Cell: is the smallest structural and functional unit of an organism, typically microscopic and consisting of cytoplasm and a nucleus enclosed in a membrane. Microscopic organisms typically consist of a single cell, which is either eukaryotic or prokaryotic.
Inflammation is associated with cognitive decline and the pathogenesis of Alzheimer's disease, although exact pathways remain elusive. To further explore the role of inflammation, we uti...
Parkinson’s disease (PD) belongs the group of synucleinopathies characterized by progressive aggregation of the neuronal protein alpha-synuclein (asyn). Diagnosis and evidence of disea...
The ability to record every spike from every neuron in a behaving animal is one of the holy grails of neuroscience. Here, Alison Hanson discusses a collaborative effort aimed at coming one s...
Behaving animals continually reconcile the internal states of their neural circuits brain-wide with incoming sensory and environmental evidence to evaluate when and how to act. The brains of...
Drug discovery programs require a robust panel of models and assays to identify and validate drug targets, support compound optimisation, and run mechanistic studies. Fully human in vitro mo...
Brain organoids are self-assembled three-dimensional cellular aggregates with cell types and tissue architectures that resemble the embryonic human brain. As they recapitulate many key featu...
Mariana Kiehl (Sr. Applications Scientist at Roche Sequencing & Life Science) describes the KAPA Total Prep FFPE workflow, a novel single-tube method for combined sequencing of DNA and R...
Traditional liver perfusion procedures – used to isolate hepatocytes – are difficult to perform and require extensive training, steady hands and long-standing experience. In this...
Multiplex immunofluorescence is a powerful tool for phenotyping cells from a single tissue slide, while preserving spatial context. The MultiOmyxTM platform, offered as an end to end service...
Proliferation biomarkers are proteins that are up-regulated in growing cells. Immunological staining of tumor tissue can provide an indication of the aggressivity of the tumor and provide in...
Learning Objectives: 1. Summarize the benefits and challenges of current preclinical methods in drug discovery and development. 2. Review new alternative methodologies (NAMs) and microphysio...
Diosgenin is a botanical steroidal saponin with anti-inflammatory, antioxidant, anti-thrombotic, anti- apoptotic, anti-depressant, and anti-nociceptive properties. However, it's unknown...
Across many cancers, mortality is associated with metastasis and acquired drug resistance, both of which often manifest in recurrent disease. Central to these phenomena is epithelial to mese...
Spatial analysis of protein or gene expression is vital to understanding the distribution, phenotypes, and interactions between cells within tumor microenvironment (TME). Traditionally, mult...
Current cancer research is hindered by the limitations of existing experimental systems, which fall short in demonstrating concordance with human studies. In this way, we aim to develop mode...
The study of a single cell, the fundamental unit of our complex bodies, has become an important field in cellular biology, and researchers are using single-cell analysis to shed new light on...
Macrophages can mediate phagocytosis of cancer cells and cytotoxic tumor killing, and engage in effective bidirectional interactions with components of the innate and adaptive immune system....
Learning Objectives Identify three ways automation improves cryosectioning techniques Demonstrate three essential elements to obtaining reproducible, high-quality sections with cryosectionin...
High-content screening (HCS) is an imaging-based, multi-parametric strategy used in drug development that generates rich datasets through multiplexing strategically chosen fluorescent dyes a...
From drug discovery to organoid modeling of disease, stem cells are increasingly being used in research as a vital tool for scientific investigation. Due to the specialized nature of stem ce...
The study of 3D organoids has transformed biomedical research, offering a more accurate representation of in vivo conditions. Maximizing the potential of 3D organoid research requires advanc...
Organoid technologies are increasingly being used as in vitro models of human development and disease because they exhibit morphogenetic, structural and functional properties that recapitula...
Calcium signaling is essential for cellular communication, orchestrating a myriad of physiological processes. As the quest for a more profound understanding of cellular dynamics intensifies,...
Join our webinar where we will highlight key features of the NovaSeq™ X series including technology innovations, product updates, and features of the on-board DRAGEN™ secondary a...
Inflammation is associated with cognitive decline and the pathogenesis of Alzheimer's disease, although exact pathways remain elusive. To further explore the role of inflammation, we uti...
Parkinson’s disease (PD) belongs the group of synucleinopathies characterized by progressive aggregation of the neuronal protein alpha-synuclein (asyn). Diagnosis and evidence of disea...
The ability to record every spike from every neuron in a behaving animal is one of the holy grails of neuroscience. Here, Alison Hanson discusses a collaborative effort aimed at coming one s...
Behaving animals continually reconcile the internal states of their neural circuits brain-wide with incoming sensory and environmental evidence to evaluate when and how to act. The brains of...
Drug discovery programs require a robust panel of models and assays to identify and validate drug targets, support compound optimisation, and run mechanistic studies. Fully human in vitro mo...
Brain organoids are self-assembled three-dimensional cellular aggregates with cell types and tissue architectures that resemble the embryonic human brain. As they recapitulate many key featu...
Mariana Kiehl (Sr. Applications Scientist at Roche Sequencing & Life Science) describes the KAPA Total Prep FFPE workflow, a novel single-tube method for combined sequencing of DNA and R...
Traditional liver perfusion procedures – used to isolate hepatocytes – are difficult to perform and require extensive training, steady hands and long-standing experience. In this...
Multiplex immunofluorescence is a powerful tool for phenotyping cells from a single tissue slide, while preserving spatial context. The MultiOmyxTM platform, offered as an end to end service...
Proliferation biomarkers are proteins that are up-regulated in growing cells. Immunological staining of tumor tissue can provide an indication of the aggressivity of the tumor and provide in...
Learning Objectives: 1. Summarize the benefits and challenges of current preclinical methods in drug discovery and development. 2. Review new alternative methodologies (NAMs) and microphysio...
Diosgenin is a botanical steroidal saponin with anti-inflammatory, antioxidant, anti-thrombotic, anti- apoptotic, anti-depressant, and anti-nociceptive properties. However, it's unknown...
Across many cancers, mortality is associated with metastasis and acquired drug resistance, both of which often manifest in recurrent disease. Central to these phenomena is epithelial to mese...
Spatial analysis of protein or gene expression is vital to understanding the distribution, phenotypes, and interactions between cells within tumor microenvironment (TME). Traditionally, mult...
Current cancer research is hindered by the limitations of existing experimental systems, which fall short in demonstrating concordance with human studies. In this way, we aim to develop mode...
The study of a single cell, the fundamental unit of our complex bodies, has become an important field in cellular biology, and researchers are using single-cell analysis to shed new light on...
Macrophages can mediate phagocytosis of cancer cells and cytotoxic tumor killing, and engage in effective bidirectional interactions with components of the innate and adaptive immune system....
Learning Objectives Identify three ways automation improves cryosectioning techniques Demonstrate three essential elements to obtaining reproducible, high-quality sections with cryosectionin...
High-content screening (HCS) is an imaging-based, multi-parametric strategy used in drug development that generates rich datasets through multiplexing strategically chosen fluorescent dyes a...
From drug discovery to organoid modeling of disease, stem cells are increasingly being used in research as a vital tool for scientific investigation. Due to the specialized nature of stem ce...
The study of 3D organoids has transformed biomedical research, offering a more accurate representation of in vivo conditions. Maximizing the potential of 3D organoid research requires advanc...
Organoid technologies are increasingly being used as in vitro models of human development and disease because they exhibit morphogenetic, structural and functional properties that recapitula...
Calcium signaling is essential for cellular communication, orchestrating a myriad of physiological processes. As the quest for a more profound understanding of cellular dynamics intensifies,...
Join our webinar where we will highlight key features of the NovaSeq™ X series including technology innovations, product updates, and features of the on-board DRAGEN™ secondary a...
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