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Chimeric antigen receptor (CAR) T-cell therapy has been extremely successful in treating relapsed/refractory B-cell malignancies, with six CAR T-cell products now FDA approved. Unfortunately...
Brian Uzzi presents two studies on innovation in science. Study one examines conditions favoring the generation of innovative, high impact ideas and study two examines the conditions that ef...
Nucleic acid agarose gel electrophoresis is a fundamental technique in molecular biology, boasting a rich history of advancements and innovations spanning over half a century. This technique...
Our lab has developed a novel platform for droplet sorting that can be used to sort enzymes by activity, and cells by metabolism. It is a passive technique that utilizes no excitation laser,...
Immuno-oncology (IO) is a type of cancer treatment that uses the body's immune system to fight cancer. It works by stimulating the immune system to recognize and attack cancer cells, while le...
In this project, we optimized a high-throughput fluorescent-based assay to assess transporter activity by measuring uptake of the substrate, ASP+ 4-(4-(dimethylamino)styryl)-N-methylpyridi...
November 13, 2020 5:00 PM PST | November 14, 2020 9:00 AM SGT
Ensuring that clinical tests are not affected by tumor heterogeneity requires a sampling methodology that captures the genomic, proteomic, and cellular diversity of entire solid tumors. Howe...
Altered enteric microorganisms in concert with host genetics shape inflammatory bowel disease (IBD) phenotypes. However, insight is limited to bacteria and fungi. We found that eukaryotic vi...
Learning Objectives: 1. Describe language disturbances in schizophrenia and its risk states. 2. Describe face expression disturbances in schizophrenia and its risk states. 3. Describe ethica...
Molecular breeding can significantly reduce the cost and time required to deliver improved plant and animal species for agricultural use. Advancements in genomic technologies are acceleratin...
Monoclonal antibodies are heterogeneous molecules that include glycosylation variants, carboxyl truncation, and deamidation that require extensive analytical characterization. These molecule...
High grade serous ovarian cancer is characterized by genomic instability, with ~50% of advanced tumors harboring homologous recombination repair (HRR) pathway deficiency (HRD). HRD results i...
Learning Objectives 1. Understand the life cycle of the malaria causing parasite, Plasmodium 2. Understand new approaches to identifying host regulators of infection 3. Describe advantages a...
Current cancer research is hindered by the limitations of existing experimental systems, which fall short in demonstrating concordance with human studies. In this way, we aim to develop mode...
One of the central tenets of biology is that our genetics—our genotype—influences the physical characteristics we manifest—our phenotype. But with more than 25,000 human ge...
Effective cellular therapies for solid tumors remain elusive. Advances in gene editing and synthetic biology offer great potential for improving the safety and functionality of engineered ce...
In line with the role of T cells as critical mediators of the adaptive immune response, recombinational and junctional diversity of the T cell receptor makes each T cell almost entirely uniq...
This presentation will discuss some of the challenges related to developing antibody therapeutics and how GenScript's comprehensive portfolio of services and products can increase the ef...
Laboratory plastics are critical to scientific research, but these plastics often have a high environmental impact. Analysis shows that a large portion......
Identifying reliable antibodies for use in immuno-oncology research is critical to address its recent growth and rapid expansion into clinical trials as mistakes in antibody validation impac...
We are leading the way in developing integrated online sampling and Process Analytical Technology (PAT) workflows for quick monitoring of critical quality attributes (CQA) to produce advance...
The ultimate promise of tumor immunotherapy is dependent on the generation of effective immunity against cancer, including CD4 and CD8 T cell responses. However, activating T cells in cancer...
Chimeric antigen receptor (CAR) T-cell therapy has been extremely successful in treating relapsed/refractory B-cell malignancies, with six CAR T-cell products now FDA approved. Unfortunately...
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