Cytogenetics: a branch of genetics that is concerned with how the chromosomes relate to cell behaviour, particularly to their behaviour during mitosis and meiosis. Changes that affect the number and/or structure of the chromosomes can cause problems with growth, development, and how the body functions. Changes to chromosome structure can disrupt genes, causing the proteins made from disrupted genes to be missing or faulty. The analysis of chromosomes in human development and disease is accomplished through classical cytogenetic procedures (such as G-banding) combined with advanced molecular techniques such as genomic microarray analysis.
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Genomic analysis of cancer cells revealed comprehensive mechanism of tumorigenesis in human patients. Among the abnormalities discovered so far, CNVs accounted for a great portion of all the...
Epigenetic modifications such as DNA methylation have long shown promise as potential biomarkers to diagnose and guide treatment of many human diseases, including multiple types of cancers....
Genomic testing based on chromosome microarray (CMA) and Next Generation Sequencing (NGS) revolutionized clinical genetics. That said, microarray, targeted panel, exome and generic whole gen...
Since the initial COVID-19 outbreak, the SARS-CoV-2 virus has mutated, resulting in a range of variants. SARS-CoV-2 variants of concern, exemplified most recently with Omicron, need to be de...