather insights into the function and overall status of the immune system. We have...
    Speaker: Samuel Rulli, PhD
    Presented at: Cancer Research & Oncology Week Virtual Event Series 2018
    Sponsored By: QIAGEN
    1
    SEP 12, 2018 | 8:00 AM
    Advancing precision immunotherapy through next generation sequencing of T-cell receptors: Part II
    Advancing precision immunotherapy through next generation sequencing...
    DATE:  September 12, 2018 TIME:  08:00am PDT, 11:00am EDT In the last presentation of this webinar series, we will continue our discussions on recent advancements i...
    Speaker: Timothy Looney, PhD
    Sponsored By: Thermo Fisher Scientific - Ion Torrent
    9
    AUG 16, 2018 | 8:00 AM
    Advancing precision immunotherapy through next-generation sequencing of T cell receptors: Part I
    Advancing precision immunotherapy through next-generation sequencing...
    DATE: August, 16, 2018TIME: 08:00AM PDTThis webinar will review recent advancements in the application of next-generation sequencing of T cell receptor beta (TCRB) chain repertoires towards...
    Speaker: Timothy Looney, PhD
    Sponsored By: Thermo Fisher Scientific - Ion Torrent
    7
     
     
  • SEP 27, 2017 | 12:00 PM
    Enhancing Checkpoint Blockade in Lymphoma with In Situ Vaccination
    Enhancing Checkpoint Blockade in Lymphoma with In Situ Vaccination
    Checkpoint blockade therapy for cancer has had tremendous impact on clinical outcomes, yet only a subset of patients respond. Recent studies show that response to checkpoint blockade does not...
    Speaker: Joshua Brody, MD
    Presented at: Cell Biology Virtual Event Series 2017
    2
    SEP 07, 2017 | 9:00 AM
    WEBINAR: Glycosylation and stabilization of programmed death ligand-1 suppresses T-cell activity
    WEBINAR: Glycosylation and stabilization of programmed death ligand-1...
    DATE: September 7, 2017TIME: 9:00AM PT, 12:00PM ETThe success of immune checkpoint blockade adds a new therapeutic category to the cancer therapy repertoire. Despite efforts made on can...
    Speaker: Chia-Wei Li, PhD
    Sponsored By: Essen BioScience
    5
    APR 11, 2017 | 8:00 AM
    WEBINAR: Enhancing Checkpoint Blockade in Lymphoma with In Situ Vaccination
    WEBINAR: Enhancing Checkpoint Blockade in Lymphoma with In Situ...
    DATE: April 11, 2017TIME: 8:00 AM PT, 11:00 AM ET Checkpoint blockade therapy for cancer has had tremendous impact on clinical outcomes, yet only a subset of patients respond....
    Speaker: Joshua Brody, MD , Michelle Poulin, PhD
    Sponsored By: Standard BioTools
    7 1
    MAY 14, 2015 | 7:30 AM
    Keynote: Using genomics to understand human health and disease
    Keynote: Using genomics to understand human health and disease
    I will discuss the use of genomic technologies - mostly ultrahigh-throughput DNA sequencing - to study normal human biology and to determine what goes wrong when we have disease. First I wil...
    Speaker: Richard Myers, PhD
    Presented at: Genetics and Genomics Virtual Event Series 2015
    6
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