TUESDAY, SEPTEMBER 29th, 2020 (12:00PM-5:00PM EDT)
11:00 AM-12:00 PM: POSTER AND EXHIBIT HALL OPEN
WINNING Young Investigator Mini-Presentations- 4 selected; featured in Poster Hall
12:00 PM EDT WEBINAR 1 WELCOME & OVERVIEW (TOTAL1 hour 20 min.)
OPENING REMARKS Organizers, Title Sponsors (10 Minutes)
KEYNOTE AND HISTORICAL PERSPECTVE (30 Minutes)
Peter Adamson, MD Past Chair of the Children’s Oncology Group (COG), Global Head, Oncology Drug Development & Lead, Pediatric Innovations Group, Sanofi, Inc; Dr. Adamson is Professor Emeritus at the Perelman School of Medicine of the University of Pennsylvania. He is Board Certified in Pediatric Hematology/Oncology and Clinical Pharmacology.
COURAGEOUS WARRIOR REMARKS – (5 minutes) Joshua Schiffman, MD, Professor of Pediatric Hematology/Oncology and Adjunct Professor of Oncological Sciences, Huntsman Cancer Center, University of Utah; Childhood Cancer Survivor
COURAGEOUS WARRIOR: Scout’s Story – (Invited, 5-7 minutes, opening)
GOLDEN RETRIEVER LIFETIME STUDY: REVIEW OF FIRST COHORT OF CANCER-AFFLICTED PARTICIPANTS (30 Minutes)`
Rodney Page, DVM, Flint Animal Cancer Center & Principal Investigator & Janet Patterson-Kane DVM, Chief Scientific Officer, Morris Animal Foundation
1:45 PM EDT 15 Minute Break: Poster Hall/Exhibit Hall open
2:00 PM EDT Program Resumes
2:00 PM WEBINAR 2: EMERGING DATASETS & DATA INTEGRATION INITIATIVES (2 Hours)
Canine Genetic and Biomarker Data in Context of Human (95 minutes)
History & Overview: Perspective from the National Cancer Institute(15 Minutes)
Amy LeBlanc, DVM Director, Comparative Oncology Program, National Cancer Institute
and Scientist, NCI Molecular Imaging Program
Amy LeBlanc, DVM, PhD Comparative Oncology Program, National Cancer Institute &
Heather Gardner DVM, DACVIM (Oncology) Tufts Cummings School of Veterinary Medicine (15 minutes together)
Will Hendricks, DVM Integrated Cancer Genomics Division, TGEN (15 minutes)
Roel Verhaak, PhD The Jackson Laboratories (15 minutes)
Andrea Webber, Assistant Head, Clinical Biomarkers Translational Oncology, Merck (15 minutes)
Discussant: Jeff Trent, PhD TGEN (Invited) (DISCUSSION: 20 Minutes)
4:00 PM WEBINAR 3: DATA-DRIVEN COMPARATIVE ONCOLOGY RESEARCH: INTELLIGENT NTEGRATION OF HUMAN/PEDIATRIC AND CANINE CANCER DATA TO FUEL DISCOVERY & ACCELERATE DRUG DEVELOPMENT (TOTAL 60 Minutes)
Significant advances in comparative research hinge on adequately defined canine genomic and immunologic profiles (genomic sequencing, mutational load, and immunologic characterizations) Efforts including the Precision Medicine and Moonshot Canine Immunotherapy initiatives are yielding exciting new datasets, which must be housed in an open-source environment (data commons) and harmonized to allow comparison/contrast with relevant human datasets. Here, leading experts provide insights into the status of various data generation and warehousing initiatives in the comparative context.
Adam Resnick, PhD Director of Data Driven Discovery in Biomedicine (D3b) at Children's Hospital of Philadelphia (CHOP) (10- 15 minutes)
Connie Sommers, PhD Program Director at National Cancer Institute (10- 15 minutes)
Matthew Breen, PhD PhD, C. Biol, FRSB. Professor, Genomics Oscar J. Fletcher Distinguished Professor, Comparative Oncology Genetics (10- 15 minutes)
Warren Kibbe, PhD Chief for Translational Biomedical Informatics in the Department of Biostatistics and Bioinformatics and Chief Data Officer for the Duke Cancer Institute (20 minutes DISCUSSION)
PROGRAM CLOSE: 5:00 PM EDT
WEDNESDAY, SEPTEMBER 30th, 2020 (12:00PM-5:00PM EDT)
11:00 AM-12:00 PM: POSTER AND EXHIBIT HALL OPEN
12:00 PM EDT PROGRAM BEGINS
12:00 PM WEBINAR 4 TITLE TBD (TOTAL 60 min)
The engagement of drug developers is critical to accelerating progress in human (especially pediatric) and canine cancers. Here we cover the challenges of uniting human, animal pharma/biotech, present case studies to demonstrate real world examples and the utility and value of intelligent integration of canine patients into the drug development pipeline. We also hear from pharma and biotech what their needs are and how they envision receiving canine data that is useful to complement and inform their preclinical and clinical drug development plans, with a particular eye also to RACE Act requirements.
Participants from Small biopharma, large pharma, regulators, veterinary oncology, pediatric oncology - TBA
Discussant: Peter Adamson , MD Global Head, Oncology Drug Development & Lead, Pediatric Innovations Group, Sanofi, Inc
1:00 PM 15 Minute BREAK POSTER AND EXHIBIT HALL OPEN, Meet the Experts Sessions
1:15 PM (EDT) WEBINAR 5 : COLLABORATIONS AT BOTH ENDS OF THE LEASH – ONGOING COMPARATIVE INIITIATIVES RELEVANT TO CHILDHOOD CANCER: PART 1: (TOTAL 90 Minutes)
Significant comparative research is underway which could inform and potentially advance our understanding of shared cancers in canines and in children and/or inform clinical trials of novel therapies or combinations for pediatric application. This section will include state of the art presentations regarding sarcomas, particularly osteosarcoma. Investigators involved in these critical projects will present updates on this ongoing research.
Dean Lee, MD, PhD Director of the Cellular Therapy and Cancer Immunology Program, Nationwide Children's Hospital and The Ohio State University Comprehensive Cancer Center. Professor of pediatrics at The Ohio State University College of Medicine and the DiMarco Family Endowed Chair in Cell Based Therapy (15 minutes)
Steven W. Dow, DVM, MS, PhD, Diplomate ACVIM Colorado State University, Flint Animal Cancer Center & Cheryl London (Tufts) (15 minutes)
Amy LeBlanc & Alex Huang, M.D., Ph.D., Case Western Reserve University School of Medicine & UH Rainbow Babies & Children's Hospital (15 minutes)
William Eward, MD, DVM Duke University School of Medicine & NC State School of Veterinary Medicine (15 minutes)
Discussant: L Lee Helman, MD Children’s Center for Cancer and Blood Diseases & Keck School of Medicine of University of Southern California (Discussion: 25 Minutes)
2:45 PM 15 Minute BREAK POSTER AND EXHIBIT HALL OPEN, Meet the Experts Sessions
3:00 WEBINAR 6 : COLLABORATIONS AT BOTH ENDS OF THE LEASH – ONGOING COMPARATIVE INIITIATIVES RELEVANT TO CHILDHOOD CANCER: PART 2 (2 Hours total)
Significant comparative research is underway which could inform and potentially advance our understanding of shared cancers in canines and in children and/or inform clinical trials of novel therapies or combinations for pediatric application. This section will include state of the art presentations regarding brain cancers (notably gliomas) and lymphoma. Investigators involved in these critical projects will present updates on this ongoing research.
Lymphoma: CAR-T Cell Immunotherapy in the Comparative Setting– 30 Minutes (Followed by Zoom Room)
Carl H. June, MD University of Pennsylvania Perelman School of Medicine &
Nicola Mason, PhD, BVetMed University of Pennsylvania School of Veterinary Medicine
Steven W. Dow, DVM, MS, PhD, Diplomate ACVIM Colorado State University, Flint Animal Cancer Center (20 Minutes)
Elias Sayour, MD, PhD Departments of Neurosurgery and Pediatrics, University of Florida. Principal investigator of the ribonucleic acid engineering laboratory at the Preston A. Wells, Jr. Center for Brain Tumor Therapy. (15 Minutes)
Melissa Rene Chambers, DVM, MD School of Medicine, University of Alabama (15 Minutes)
Moderator: Jay Philip Storm, MD, Chief of Neurosurgery, Children’s Hospital of Pennsylvania DISCUSSION 20 Minutes
PROGRAM CLOSE: 5:00 PM EDT
More great speakers added daily!
Dr. Patterson-Kane received her veterinary degree and PhD from Massey University, New Zealand. She completed specialty training in the field of veterinary anatomic pathology at the University of Florida followed by the University of Kentucky, before becoming board-certified in 1999. Dr. Patterson-Kane was a faculty member at the Royal Veterinary College (University of London), and then the University of Queensland (Australia), before holding the Chair in Veterinary Pathology at the University of Glasgow (United Kingdom). After leaving academia in 2014 she worked in private diagnostics and the biotechnology industry before joining the Morris Animal foundation as Chief Scientific Officer in 2019.
Dr. Patterson-Kane’s research interests are broad, including cellular stress and ageing, and cancer pathology. She is co-author of the only currently available equine oncology textbook, ‘Clinical Equine Oncology’.
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