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    Gene signatures

    Gene signatures describe specific, unique characteristics of a group of genes located in a biological cell or tissue. Gene signatures can be used to diagnose diseases, including cancer. Additionally, understanding gene signatures can inform on the prognosis of disease or determine optimal treatment planning.

    Webinars

    • MAR 14, 2019 | 9:00 AM
      A Gene Expression Based Screening Platform for Mouse Models of Late-Onset Alzheimer's Disease
      A Gene Expression Based Screening Platform for Mouse Models of...
      Late-onset Alzheimer’s disease (LOAD) is the most common form of dementia worldwide. To date, animal models of Alzheimer’s have focused on rare familial mutations, due to a lack o...
      Speaker: Greg Carter, PhD
      Presented at: Neuroscience Virtual Event Series 2019
      Sponsored By: NanoString Technologies
      2
      OCT 11, 2018 | 1:30 PM
      Exploiting Cis-Regulatory Enhancers as Therapeutic Targets in Cancer
      Exploiting Cis-Regulatory Enhancers as Therapeutic Targets in...
      Recent work has identified epigenomic features of distal regulatory elements to be dynamic and defining indicators of cellular specification and transformation. Of particular relevance is our...
      Speaker: Martin Hirst, PhD
      Presented at: Cancer Research & Oncology Week Virtual Event Series 2018
      1
      OCT 10, 2018 | 1:30 PM
      Discovery of Biomarkers Predictive of Anticancer Drug Response in Preclinical Settings
      Discovery of Biomarkers Predictive of Anticancer Drug Response...
      Some Abstract...
      Speaker: Benjamin Haibe-Kains, PhD
      Presented at: Cancer Research & Oncology Week Virtual Event Series 2018
      1
      OCT 10, 2018 | 10:30 AM
      Microbiome Signatures in Gynecologic Cancers
      Microbiome Signatures in Gynecologic Cancers
      The microbiome signatures in the context of gynecologic cancers (endometrial and ovarian) and the potential for their clinical use will be discussed. The use of microfluidic technologies to i...
      Speaker: Marina Walther-Antonio, PhD
      Presented at: Cancer Research & Oncology Week Virtual Event Series 2018
      3
      OCT 03, 2018 | 12:00 PM
      Using CRISPR and Stem Cells to Treat Genetic Disease
      Using CRISPR and Stem Cells to Treat Genetic Disease
      Decoding human genetic disease allows us to develop models of the pathology that can be directly tested with gene correction or targeted drug therapy.  Dominant negative mutations are pa...
      Speaker: Bruce Conklin, MD
      Presented at: CRISPR Virtual Event Series 2018
      1
      APR 12, 2018 | 10:30 AM
      The Genome in 3D: A Clinical Biomarker Platform
      The Genome in 3D: A Clinical Biomarker Platform
      In genomics, as in life, you need to be in the right place at the right time, and you need integrity, to be credible. Since the availability of the human genome sequence, there's been an...
      Speaker: Kevin Little, PhD
      Presented at: Molecular Diagnostics Virtual Event Series 2018
      1
      NOV 15, 2017 | 9:00 AM
      WEBINAR: The essential role of miRNA and mRNA on cancer progression and biomarker discovery
      WEBINAR: The essential role of miRNA and mRNA on cancer progression...
      DATE: November 15, 2017TIME: 09:00am PST, 12:00pm ESTMicroRNAs (miRNA) are a class of small non-coding RNAs (approximately 21 nt long) that bind complementary sequences in target mRNAs...
      Speaker: Dr. Malte Buchholz
      Sponsored By: Thermo Fisher Scientific - Applied Biosystems
      6
      NOV 14, 2017 | 12:00 PM
      WEBINAR: Exosome miRNA sequencing for biomarker profiling using the Ion S5 System and Ion Total RNA-seq kit
      WEBINAR: Exosome miRNA sequencing for biomarker profiling using...
      DATE: November 14, 2017TIME: 12:00pm PST, 03:00pm ESTLearning Objectives: How to maximise RNA yield and extraction from exosomes and biological fluids How to construct small RNA...
      Speaker: Dr. Lesley Cheng
      Sponsored By: Thermo Fisher Scientific - Ion Torrent
      9
      NOV 09, 2017 | 9:00 AM
      Accelerating Immuno-Oncology Research with the PanCancer IO 360™ Gene Expression Panel, Advanced Data Analysis Service, and Signature Development
      Accelerating Immuno-Oncology Research with the PanCancer IO 360™...
      Transcriptional profiling of the tumor microenvironment can lead to insights about the interaction between the tumor and immune system. This facilitates investigation of immune evasion mechan...
      Speaker: Sarah Warren, PhD , Patrick Danaher, PhD
      Presented at: Clinical Diagnostics & Research Virtual Event Series 2017
      Sponsored By: NanoString Technologies
      1
      OCT 17, 2017 | 8:00 AM
      WEBINAR: Transcriptomics to decipher the pathobiology of drug resistance and enable targeted therapeutics
      WEBINAR: Transcriptomics to decipher the pathobiology of drug...
      DATE: October 17, 2017TIME: 08:00am PDT, 11:00am EDTResearching and understanding the mechanisms of drug resistance are essential to determine therapies that are more effective on an in...
      Speaker: Yesim Gökmen-Polar, PhD
      Sponsored By: Thermo Fisher Scientific - Applied Biosystems
      8 1
      OCT 12, 2017 | 12:00 PM
      Comprehensive genomic and transcriptomic analysis of acral melanoma: A path towards therapeutic development
      Comprehensive genomic and transcriptomic analysis of acral melanoma:...
      Acral lentiginous melanoma (ALM) is a rare sun-shielded melanoma subtype associated with worse survival than cutaneous melanoma (CM), a more common form of skin cancer linked to exposure to u...
      Speaker: Winnie Liang, PhD
      Presented at: Cancer Research & Oncology Week Virtual Event Series 2017
      1
      OCT 12, 2017 | 6:00 AM
      Inference of gene signatures associated with response and resistance to targeted and immunotherapies
      Inference of gene signatures associated with response and resistance...
      We developed two computational methods, CARE and TIDE, to predict response and resistance to targeted therapies and immunotherapies. CARE infers gene signatures of targeted therapy response b...
      Speaker: Xiaole Shirley Liu, PhD
      Presented at: Cancer Research & Oncology Week Virtual Event Series 2017
      1
      APR 12, 2017 | 10:30 AM
      Prediction of enzalutamide sensitivity in triple negative breast cancer
      Prediction of enzalutamide sensitivity in triple negative breast...
      A recent clinical trial of the AR inhibitor enzalutamide in patients with TNBC included an exploratory endpoint using RNA sequencing to identify a genomic signature of patients likely to resp...
      Speaker: Joel Parker, PhD
      Presented at: Molecular Diagnostics Virtual Event Series 2017
      Sponsored By: NanoString Technologies
      2
      FEB 23, 2017 | 12:00 PM
      Recent progress in cellular medicine with an eye to precision medicine
      Recent progress in cellular medicine with an eye to precision...
      Despite vast investment for decades in cancer research and development, cancer is still among the leading causes of death worldwide and its toll is expected to rise by about 70% over the next...
      Speaker: Giacinto Scoles, PhD
      Presented at: Precision Medicine Virtual Event Series 2017
      2
      FEB 22, 2017 | 1:30 PM
      Integrating genomics platforms and data in Biobanks
      Integrating genomics platforms and data in Biobanks
      Biobanks are a powerful resource in the advancement of precision medicine, and integrating large scale genomics data across Biobank cohorts offer opportunities to further enhance and expedite...
      Speaker: Sami Amr, PhD
      Presented at: Precision Medicine Virtual Event Series 2017
      2
      FEB 22, 2017 | 9:00 AM
      The Microbiome-Gut-Brain Axis: Linking Gastrointestinal and Neurobehavioral Processes in Autism Spectrum Disorder
      The Microbiome-Gut-Brain Axis: Linking Gastrointestinal and Neurobehavioral...
      Gastrointestinal (GI) disorders are now widely recognized as a clinical symptom of autism spectrum disorder (ASD), and research into the microbiome-gut-brain axis is beginning to reveal the i...
      Speaker: Ruth Luna, PhD, MB (ASCP) CM
      Presented at: Precision Medicine Virtual Event Series 2017
      6
      FEB 09, 2017 | 6:00 AM
      Continuous Professional Development (CPD) in Laboratory Animal Science, a continuous improvement in animal welfare and science
      Continuous Professional Development (CPD) in Laboratory Animal...
      DATE: February 9, 2017TIME: 6:00am PT, 9:00am ETThere is no professional area in which CPD is more necessary than in the field of laboratory animals. The continuous advancement of scien...
      Speaker: Patri Vergara, DVM, PhD, DipECLAM
      Presented at: Laboratory Animal Sciences Virtual Event Series 2017
      3
      OCT 06, 2016 | 7:30 AM
      Keynote Speaker: Reference Component Analysis of Single Cell Transcriptomes Reveals Cellular Heterogeneity in Colorectal Cancer
      Keynote Speaker: Reference Component Analysis of Single Cell Transcriptomes...
      Intra-tumor heterogeneity is a major obstacle to cancer treatment. Existing single-cell studies of intra-tumor heterogeneity have largely focused on DNA mutations; functional heterogeneity is...
      Speaker: Shyam Prabhakar, PhD
      Presented at: Cancer Research & Oncology Week Virtual Event Series 2016
      2
      AUG 30, 2016 | 8:00 AM
      Translating Pluripotent Stem Cell Therapies For Focal Brain Disorders
      Translating Pluripotent Stem Cell Therapies For Focal Brain Disorders
      A major challenge for the clinical application of pluripotent stem cell therapy for neurodegenerative diseases is large-scale manufacturing and cryopreservation of neurons and glia that can b...
      Speaker: Dustin Wakeman, PhD
      Presented at: 4th Annual 24 Hours of Stem Cells™ virtual event
      1
      OCT 28, 2015 | 11:00 AM
      The Hidden Effects of Epigenetic Discoveries
      The Hidden Effects of Epigenetic Discoveries
      DATE: October 28th, 2015TIME: 11am Pacific time, 2pm Eastern timeNew discoveries uncover that exposure to current environmental, dietary, behavioral, and medical conditions can significantly...
      Speaker: Jeffrey Kim, PhD , Christopher Scharer, PhD , Carlos Barrero, MD
      Sponsored By: Rockland
      25
      OCT 08, 2015 | 8:00 AM
      WEBINAR: Proteome Profiling of the Tumor Microenvironment: Role of Human Primary Fibroblasts Derived Exosomes in Oral Cancer Progression
      WEBINAR: Proteome Profiling of the Tumor Microenvironment: Role...
      During the development of oral cancer (OC), cancer-associated fibroblasts (CAFs) create a supporting niche by maintaining a bidirectional crosstalk with cancer cells, mediated by classically ...
      Speaker: Simona Principe, PhD
      Presented at: Beckman Coulter Life Sciences Virtual Trade Show
      Sponsored By: Beckman Coulter Life Sciences, Beckman Coulter Life Sciences
      11
      MAY 14, 2015 | 12:00 PM
      Make your clinical sequencing count: technical and content decisions for improved disease targeted panels
      Make your clinical sequencing count: technical and content decisions...
      With current NGS platforms, the boundaries of variant detection and gene content for genetic disease panels has been vastly expanded leading to increases in detection rates. However these pla...
      Speaker: Sami Amr, PhD
      Presented at: Genetics and Genomics Virtual Event Series 2015
      3
      MAY 13, 2015 | 6:00 AM
      Predictive Gene Signatures: Molecular Markers Distinguishing Colon Adenomatous Polyp and Carcinoma
      Predictive Gene Signatures: Molecular Markers Distinguishing Colon...
      Cancers exhibit abnormal molecular signatures associated with disease initiation and progression. Molecular signatures could improve cancer screening, detection, drug development and selectio...
      Speaker: Janice Drew, PhD
      Presented at: Genetics and Genomics Virtual Event Series 2015
      0
      OCT 29, 2014 | 9:00 AM
      miRNA Biomarker Discovery: Technologies, workflows, and data analysis solutions for discovering your unique signature
      miRNA Biomarker Discovery: Technologies, workflows, and data analysis...
      Circulating miRNAs have great potential as biomarkers due to their aberrant expression in cancer and other diseases. However, miRNAs from body fluids are hard to obtain in amounts sufficient...
      Speaker: Jonathan Shaffer, PhD, MBA
      Presented at: Cancer: Research, Discovery and Therapeutics Virtual Event Series 2014
      18
    MAR 14, 2019 | 9:00 AM
    A Gene Expression Based Screening Platform for Mouse Models of Late-Onset Alzheimer's Disease
    A Gene Expression Based Screening Platform for Mouse Models of...
    Late-onset Alzheimer’s disease (LOAD) is the most common form of dementia worldwide. To date, animal models of Alzheimer’s have focused on rare familial mutations, due to a lack o...
    Speaker: Greg Carter, PhD
    Presented at: Neuroscience Virtual Event Series 2019
    Sponsored By: NanoString Technologies
    2
    OCT 11, 2018 | 1:30 PM
    Exploiting Cis-Regulatory Enhancers as Therapeutic Targets in Cancer
    Exploiting Cis-Regulatory Enhancers as Therapeutic Targets in...
    Recent work has identified epigenomic features of distal regulatory elements to be dynamic and defining indicators of cellular specification and transformation. Of particular relevance is our...
    Speaker: Martin Hirst, PhD
    Presented at: Cancer Research & Oncology Week Virtual Event Series 2018
    1
    OCT 10, 2018 | 1:30 PM
    Discovery of Biomarkers Predictive of Anticancer Drug Response in Preclinical Settings
    Discovery of Biomarkers Predictive of Anticancer Drug Response...
    Some Abstract...
    Speaker: Benjamin Haibe-Kains, PhD
    Presented at: Cancer Research & Oncology Week Virtual Event Series 2018
    1
    OCT 10, 2018 | 10:30 AM
    Microbiome Signatures in Gynecologic Cancers
    Microbiome Signatures in Gynecologic Cancers
    The microbiome signatures in the context of gynecologic cancers (endometrial and ovarian) and the potential for their clinical use will be discussed. The use of microfluidic technologies to i...
    Speaker: Marina Walther-Antonio, PhD
    Presented at: Cancer Research & Oncology Week Virtual Event Series 2018
    3
    OCT 03, 2018 | 12:00 PM
    Using CRISPR and Stem Cells to Treat Genetic Disease
    Using CRISPR and Stem Cells to Treat Genetic Disease
    Decoding human genetic disease allows us to develop models of the pathology that can be directly tested with gene correction or targeted drug therapy.  Dominant negative mutations are pa...
    Speaker: Bruce Conklin, MD
    Presented at: CRISPR Virtual Event Series 2018
    1
     
     
  • APR 12, 2018 | 10:30 AM
    The Genome in 3D: A Clinical Biomarker Platform
    The Genome in 3D: A Clinical Biomarker Platform
    In genomics, as in life, you need to be in the right place at the right time, and you need integrity, to be credible. Since the availability of the human genome sequence, there's been an...
    Speaker: Kevin Little, PhD
    Presented at: Molecular Diagnostics Virtual Event Series 2018
    1
    NOV 15, 2017 | 9:00 AM
    WEBINAR: The essential role of miRNA and mRNA on cancer progression and biomarker discovery
    WEBINAR: The essential role of miRNA and mRNA on cancer progression...
    DATE: November 15, 2017TIME: 09:00am PST, 12:00pm ESTMicroRNAs (miRNA) are a class of small non-coding RNAs (approximately 21 nt long) that bind complementary sequences in target mRNAs...
    Speaker: Dr. Malte Buchholz
    Sponsored By: Thermo Fisher Scientific - Applied Biosystems
    6
    NOV 14, 2017 | 12:00 PM
    WEBINAR: Exosome miRNA sequencing for biomarker profiling using the Ion S5 System and Ion Total RNA-seq kit
    WEBINAR: Exosome miRNA sequencing for biomarker profiling using...
    DATE: November 14, 2017TIME: 12:00pm PST, 03:00pm ESTLearning Objectives: How to maximise RNA yield and extraction from exosomes and biological fluids How to construct small RNA...
    Speaker: Dr. Lesley Cheng
    Sponsored By: Thermo Fisher Scientific - Ion Torrent
    9
    NOV 09, 2017 | 9:00 AM
    Accelerating Immuno-Oncology Research with the PanCancer IO 360™ Gene Expression Panel, Advanced Data Analysis Service, and Signature Development
    Accelerating Immuno-Oncology Research with the PanCancer IO 360™...
    Transcriptional profiling of the tumor microenvironment can lead to insights about the interaction between the tumor and immune system. This facilitates investigation of immune evasion mechan...
    Speaker: Sarah Warren, PhD , Patrick Danaher, PhD
    Presented at: Clinical Diagnostics & Research Virtual Event Series 2017
    Sponsored By: NanoString Technologies
    1
    OCT 17, 2017 | 8:00 AM
    WEBINAR: Transcriptomics to decipher the pathobiology of drug resistance and enable targeted therapeutics
    WEBINAR: Transcriptomics to decipher the pathobiology of drug...
    DATE: October 17, 2017TIME: 08:00am PDT, 11:00am EDTResearching and understanding the mechanisms of drug resistance are essential to determine therapies that are more effective on an in...
    Speaker: Yesim Gökmen-Polar, PhD
    Sponsored By: Thermo Fisher Scientific - Applied Biosystems
    8 1
     
     
  • OCT 12, 2017 | 12:00 PM
    Comprehensive genomic and transcriptomic analysis of acral melanoma: A path towards therapeutic development
    Comprehensive genomic and transcriptomic analysis of acral melanoma:...
    Acral lentiginous melanoma (ALM) is a rare sun-shielded melanoma subtype associated with worse survival than cutaneous melanoma (CM), a more common form of skin cancer linked to exposure to u...
    Speaker: Winnie Liang, PhD
    Presented at: Cancer Research & Oncology Week Virtual Event Series 2017
    1
    OCT 12, 2017 | 6:00 AM
    Inference of gene signatures associated with response and resistance to targeted and immunotherapies
    Inference of gene signatures associated with response and resistance...
    We developed two computational methods, CARE and TIDE, to predict response and resistance to targeted therapies and immunotherapies. CARE infers gene signatures of targeted therapy response b...
    Speaker: Xiaole Shirley Liu, PhD
    Presented at: Cancer Research & Oncology Week Virtual Event Series 2017
    1
    APR 12, 2017 | 10:30 AM
    Prediction of enzalutamide sensitivity in triple negative breast cancer
    Prediction of enzalutamide sensitivity in triple negative breast...
    A recent clinical trial of the AR inhibitor enzalutamide in patients with TNBC included an exploratory endpoint using RNA sequencing to identify a genomic signature of patients likely to resp...
    Speaker: Joel Parker, PhD
    Presented at: Molecular Diagnostics Virtual Event Series 2017
    Sponsored By: NanoString Technologies
    2
    FEB 23, 2017 | 12:00 PM
    Recent progress in cellular medicine with an eye to precision medicine
    Recent progress in cellular medicine with an eye to precision...
    Despite vast investment for decades in cancer research and development, cancer is still among the leading causes of death worldwide and its toll is expected to rise by about 70% over the next...
    Speaker: Giacinto Scoles, PhD
    Presented at: Precision Medicine Virtual Event Series 2017
    2
    FEB 22, 2017 | 1:30 PM
    Integrating genomics platforms and data in Biobanks
    Integrating genomics platforms and data in Biobanks
    Biobanks are a powerful resource in the advancement of precision medicine, and integrating large scale genomics data across Biobank cohorts offer opportunities to further enhance and expedite...
    Speaker: Sami Amr, PhD
    Presented at: Precision Medicine Virtual Event Series 2017
    2
     
     
  • FEB 22, 2017 | 9:00 AM
    The Microbiome-Gut-Brain Axis: Linking Gastrointestinal and Neurobehavioral Processes in Autism Spectrum Disorder
    The Microbiome-Gut-Brain Axis: Linking Gastrointestinal and Neurobehavioral...
    Gastrointestinal (GI) disorders are now widely recognized as a clinical symptom of autism spectrum disorder (ASD), and research into the microbiome-gut-brain axis is beginning to reveal the i...
    Speaker: Ruth Luna, PhD, MB (ASCP) CM
    Presented at: Precision Medicine Virtual Event Series 2017
    6
    FEB 09, 2017 | 6:00 AM
    Continuous Professional Development (CPD) in Laboratory Animal Science, a continuous improvement in animal welfare and science
    Continuous Professional Development (CPD) in Laboratory Animal...
    DATE: February 9, 2017TIME: 6:00am PT, 9:00am ETThere is no professional area in which CPD is more necessary than in the field of laboratory animals. The continuous advancement of scien...
    Speaker: Patri Vergara, DVM, PhD, DipECLAM
    Presented at: Laboratory Animal Sciences Virtual Event Series 2017
    3
    OCT 06, 2016 | 7:30 AM
    Keynote Speaker: Reference Component Analysis of Single Cell Transcriptomes Reveals Cellular Heterogeneity in Colorectal Cancer
    Keynote Speaker: Reference Component Analysis of Single Cell Transcriptomes...
    Intra-tumor heterogeneity is a major obstacle to cancer treatment. Existing single-cell studies of intra-tumor heterogeneity have largely focused on DNA mutations; functional heterogeneity is...
    Speaker: Shyam Prabhakar, PhD
    Presented at: Cancer Research & Oncology Week Virtual Event Series 2016
    2
    AUG 30, 2016 | 8:00 AM
    Translating Pluripotent Stem Cell Therapies For Focal Brain Disorders
    Translating Pluripotent Stem Cell Therapies For Focal Brain Disorders
    A major challenge for the clinical application of pluripotent stem cell therapy for neurodegenerative diseases is large-scale manufacturing and cryopreservation of neurons and glia that can b...
    Speaker: Dustin Wakeman, PhD
    Presented at: 4th Annual 24 Hours of Stem Cells™ virtual event
    1
    OCT 28, 2015 | 11:00 AM
    The Hidden Effects of Epigenetic Discoveries
    The Hidden Effects of Epigenetic Discoveries
    DATE: October 28th, 2015TIME: 11am Pacific time, 2pm Eastern timeNew discoveries uncover that exposure to current environmental, dietary, behavioral, and medical conditions can significantly...
    Speaker: Jeffrey Kim, PhD , Christopher Scharer, PhD , Carlos Barrero, MD
    Sponsored By: Rockland
    25
     
     
  • OCT 08, 2015 | 8:00 AM
    WEBINAR: Proteome Profiling of the Tumor Microenvironment: Role of Human Primary Fibroblasts Derived Exosomes in Oral Cancer Progression
    WEBINAR: Proteome Profiling of the Tumor Microenvironment: Role...
    During the development of oral cancer (OC), cancer-associated fibroblasts (CAFs) create a supporting niche by maintaining a bidirectional crosstalk with cancer cells, mediated by classically ...
    Speaker: Simona Principe, PhD
    Presented at: Beckman Coulter Life Sciences Virtual Trade Show
    Sponsored By: Beckman Coulter Life Sciences, Beckman Coulter Life Sciences
    11
    MAY 14, 2015 | 12:00 PM
    Make your clinical sequencing count: technical and content decisions for improved disease targeted panels
    Make your clinical sequencing count: technical and content decisions...
    With current NGS platforms, the boundaries of variant detection and gene content for genetic disease panels has been vastly expanded leading to increases in detection rates. However these pla...
    Speaker: Sami Amr, PhD
    Presented at: Genetics and Genomics Virtual Event Series 2015
    3
    MAY 13, 2015 | 6:00 AM
    Predictive Gene Signatures: Molecular Markers Distinguishing Colon Adenomatous Polyp and Carcinoma
    Predictive Gene Signatures: Molecular Markers Distinguishing Colon...
    Cancers exhibit abnormal molecular signatures associated with disease initiation and progression. Molecular signatures could improve cancer screening, detection, drug development and selectio...
    Speaker: Janice Drew, PhD
    Presented at: Genetics and Genomics Virtual Event Series 2015
    0
    OCT 29, 2014 | 9:00 AM
    miRNA Biomarker Discovery: Technologies, workflows, and data analysis solutions for discovering your unique signature
    miRNA Biomarker Discovery: Technologies, workflows, and data analysis...
    Circulating miRNAs have great potential as biomarkers due to their aberrant expression in cancer and other diseases. However, miRNAs from body fluids are hard to obtain in amounts sufficient...
    Speaker: Jonathan Shaffer, PhD, MBA
    Presented at: Cancer: Research, Discovery and Therapeutics Virtual Event Series 2014
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