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    Single-Molecule

    Single-Molecule methods provide access to details of a population's characteristics that are obscured by ensemble averaging. It is a powerful method used to examine a multitude of phenomena using advanced techniques such as total internal reflection (TIRF) and superresolution imaging.

    Webinars

    • DEC 10, 2024 | 9:00 AM
      Expanding Proteomic Horizons with Single-Molecule Proteome Analysis
      Expanding Proteomic Horizons with Single-Molecule Proteome Analysis
      To-date, proteomic analysis has been severely limited in scale and resolution. Analyzing protein samples using an intact, single-molecule approach holds th...
      Speaker: Parag Mallick, Ph.D.
      Sponsored By: Nautilus Biotechnology
      21
      MAR 27, 2024 | 9:00 AM
      PART 1: Utilizing the 6-base genome to investigate the dynamics of enhancer DNA methylation during cellular differentiation
      PART 1: Utilizing the 6-base genome to investigate the dynamics...
      Join Dr. Emily Hodges, assistant professor of biochemistry at Vanderbilt University, to learn more about how the Hodges Lab is utilizing the 6-base genome to investigate the dynamics of enha...
      Speaker: Dr. Emily Hodges
      Sponsored By: biomodal
      11
      MAR 26, 2024 | 9:00 AM
      Expanding Proteomic Horizons with Single-Molecule Proteome and Proteoform Analysis
      Expanding Proteomic Horizons with Single-Molecule Proteome and...
      The field of proteomics is undergoing a revolution to better quantify proteins and unlock the dynamic and valuable source of functional biological insight held in the proteome. Single-molecu...
      Speaker: Parag Mallick, Ph.D. , Andreas Hühmer, Ph.D.
      Sponsored By: Nautilus Biotechnology
      9
      MAR 20, 2024 | 8:00 AM
      Introducing the first dual reporter application for Luminex xMAP INTELLIFLEX DR-SE Instruments:  measurement of phosphorylated and total proteins on the same bead
      Introducing the first dual reporter application for Luminex xMAP...
      Luminex and Thermo Fisher Scientific are excited to feature two presentations highlighting the advanced features of the Invitrogen™ Luminex® xMAP® INTELLIFLEX™ DR-SE inst...
      Speaker: Sherry Dunbar, Ph.D., MBA , Sigrun Badrnya, Ph.D.
      Sponsored By: Thermo Fisher Scientific
      11
      On Demand
      C.E. CREDITS
      Picodroplets Enabling High Throughput Single Cell Screening and Isolation
      Picodroplets Enabling High Throughput Single Cell Screening and...
      The study of a single cell, the fundamental unit of our complex bodies, has become an important field in cellular biology, and researchers are using single-cell analysis to shed new light on...
      Speaker: Romina Durigon, PhD
      Presented at: Drug Discovery & Development Virtual Event Series 2024
      4
      SEP 12, 2023 | 8:00 AM
      Cell-based SPR Microscopy application in drug discovery
      Cell-based SPR Microscopy application in drug discovery
      SPRm (Surface Plasmon Resonance Microscopy) is a novel technology that enables label-free and real-time measurements of the binding affinity and kinetics of small molecules to G protein-coup...
      Speaker: Dr. Shijie Wu , Dr. Marie-Laure Rives
      Sponsored By: Biosensing Instrument
      12
      JUN 15, 2023 | 9:00 AM
      Empowering next-generation therapy development with electrophoresis technology and streamlined data integration
      Empowering next-generation therapy development with electrophoresis...
      Advancements in protein and gene therapy research have led to more complex modalities being developed. In addition, the desire for a deeper understanding of these molecules enhances the need...
      Speaker: Philip Hoang
      Sponsored By: SCIEX
      12
      MAY 16, 2023 | 8:00 AM
      Multivalent RNA CAR-T cell for malignant glioma
      Multivalent RNA CAR-T cell for malignant glioma
      The therapeutic use of chimeric antigen receptor T cells has achieved significant success in the treatment of B cells malignancies. Despite promising results in mouse tumor models, a similar...
      Speaker: Prof. Denis Migliorini
      Sponsored By: MaxCyte®
      13
      MAR 16, 2023 | 8:00 AM
      Studying protein polymerization with mass photometry
      Studying protein polymerization with mass photometry
      Date: March 16, 2023 Time: 8:00am (PST), 11:00am (EST), 5:00pm (CET) Protein polymerization underpins major biological processes, such as cell division and intracellular transport, while und...
      Speaker: Nikolas Hundt
      Sponsored By: Refeyn
      20
      FEB 22, 2023 | 10:30 AM
      Using Single B Technology to Develop Lead Antibody Molecules on GPCR Targets with Live Q&A
      Using Single B Technology to Develop Lead Antibody Molecules on...
      Immunogens with native conformation and a high-throughput IgG cloning platform are two of the most important key components for high quality lead antibody molecules discovery. DIMABIO’...
      Speaker: Donghui Ma, PhD
      Presented at: Drug Discovery & Development Virtual Event Series 2023
      Sponsored By: DIMA Biotech
      3
      FEB 22, 2023 | 5:30 AM
      Novel Bioassays in Picodroplets for Single-Cell Analysis
      Novel Bioassays in Picodroplets for Single-Cell Analysis
      Many current technologies used in drug discovery and preclinical development programmes typically involve multi-step operations, extensive hands-on time, and lengthy liquid handling processe...
      Speaker: Romina Durigon, PhD
      Presented at: Drug Discovery & Development Virtual Event Series 2023
      2
      FEB 15, 2023 | 7:00 AM
      Scattering Microscopy: Label-Free Imaging Approaches
      Scattering Microscopy: Label-Free Imaging Approaches
      Date: February 15, 2023 Time: 7:00am (PST), 10:00pm (EST), 4:00pm (CET) While not all microscopy samples can fluoresce, all can scatter light, and this scattered light can be imaged. This ha...
      Speaker: Philipp Kukura , Francesco Reina , Matthew Kose-Dunn , Phil Allen
      Sponsored By: Teledyne Photometrics
      28
      JAN 25, 2023 | 10:00 AM
      Single-Molecule Proteomics using Protein Identification by Short-epitope Mapping
      Single-Molecule Proteomics using Protein Identification by Short-epitope...
      Date: January 25, 2023 Time: 10:00am (PST), 1:00pm (EST), 7:00pm (CET) The field of proteomics is poised for a single-molecule revolution – enabling more comprehensive analysis of the...
      Speaker: Parag Mallick, Ph.D.
      Sponsored By: Nautilus Biotechnology
      19
      NOV 08, 2022 | 8:00 AM
      22x Assays Revolutionized and Still Turning! - DURAClone Dry Reagents for Flow Cytometry
      22x Assays Revolutionized and Still Turning! - DURAClone Dry Reagents...
      Date: November 08, 2022 Time: 8:00am (PST), 11:00am (EST), 5:00pm (CEST) While flow cytometry shines by its flexibility, it requires a high level of expertise in antibody panel development,...
      Speaker: Michael Kapinsky, PhD
      Sponsored By: Beckman Coulter Life Sciences
      14
      OCT 20, 2022 | 9:00 AM
      Immune Secrets of the Lymph Node Revealed by Spatial Genomics
      Immune Secrets of the Lymph Node Revealed by Spatial Genomics
      Date: October 13, 2022 Time: 11:00am (PDT), 12:00pm (EDT), 6:00pm (CEST) Single-cell atlases mapping immune cells provide hints on how immune cells mature, attenuate, and disseminate through...
      Speaker: Jason Reeves
      Sponsored By: NanoString Technologies
      10 1
      OCT 19, 2022 | 6:00 AM
      Beyond affinity: antibody discovery, optimization, and developability screening from mammalian display libraries
      Beyond affinity: antibody discovery, optimization, and developability...
      Date: October 19, 2022 Time: 6:00am (PDT), 9:00am (EDT), 2:00pm (CEST) It is important that clinical drug candidates not only have appropriate affinity and target specificity, but also have...
      Speaker: Peter Slavny, PhD
      Sponsored By: MaxCyte®
      13
      SEP 27, 2022 | 10:00 AM
      Spatial Single Cell Characterization of Alzheimer's Disease in Mouse and Human Hippocampus
      Spatial Single Cell Characterization of Alzheimer's Disease in...
      Date: September 27, 2022 Time: 10:00am (PDT), 1:00pm (EDT), 7:00pm (CEST) Alzheimer’s disease is the most common cause of dementia and the seventh leading cause of death in the United...
      Speaker: Vikram Devgan , Miranda Orr
      Sponsored By: NanoString Technologies
      10
      SEP 14, 2022 | 10:00 AM
      Flow Virometry Sorting, B cell Cloning and Evaluation - CytoFLEX SRT and Viral Research
      Flow Virometry Sorting, B cell Cloning and Evaluation - CytoFLEX...
      Date: September 14, 2022 Time: 10:00am (PDT), 1:00pm (EDT), 7:00pm (CEST) Virus-like particles (VLPs) are nanostructures that possess diverse applications in therapeutics, immunization, and...
      Speaker: John Tigges , James McCracken , Cecilia Cavazzoni
      Sponsored By: Beckman Coulter Life Sciences
      18
      AUG 24, 2022 | 7:00 AM
      Light Field Microscopy Camera Solutions
      Light Field Microscopy Camera Solutions
      Date: August 24, 2022 Time: 7:00am (PDT), 10:00pm (EDT), 4:00pm (CEST) Light field microscopy was first introduced in 2006, and allows users to capture the 4D light field within the microsco...
      Speaker: Matthew Kose-Dunn , Phil Allen , Liang Gao , Shu Jia
      Sponsored By: Teledyne Photometrics
      23
      JUL 19, 2022 | 8:00 AM
      Getting started in Cryo-EM
      Getting started in Cryo-EM
      Date: July 19, 2022 Time: 8:00am (PDT), 11:00am (EDT), 5:00pm (CEST) Cryo-EM is rapidly becoming the method of choice for structural biologists and biochemists around the world, helping thes...
      Speaker: Melissa Chambers , Natalia de Val
      Presented at: Thermo Fisher Scientific - Electron Microscopy Webinars
      Sponsored By: Thermo Fisher Scientific
      9
      JUL 14, 2022 | 8:00 AM
      Imaging long-range neuronal connections in the mouse brain by light sheet fluorescence expansion microscopy
      Imaging long-range neuronal connections in the mouse brain by...
      Date: July 14, 2022 Time: 8:00am (PDT), 11:00am (EDT), 5:00pm (CEST) Sensory perception is modulated in a top-down fashion by higher brain regions to regulate behavioral responses. In olfact...
      Speaker: Prof. Ulrich Kubitscheck , Dr. Martin Schwarz , Juan Rodríguez
      Sponsored By: Miltenyi Biotec
      13
      JUN 28, 2022 | 7:00 AM
      sCMOS Cameras For Light-Sheet Microscopy
      sCMOS Cameras For Light-Sheet Microscopy
      Date: June 28, 2022 Time: 3:00pm (BST), 4:00pm (CET), 9:00am (CST), 7am (PST) Light-sheet microscopy is an extremely versatile imaging technique with a vast range of implementations that are...
      Speaker: Prof. Ulrich Kubitscheck , Dr. Abhishek Kumar , Matthew Kose-Dunn , Phil Allen
      Sponsored By: Teledyne Photometrics
      17
      JUN 22, 2022 | 10:00 AM
      Making Therapeutic Antibodies Simple, Fast and Safe
      Making Therapeutic Antibodies Simple, Fast and Safe
      Date: June 22, 2022 Time: 10:00am (PDT), 1:00pm (EDT), 7:00pm (CEST) Rabbits have a robust and unique immune system that enables the generated antibodies with superior specificity, affinity,...
      Speaker: Lidan Ding
      Sponsored By: GenScript
      17
      JUN 21, 2022 | 10:00 AM
      Delivering Single-Molecule Proteomics at Scale using Protein Identification by Short epitope Mapping
      Delivering Single-Molecule Proteomics at Scale using Protein Identification...
      Date: June 21, 2022 Time: 10:00am (PST), 1:00pm (EST), 7:00pm (CEST) The proteome is perhaps the most dynamic and valuable source of functional biological insight. Here, we introduce a novel...
      Speaker: Parag Mallick, Ph.D.
      Sponsored By: Nautilus Biotechnology
      9
    DEC 10, 2024 | 9:00 AM
    Expanding Proteomic Horizons with Single-Molecule Proteome Analysis
    Expanding Proteomic Horizons with Single-Molecule Proteome Analysis
    To-date, proteomic analysis has been severely limited in scale and resolution. Analyzing protein samples using an intact, single-molecule approach holds th...
    Speaker: Parag Mallick, Ph.D.
    Sponsored By: Nautilus Biotechnology
    21
    MAR 27, 2024 | 9:00 AM
    PART 1: Utilizing the 6-base genome to investigate the dynamics of enhancer DNA methylation during cellular differentiation
    PART 1: Utilizing the 6-base genome to investigate the dynamics...
    Join Dr. Emily Hodges, assistant professor of biochemistry at Vanderbilt University, to learn more about how the Hodges Lab is utilizing the 6-base genome to investigate the dynamics of enha...
    Speaker: Dr. Emily Hodges
    Sponsored By: biomodal
    11
    MAR 26, 2024 | 9:00 AM
    Expanding Proteomic Horizons with Single-Molecule Proteome and Proteoform Analysis
    Expanding Proteomic Horizons with Single-Molecule Proteome and...
    The field of proteomics is undergoing a revolution to better quantify proteins and unlock the dynamic and valuable source of functional biological insight held in the proteome. Single-molecu...
    Speaker: Parag Mallick, Ph.D. , Andreas Hühmer, Ph.D.
    Sponsored By: Nautilus Biotechnology
    9
    MAR 20, 2024 | 8:00 AM
    Introducing the first dual reporter application for Luminex xMAP INTELLIFLEX DR-SE Instruments:  measurement of phosphorylated and total proteins on the same bead
    Introducing the first dual reporter application for Luminex xMAP...
    Luminex and Thermo Fisher Scientific are excited to feature two presentations highlighting the advanced features of the Invitrogen™ Luminex® xMAP® INTELLIFLEX™ DR-SE inst...
    Speaker: Sherry Dunbar, Ph.D., MBA , Sigrun Badrnya, Ph.D.
    Sponsored By: Thermo Fisher Scientific
    11
    On Demand
    C.E. CREDITS
    Picodroplets Enabling High Throughput Single Cell Screening and Isolation
    Picodroplets Enabling High Throughput Single Cell Screening and...
    The study of a single cell, the fundamental unit of our complex bodies, has become an important field in cellular biology, and researchers are using single-cell analysis to shed new light on...
    Speaker: Romina Durigon, PhD
    Presented at: Drug Discovery & Development Virtual Event Series 2024
    4
     
     
  • SEP 12, 2023 | 8:00 AM
    Cell-based SPR Microscopy application in drug discovery
    Cell-based SPR Microscopy application in drug discovery
    SPRm (Surface Plasmon Resonance Microscopy) is a novel technology that enables label-free and real-time measurements of the binding affinity and kinetics of small molecules to G protein-coup...
    Speaker: Dr. Shijie Wu , Dr. Marie-Laure Rives
    Sponsored By: Biosensing Instrument
    12
    JUN 15, 2023 | 9:00 AM
    Empowering next-generation therapy development with electrophoresis technology and streamlined data integration
    Empowering next-generation therapy development with electrophoresis...
    Advancements in protein and gene therapy research have led to more complex modalities being developed. In addition, the desire for a deeper understanding of these molecules enhances the need...
    Speaker: Philip Hoang
    Sponsored By: SCIEX
    12
    MAY 16, 2023 | 8:00 AM
    Multivalent RNA CAR-T cell for malignant glioma
    Multivalent RNA CAR-T cell for malignant glioma
    The therapeutic use of chimeric antigen receptor T cells has achieved significant success in the treatment of B cells malignancies. Despite promising results in mouse tumor models, a similar...
    Speaker: Prof. Denis Migliorini
    Sponsored By: MaxCyte®
    13
    MAR 16, 2023 | 8:00 AM
    Studying protein polymerization with mass photometry
    Studying protein polymerization with mass photometry
    Date: March 16, 2023 Time: 8:00am (PST), 11:00am (EST), 5:00pm (CET) Protein polymerization underpins major biological processes, such as cell division and intracellular transport, while und...
    Speaker: Nikolas Hundt
    Sponsored By: Refeyn
    20
    FEB 22, 2023 | 10:30 AM
    Using Single B Technology to Develop Lead Antibody Molecules on GPCR Targets with Live Q&A
    Using Single B Technology to Develop Lead Antibody Molecules on...
    Immunogens with native conformation and a high-throughput IgG cloning platform are two of the most important key components for high quality lead antibody molecules discovery. DIMABIO’...
    Speaker: Donghui Ma, PhD
    Presented at: Drug Discovery & Development Virtual Event Series 2023
    Sponsored By: DIMA Biotech
    3
     
     
  • FEB 22, 2023 | 5:30 AM
    Novel Bioassays in Picodroplets for Single-Cell Analysis
    Novel Bioassays in Picodroplets for Single-Cell Analysis
    Many current technologies used in drug discovery and preclinical development programmes typically involve multi-step operations, extensive hands-on time, and lengthy liquid handling processe...
    Speaker: Romina Durigon, PhD
    Presented at: Drug Discovery & Development Virtual Event Series 2023
    2
    FEB 15, 2023 | 7:00 AM
    Scattering Microscopy: Label-Free Imaging Approaches
    Scattering Microscopy: Label-Free Imaging Approaches
    Date: February 15, 2023 Time: 7:00am (PST), 10:00pm (EST), 4:00pm (CET) While not all microscopy samples can fluoresce, all can scatter light, and this scattered light can be imaged. This ha...
    Speaker: Philipp Kukura , Francesco Reina , Matthew Kose-Dunn , Phil Allen
    Sponsored By: Teledyne Photometrics
    28
    JAN 25, 2023 | 10:00 AM
    Single-Molecule Proteomics using Protein Identification by Short-epitope Mapping
    Single-Molecule Proteomics using Protein Identification by Short-epitope...
    Date: January 25, 2023 Time: 10:00am (PST), 1:00pm (EST), 7:00pm (CET) The field of proteomics is poised for a single-molecule revolution – enabling more comprehensive analysis of the...
    Speaker: Parag Mallick, Ph.D.
    Sponsored By: Nautilus Biotechnology
    19
    NOV 08, 2022 | 8:00 AM
    22x Assays Revolutionized and Still Turning! - DURAClone Dry Reagents for Flow Cytometry
    22x Assays Revolutionized and Still Turning! - DURAClone Dry Reagents...
    Date: November 08, 2022 Time: 8:00am (PST), 11:00am (EST), 5:00pm (CEST) While flow cytometry shines by its flexibility, it requires a high level of expertise in antibody panel development,...
    Speaker: Michael Kapinsky, PhD
    Sponsored By: Beckman Coulter Life Sciences
    14
    OCT 20, 2022 | 9:00 AM
    Immune Secrets of the Lymph Node Revealed by Spatial Genomics
    Immune Secrets of the Lymph Node Revealed by Spatial Genomics
    Date: October 13, 2022 Time: 11:00am (PDT), 12:00pm (EDT), 6:00pm (CEST) Single-cell atlases mapping immune cells provide hints on how immune cells mature, attenuate, and disseminate through...
    Speaker: Jason Reeves
    Sponsored By: NanoString Technologies
    10 1
     
     
  • OCT 19, 2022 | 6:00 AM
    Beyond affinity: antibody discovery, optimization, and developability screening from mammalian display libraries
    Beyond affinity: antibody discovery, optimization, and developability...
    Date: October 19, 2022 Time: 6:00am (PDT), 9:00am (EDT), 2:00pm (CEST) It is important that clinical drug candidates not only have appropriate affinity and target specificity, but also have...
    Speaker: Peter Slavny, PhD
    Sponsored By: MaxCyte®
    13
    SEP 27, 2022 | 10:00 AM
    Spatial Single Cell Characterization of Alzheimer's Disease in Mouse and Human Hippocampus
    Spatial Single Cell Characterization of Alzheimer's Disease in...
    Date: September 27, 2022 Time: 10:00am (PDT), 1:00pm (EDT), 7:00pm (CEST) Alzheimer’s disease is the most common cause of dementia and the seventh leading cause of death in the United...
    Speaker: Vikram Devgan , Miranda Orr
    Sponsored By: NanoString Technologies
    10
    SEP 14, 2022 | 10:00 AM
    Flow Virometry Sorting, B cell Cloning and Evaluation - CytoFLEX SRT and Viral Research
    Flow Virometry Sorting, B cell Cloning and Evaluation - CytoFLEX...
    Date: September 14, 2022 Time: 10:00am (PDT), 1:00pm (EDT), 7:00pm (CEST) Virus-like particles (VLPs) are nanostructures that possess diverse applications in therapeutics, immunization, and...
    Speaker: John Tigges , James McCracken , Cecilia Cavazzoni
    Sponsored By: Beckman Coulter Life Sciences
    18
    AUG 24, 2022 | 7:00 AM
    Light Field Microscopy Camera Solutions
    Light Field Microscopy Camera Solutions
    Date: August 24, 2022 Time: 7:00am (PDT), 10:00pm (EDT), 4:00pm (CEST) Light field microscopy was first introduced in 2006, and allows users to capture the 4D light field within the microsco...
    Speaker: Matthew Kose-Dunn , Phil Allen , Liang Gao , Shu Jia
    Sponsored By: Teledyne Photometrics
    23
    JUL 19, 2022 | 8:00 AM
    Getting started in Cryo-EM
    Getting started in Cryo-EM
    Date: July 19, 2022 Time: 8:00am (PDT), 11:00am (EDT), 5:00pm (CEST) Cryo-EM is rapidly becoming the method of choice for structural biologists and biochemists around the world, helping thes...
    Speaker: Melissa Chambers , Natalia de Val
    Presented at: Thermo Fisher Scientific - Electron Microscopy Webinars
    Sponsored By: Thermo Fisher Scientific
    9
     
     
  • JUL 14, 2022 | 8:00 AM
    Imaging long-range neuronal connections in the mouse brain by light sheet fluorescence expansion microscopy
    Imaging long-range neuronal connections in the mouse brain by...
    Date: July 14, 2022 Time: 8:00am (PDT), 11:00am (EDT), 5:00pm (CEST) Sensory perception is modulated in a top-down fashion by higher brain regions to regulate behavioral responses. In olfact...
    Speaker: Prof. Ulrich Kubitscheck , Dr. Martin Schwarz , Juan Rodríguez
    Sponsored By: Miltenyi Biotec
    13
    JUN 28, 2022 | 7:00 AM
    sCMOS Cameras For Light-Sheet Microscopy
    sCMOS Cameras For Light-Sheet Microscopy
    Date: June 28, 2022 Time: 3:00pm (BST), 4:00pm (CET), 9:00am (CST), 7am (PST) Light-sheet microscopy is an extremely versatile imaging technique with a vast range of implementations that are...
    Speaker: Prof. Ulrich Kubitscheck , Dr. Abhishek Kumar , Matthew Kose-Dunn , Phil Allen
    Sponsored By: Teledyne Photometrics
    17
    JUN 22, 2022 | 10:00 AM
    Making Therapeutic Antibodies Simple, Fast and Safe
    Making Therapeutic Antibodies Simple, Fast and Safe
    Date: June 22, 2022 Time: 10:00am (PDT), 1:00pm (EDT), 7:00pm (CEST) Rabbits have a robust and unique immune system that enables the generated antibodies with superior specificity, affinity,...
    Speaker: Lidan Ding
    Sponsored By: GenScript
    17
    JUN 21, 2022 | 10:00 AM
    Delivering Single-Molecule Proteomics at Scale using Protein Identification by Short epitope Mapping
    Delivering Single-Molecule Proteomics at Scale using Protein Identification...
    Date: June 21, 2022 Time: 10:00am (PST), 1:00pm (EST), 7:00pm (CEST) The proteome is perhaps the most dynamic and valuable source of functional biological insight. Here, we introduce a novel...
    Speaker: Parag Mallick, Ph.D.
    Sponsored By: Nautilus Biotechnology
    9
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