Research and Development: innovative activities performed by corporations or governments for the creation, discovery  and advancement of services and products. 
            
            
            
         
     
    
        
                    
                                    
                
         
                
                    
                                        
                        
                    
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        Employing a metagenomic search, we identified a family of miniature CRISPR-Cas type V-L systems capable of RNA-guided dsDNA target cleavage without a tracrRNA. A bacterial depletion screen r...
     
 
 
                                    
                                                                    
                                    
                                        
    
    
    
        Cell-based immunotherapy has become the new-generation cancer medicine, and “off-the-shelf” cell products that can be manufactured at large scale and distributed readily to treat...
    
    
            
     
                                     
                                    
                                                                    
                                    
                                        
    
    
    
        Microorganisms have always been integral to natural circular processes in the environment. They serve an important role in converting complex biological molecules into central building block...
    
    
            
     
                                     
                                    
                                                                    
                                    
                                        
    
    
    
        Genetically modified cell models accelerate the development of safe and effective therapeutics, making them indispensable in the quest for new drugs. Through manipulation of cell line geneti...
    
    
            
     
                                     
                                    
                                                                    
                                    
                                        
    
    
    
        Chimeric antigen receptor (CAR)-reprogrammed immune cells offer exciting therapeutic potential for addressing oncology, autoimmune diseases, transplant medicine, and infections. However, cur...