OCT 3, 2018 Opens: 6:00 AM PDT

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CRISPR 2018

Name: CRISPR 2018
Start: 2018-10-03T06:00:00-07:00
Location: Labroots

LabRoots invites you to the First Annual CRISPR Virtual Event! With continued adoption and integration in research labs, CRISPR gene editing has gained importance both as a research tool in drug discovery, screening, and therapeutic development. This inaugural event will bring together thought leaders from academia, trained researcher from clinical laboratories, and industry experts from pharmaceutical to biotech.

This exciting new field is faced with new challenges and limitations. Experts will share case studies and experiences regarding best practices to guide RNA design, effects associated with CRISPR/Cas and address appropriate alternatives that are currently being developed.

The 2018 event will cover a range of topics, such as:

In Vivo Genome Editing with CRISPR
Engineering T Cell Circuitry
Harnessing CRISPR-Cas9 to Enhance Genome Editing
Measurements and Standards
CRISPR-Based Gene Editing for Drug Discovery & Targeted Therapies
Next-gen editing tools

This complimentary conference offers a fantastic opportunity to benefit from interacting with a global community of like-minded colleagues from the comfort of home. Topics of discussion include the distinctions and abilities of CRISPR-based editing, next-gen editing tools, precision in gene editing and using CRISPR for drug discovery. As our first-ever annual event on CRISPR, we aim to further the conversation of cannabis sciences and analytical research.

Our virtual conference allows you to participate in a global setting with no travel or cost to you. You can take part in exactly those parts which you are interested in and be back at your desk or bench in an instant. Virtual events remove time and place restrictions and ensure that everyone who wants to participate can do so. This virtual conference also offers increased reach for the global clinical community with a high degree of interaction through live-streaming video and chat sessions.

Call for Posters — Virtual poster sessions offer the opportunity to present data to a global audience via a PDF poster and video summary, and discuss results with interested colleagues through email. Plan now to have your poster included in the 2018 CRISPR Virtual Event. Submission is free. Submit your abstract here.

Continuing Education
By participating in this virtual event and watching webcast presentations, you can earn Free Continuing Education (PACE) credits. To earn educational credits, you must view an entire presentation. Following the presentation, you must click on the educational credit link provided for that particular speaker and follow the required process. Once you have completed the process, you will receive a certificate for the educational credit.

Use #LRcrispr to follow the conversation

Speakers

Samantha Maragh, PhD

Leader, Genome Editing Program, National Institute of Standards and Technology (NIST)
Bruce Conklin, MD

Senior Investigator, Gladstone Institute of Cardiovascular Disease, Professor Department of Medicine, Division of Genomic Medicine, University of California, San Francisco
Devang Mehta, PhD

Post Doctoral Fellow, University of Alberta
Dipali Sashital, PhD

Assistant Professor, Department of Biochemistry, Biophysics and Molecular Biology, Iowa State University
Xiaobo Zhou, PhD

Assistant Professor of Medicine, Brigham and Women's Hospital, Harvard
Lihua Zhu, PhD

Professor and Director of Bioinformatics Core, University of Massachusetts Medical School

Show Resources

Agenda

Download Agenda

OCT 03, 2018 09:00 AM PDT
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CRISPRseek and GUIDEseq for Design of Target-Specific Guide RNAs in CRISPR-Cas9 Genome-Editing Systems

Speaker: Lihua Zhu, PhD

The most recently developed genome editing system, CRISPR-Cas9 has greater inherent flexibility than prior programmable nuclease platforms. Because of its simplicity and efficacy, this technology is revolutionizing biological studies and holds tremendous promise for therapeutic applications. However, imperfect cleavage specificity of CRISPR-Cas9 nuclease within the genome is a cause for concern for its therapeutic application. To facilitate the adoption and improvement of this technology, we have developed CRISPRseek for designing target specific gRNAs, and GUIDEseq for identifying genome-wide offtarget sites from GUIDE-seq and CIRCLE-seq experiments to assess the precision of engineered CIRSPR-Cas9 nucleases. In this talk, I will give an introduction to the CRISPR genome editing, GUIDE-seq and CIRCLE-seq technologies, followed by an overview of the functionalities of CRISPRseek and GUIDEseq. By the end of talk, the participants should be able to design target-specific gRNAs for various cas9 nucleases and genomes using CRISPRseek, and analyze GUIDE-seq and CIRCLE-seq data using GUIDEseq.

SEE ABSTRACT | Continuing Education: P.A.C.E. CE
OCT 03, 2018 10:30 AM PDT
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Can We Use CRISPR-Cas9 as a Eukaryotic Immune System? A Case Study in the Orphan Crop Plant, Cassava

Speaker: Devang Mehta, PhD

The CRISPR-Cas9 bacterial immune system has revolutionized genetic engineering by enabling the precise editing for eukaryotic genomes. My research has been motivated by the idea of harnessing CRISPR’s ability to cleave specific DNA sequences as an immune system in plants. In order to do this, I worked on cassava, a root plant that forms a staple in tropical diets and feeds almost a billion people globally. Since cassava cultivation in Africa is severely curtailed by the impact of DNA viruses, this system served as an excellent test for using CRISPR for engineering virus resistance. In this talk I will describe our experiments as well experiments in other plants aimed to engineer a functional CRISPR system in plants. I will talk about our unexpected findings, how they impact future research in this arena, and the steps ahead. I will also discuss how my research shows the importance of good science communication when it comes to new technologies like CRISPR.

SEE ABSTRACT | Continuing Education: P.A.C.E. CE
OCT 03, 2018 12:00 PM PDT
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Mechanisms of CRISPR-Cas Systems: From Adaptive Immunity to Biotechnology

Speaker: Dipali Sashital, PhD

All forms of life require immune systems to stave off infection from viruses and other pathogens. In bacteria and archaea, clustered regularly interspaced short palindromic repeats (CRISPR) arrays and CRISPR-associated (Cas) proteins provide adaptive immunity against invading DNA from bacteriophages and plasmids. During infection, host cells adapt by storing short segments of foreign DNA in CRISPR arrays, providing heritable molecular memories of the infection. CRISPR-derived RNAs guide Cas complexes to bind and cleave the specific matching region of the foreign nucleic acids, thus neutralizing the infection. The unique, programmable DNA cleavage activity of CRISPR-Cas systems has been widely adapted for genome editing. In addition to providing revolutionary biotechnological tools, fundamental research into CRISPR/Cas systems has deepened our understanding of the complex molecular warfare that occurs between bacteria and their invaders. I will present recent mechanistic insights into CRISPR-Cas systems that reveal how bacteria adapt to rapidly evolving viruses.

SEE ABSTRACT | Continuing Education: P.A.C.E. CE

OCT 03, 2018 09:00 AM PDT
Add to Calendar Select one of the following: iCal Google Calendar Outlook Calendar Yahoo Calendar

CRISPRseek and GUIDEseq for Design of Target-Specific Guide RNAs in CRISPR-Cas9 Genome-Editing Systems

Speaker: Lihua Zhu, PhD

The most recently developed genome editing system, CRISPR-Cas9 has greater inherent flexibility than prior programmable nuclease platforms. Because of its simplicity and efficacy, this technology is revolutionizing biological studies and holds tremendous promise for therapeutic applications. However, imperfect cleavage specificity of CRISPR-Cas9 nuclease within the genome is a cause for concern for its therapeutic application. To facilitate the adoption and improvement of this technology, we have developed CRISPRseek for designing target specific gRNAs, and GUIDEseq for identifying genome-wide offtarget sites from GUIDE-seq and CIRCLE-seq experiments to assess the precision of engineered CIRSPR-Cas9 nucleases. In this talk, I will give an introduction to the CRISPR genome editing, GUIDE-seq and CIRCLE-seq technologies, followed by an overview of the functionalities of CRISPRseek and GUIDEseq. By the end of talk, the participants should be able to design target-specific gRNAs for various cas9 nucleases and genomes using CRISPRseek, and analyze GUIDE-seq and CIRCLE-seq data using GUIDEseq.

SEE ABSTRACT | Continuing Education: P.A.C.E. CE
OCT 03, 2018 10:30 AM PDT
Add to Calendar Select one of the following: iCal Google Calendar Outlook Calendar Yahoo Calendar

Can We Use CRISPR-Cas9 as a Eukaryotic Immune System? A Case Study in the Orphan Crop Plant, Cassava

Speaker: Devang Mehta, PhD

The CRISPR-Cas9 bacterial immune system has revolutionized genetic engineering by enabling the precise editing for eukaryotic genomes. My research has been motivated by the idea of harnessing CRISPR’s ability to cleave specific DNA sequences as an immune system in plants. In order to do this, I worked on cassava, a root plant that forms a staple in tropical diets and feeds almost a billion people globally. Since cassava cultivation in Africa is severely curtailed by the impact of DNA viruses, this system served as an excellent test for using CRISPR for engineering virus resistance. In this talk I will describe our experiments as well experiments in other plants aimed to engineer a functional CRISPR system in plants. I will talk about our unexpected findings, how they impact future research in this arena, and the steps ahead. I will also discuss how my research shows the importance of good science communication when it comes to new technologies like CRISPR.

SEE ABSTRACT | Continuing Education: P.A.C.E. CE
OCT 03, 2018 12:00 PM PDT
Add to Calendar Select one of the following: iCal Google Calendar Outlook Calendar Yahoo Calendar

Mechanisms of CRISPR-Cas Systems: From Adaptive Immunity to Biotechnology

Speaker: Dipali Sashital, PhD

All forms of life require immune systems to stave off infection from viruses and other pathogens. In bacteria and archaea, clustered regularly interspaced short palindromic repeats (CRISPR) arrays and CRISPR-associated (Cas) proteins provide adaptive immunity against invading DNA from bacteriophages and plasmids. During infection, host cells adapt by storing short segments of foreign DNA in CRISPR arrays, providing heritable molecular memories of the infection. CRISPR-derived RNAs guide Cas complexes to bind and cleave the specific matching region of the foreign nucleic acids, thus neutralizing the infection. The unique, programmable DNA cleavage activity of CRISPR-Cas systems has been widely adapted for genome editing. In addition to providing revolutionary biotechnological tools, fundamental research into CRISPR/Cas systems has deepened our understanding of the complex molecular warfare that occurs between bacteria and their invaders. I will present recent mechanistic insights into CRISPR-Cas systems that reveal how bacteria adapt to rapidly evolving viruses.

SEE ABSTRACT | Continuing Education: P.A.C.E. CE

Posters

POSTER SUBMISSION GUIDELINES

Virtual poster sessions offer the opportunity to present data to a global audience via a PDF poster and video summary, and discuss results with interested colleagues through email. Posters should be submitted as a PowerPoint file. Presentations should incorporate illustrative materials such as tables, graphs, photographs, and large-print text. This content is not peer-reviewed. Submission is free.

SUBMIT YOUR ABSTRACT

Enter the following information to this Submission Form:

Poster Title
Your Name
Your Institution
Your Email
Abstract describing the poster

All submitted abstracts will be reviewed and decisions regarding acceptance will be made as abstracts are received. You will be notified within one week of receipt about acceptance. Further details and registration materials will be provided at that time. You do not have to be present in order to have a poster displayed. Only those abstracts approved by LabRoots may display posters at this event.

If accepted, you will also have the opportunity to record a 3-5 minute summary video for each poster. LabRoots will work with each individual to create these videos. Video links and email contact information will be included on each poster displayed.

Questions? Email Posters@LabRoots.com

LabRoots Policy

Speakers

Samantha Maragh, PhD
Leader, Genome Editing Program, National Institute of Standards and Technology (NIST)

Biography
Samantha leads NIST's Genome Editing Program including the NIST Genome Editing Consortium, which supports measurements, standards and assay qualification for confidence in genome editing applications with an emphasis on gene and cell therapy. She has 13 years of experience working on projects supporting better measurements and assays for early detection of cancer biomarkers in collaboration with the National Cancer Institute's Early Detection Research Network. Her research is focused on measurement assurance and technology development for genome editing, bioassay and biomarker validation, with applications in engineering biology, precision/regenerative medicine, and cancer biology. Samantha also represents the U.S. as a technical expert to the International Standards Organizations Technical Committee on Biotechnology (ISO TC 276). She is currently a U.S. liaison representing the interests and expertise of the U.S. on standards relating to nucleic acids measurements.
Bruce Conklin, MD

Senior Investigator, Gladstone Institute of Cardiovascular Disease, Professor Department of Medicine, Division of Genomic Medicine, University of California, San Francisco
Devang Mehta, PhD
Post Doctoral Fellow, University of Alberta

Biography
Devang Mehta is a synthetic biologist, plant scientist & science-writer who's also interested in shaping policy. He is a systems & synthetic biologist by training and recently completed his PhD in Plant Biotechnology at ETH Zurich. He is interested in studying how complex biological systems work and interact and wants to try and apply this knowledge to solve global problems using new biotechnology. Currently, he is trying to unravel the G-value paradox in plants, and trying to discover the mechanisms by which plants (and other eukaryotes) produce complexity while having a limited set of genes. He wants to use this knowledge to "fine-tune" plant metabolism. For his PhD, he worked on the tropical plant cassava, which feeds about a billion people worldwide. He analysed different genetic engineering approaches to tackle virus disease in cassava, particularly in the context of complex virus populations. He has also invented a new DNA sequencing method which enables in-depth, accurate analysis of plant virus genomes.
Dipali Sashital, PhD
Assistant Professor, Department of Biochemistry, Biophysics and Molecular Biology, Iowa State University

Biography
Dipali Sashital is an assistant professor in the Roy J. Carver Department of Biochemistry, Biophysics & Molecular Biology at Iowa State University. She received her PhD from the University of Wisconsin, Madison. Following postdoctoral studies with Jennifer Doudna at University of California, Berkeley and Jamie Williamson The Scripps Research Institute, La Jolla, Dr. Sashital joined the faculty at Iowa State in January, 2014. The Sashital lab studies the mechanisms of CRISPR-Cas adaptive immunity using a combination of genetic, biochemical, biophysical and structural tools.
Xiaobo Zhou, PhD
Assistant Professor of Medicine, Brigham and Women's Hospital, Harvard

Biography
Dr. Zhou has been leading the Functional Genomics research team at the Brigham and Women's Hospital, Harvard Medical School since 2009. Her group focuses on deciphering function of human genome, mainly genetic regions identified by genome-wide association studies (GWAS) or eQTL analysis in respiratory diseases. Through interpreting biological meanings of GWAS findings, her lab aims to identify novel drug targets in complex pulmonary diseases. To interpret biological meaning of genetic variants/regions associated with complex diseases, Dr. Zhou's group has established a pipeline to dissect local chromatin structure surrounding GWAS and eQTL SNPs, including ChIP, FAIRE (Formaldehyde-Assisted Isolation of Regulatory Elements), 3C (chromatin conformation capture) and 4C(chromatin conformation capture sequencing). We also recently applied a high-throughput screening to identify functional variants within GWAS loci by massively paralleled reporter assay (MPRA). The state-of-the-art genome editing method, mainly CRISPR/Cas-9 has also been routinely applied to identify functional regulatory variants in a semi-high-throughput way and to asses function of novel GWAS genes. Additionally, to pursue further mechanistic studies on GWAS candidate genes, her group characterized protein interactome in vitro and generated knockout and transgenic mouse lines in disease relevant murine models. In collaboration with multiple cross-functional groups, he group has identified functional variants in the HHIP and FAM13A two COPD GWAS loci and also identified novel druggable pathways associated with genetic predispositions in COPD. Additionally, Functional Genomics Laboratory led by her has also developed customized experimental validations on networks built upon various human -omics datasets, including genomics, proteomics and genetics data.
Lihua Zhu, PhD
Professor and Director of Bioinformatics Core, University of Massachusetts Medical School

Biography
Lihua Julie Zhu obtained her Ph.D. in Nutritional Sciences from the University of Wisconsin-Madison in 1999, and her M.S. in Computer Science from DePaul University in Chicago in 2001. She joined the Bioinformatics Core of the Robert H. Lurie Comprehensive Cancer Center (RHLCCC) of Northwestern University in 2001, where she was the Director of Bioinformatics Consulting Core from 2003 to 2005 and the Director of Clinical Informatics Group from 2005 to 2007. She joined the University of Massachusetts Medical School (UMMS) as the head of Bioinformatics core of Program in Gene Function and Expression (PGFE) in 2007. Dr. Zhu is currently a professor and the head of Bioinformatics Core in the Department of Molecular, Cell and Cancer Biology (MCCB) of UMMS.

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