Get closer to in vivo predictions with Gibco cell culture systems. Our systems allow you to closely mimic the in vivo state and generate more physiologically relevant data. Each lot of primary cells is performance tested for viability and growth potential.
As a startup, Illumina aspired to transform human health. Our initial products enabled researchers to explore DNA at an entirely new scale, helping them create the first map of gene variations associated with health, disease, and drug response. Every breakthrough opened up a new
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world, and showed us how much further there is to go.
NanoCellect is committed to empowering every scientist to make discoveries one cell at a time, with modern and simple technologies for cell based assays. Our microfluidic flow cytometry platforms enable biomedical scientists to analyze and sort cells required for drug discovery
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diagnostics, and basic research. The company was founded in late 2009 as a spinout from UCSD and dedicated 6 years developing the foundation of the WOLF's technology before introducing the WOLF to early adopters. Initial funding of R&D was graciously funded by multiple NIH SBIR grants and contracts. We are backed by Illumina Ventures, FusionX Ventures, Anzu Partners, Agilent Technologies, Vertical Ventures (Highlander Fund and Triton Fund) and other private investors.
The Sartorius Group is a leading international partner of biopharmaceutical research and the industry. With innovative laboratory instruments and consumables, the Group's Lab Products & Services Division concentrates on serving the needs of laboratories performing research and
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quality control at pharma and biopharma companies and those of academic research institutes. The Bioprocess Solutions Division with its broad product portfolio focusing on single-use solutions helps customers to manufacture biotech medications and vaccines safely and efficiently.
Bio-Rad's Single-Cell ATAC-Seq (scATAC-Seq) enables genome-wide profiling of epigenomic landscape at the single-cell level with high number of reads per cell so you can better understand the mechanisms that drive how genes are regulated.
At MicroGEM, we have re-invented nucleic acid extraction. We replace traditional extraction methods with a temperature-driven, enzymatic approach, enabling high-quality extracts from low abundance transcripts and small sample volumes. Leveraging our prepGEM Universal thermophilic
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enzyme, this simple, single-tube process protects precious samples and ensures DNA is preserved - all in minutes, not hours. With no need for harsh chemicals, multiple washes, or further purification, prepGEM Universal is an ideal addition to genotyping toolkits.
Andor are global leaders in the development and manufacture of high performance scientific digital cameras, microscopy systems and spectrographs for academic, industrial and government applications. Through continuous dialogue with our customers and strong teamwork, we continue
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to innovate ground-breaking products, improving the world in which we live.
ATCC is the premier global biological materials resource and standards organization whose mission focuses on the acquisition, authentication, production, preservation, development, and distribution of standard reference microorganisms, cell lines, and other materials. While
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maintaining traditional collection materials, ATCC develops high quality products, standards, and services to support scientific research and breakthroughs that improve the health of global populations.
Founded by research scientists in 1999, Cell Signaling Technology (CST) is a private, family-owned company headquartered in Danvers, Massachusetts with over 400 employees worldwide. Active in the field of applied systems biology research, particularly as it relates to cancer, CST
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understands the importance of using antibodies with high levels of specificity and lot-to-lot consistency. It's why we produce all of our antibodies in house, and perform painstaking validations for multiple applications. And the same CST scientists who produce our antibodies also provide technical support for customers, helping them design experiments, troubleshoot, and achieve reliable results. We do this because that's what we'd want if we were in the lab. Because, actually, we are.
At Atlas Antibodies we have a very clear mission: To provide our customers with advanced research reagents targeting all human proteins. The Human Protein Atlas (HPA) project released the first version of a complete tissue-based map of human protein expression using antibodies in
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November 2014. In close partnership with the HPA project, we continue to develop advanced antibodies and advanced reagents for Mass Spectrometry (MS)-based quantitative proteomics. Of the possible 20,000 protein coding genes in the human body we already have over 18,000 antibodies covering 15,000 gene products and an additional 19,000 protein quantification MS-standards representing 13,000 protein targets.
The 3rd Annual Cell Biology Virtual Event is now available for OnDemand viewing. This years event provides an opportunity to discuss recent discoveries in biological research, advancements in techniques, and tool developments in cell research.
Cell Biology 2019 Virtual Event continues to create a valuable platform for inspiring global and interdisciplinary collaboration in a virtual environment, to study cells – their physiological properties, structure, the organelles they contain, environmental interactions, life cycle, division and death, on a microscopic and molecular level.
This years event includes the following tracks:
Spatial Omics
Microbiome
Cell Biology of Genetic Diseases
Our virtual conference allows you to participate in a global setting with no travel or cost to you. The event will remain open 6 months from the date of the live event. The webinars will be available for unlimited on-demand viewing. This virtual conference also offers increased reach for the global cell biology community with a high degree of interaction through live-streaming video and chat sessions.
Continuing Education
LabRoots is approved as a provider of continuing education programs in the clinical laboratory sciences by the ASCLS P.A.C.E. ® Program. By attending this event, you can earn 1 Continuing Education credit per presentation for a maximum of 14 credits.
Twelveyears ago LabRoots launched a new system of learning for a global scientific audience. Now, the 2021 Clinical Diagnostics and Research Virtual Event will again bring together clinician...
Thirteen years ago Labroots launched a new system of learning for a global scientific audience. Now, the 2022 Clinical Diagnostics and Research Virtual Event will again bring together clinic...
LabRoots is excited to bring academia and industry, research experts, virologists, microbiologists, healthcare professionals, and leading biomedical scientists under one roof at our 7 th Ann...
LabRoots is excited to bring academia and industry, research experts, virologists, microbiologists, healthcare professionals, and leading biomedical scientists under one roof at our 8th Annu...
LabRoots is pleased to announce the 11th Annual Laboratory Animal Science Virtual Conference which will take place on February 10, 2022 . This is a premier online-only conference that will b...
Welcome to the 5th Annual Laboratory Automation & Informatics Virtual Event ; a free virtual conference for professionals interested in the most recent technologies for today’s la...
Director - Consumables, Product Development, 10x Genomics
RNA-Seq has been used for the past decade to gain significant insights into gene expression. Using bulk methods however only allow for an understanding of the average gene expression within a tissue. Single cell RNA-seq gives a much more insightful picture of what is happening at the cellular level, but by dissociating tissues into their cellular components valuable information about tissue organization and cell to cell interactions are lost. The Visium Spatial Gene Expression Solution provides researchers with the ability to analyze gene expression across histological tissue sections using unbiased, spatially barcoded, mRNA capture probes. This discovery platform supports the analysis of all polyadenylated transcript and can be used to analyze thousands of genes and tens of thousands of transcripts within a few square microns of tissue. Here we demonstrate the platform’s capabilities to analyze a variety of human and mouse tissues giving deeper insight into the relationships between tissue morphology and gene expression.
The active shaping of biological membranes is essential for a variety of cellular functions including but not limited to cell migration, cell division, organelle morphology, and cell and membrane fusion. To this end, cells have evolved the ability to shape membranes through interactions between lipids and membrane shaping proteins or through direct modification of membrane lipids. Exactly how and when cells choose to employ these distinct membrane shaping tools remains a topic of intense study. Using the ciliate, Tetrahymena thermophila, our lab is trying to identify novel membrane shaping mechanisms and the signaling pathways by which they are regulated.
Learning Objectives:
1. Tetrahymena mating requires cell-cell fusion and selective autophagy
2. Membrane shaping proteins, Reticulon and SNX4, may play a role in cell-cell fusion and selective autophagy respectively
Graduate Student in the Aguilar lab at the Department of Biological Sciences, Purdue University
Lowe syndrome (LS) is a lethal X-linked genetic disorder caused by caused by mutations in OCRL1 gene, which encodes a lipid phosphatase Ocrl1, important for many cellular processes. Our lab identified that lack of Ocrl1 function results in defects in cell spreading, cell migration and primary cilia assembly. Over 200 OCRL1 mutations have been identified in LS, but their specific impact on cellular processes is unknown. The phosphatase domain is a hotspot for disease-causing mutations harboring over 80 unique missense mutations. Our results indicate that different mutations within this domain have different effects on Ocrl1 distribution and on triggering cellular phenotypes. This is the first study to establish the link between genotype and phenotype in Lowe syndrome.
Learning Objectives:
1. Studying the relationship between of genotype and phenotype of Lowe Syndrome patients.
2. Learning the function of different domains of Ocrl1 in different cellular processes.
The ability to discern spatial gene expression differences in complex biological systems is critical to our understanding of developmental biology and the progression of disease. However, the complexity presented by heterogeneous tissue has been historically difficult to overcome. Immunohistochemistry, ISH, and H&E staining, foundational tools for understanding tissue architecture, are based on a combination of gene expression and cell morphology information. Though recent advances in RNA sequencing (RNA-seq) have made it possible to obtain unbiased high-throughput gene expression data, these experiments require dissociated cells and cannot preserve morphological context, until now.
The Visium Spatial Gene Expression Solution from 10x Genomics analyzes complete transcriptomes in intact tissue sections, allowing you to discover genes and markers relevant to your research without having to rely on known targets. Preserving spatial resolution offers critical information for understanding the relationships between cellular function, phenotype, and location in the tissue.
Environment drives bacterial functional diversification. Molecular functional abilities of individual microbes and microbiomes from different envrionment conditions, such as temperature or salinity or even the sick or healthy individual gut, are clearly different. Understanding the functions encoded in the (meta)genomes of microbiomes is thus vital for mapping their environmental preferences. The high-throughput (meta)genomic sequencing, coupled with the growing computational resources, has unlocked new horizons. However, making sense of this deluge of data requires efficient and accurate analytical techniques. The attendees are expected to leave the presentation with understandings the concept of how environment impacts on micro[biom]e functions and computational tools that we built to facilitate the analysis.
Early detection is critical for improved survival in melanoma. Melanocytic nevi are extremely common benign tumors that mimic melanoma and are therefore commonly biopsied. Currently, the detection of melanoma is based on histological examination; however, disagreement between pathologists occurs in up to 10-25% of cases. Yet many indeterminate tumors are characterized by low cellularity and purity posing challenges to the currently available molecular technologies. Therefore, spatial genomics technologies for the detection of melanoma are needed to address many of these challenges. This presentation discusses a spatially resolved multiplex RNA analysis of 1,412 genes using formalin-fixed paraffin-embedded melanocytic tumors with the GeoMx™ Digital Spatial Profiler*
*FOR RESEARCH USE ONLY. Not for use in diagnostic procedures.
Senior Scientist at The Hospital for Sick Children and Professor of Biochemistry, University of Toronto.
The innate immune response requires continuous surveillance of the environment, and the ability to detect and react to pathogens and danger signals. Phagocytosis –the ingestion of particulate matter ≥0.5 µm in diameter– and macropinocytosis –the gulping of large volumes of extracellular fluid– are key components of innate immunity. Both processes are complex and elegant, involving receptors and signal transduction, as well as cytoskeletal and membrane remodeling; a compendium of cell biology! These processes are often subverted by viruses, bacteria and fungi that take advantage of the host cells to establish a niche that favors their growth, replication and dissemination. My presentation will consist of a review of basic aspects of phagocytosis and macropinocytosis, followed by two sections describing recent advances in the field that have revealed the involvement of unique cytoskeletal structures (in the case of phagocytosis) and of ion channels (in macropinocytosis).
Learning objectives:
1. Understand the stages and functional roles of macropinocytosis and phagocytosis.
2. Appreciate the key role of phosphoinositides and inorganic ions in signaling and driving the formation and maturation of phagosomes and macropinosomes.
Co-Founder and CSO, BioSpyder Technologies, Inc., Professor, University of Arizona College of Pharmacy
Spatial transcriptomics methods permit gene expression from focal areas within a tissue to be profiled while maintaining the morphologic context of the tissue microenvironment. This presentation will address considerations based on the needs of a study for selecting the best fit to what are new methods still in their infancy. These important considerations start with; i) whether focal profiling will provide data that profiling of bulk tissue will not; ii) is it necessary to profile single cells or are larger focal areas such as single glands sufficient; iii) what is the size of such histologic regions and Is it necessary to have histologically discrete profiling without cross-contamination from adjacent histologic regions or cells; iv) What is the throughput required, just a few sections or lots of sections from 100+ tissues, animals, or subjects, and within each section, how many focal areas; v) Is it desirable to measure splice variants, snRNA, long non-coding RNA, histones - if so, then a 3’ biased assay method would be unsuited for the need vi) What tissue type does the method use, and how does that match up with what the investigator has available - Frfsh frozen, FFPE, H&E stained, antibody-stained; vii) What is the sensitivity – can all the genes measured from a bulk sample, including low expressed ones be measured; viii) What is the dynamic range; i.e. can a broad range of expressed genes from low to high be measured quantitatively at the same time. As methods continue in their development, the choice will also be whether the investigator wants to measure a panel of antigens at the same time as gene expression. If so, can this be from different serial sections, or does it have to be from the same section, same focal area. And of course, there is the question of cost. Different methods will be presented within the context of these questions, and spatial profiling data using TempO-Seq® will be provided to demonstrate several of these considerations. This data will also demonstrate the potential of spatial profiling in understanding the specificity and context of gene expression within the tissue microenvironment.
Assistant Professor, Department of Biology, North Carolina Central University
Neuroinflammation has been implicated as a factor in alcohol-induced neurodegeneration, but the role of the neuroimmune system in alcohol consumption has only recently come to the forefront. The drinking in the dark paradigm (DID) is an alcohol use disorder model that is uniquely suited to study the consummatory mechanisms of binge drinking. Our recent work has characterized the neuroimmune response following ethanol consumption in the DID. Our results indicate that a history of binge-like ethanol drinking promotes a proinflammatory cytokine response in the amygdala and hippocampus. Importantly, direct administration of anti-inflammatory cytokines can reduce ethanol consumption. These findings highlight the reciprocal relationship between alcohol abuse and the neuroimmune response. Alcohol misuse dysregulates cytokine concentrations but manipulating the neuroimmune response may curb excessive consumption.
Learning Objectives:
1. Understand that binge drinking can alter neuroimmune cells and function
2. Describe how manipulation of cytokines reduces binge drinking
Co-Founder and CSO, BioSpyder Technologies, Inc., Professor, University of Arizona College of Pharmacy
Spatial transcriptomics methods permit gene expression from focal areas within a tissue to be profiled while maintaining the morphologic context of the tissue microenvironment. This presentation will address considerations based on the needs of a study for selecting the best fit to what are new methods still in their infancy. These important considerations start with; i) whether focal profiling will provide data that profiling of bulk tissue will not; ii) is it necessary to profile single cells or are larger focal areas such as single glands sufficient; iii) what is the size of such histologic regions and Is it necessary to have histologically discrete profiling without cross-contamination from adjacent histologic regions or cells; iv) What is the throughput required, just a few sections or lots of sections from 100+ tissues, animals, or subjects, and within each section, how many focal areas; v) Is it desirable to measure splice variants, snRNA, long non-coding RNA, histones - if so, then a 3’ biased assay method would be unsuited for the need vi) What tissue type does the method use, and how does that match up with what the investigator has available - Frfsh frozen, FFPE, H&E stained, antibody-stained; vii) What is the sensitivity – can all the genes measured from a bulk sample, including low expressed ones be measured; viii) What is the dynamic range; i.e. can a broad range of expressed genes from low to high be measured quantitatively at the same time. As methods continue in their development, the choice will also be whether the investigator wants to measure a panel of antigens at the same time as gene expression. If so, can this be from different serial sections, or does it have to be from the same section, same focal area. And of course, there is the question of cost. Different methods will be presented within the context of these questions, and spatial profiling data using TempO-Seq® will be provided to demonstrate several of these considerations. This data will also demonstrate the potential of spatial profiling in understanding the specificity and context of gene expression within the tissue microenvironment.
Early detection is critical for improved survival in melanoma. Melanocytic nevi are extremely common benign tumors that mimic melanoma and are therefore commonly biopsied. Currently, the detection of melanoma is based on histological examination; however, disagreement between pathologists occurs in up to 10-25% of cases. Yet many indeterminate tumors are characterized by low cellularity and purity posing challenges to the currently available molecular technologies. Therefore, spatial genomics technologies for the detection of melanoma are needed to address many of these challenges. This presentation discusses a spatially resolved multiplex RNA analysis of 1,412 genes using formalin-fixed paraffin-embedded melanocytic tumors with the GeoMx™ Digital Spatial Profiler*
*FOR RESEARCH USE ONLY. Not for use in diagnostic procedures.
The ability to discern spatial gene expression differences in complex biological systems is critical to our understanding of developmental biology and the progression of disease. However, the complexity presented by heterogeneous tissue has been historically difficult to overcome. Immunohistochemistry, ISH, and H&E staining, foundational tools for understanding tissue architecture, are based on a combination of gene expression and cell morphology information. Though recent advances in RNA sequencing (RNA-seq) have made it possible to obtain unbiased high-throughput gene expression data, these experiments require dissociated cells and cannot preserve morphological context, until now.
The Visium Spatial Gene Expression Solution from 10x Genomics analyzes complete transcriptomes in intact tissue sections, allowing you to discover genes and markers relevant to your research without having to rely on known targets. Preserving spatial resolution offers critical information for understanding the relationships between cellular function, phenotype, and location in the tissue.
The active shaping of biological membranes is essential for a variety of cellular functions including but not limited to cell migration, cell division, organelle morphology, and cell and membrane fusion. To this end, cells have evolved the ability to shape membranes through interactions between lipids and membrane shaping proteins or through direct modification of membrane lipids. Exactly how and when cells choose to employ these distinct membrane shaping tools remains a topic of intense study. Using the ciliate, Tetrahymena thermophila, our lab is trying to identify novel membrane shaping mechanisms and the signaling pathways by which they are regulated.
Learning Objectives:
1. Tetrahymena mating requires cell-cell fusion and selective autophagy
2. Membrane shaping proteins, Reticulon and SNX4, may play a role in cell-cell fusion and selective autophagy respectively
Assistant Professor, Department of Biology, North Carolina Central University
Neuroinflammation has been implicated as a factor in alcohol-induced neurodegeneration, but the role of the neuroimmune system in alcohol consumption has only recently come to the forefront. The drinking in the dark paradigm (DID) is an alcohol use disorder model that is uniquely suited to study the consummatory mechanisms of binge drinking. Our recent work has characterized the neuroimmune response following ethanol consumption in the DID. Our results indicate that a history of binge-like ethanol drinking promotes a proinflammatory cytokine response in the amygdala and hippocampus. Importantly, direct administration of anti-inflammatory cytokines can reduce ethanol consumption. These findings highlight the reciprocal relationship between alcohol abuse and the neuroimmune response. Alcohol misuse dysregulates cytokine concentrations but manipulating the neuroimmune response may curb excessive consumption.
Learning Objectives:
1. Understand that binge drinking can alter neuroimmune cells and function
2. Describe how manipulation of cytokines reduces binge drinking
Graduate Student in the Aguilar lab at the Department of Biological Sciences, Purdue University
Lowe syndrome (LS) is a lethal X-linked genetic disorder caused by caused by mutations in OCRL1 gene, which encodes a lipid phosphatase Ocrl1, important for many cellular processes. Our lab identified that lack of Ocrl1 function results in defects in cell spreading, cell migration and primary cilia assembly. Over 200 OCRL1 mutations have been identified in LS, but their specific impact on cellular processes is unknown. The phosphatase domain is a hotspot for disease-causing mutations harboring over 80 unique missense mutations. Our results indicate that different mutations within this domain have different effects on Ocrl1 distribution and on triggering cellular phenotypes. This is the first study to establish the link between genotype and phenotype in Lowe syndrome.
Learning Objectives:
1. Studying the relationship between of genotype and phenotype of Lowe Syndrome patients.
2. Learning the function of different domains of Ocrl1 in different cellular processes.
Senior Scientist at The Hospital for Sick Children and Professor of Biochemistry, University of Toronto.
The innate immune response requires continuous surveillance of the environment, and the ability to detect and react to pathogens and danger signals. Phagocytosis –the ingestion of particulate matter ≥0.5 µm in diameter– and macropinocytosis –the gulping of large volumes of extracellular fluid– are key components of innate immunity. Both processes are complex and elegant, involving receptors and signal transduction, as well as cytoskeletal and membrane remodeling; a compendium of cell biology! These processes are often subverted by viruses, bacteria and fungi that take advantage of the host cells to establish a niche that favors their growth, replication and dissemination. My presentation will consist of a review of basic aspects of phagocytosis and macropinocytosis, followed by two sections describing recent advances in the field that have revealed the involvement of unique cytoskeletal structures (in the case of phagocytosis) and of ion channels (in macropinocytosis).
Learning objectives:
1. Understand the stages and functional roles of macropinocytosis and phagocytosis.
2. Appreciate the key role of phosphoinositides and inorganic ions in signaling and driving the formation and maturation of phagosomes and macropinosomes.
Environment drives bacterial functional diversification. Molecular functional abilities of individual microbes and microbiomes from different envrionment conditions, such as temperature or salinity or even the sick or healthy individual gut, are clearly different. Understanding the functions encoded in the (meta)genomes of microbiomes is thus vital for mapping their environmental preferences. The high-throughput (meta)genomic sequencing, coupled with the growing computational resources, has unlocked new horizons. However, making sense of this deluge of data requires efficient and accurate analytical techniques. The attendees are expected to leave the presentation with understandings the concept of how environment impacts on micro[biom]e functions and computational tools that we built to facilitate the analysis.
Dr. Sergio Grinstein completed his Ph.D. in 1976 at the Centro de Investigacion, in Mexico City. He then spent two years as a post-doctoral fellow at the Hospital For Sick Children in Toronto, followed by a year in the Department of Biochemistry at the Federal Institute of Technology in Zurich. He is currently working at the Hospital For Sick Children in Toronto, where he was Head of the Programme in Cell Biology from 1987-2007 and has been Professor of Biochemistry at the University of Toronto since 1988. Dr. Grinstein was an International Scholar of the Howard Hughes Medical Institute, a recipient of the Medical Research Council Distinguished Scientist Award and of the Michael Smith Award of the Canadian Institutes for Health Research and is a Fellow of the Royal Society of Canada. He held the Pitblado Chair in Cell Biology at the Hospital for Sick Children from 2000-2015.
Zachary Bent
Director - Consumables, Product Development, 10x Genomics
Zach received his B.A. in Biological Sciences from Cornell University and a PhD in Microbiology with a Designated Emphasis in Biotechnology from UC Davis. His postdoctoral research focused on developing novel RNA-Seq protocols and methods to use RNA-Seq in the study of host-pathogen interactions. Since joining 10x, Zach has worked on the launch of GEMCode, Single Cell 3' v1, v2, and v3, Single Cell 5'/V(D)J, Single Cell-CNV, and Single Cell-ATAC. He is currently leading the development of the Visium Spatial Gene Expression Solution.
Sabrice Guerrier is an Associate Professor of Biology at Millsaps College. He earned a Ph.D. in Pharmacology at The University of North Carolina at Chapel Hill and was a postdoctoral fellow at the Mayo Clinic-Rochester. Following a Howard Hughes Medical Institute (HHMI) funded visiting professorship at Carleton College, Sabrice joined the faculty at Millsaps College. At Millsaps, Sabrice teaches a variety of cell biology course and his research lab uses the ciliate, Tetrahymena thermophila to identify and characterize molecules that regulate membrane curvature.
Margaret Hoang, PhD
Senior Scientist, Research & Development, NanoString Technologies, Inc.
Dr. Margaret Hoang is a Senior Scientist and Next-Generation Sequencing (NGS) Technical Lead at Nanostring Technologies. She applies her expertise in Cancer Genomics and NGS in the development of the GeoMx Digital Spatial Profiler (DSP) sequencing readout capability. Prior to Nanostring, she was a Post-doctoral Fellow at Johns Hopkins School of Medicine characterizing mutational signatures induced by environmental mutagens in urothelial cancers. Margaret received her B.S. in Biochemistry from University of Washington and Ph.D. in Biology from Johns Hopkins University.
Maija Kiuru, PhD
Assistant Professor of Clinical Dermatology and Pathology, UC Davis
Dr. Maija Kiuru is a dual board-certified practicing dermatologist and dermatopathologist and a physician-scientist at University of California, Davis. Dr. Kiuru received her MD degree and PhD in medical genetics from the University of Helsinki, Finland. Her thesis on hereditary leiomyomatosis and renal cell cancer (HLRCC) established the association between aggressive renal cell carcinoma, uterine fibroids, and cutaneous leiomyomas and identified the predisposing germline mutation in FH gene. She continued her research training as a postdoctoral fellow at Weill Cornell Medical College and Columbia University in New York. This research culminated in the discovery of PLCD1 mutations in hereditary leukonychia, revealing a new gene in nail biology, and identifying novel stem cell therapies for hereditary skin blistering disorders. Dr. Kiuru received her clinical training in dermatology and dermatopathology at Weill Cornell Medical College and Memorial Sloan Kettering Cancer Center in New York.
Dr. Kiuru's research focuses on genetics of familial skin disorders and cutaneous tumors. As a practicing dermatopathologists and dermatologist, one of her aims include identification of molecular markers of early melanomagenesis to improve diagnostic accuracy of melanocytic tumors. She is the recipient of NIH K23 and NIH K12 Career Development Awards, and the Dermatology Foundation Career Development Award in Dermatopathology. Dr. Kiuru has published numerous peer-reviewed articles, review articles, and book chapters, including in journals such as Nature Genetics, Nature Reviews Cancer, PNAS, Cancer Research, Cell Stem Cell, and American Journal of Human Genetics, and has lectured at many national and international meetings.
S. Alex Marshall, PhD
Assistant Professor, Department of Biology, North Carolina Central University
Dr. Marshall is an Assistant Professor in the department of Biological and Biomedical Sciences at North Carolina Central University in Durham, NC. He was previously in the Basic Pharmaceutical Science Department in High Point University's Fred Wilson School of Pharmacy. He received his undergraduate degree from the University of Florida and his doctorate in pharmaceutical sciences from the University of Kentucky. Throughout his academic career, his research has focused on how alcohol abuse fundamentally changes the brain increasing the susceptibility for addiction.
Swetha Ramadesikan
Graduate Student in the Aguilar lab at the Department of Biological Sciences, Purdue University
I am Swetha Ramadesikan. I am a graduate student (nearly finished 😊) in the Aguilar lab at the Dept. of Biological Sciences, Purdue University. I am studying a rare developmental disease called Lowe Syndrome. This is an X-linked disease caused by mutations in the gene OCRL1 (encodes a lipid 5' phosphatase) and affected males suffer from kidney, ocular and neurological complications. I am interested in understanding how various mutations in OCRL1 lead to differential patient symptoms and cellular phenotypes. We believe that this will help us understand the relationship between patient genotype and phenotype and provide the foundation for more personalized diagnosis, prognosis and also therapeutic strategies. I am from India and got my Bachelor's degree in Bioengineering from SASTRA University, Tanjore India. I have always been interested in connecting the dots between what we learn from cellular behavior, to what it translates into organ physiology and thereby health and disease and hope to continue to be involved in a similar area of research in the future. In my free time, I like to (try) and catch up on reading, practise music, play table tennis and enjoy cooking!
Nikhil received a B.S. in Chemical Engineering from Johns Hopkins University followed by a PhD in Bioengineering conducting research in cardiovascular tissue engineering from UC San Diego. Since completing his PhD he has had numerous roles in industry beginning in R&D and transitioning to lead commercialization efforts in the NGS and life science space. He is currently leading the commercial launch of the Visium Spatial Gene Expression Platform at 10x Genomics.
Bruce Seligmann, PhD
Co-Founder and CSO, BioSpyder Technologies, Inc., Professor, University of Arizona College of Pharmacy
Bruce began his research career at the NIH, within the Laboratory of Clinical Investigation, NIAID, developing novel technology to monitor the function of cells and identify the basis for disease. He continued that through his work at Ciba-Geigy (now Novartis) where he worked with management to bring molecular biology out of an institute and into the drug discovery project team for the first time within that company, and implemented novel assays to accelerate the drug discovery programs he led, including novel testing of samples to demonstrate efficacy in the human through Phase I. He joined Selectide, a leader in combinatorial chemistry during the infancy of this new paradigm, as the VP of Research and Dev. and transformed it from a peptide company to a small molecule combinatorial chemistry leader, resulting it its sale to Marion Merrell Dow (now Sanofi). After serving as its center director. He left what had become Hoechst Marion Roussel to found SIDDCO around a novel combinatorial chemistry consortium services business plan and then founded HTG Molecular (now trading under the symbol HTGM), inventing (US 2014/0235460) and leading the development of a novel gene expression platform, marketed as the EdgeSeq platform. He left to co-found BioSpyder and develop its TempO-Seq® sequencing-based platform and applications. All of BioSpyder's research program, and initially all its staff until commercial sales began, was supported by grants and contracts he wrote and/or was key, and grant support continues to fund the research program. This effort resulted in the development of the TempO-Seq™ targeted sequencing platform (US 9,856,521; US 9,938,566; US 9,957,550), launched in 2016 (1,2). Launched assays include a human whole transcriptome assay (measuring 38,000+ RefSeq ID's), human surrogate assay (~2700 genes, the EPA S1500V 2, (Mav, et. al. PLOSone, 2018; doi.org/10.1371/journal.pone.0191105), human pan cancer assay of ~5,000 genes, and rat and mouse whole transcriptome and surrogate assays. Commercial kits include kits for the measurement from cells and frozen tissue (1,2) or FFPE tissue (3,4). TempO-Seq has enabled high throughput generation of QSAR-quality dose response data using a focused gene panel (5 and Ramaiahgri, et al, Tox. Sci. 2019. doi.org/10.1093/toxsci/kfz065) for use in quantitative safety assessment drug discovery, or mechanistic/mode of action studies. Validation of applications for single cells using FACS and Digital Spatial Molecular Profiling (DSMP) permitting profiling from H&E or antibody-stained FFPE tissue down to focal areas of 20 μm are ongoing. Diagnostic applications are being pursued.
Dr. Chengsheng Zhu is a postdoctoral associate at Rutgers University. He received his B.S. in Biology from Fudan University, China, M.S. in Biology from Central Michigan University, and Ph.D. in Microbiology and Molecular Genetics from Rutgers University. During his Ph.D. and postdoctoral training, Chengsheng has been focusing on building computational tools for functional annotation of microbial (meta)genomes and characterizing microbial functional signatures of different environment conditions.
Virtual poster sessions offer the opportunity to present data to a global audience via a PDF poster and video summary, and discuss results with interested colleagues through email. Posters should be submitted as a PowerPoint file. Presentations should incorporate illustrative materials such as tables, graphs, photographs, and large-print text. This content is not peer-reviewed. Submission is free.
All submitted abstracts will be reviewed and decisions regarding acceptance will be made as abstracts are received. You will be notified within one week of receipt about acceptance. Further details and registration materials will be provided at that time. You do not have to be present in order to have a poster displayed. Only those abstracts approved by LabRoots may display posters at this event.
If accepted, you will also have the opportunity to record a 3-5 minute summary video for each poster. LabRoots will work with each individual to create these videos. Video links and email contact information will be included on each poster displayed.
The speakers below have been approved for Continuing Education Credits. To redeem your credits, locate the presentation you watched and click on the CE buttons for further direction. For more general information regarding continuing education, the processes to receive credits, and the accreditation bodies, Click here
Dr. Antonio T. Baines is an Associate Professor in the Department of Biology at North Carolina Central University (NCCU) and an adjunct professor in the Department of Pharmacology in the School of Medicine at the University of North Carolina (UNC) Chapel Hill. He earned a
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bachelors degree in biology from Norfolk State University and a doctorate in pharmacology and toxicology from the University of Arizona. Afterwards, Dr. Baines accepted a postdoctoral fellowship at UNC in pharmacology and radiation oncology under Drs. Channing Der and Adrienne Cox. His research focused on understanding the role of the Ras oncogene as a molecular target in pancreatic cancer oncogenesis. In August 2006, Dr. Baines accepted a tenure-track faculty position at NCCU where he currently teaches and conducts research as a cancer biologist. Also, he mentors high school, undergraduate, and graduate students in his laboratory. Pancreatic cancer is the 4th most common cause of cancer deaths in the United States with a high mortality rate and very limited treatment options. The overall focus of Dr. Baines research program is to identify and validate novel molecular targets in pancreatic cancer which can be targeted by potential cancer therapeutics. Additionally, his lab aims to understand the role of these molecular targets in the development and progression of normal cells transforming into cancer cells of the pancreas. Currently, Dr Baines studies the functional significance of the oncogenic Pim kinase family in pancreatic cancer growth and development. He hypothesizes that inhibition of these enzymes will be an effective approach for antagonizing the aberrant growth of pancreatic carcinoma. In addition to working with colleagues in academia, he collaborates with various pharmaceutical companies that are developing Pim inhibitors. Results from his studies will allow for critical validation of these kinases as novel therapeutic targets for pancreatic cancer treatment. Dr. Baines research has been funded by NIH and other grant sources. He has presented his research at various national scientific meetings such as the Society of Toxicology and the American Association for Cancer Research. In addition, Dr. Baines has given invited research seminars at universities such as Duke University, UNC-Chapel Hill, North Carolina Agricultural and Technical (A&T) State University, Indiana University, North Carolina State University, University of Missouri-Kansas City and Massachusetts Institute of Technology (MIT).
Dr. Aguilar obtained his PhD degree in Immunochemistry from the School of Pharmacy and Biochemistry, University of Buenos Aires, Argentina. Dr. Aguilar pursued his post-doctoral training at the National institutes of Health in Bethesda, MD in the lab of the well-known cell
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biologist Dr. Juan Bonifacino. In 2005, after a period as Associate Research Scientist at The Johns Hopkins University (in Dr. Beverly Wendland lab), Dr. Aguilar joined the Faculty of the Department of Biological Sciences at Purdue University. There, his group studies the mechanisms linking endocytosis and signaling in health and disease. In order to pursue its research goals, the Aguilar lab routinely use biophysical, biochemical and genetic approaches.
Matt entered the research field over 20 years ago as a lab animal technician at the TSI/Mason contract research facility. He has worked at both contract facilities such as TSI and OREAD Biosafety as well in industry at Pharmacia, Pfizer, and Sanofi-Aventis. During that period he
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has performed a variety of surgical procedures including device implantation, transplants, orthopedic defect, ocular and vascular implants, cardiac surgery, and brain and spinal procedures. His experience ranges from mice and rats to non-human primates and livestock. In addition, he holds four patents for novel surgical devices and implants and has been training technicians, scientists, veterinarians, and physicians in surgical techniques and procedures for over 15 years. Outside of the surgical realm, he has been a study director, sonographer, Safety Pharmacology scientist, and manager. Currently Matt supervises a team of technicians and surgeon-technicians at Genzyme who support the Boston hub and perform over 1250 surgical procedures a year. Matt was also on the board of directors for the Academy of Surgical Research for over ten years, serving as their program chair for three of them as well as educational chair for two. Currently he is the program chairman for the New England branch of AALAS.
Brian McNally received his doctorate in Cell & Molecular Biology at University of Texas Southwestern Medical Center, where he focused on the transcriptional mechanisms governing polycystic kidney disease, renal cancer and development. His post-doctoral fellowship concentrated on
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the regulatory relationship between the proteasome and Toll-like receptor signaling at the University of Maryland Medical School in the Department of Immunology and Microbiology. Brian has fifteen years of practical experience at the laboratory bench, and his work has been published in peer-reviewed journals and presented at international conferences. In 2008, he transitioned to industry to commercialize new biomedical products including assays, reagents and software. Brian has been with Canon BioMedical since its inception last year. He is passionate about partnering with life scientists to develop the next wave of biomedical solutions.
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