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Analytical Method Validation work is based on a variety of guidelines and requirements hence being time-consuming and stressful. Reducing this work and improving efficiency while ensuring th...
NSD2 catalyzes the mono- and di-methylation of the e-amine of lysine 36 from histone H3, utilizing the methyl donor S-adenosyl-L-methionine. Increased catalytic activity of NSD2, either by ov...
Ageing is a complex process that has been observed in all biological systems at every level of organisation. Some anti-ageing interventions have demonstrated life-extending effects in model o...
The complete assembly of each human chromosome is essential for understanding human biology and evolution. Using complementary long-read sequencing technologies, we complete the first linear...
Nanopore sequencing has enormous potential for application to cancer, but specifically offers advantages into two main arenas, epigenetics and structural variation. Methylation is well-known...
The immune system is linked to an increasing number of medical diseases, including lately also severe mental disorders. Hence, infections, autoimmunity and other immune responses could be inv...
Holotomography (HT) uses laser interferometry to measure 3-D refractive index (RI) distribution. HT serves as a powerful tool for imaging small transparent objects, such as biological cells a...
Often overlooked but critical to most cannabis laboratory operations is sample workflow and sample preparation, having these areas figured out early in the start-up process is essential &nda...
The circulating T-cell receptor (TCR) repertoire is a dynamic representation of overall immune responses in an individual. Here we aimed to correlate pre-treatment circulating TCR repertoire...
The human enteric nervous system (ENS) is derived from the neural crest and represents a complex network of ~500 million neurons with dozens of distinct neurotransmitter and hormone subtypes ...
Tuberculosis has killed more than one billion people in the last 200 years. It is the oldest and the deadliest human pathogen, recently surpassing HIV. Its adaptation to host and drug pressur...
Thermo Fisher Scientific has developed an advanced assay to qualify FBS for use with ESCs. This assay is designed to sustain undifferentiated ES cells while maintaining karyotype integr...
The opioid crisis has put significant strain on the healthcare system and resources, including the clinical laboratory which has seen significant increases in requests for urine drug screeni...
Since the outbreak of the Covid-19 pandemic, the development of diagnostics for both the virus (molecular) and the host immune response (serological) has become essential for monitoring the...
Solid phase microextraction (SPME) is a versatile, non-exhaustive sample preparation tool that has been demonstrated to be well-suited for facile and effective analysis of a broad range of co...
Two-dimensional (2D) 1H-13C methyl correlated NMR is increasingly being recognized as a powerful tool to characterize the higher order structure (HOS) of monoclonal antibody (mAb) therapeutic...
Current methods for human induced pluripotent stem cells (hiPSC) derivation, expansion and differentiation can be limited in scalability and costly (due to their labor intensive nature). This...
Community acquired pneumonia affects over 5 million Americans and 6 million Europeans annually. Typically 5-10% will be admitted to hospital. It is a condition that more often affects the eld...
In this time of incredible promise for genomic medicine, the Genomes2People (G2P) Research Program in Translational Genomics and Health Outcomes, directed by Robert C. Green, MD, MPH, is crea...
The oncogenic transcription factor c-MYC (MYC) is deregulated, and often overexpressed, in more than 50% of cancers. MYC deregulation is associated with poor prognosis and aggressive disease,...
The CRISPR-Cas9 system is being widely used for genome engineering in many different biological applications. It was originally adapted from the bacterial Type II CRISPR system and uses a Cas...
Although there have been enormous advances in gene sequencing, the results give massive amounts of data that only point to disease risk. Major health factors, including diet, lifestyle, envir...
Whole genome sequencing of bacterial isolates via next-generation sequencing is becoming a standard approach for clinical microbiology and bio-surveillance labs seeking to conduct outbreak in...
Monitoring protein biomarkers in cerebrospinal fluid (CSF) of patients with Alzheimer’s Disease (AD) has been highly beneficial to understanding disease progression. While several...
The agricultural sector has been through significant changes since the 2018 Farm Bill was enacted. Hemp production was legalized at the federal level in the United States. Hemp production an...
The aim of the learning healthcare system is to leverage data stored in the electronic health record (EHR) to gain insights into and improve healthcare delivery. Laboratory testing represents...
Detection and/or amplification of target DNA sequences by polymerase chain reaction (PCR) is a prevalent method in molecular biology. PCR has a broad range of applications, including use in...
Analytical Method Validation work is based on a variety of guidelines and requirements hence being time-consuming and stressful. Reducing this work and improving efficiency while ensuring th...
