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Genomic testing based on chromosome microarray (CMA) and Next Generation Sequencing (NGS) revolutionized clinical genetics. That said, microarray, targeted panel, exome and generic whole gen...
This presentation will present findings from studies based on Danish nationwide registers investigating the link between all treated infections and the risk of mental disorders. The studies w...
When violent crimes are committed, the crime scene is usually covered with blood. Blood may be shed when the person is standing, sitting, or on the ground. The weapon that caused blood to be...
Recent discoveries in stem cell biology have increased the importance of stem cells in therapeutics and have improved researchers’ understanding of normal and disease processes. The inh...
The detection of circulating molecular biomarkers is useful for monitoring pathogenic processes and response to therapeutic intervention1,2. In cancer, genomic and proteomic biomarkers are us...
With the passing of the 2018 Farm Bill legalizing hemp, farmers are allowed to grow hemp. Like any other agricultural crop, pesticides are applied to hemp plants to protect it from pests and...
The public health burden of Treatment Resistant Depression (TRD) has prompted clinical trials of deep brain stimulation (DBS) that have, unfortunately, produced inconsistent outcomes. Potent...
Tumor heterogeneity is a hallmark of cancer and can have significant impact on identifying drivers, including those that may be therapeutically relevant. Although, the traditional sequencing...
The nuclear proliferation biomarker Ki-67 has multiple potential roles in breast and other cancers, both as a prognostic but also predictive marker. However, several studies have shown that...
We describe a mass spectrometry (MS) analytical platform resulting from the novel integration of acoustic droplet ejection (ADE) technology, an open-port interface (OPI), and electrospray io...
Tuberculosis has killed more than one billion people in the last 200 years. It is the oldest and the deadliest human pathogen, recently surpassing HIV. Its adaptation to host and drug pressur...
Launched in early 2015, the Precision Medicine Initiative (PMI) takes advantage of the progress made in genomic testing – progress largely driven by rapid advances in DNA sequencing tec...
Every year, approximately 800,000 critically ill patients are hospitals in the USA with undiagnosed infections. The only option is to treat these patients with broad-spectrum antimicrobial th...
In this time of incredible promise for genomic medicine, the Genomes2People (G2P) Research Program in Translational Genomics and Health Outcomes, directed by Robert C. Green, MD, MPH, is crea...
Next-generation DNA sequencing has opened new possibilities for microbial water quality monitoring, particularly for addressing emerging concerns like antibiotic resistance and opportunistic...
In general, once a receptor drug target has been validated for the treatment of a particular condition, either a high throughput screen is carried out to identify potential hits, or existing...
An unbiased metagenomic next-generation approach (mNGS) been shown to be useful in the broad identification of pathogens in clinical samples for infectious disease diagnosis, including viruse...
Infectious diseases, such as COVID-19, are challenging to study in animal models due to species differences, and conventional 2D cell-based systems lack the complexity to appropriately model...
When producing a quality vaccine, all manufacturers must confirm the purity as well as the stability of their formulation and final product. Sample quantity and measurement time are often th...
Actions are not mediated solely by cortical processes but rely on communication within basal ganglia-thalamocortical loops. Speech is one example, although how the basal ganglia participate i...
Cannabidiol (CBD) has emerged as a promising anti-epileptic drug in otherwise treatment-resistant genetic epileptic disorders. However, the clinical trials have been limited by their use of C...
G-protein coupled receptors (GPCRs) represent the single largest class of druggable targets in the human genome. Of the 390 or so druggable and non-olfactory human GPCRs there exist many whic...
Pancreatic ductal adenocarcinoma (PDAC) has a five-year survival rate of only 9%. Acquired drug resistance is a major factor that limits the effectiveness of chemotherapy. Exosomes, secreted...
This presentation will discuss the use of the FDA EUA process to implement SARS-CoV-2 assays to address the COVID-19 pandemic. The use of a team-based approach, through an Incident Command s...
Whether you are performing killing assays, immunophenotyping of TILs, characterizing the tumor microenvironment, or investigating immunogenicity, primary cells are essential for the discovery...
Opportunities for plant science to contribute to global food security include increasing the yield and quality of crops, making plants less susceptible to pests and and more resistant to her...
Genomic testing based on chromosome microarray (CMA) and Next Generation Sequencing (NGS) revolutionized clinical genetics. That said, microarray, targeted panel, exome and generic whole gen...
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