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    Drug Discovery

    Drug Discovery: drug discovery is the process by which new candidate medications are discovered. Historically, drugs were discovered through identifying the active ingredient from traditional remedies or by serendipitous discovery. Modern drug discovery involves the identification of screening hits, medicinal chemistry and optimization of those hits to increase the affinity, selectivity (to reduce the potential of side effects), efficacy/potency, metabolic stability (to increase the half-life), and oral bioavailability.

    Webinars

    • FEB 08, 2017 | 1:30 PM
      Managing genetically modified rodent strains: focus on the genotype and genetic background
      Managing genetically modified rodent strains: focus on the genotype...
      DATE: February 8, 2017TIME: 1:30pm PT, 4:30pm ETThe powerful and expanding use of genetically modified mice introduces important aspects of genetics in managing these strains for breedi...
      Speaker: Steve Fiering, PhD
      Presented at: Laboratory Animal Sciences Virtual Event Series 2017
      5 1
      FEB 08, 2017 | 1:30 PM
      Safety and pharmacokinetic profiles of different buprenorphine SR doses in a rabbit model
      Safety and pharmacokinetic profiles of different buprenorphine...
      DATE: February 8, 2017TIME: 1:30pm PT, 4:30pm ETIn rabbits, buprenorphine instant release (IR) is commonly used to alleviate pain, especially in surgical models. However, maintenan...
      Speaker: Andrea Zanetti, DVM, PhD, SRS
      Presented at: Laboratory Animal Sciences Virtual Event Series 2017
      3
      FEB 08, 2017 | 12:00 PM
      Creating and Maintaining an Effective and Efficient In-Vivo Surgical Training Program
      Creating and Maintaining an Effective and Efficient In-Vivo Surgical...
      DATE: February 8, 2017TIME: 12:00pm PT, 3:00pm ETIn-vivo surgical models are becoming more prevalent and more critical to the drug development process.  As the vast majority of ind...
      Speaker: Matthew Flegal, BS, SRS
      Presented at: Laboratory Animal Sciences Virtual Event Series 2017
      5
      FEB 08, 2017 | 12:00 PM
      Availability and Management of Genetically Engineered Swine Models for Biomedical Research
      Availability and Management of Genetically Engineered Swine Models...
      DATE: February 8, 2017TIME: 12:00pm PT, 3:00pm ETLarge animal models have recently become a staple in biomedical research.  The pig’s similarities to humans in terms of genet...
      Speaker: Eric Walters, PhD
      Presented at: Laboratory Animal Sciences Virtual Event Series 2017
      2
      FEB 08, 2017 | 10:30 AM
      Biosecurity, Reproductive and Social Management of Cat Research Colonies
      Biosecurity, Reproductive and Social Management of Cat Research...
      DATE: February 8, 2017TIME: 10:30am PT, 1:30pm ETThe cat remains an important comparative species for studying the long-term safety and efficacy of emergent medical modalities, such as...
      Speaker: James Kehler VMD, PhD
      Presented at: Laboratory Animal Sciences Virtual Event Series 2017
      2
      FEB 08, 2017 | 10:30 AM
      Obtaining non-invasive readouts and early safety signals from rodent models
      Obtaining non-invasive readouts and early safety signals from...
      DATE: February 8, 2017TIME: 10:30am PT, 1:30pm ETThe utility of animal models in drug development is limited, in part, by the measures available to researchers for monitoring animals. I...
      Speaker: Laura Schaevitz, PhD
      Presented at: Laboratory Animal Sciences Virtual Event Series 2017
      3
      FEB 08, 2017 | 9:00 AM
      Rabbit Breeding: Standards and Practices
      Rabbit Breeding: Standards and Practices
      DATE: February 8, 2017TIME: 9:00am PT, 12:00pm ETThere are many factors involved in rabbit breeding that impact performance.  In this evaluation of a Dutch Belted rabbit breeding c...
      Speaker: Kathryn Cavanaugh
      Presented at: Laboratory Animal Sciences Virtual Event Series 2017
      1
      FEB 08, 2017 | 9:00 AM
      Evaluating the Effectiveness of Training  for Animal Care and Use Personnel
      Evaluating the Effectiveness of Training for Animal Care and...
      DATE: February 8, 2017TIME: 9:00am PT, Noon ETTraining programs for animal care and use personnel are integral to both animal welfare and quality research outcomes. There are a variety...
      Speaker: Melissa Dyson MS, DVM, DACLAM
      Presented at: Laboratory Animal Sciences Virtual Event Series 2017
      2
      FEB 08, 2017 | 7:30 AM
      KEYNOTE: Rodent Surgery... Aseptic Technique Made Easy... and Other Tips
      KEYNOTE: Rodent Surgery... Aseptic Technique Made Easy... and...
      DATE: February 8, 2017TIME: 7:30am PT, 10:30am ETMany of us who believe in the importance of aseptic rodent surgery have lived through the frustration of trying to implement rodent asep...
      Speaker: Marcel Perret-Gentil, DVM, MS
      Presented at: Laboratory Animal Sciences Virtual Event Series 2017
      4 3
      FEB 08, 2017 | 6:00 AM
      Impact of Two Formulations of Buprenorphine on Postsurgical Condition in Mice
      Impact of Two Formulations of Buprenorphine on Postsurgical Condition...
      DATE: February 8, 2017TIME: 6:00am PT, 9:00 ETSeveral regulatory bodies require that animals used in biomedical and behavioral research exposed to procedures that may cause more th...
      Speaker: Nicole Herndon, DVM
      Presented at: Laboratory Animal Sciences Virtual Event Series 2017
      7
      FEB 08, 2017 | 6:00 AM
      Producing Petri Puppies: Gamete Collection and In Vitro Fertilization in the Domestic Dog
      Producing Petri Puppies: Gamete Collection and In Vitro Fertilization...
      DATE: February 8, 2017TIME: 6:00am PT, 9:00am ETDevelopment of assisted reproductive technologies in the dog has lagged behind many other domestic and laboratory animal species, due in...
      Speaker: Jennifer Nagashima, PhD
      Presented at: Laboratory Animal Sciences Virtual Event Series 2017
      2
      FEB 07, 2017 | 10:00 AM
      WEBINAR: Beyond 100,000: Insights & Lessons from Large-Scale Sequencing in the Cloud
      WEBINAR: Beyond 100,000: Insights & Lessons from Large-Scale Sequencing...
      DATE: February 7, 2017TIME: 10:00am PT, 1:00pm ETIn this webinar, Jeffrey G. Reid, PhD, Executive Director and Head of Genome Informatics at Regeneron Pharmaceuticals, will sh...
      Speaker: Jeffrey Reid, PhD
      Sponsored By: DNAnexus
      13 3
      JAN 26, 2017 | 8:00 AM
      WEBINAR: Fast, Simple and Sensitive Electrochemical Biosensing using Screen-Printed Electrodes: A high throughput solution
      WEBINAR: Fast, Simple and Sensitive Electrochemical Biosensing...
      DATE:  January 26, 2017TIME: 8:00am PT, 11:00am ETThe demand for low-cost, disposable devices with short response times capable of performing routine electrochemical biosensing has...
      Speaker: Susana Campuzano, PhD , Laura Fernández Llano, PhD
      Sponsored By: Metrohm USA
      12
      DEC 14, 2016 | 7:30 AM
      Advances in modeling human diseases using induced pluripotent stem cell-derived cellular models
      Advances in modeling human diseases using induced pluripotent...
      DATE: December 14, 2016 TIME: 7:30am PT, 10:30am ET A major hurdle in developing relevant disease models for drug discovery is access to the healthy and diseased tissue of interest; induc...
      Speaker: T.K. Feaster, PhD , Kile Mangan, PhD
      Sponsored By: Cellular Dynamics, Cellular Dynamics
      7 1
      DEC 07, 2016 | 9:00 AM
      The Interplay of Kinase Broad Profiling and Phenotypic Screening
      The Interplay of Kinase Broad Profiling and Phenotypic Screening
      DATE: December 7, 2016 TIME: 9:00 AM PT, 12:00 PM ET Kinases play important roles in many biological signaling pathways. Kinase inhibitors are therefore potentially found as actives in ty...
      Speaker: Edgar Jacoby, Ph.D.
      Sponsored By: DiscoverX, DiscoverX
      4
      DEC 06, 2016 | 11:00 AM
      Expansion of Human Stem Cells in BioBLU Single-Use Vessels from Eppendorf
      Expansion of Human Stem Cells in BioBLU Single-Use Vessels from...
      DATE: December 6, 2016 TIME: 11:00am PT, 2:00pm ET Experimentation involving human stem cells (HSCs) is one of the fastest growing fields in research and development due, in large part, t...
      Speaker: Stacey Willard, PhD
      Sponsored By: Eppendorf, Eppendorf
      5 1
      NOV 17, 2016 | 1:00 PM
      Initiatives to advance stem cell science and medicine at California's $3 billion stem cell agency
      Initiatives to advance stem cell science and medicine at California's...
      The mission of the California Institute for Regenerative Medicine (CIRM) is to accelerate stem cell treatments to patients with unmet medical needs.  With $3 billion in funding and 300 a...
      Speaker: Stephen Lin, PhD
      Presented at: 4th Annual 24 Hours of Stem Cellsâ„¢ virtual event
      4
      NOV 17, 2016 | 9:00 AM
      From bench to BLA - a review of common regulatory questions
      From bench to BLA - a review of common regulatory questions
      This panel will discuss quality requirements of ancillary materials used in cell therapy manufacturing, relevant standards and how requirements vary by phase.  Participants will learn wh...
      Speaker: Joyce Frey-Vasconcells, PhD , Michael Mendicino, PhD , Kelli Tanzella, PhD
      Presented at: 4th Annual 24 Hours of Stem Cellsâ„¢ virtual event
      3
      NOV 16, 2016 | 4:00 PM
      Evolving your media system for modern stem cell applications
      Evolving your media system for modern stem cell applications
      Culture systems for pluripotent stem cell (PSC) expansion enable generation of a nearly unlimited pool of cells for downstream differentiation, disease modeling, drug discovery, and therapeut...
      Speaker: Rhonda Newman, PhD
      Presented at: 4th Annual 24 Hours of Stem Cellsâ„¢ virtual event
      4
      NOV 09, 2016 | 9:00 AM
      A duplexed assay to measure GPCR-mediated calcium signaling and β-Arrestin recruitment from single well using FDSS/µCell functional screening system
      A duplexed assay to measure GPCR-mediated calcium signaling and...
      DATE: November 9th, 2016 TIME: 9:00 AM PT, 12:00 PM ET The screening and functional characterization of novel ligands for G-Protein Coupled Receptors (GPCR) remains a key focus in drug di...
      Speaker: Thierry Calmels, PhD
      Sponsored By: DiscoverX, DiscoverX
      3
      NOV 03, 2016 | 6:00 AM
      Mutation Detection Simplified: From Liquid Biopsy in clinical oncology to the detection of Drug Resistance Associated Mutations in virology
      Mutation Detection Simplified: From Liquid Biopsy in clinical...
      Sanger sequencing and polymerase chain reaction (PCR) methods have been the standard molecular methods in clinical diagnostics for decades.  Next-Generation Sequencing (NGS) technology r...
      Speaker: Gerd Michel, PhD , Lou Welebob
      Presented at: Clinical Diagnostics & Research Virtual Event Series 2016
      5
      NOV 02, 2016 | 1:30 PM
      A Platform to Digitize Biology: A Potential Pathway to Exponential Medicine
      A Platform to Digitize Biology: A Potential Pathway to Exponential...
      Today there are about 7B mobile phone worldwide and about 50,000 mobile health applications actively changing the landscape of how healthcare will be delivered in the next years. While numero...
      Speaker: John McDevitt, PhD
      Presented at: Clinical Diagnostics & Research Virtual Event Series 2016
      4
      OCT 25, 2016 | 9:00 AM
      Displaying Data And Structures in Spotfire
      Displaying Data And Structures in Spotfire
      DATE: October 25th, 2016TIME:  9:00 AM PT, 12:00 PM ETTIBCO Spotfire is a powerful data visualization platform. Its functionality can be extended by creating custom tools. The...
      Speaker: Klaus Dress
      Sponsored By: Revvity
      9 1
      OCT 11, 2016 | 8:00 AM
      Pro-Enkephalin: A Novel New Biomarker for Assessment of Kidney Function, Early Prediction and Identification of Acute Kidney Injury
      Pro-Enkephalin: A Novel New Biomarker for Assessment of Kidney...
      DATE:  October 11, 2016 TIME:  8:00am PT, 11:00 ET Chronic Renal Dysfunction (CKD) and Acute Kidney Injury (AKI) are increasing in prevalence today and can be escalated due to d...
      Speaker: Alan Maisel, M.D.
      Sponsored By: Sphingotec LLC, Sphingotec LLC
      24 1
    FEB 08, 2017 | 1:30 PM
    Managing genetically modified rodent strains: focus on the genotype and genetic background
    Managing genetically modified rodent strains: focus on the genotype...
    DATE: February 8, 2017TIME: 1:30pm PT, 4:30pm ETThe powerful and expanding use of genetically modified mice introduces important aspects of genetics in managing these strains for breedi...
    Speaker: Steve Fiering, PhD
    Presented at: Laboratory Animal Sciences Virtual Event Series 2017
    5 1
    FEB 08, 2017 | 1:30 PM
    Safety and pharmacokinetic profiles of different buprenorphine SR doses in a rabbit model
    Safety and pharmacokinetic profiles of different buprenorphine...
    DATE: February 8, 2017TIME: 1:30pm PT, 4:30pm ETIn rabbits, buprenorphine instant release (IR) is commonly used to alleviate pain, especially in surgical models. However, maintenan...
    Speaker: Andrea Zanetti, DVM, PhD, SRS
    Presented at: Laboratory Animal Sciences Virtual Event Series 2017
    3
    FEB 08, 2017 | 12:00 PM
    Creating and Maintaining an Effective and Efficient In-Vivo Surgical Training Program
    Creating and Maintaining an Effective and Efficient In-Vivo Surgical...
    DATE: February 8, 2017TIME: 12:00pm PT, 3:00pm ETIn-vivo surgical models are becoming more prevalent and more critical to the drug development process.  As the vast majority of ind...
    Speaker: Matthew Flegal, BS, SRS
    Presented at: Laboratory Animal Sciences Virtual Event Series 2017
    5
    FEB 08, 2017 | 12:00 PM
    Availability and Management of Genetically Engineered Swine Models for Biomedical Research
    Availability and Management of Genetically Engineered Swine Models...
    DATE: February 8, 2017TIME: 12:00pm PT, 3:00pm ETLarge animal models have recently become a staple in biomedical research.  The pig’s similarities to humans in terms of genet...
    Speaker: Eric Walters, PhD
    Presented at: Laboratory Animal Sciences Virtual Event Series 2017
    2
    FEB 08, 2017 | 10:30 AM
    Biosecurity, Reproductive and Social Management of Cat Research Colonies
    Biosecurity, Reproductive and Social Management of Cat Research...
    DATE: February 8, 2017TIME: 10:30am PT, 1:30pm ETThe cat remains an important comparative species for studying the long-term safety and efficacy of emergent medical modalities, such as...
    Speaker: James Kehler VMD, PhD
    Presented at: Laboratory Animal Sciences Virtual Event Series 2017
    2
     
     
  • FEB 08, 2017 | 10:30 AM
    Obtaining non-invasive readouts and early safety signals from rodent models
    Obtaining non-invasive readouts and early safety signals from...
    DATE: February 8, 2017TIME: 10:30am PT, 1:30pm ETThe utility of animal models in drug development is limited, in part, by the measures available to researchers for monitoring animals. I...
    Speaker: Laura Schaevitz, PhD
    Presented at: Laboratory Animal Sciences Virtual Event Series 2017
    3
    FEB 08, 2017 | 9:00 AM
    Rabbit Breeding: Standards and Practices
    Rabbit Breeding: Standards and Practices
    DATE: February 8, 2017TIME: 9:00am PT, 12:00pm ETThere are many factors involved in rabbit breeding that impact performance.  In this evaluation of a Dutch Belted rabbit breeding c...
    Speaker: Kathryn Cavanaugh
    Presented at: Laboratory Animal Sciences Virtual Event Series 2017
    1
    FEB 08, 2017 | 9:00 AM
    Evaluating the Effectiveness of Training  for Animal Care and Use Personnel
    Evaluating the Effectiveness of Training for Animal Care and...
    DATE: February 8, 2017TIME: 9:00am PT, Noon ETTraining programs for animal care and use personnel are integral to both animal welfare and quality research outcomes. There are a variety...
    Speaker: Melissa Dyson MS, DVM, DACLAM
    Presented at: Laboratory Animal Sciences Virtual Event Series 2017
    2
    FEB 08, 2017 | 7:30 AM
    KEYNOTE: Rodent Surgery... Aseptic Technique Made Easy... and Other Tips
    KEYNOTE: Rodent Surgery... Aseptic Technique Made Easy... and...
    DATE: February 8, 2017TIME: 7:30am PT, 10:30am ETMany of us who believe in the importance of aseptic rodent surgery have lived through the frustration of trying to implement rodent asep...
    Speaker: Marcel Perret-Gentil, DVM, MS
    Presented at: Laboratory Animal Sciences Virtual Event Series 2017
    4 3
    FEB 08, 2017 | 6:00 AM
    Impact of Two Formulations of Buprenorphine on Postsurgical Condition in Mice
    Impact of Two Formulations of Buprenorphine on Postsurgical Condition...
    DATE: February 8, 2017TIME: 6:00am PT, 9:00 ETSeveral regulatory bodies require that animals used in biomedical and behavioral research exposed to procedures that may cause more th...
    Speaker: Nicole Herndon, DVM
    Presented at: Laboratory Animal Sciences Virtual Event Series 2017
    7
     
     
  • FEB 08, 2017 | 6:00 AM
    Producing Petri Puppies: Gamete Collection and In Vitro Fertilization in the Domestic Dog
    Producing Petri Puppies: Gamete Collection and In Vitro Fertilization...
    DATE: February 8, 2017TIME: 6:00am PT, 9:00am ETDevelopment of assisted reproductive technologies in the dog has lagged behind many other domestic and laboratory animal species, due in...
    Speaker: Jennifer Nagashima, PhD
    Presented at: Laboratory Animal Sciences Virtual Event Series 2017
    2
    FEB 07, 2017 | 10:00 AM
    WEBINAR: Beyond 100,000: Insights & Lessons from Large-Scale Sequencing in the Cloud
    WEBINAR: Beyond 100,000: Insights & Lessons from Large-Scale Sequencing...
    DATE: February 7, 2017TIME: 10:00am PT, 1:00pm ETIn this webinar, Jeffrey G. Reid, PhD, Executive Director and Head of Genome Informatics at Regeneron Pharmaceuticals, will sh...
    Speaker: Jeffrey Reid, PhD
    Sponsored By: DNAnexus
    13 3
    JAN 26, 2017 | 8:00 AM
    WEBINAR: Fast, Simple and Sensitive Electrochemical Biosensing using Screen-Printed Electrodes: A high throughput solution
    WEBINAR: Fast, Simple and Sensitive Electrochemical Biosensing...
    DATE:  January 26, 2017TIME: 8:00am PT, 11:00am ETThe demand for low-cost, disposable devices with short response times capable of performing routine electrochemical biosensing has...
    Speaker: Susana Campuzano, PhD , Laura Fernández Llano, PhD
    Sponsored By: Metrohm USA
    12
    DEC 14, 2016 | 7:30 AM
    Advances in modeling human diseases using induced pluripotent stem cell-derived cellular models
    Advances in modeling human diseases using induced pluripotent...
    DATE: December 14, 2016 TIME: 7:30am PT, 10:30am ET A major hurdle in developing relevant disease models for drug discovery is access to the healthy and diseased tissue of interest; induc...
    Speaker: T.K. Feaster, PhD , Kile Mangan, PhD
    Sponsored By: Cellular Dynamics, Cellular Dynamics
    7 1
    DEC 07, 2016 | 9:00 AM
    The Interplay of Kinase Broad Profiling and Phenotypic Screening
    The Interplay of Kinase Broad Profiling and Phenotypic Screening
    DATE: December 7, 2016 TIME: 9:00 AM PT, 12:00 PM ET Kinases play important roles in many biological signaling pathways. Kinase inhibitors are therefore potentially found as actives in ty...
    Speaker: Edgar Jacoby, Ph.D.
    Sponsored By: DiscoverX, DiscoverX
    4
     
     
  • DEC 06, 2016 | 11:00 AM
    Expansion of Human Stem Cells in BioBLU Single-Use Vessels from Eppendorf
    Expansion of Human Stem Cells in BioBLU Single-Use Vessels from...
    DATE: December 6, 2016 TIME: 11:00am PT, 2:00pm ET Experimentation involving human stem cells (HSCs) is one of the fastest growing fields in research and development due, in large part, t...
    Speaker: Stacey Willard, PhD
    Sponsored By: Eppendorf, Eppendorf
    5 1
    NOV 17, 2016 | 1:00 PM
    Initiatives to advance stem cell science and medicine at California's $3 billion stem cell agency
    Initiatives to advance stem cell science and medicine at California's...
    The mission of the California Institute for Regenerative Medicine (CIRM) is to accelerate stem cell treatments to patients with unmet medical needs.  With $3 billion in funding and 300 a...
    Speaker: Stephen Lin, PhD
    Presented at: 4th Annual 24 Hours of Stem Cellsâ„¢ virtual event
    4
    NOV 17, 2016 | 9:00 AM
    From bench to BLA - a review of common regulatory questions
    From bench to BLA - a review of common regulatory questions
    This panel will discuss quality requirements of ancillary materials used in cell therapy manufacturing, relevant standards and how requirements vary by phase.  Participants will learn wh...
    Speaker: Joyce Frey-Vasconcells, PhD , Michael Mendicino, PhD , Kelli Tanzella, PhD
    Presented at: 4th Annual 24 Hours of Stem Cellsâ„¢ virtual event
    3
    NOV 16, 2016 | 4:00 PM
    Evolving your media system for modern stem cell applications
    Evolving your media system for modern stem cell applications
    Culture systems for pluripotent stem cell (PSC) expansion enable generation of a nearly unlimited pool of cells for downstream differentiation, disease modeling, drug discovery, and therapeut...
    Speaker: Rhonda Newman, PhD
    Presented at: 4th Annual 24 Hours of Stem Cellsâ„¢ virtual event
    4
    NOV 09, 2016 | 9:00 AM
    A duplexed assay to measure GPCR-mediated calcium signaling and β-Arrestin recruitment from single well using FDSS/µCell functional screening system
    A duplexed assay to measure GPCR-mediated calcium signaling and...
    DATE: November 9th, 2016 TIME: 9:00 AM PT, 12:00 PM ET The screening and functional characterization of novel ligands for G-Protein Coupled Receptors (GPCR) remains a key focus in drug di...
    Speaker: Thierry Calmels, PhD
    Sponsored By: DiscoverX, DiscoverX
    3
     
     
  • NOV 03, 2016 | 6:00 AM
    Mutation Detection Simplified: From Liquid Biopsy in clinical oncology to the detection of Drug Resistance Associated Mutations in virology
    Mutation Detection Simplified: From Liquid Biopsy in clinical...
    Sanger sequencing and polymerase chain reaction (PCR) methods have been the standard molecular methods in clinical diagnostics for decades.  Next-Generation Sequencing (NGS) technology r...
    Speaker: Gerd Michel, PhD , Lou Welebob
    Presented at: Clinical Diagnostics & Research Virtual Event Series 2016
    5
    NOV 02, 2016 | 1:30 PM
    A Platform to Digitize Biology: A Potential Pathway to Exponential Medicine
    A Platform to Digitize Biology: A Potential Pathway to Exponential...
    Today there are about 7B mobile phone worldwide and about 50,000 mobile health applications actively changing the landscape of how healthcare will be delivered in the next years. While numero...
    Speaker: John McDevitt, PhD
    Presented at: Clinical Diagnostics & Research Virtual Event Series 2016
    4
    OCT 25, 2016 | 9:00 AM
    Displaying Data And Structures in Spotfire
    Displaying Data And Structures in Spotfire
    DATE: October 25th, 2016TIME:  9:00 AM PT, 12:00 PM ETTIBCO Spotfire is a powerful data visualization platform. Its functionality can be extended by creating custom tools. The...
    Speaker: Klaus Dress
    Sponsored By: Revvity
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    OCT 11, 2016 | 8:00 AM
    Pro-Enkephalin: A Novel New Biomarker for Assessment of Kidney Function, Early Prediction and Identification of Acute Kidney Injury
    Pro-Enkephalin: A Novel New Biomarker for Assessment of Kidney...
    DATE:  October 11, 2016 TIME:  8:00am PT, 11:00 ET Chronic Renal Dysfunction (CKD) and Acute Kidney Injury (AKI) are increasing in prevalence today and can be escalated due to d...
    Speaker: Alan Maisel, M.D.
    Sponsored By: Sphingotec LLC, Sphingotec LLC
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