Transgenic is a term that describes an organism containing genes from another organism put into its genome through recombinant DNA techniques. An example of its usage is the term transgenic organism. A transgenic organism is one that contains a gene or genes which have been artificially inserted instead of the organism acquiring them through reproduction. A transgenic animal, for instance, would be an animal that underwent genetic engineering. It often contains material from at least one unrelated organism, e.g. from a virus, a plant, or from another animal. The process of introducing an exogenous gene is called transgenesis. One of its essential applications is for experimental research processes. Animal models are being created to introduce a particular disease for experimental studies. These models are referred to as transgenic disease models. Experimental mouse model, particularly referred to as transgenic mouse, is a mouse with a piece of foreign lincor DNA integrated into its genome through recombinant DNA techniques.
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Organoids are three-dimensional (3D) multi-cellular, microtissues derived from stem cells that closely mimic the complex structure and functionality of human organs. They offer more accurate...
To bring your cutting-edge cell and gene therapies to the patients that need them as quickly as possible, you need access to the most knowledgeable scientists, innovative technologies, metho...
Organoids are three-dimensional (3D) multi-cellular, microtissues derived from stem cells that closely mimic the complex structure and functionality of human organs. They offer more accurate...
Register to learn more about how to rapidly and reproducibly drive your developmental efforts forward by leveraging MaxCyte’s flow electroporation technology. Labs adopt this scalable...
Inefficient knock-in of transgene cargos limits the potential of cell-based medicines. In this study, we used a CRISPR nuclease that targets a site within an exon of an essential gene and de...
The use of adeno-associated viruses (AAV) as gene delivery vectors has vast potential for the treatment of many severe human diseases. A small group of intensively studied AAV capsids have b...
Chimeric antigen receptor (CAR)-reprogrammed immune cells offer exciting therapeutic potential for addressing oncology, autoimmune diseases, transplant medicine, and infections. However, cur...
Date: April 11, 2023 Time: 8:00am (PDT), 11:00am (EDT), 5:00pm (CEST) Duchenne muscular dystrophy is caused by mutations in the dystrophin encoding DMD gene that disrupt the reading frame. M...
Date: March 30, 2023 Time: 5:00pm (PST), 8:00pm (EST) March 31, 2023 9:00am (JST) Chimeric antigen receptor T cell (CAR-T) therapy is still challenging in targeting solid malignancies. The q...
Preclinical research and development are the cornerstone of modern drug discovery. A variety of biological systems including in vitro, 3D cultures, and organoids are essential tools, with ul...
Date: March 08, 2023 Time: 9:00am (PST), 12:00pm (EST), 6:00pm (CET) An unbiased characterization of the human microbiome is crucial to a more complete understanding of microbial effect on h...
Animal models present a unique opportunity to understand molecular mechanisms of pathological changes involved in cognitive dysfunction in neurological disorders. However, most of the work f...
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