Cell Line Development
Cell Line Development: Stable cell lines are widely used in a number of important applications including biologics (e.g. recombinant protein and monoclonal antibody) production, drug screening, and gene functional studies. The process of developing stable cell lines often starts with transfecting selected host cells, typically CHO or HEK 293 cells, with desired plasmids. After transfection, researchers then screen and quantify high-expressing clones. Once these high producers are identified, the cell lines and/or the proteins produced by the cells are validated. The manual screening methods traditionally used for cell line development are time-consuming and labor-intensive, creating a great demand for high-throughput, automated solutions for such efforts.
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FEB 19, 2020Immunology
FEB 19, 2020What do the gut microbiome, antibodies, and rainbow trout have in common? A lot, says researcher J. Oriol Sunyer from the University of Pennsylvania’...WRITTEN BY: Tara FernandezFEB 12, 2020Genetics & Genomics
FEB 12, 2020The activity of genes can be altered with chemical tags that get added to the genome, so-called epigenetic modifications....WRITTEN BY: Carmen LeitchFEB 04, 2020Microbiology
FEB 04, 2020The human metapneumovirus (HMPV) might now be well-known, but it is the second biggest cause of respiratory infections....WRITTEN BY: Carmen LeitchFEB 04, 2020Cancer
FEB 04, 2020Researchers from Osaka University have recently discovered a new function of the multifunctional enzyme entitled serine racemase (SRR). According to the te...WRITTEN BY: Kathryn DeMuth SullivanJAN 27, 2020Genetics & Genomics
JAN 27, 2020Machine learning algorithms are increasingly being applied to the vast amount of genetic data that has been generated over the past decade....WRITTEN BY: Carmen LeitchJAN 21, 2020Drug Discovery & Development
JAN 21, 2020The FDA has recently approved Ayvakit (avapritinib) for the treatment of unresectable and metastatic gastrointestinal stromal tumor (GIST) that occurs most...WRITTEN BY: Nouran AminJAN 21, 2020Cell & Molecular Biology
JAN 21, 2020Drugs have to be rigorously tested before they can be offered to patients, so it can be much easier to find more than one application for a medication....WRITTEN BY: Carmen LeitchJAN 20, 2020Cancer
JAN 20, 2020A study from MIT. Harvard and the Dana-Farber Cancer Institute has concluded that almost 50 existing non-oncological drugs have anti-cancer properties capa...WRITTEN BY: Kathryn DeMuth SullivanJAN 07, 2020Immunology
JAN 07, 2020T cells may be able to reach their full potential in the fight against cancer with a little nudge. In 2010, scientists first observed CD4+ T cells transiti...WRITTEN BY: Kara MarkerDEC 31, 2019Genetics & Genomics
DEC 31, 2019He Jiankui, the scientist behind the world’s first gene-edited babies in 2018, has been sentenced to three years in prison by Chinese authorities for...WRITTEN BY: Annie LennonDEC 25, 2019Drug Discovery & Development
DEC 25, 2019The US Food and Drug Administration has granted accelerated approval to new breast cancer drug, trastuzumab deruxtecan. The drug’s increasing recogni...WRITTEN BY: Annie LennonDEC 18, 2019Genetics & Genomics
DEC 18, 2019Cancer cells can adapt to mutations in the genome that might kill the cells by altering the activity of their genes....WRITTEN BY: Carmen LeitchDEC 18, 2019Cancer
DEC 18, 2019Pancreatic cancer is a dangerous disease for two reasons: its stealth and its resistance to many anti-cancer drugs. The American Cancer Society estimates t...WRITTEN BY: Kathryn DeMuth SullivanDEC 17, 2019Microbiology
DEC 17, 2019There may be a small silver lining to getting a cold or the flu....WRITTEN BY: Carmen LeitchDEC 12, 2019Cell & Molecular Biology
DEC 12, 2019While the human genome has been sequenced, there are plenty of parts of it that we don't know much about....WRITTEN BY: Carmen LeitchDEC 11, 2019Drug Discovery & Development
DEC 11, 2019Biomedical researchers at the University of California—Riverside, found that the therapeutic drug ‘tofacitinib’ used in treating autoimmu...WRITTEN BY: Nouran AminDEC 11, 2019Drug Discovery & Development
DEC 11, 2019Researchers using mouse models of Alzheimer disease were able to demonstrate that the investigational drug candidates ‘CMS121’ and ‘J147&...WRITTEN BY: Nouran AminDEC 10, 2019Immunology
DEC 10, 2019A specialized form of T cell emerges as a new focus for gastrointestinal health research, specifically in the context of inflammatory bowel disease (IBD) f...WRITTEN BY: Kara MarkerDEC 01, 2019Cell & Molecular Biology
DEC 01, 2019Since the CRISPR gene editor was created, researchers around the world have tweaked and refined the tool to use it in a variety of ways....WRITTEN BY: Carmen LeitchNOV 25, 2019Drug Discovery & Development
NOV 25, 2019Researchers have long known that the cause behind Alexander disease is a genetic culprit—mainly a mutation leading to the production of a defective p...WRITTEN BY: Nouran AminNOV 24, 2019Cell & Molecular Biology
NOV 24, 2019Proteins are critical to biology, and are generated by vital, ancient cellular structures called ribosomes....WRITTEN BY: Carmen LeitchNOV 18, 2019Drug Discovery & Development
NOV 18, 2019Sickle cell disease affects approximately 100,000 Americans. Currently, the only available cure for the disease is a costly bone marrow transplant, putting...WRITTEN BY: Annie LennonNOV 06, 2019Drug Discovery & Development
NOV 06, 2019Scientists at Karolinska Institutet in Sweden were able to pinpoint 10 tumor-specific potential drug targets for the fatal and incurable brain cancer, glio...WRITTEN BY: Nouran AminNOV 01, 2019Chemistry & Physics
NOV 01, 2019In a recent study, a group of biomedical researchers at Michigan State University developed a new platform for tweaking light-activated dyes that can enable diagnostic imaging, image-guided s...WRITTEN BY: Yin (Daniel) Duan
FEB 19, 2020
Immunology
FEB 19, 2020
What do the gut microbiome, antibodies, and rainbow trout have in common? A lot, says researcher J. Oriol Sunyer from the University of Pennsylvania’...
WRITTEN BY:
Tara Fernandez
FEB 12, 2020
Genetics & Genomics
FEB 12, 2020
The activity of genes can be altered with chemical tags that get added to the genome, so-called epigenetic modifications....
WRITTEN BY:
Carmen Leitch
FEB 04, 2020
Microbiology
FEB 04, 2020
The human metapneumovirus (HMPV) might now be well-known, but it is the second biggest cause of respiratory infections....
WRITTEN BY:
Carmen Leitch
FEB 04, 2020
Cancer
FEB 04, 2020
Researchers from Osaka University have recently discovered a new function of the multifunctional enzyme entitled serine racemase (SRR). According to the te...
WRITTEN BY:
Kathryn DeMuth Sullivan
JAN 27, 2020
Genetics & Genomics
JAN 27, 2020
Machine learning algorithms are increasingly being applied to the vast amount of genetic data that has been generated over the past decade....
WRITTEN BY:
Carmen Leitch
JAN 21, 2020
Drug Discovery & Development
JAN 21, 2020
The FDA has recently approved Ayvakit (avapritinib) for the treatment of unresectable and metastatic gastrointestinal stromal tumor (GIST) that occurs most...
WRITTEN BY:
Nouran Amin
JAN 21, 2020
Cell & Molecular Biology
JAN 21, 2020
Drugs have to be rigorously tested before they can be offered to patients, so it can be much easier to find more than one application for a medication....
WRITTEN BY:
Carmen Leitch
JAN 20, 2020
Cancer
JAN 20, 2020
A study from MIT. Harvard and the Dana-Farber Cancer Institute has concluded that almost 50 existing non-oncological drugs have anti-cancer properties capa...
WRITTEN BY:
Kathryn DeMuth Sullivan
JAN 07, 2020
Immunology
JAN 07, 2020
T cells may be able to reach their full potential in the fight against cancer with a little nudge. In 2010, scientists first observed CD4+ T cells transiti...
WRITTEN BY:
Kara Marker
DEC 31, 2019
Genetics & Genomics
DEC 31, 2019
He Jiankui, the scientist behind the world’s first gene-edited babies in 2018, has been sentenced to three years in prison by Chinese authorities for...
WRITTEN BY:
Annie Lennon
DEC 25, 2019
Drug Discovery & Development
DEC 25, 2019
The US Food and Drug Administration has granted accelerated approval to new breast cancer drug, trastuzumab deruxtecan. The drug’s increasing recogni...
WRITTEN BY:
Annie Lennon
DEC 18, 2019
Genetics & Genomics
DEC 18, 2019
Cancer cells can adapt to mutations in the genome that might kill the cells by altering the activity of their genes....
WRITTEN BY:
Carmen Leitch
DEC 18, 2019
Cancer
DEC 18, 2019
Pancreatic cancer is a dangerous disease for two reasons: its stealth and its resistance to many anti-cancer drugs. The American Cancer Society estimates t...
WRITTEN BY:
Kathryn DeMuth Sullivan
DEC 17, 2019
Microbiology
DEC 17, 2019
There may be a small silver lining to getting a cold or the flu....
WRITTEN BY:
Carmen Leitch
DEC 12, 2019
Cell & Molecular Biology
DEC 12, 2019
While the human genome has been sequenced, there are plenty of parts of it that we don't know much about....
WRITTEN BY:
Carmen Leitch
DEC 11, 2019
Drug Discovery & Development
DEC 11, 2019
Biomedical researchers at the University of California—Riverside, found that the therapeutic drug ‘tofacitinib’ used in treating autoimmu...
WRITTEN BY:
Nouran Amin
DEC 11, 2019
Drug Discovery & Development
DEC 11, 2019
Researchers using mouse models of Alzheimer disease were able to demonstrate that the investigational drug candidates ‘CMS121’ and ‘J147&...
WRITTEN BY:
Nouran Amin
DEC 10, 2019
Immunology
DEC 10, 2019
A specialized form of T cell emerges as a new focus for gastrointestinal health research, specifically in the context of inflammatory bowel disease (IBD) f...
WRITTEN BY:
Kara Marker
DEC 01, 2019
Cell & Molecular Biology
DEC 01, 2019
Since the CRISPR gene editor was created, researchers around the world have tweaked and refined the tool to use it in a variety of ways....
WRITTEN BY:
Carmen Leitch
NOV 25, 2019
Drug Discovery & Development
NOV 25, 2019
Researchers have long known that the cause behind Alexander disease is a genetic culprit—mainly a mutation leading to the production of a defective p...
WRITTEN BY:
Nouran Amin
NOV 24, 2019
Cell & Molecular Biology
NOV 24, 2019
Proteins are critical to biology, and are generated by vital, ancient cellular structures called ribosomes....
WRITTEN BY:
Carmen Leitch
NOV 18, 2019
Drug Discovery & Development
NOV 18, 2019
Sickle cell disease affects approximately 100,000 Americans. Currently, the only available cure for the disease is a costly bone marrow transplant, putting...
WRITTEN BY:
Annie Lennon
NOV 06, 2019
Drug Discovery & Development
NOV 06, 2019
Scientists at Karolinska Institutet in Sweden were able to pinpoint 10 tumor-specific potential drug targets for the fatal and incurable brain cancer, glio...
WRITTEN BY:
Nouran Amin
NOV 01, 2019
Chemistry & Physics
NOV 01, 2019
In a recent study, a group of biomedical researchers at Michigan State University developed a new platform for tweaking light-activated dyes that can enable diagnostic imaging, image-guided s...
WRITTEN BY:
Yin (Daniel) Duan
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