Clinical Diagnostics: The identification of a disease in regards to a patient's complaints based merely on signs, symptoms, and medical history of the patient rather than on laboratory examination or medical imaging.
Using high throughput next-generation sequencing to simultaneously search large number of genes for pathogenic mutations has numerous advantages. It decreases the pressure to narrow the dif...
Alzheimers disease (AD) is a common neurodegenerative disorder characterized clinically by progress decline in memory and thinking and pathologically by the presence of senile plaques and neu...
Alzheimers disease (AD) is a neurodegenerative disorder producing cognitive impairment and dementia in millions of elders. Currently no treatment is effective to slow the progression of AD. M...
Neuroimaging plays a large role in our pursuit of the understanding of behavior and cognition in health and disease. The past decade has seen the emergence of a wealth of resources that suppo...
With a rising prevalence recently exceeding 1%, autism spectrum disorder (ASD) has become a pressing public health issue. Crucial hurdles on the way to targeted treatments are (i) the relianc...
When speaking of neurodegenerative diseases, average public is not made aware of the true cost that brain related disorders have on annual budget. The true impact on economy is not usually...
The Brain Research through Advancing Innovative Neurotechnologies (BRAIN) Initiative is part of a new Presidential focus aimed at revolutionizing our understanding of the human brain. By acce...
Late onset dementia is usually a multi-factorial disease wherein cumulative pathological brain insults (of more than one pathology) results in progressive cognitive decline which ultimately l...
Huntington's disease (HD) is a progressive, inherited, degenerative brain disorder that produces physical, mental and emotional changes. Named for George Huntington, the physician who fi...
The brain is a complex, densely wired circuit made out of heterogeneous cells, which vary in their shapes, molecular composition, and patterns of connectivity. In order to help discover how n...
Connectomics is a new field of research that aims to map the synapses of the nervous system in order to construct a wiring diagram of all the neural circuits. It is necessary to use the elect...
The Willerth lab investigates how to engineer neural tissue by combining pluripotent stem cells, controlled drug delivery and biomaterial scaffolds. When generating these replacement tissues,...
ATP-binding cassette transporter A1 (ABCA1) mediates cholesterol efflux to lipid-free apolipoproteins such as apolipoprotein A-I (apoA-I) and apolipoprotein E (apoE). ABCA1 is essential regul...
Synaptic dysfunction and loss caused by age-dependent accumulation of synaptotoxic Amyloid beta (Abeta)1-42 oligomers is proposed to underlie cognitive decline in Alzheimers disease (AD). Syn...
Neuron-glial interactions are increasingly recognized as being key for physiological and pathological processes in the central nervous system. Microglia have been found to play a causal role...
Dendritic spine shape enables sequestering of subcellular components needed for synaptic plasticity, including polyribosomes for local protein synthesis, smooth endoplasmic reticulum (SER) to...
The Brain Research through Advancing Innovative Neurotechnologies (BRAIN) Initiative is part of a new Presidential focus aimed at revolutionizing our understanding of the human brain. By...
Down syndrome (DS) is a complex multi-system disorder affecting more than 5.8 million individuals around the world and it causes significant physical, psychological, and cognitive abnormaliti...
Multiple Sclerosis (MS) is an autoimmune disease that leads to widespread pathology within the central nervous system (CNS) and is the most common cause of neurologic disability among young a...
In physical systems built with many components, emergent properties, such as magnetism, are often generated from the interactions among these particles. These emergent properties are often in...
Making precision cancer care a future reality requires novel approachesto finding treatment targets in cancers. Single-gene assays currently performed in clinical research laboratories are in...
Laboratory rats and mice are the most used animal species in scientific research, but still having a lot of information available about them, there are many places in Latin America where ther...
Using high throughput next-generation sequencing to simultaneously search large number of genes for pathogenic mutations has numerous advantages. It decreases the pressure to narrow the dif...
Alzheimers disease (AD) is a common neurodegenerative disorder characterized clinically by progress decline in memory and thinking and pathologically by the presence of senile plaques and neu...
Alzheimers disease (AD) is a neurodegenerative disorder producing cognitive impairment and dementia in millions of elders. Currently no treatment is effective to slow the progression of AD. M...
Neuroimaging plays a large role in our pursuit of the understanding of behavior and cognition in health and disease. The past decade has seen the emergence of a wealth of resources that suppo...
With a rising prevalence recently exceeding 1%, autism spectrum disorder (ASD) has become a pressing public health issue. Crucial hurdles on the way to targeted treatments are (i) the relianc...
When speaking of neurodegenerative diseases, average public is not made aware of the true cost that brain related disorders have on annual budget. The true impact on economy is not usually...
The Brain Research through Advancing Innovative Neurotechnologies (BRAIN) Initiative is part of a new Presidential focus aimed at revolutionizing our understanding of the human brain. By acce...
Late onset dementia is usually a multi-factorial disease wherein cumulative pathological brain insults (of more than one pathology) results in progressive cognitive decline which ultimately l...
Huntington's disease (HD) is a progressive, inherited, degenerative brain disorder that produces physical, mental and emotional changes. Named for George Huntington, the physician who fi...
The brain is a complex, densely wired circuit made out of heterogeneous cells, which vary in their shapes, molecular composition, and patterns of connectivity. In order to help discover how n...
Connectomics is a new field of research that aims to map the synapses of the nervous system in order to construct a wiring diagram of all the neural circuits. It is necessary to use the elect...
The Willerth lab investigates how to engineer neural tissue by combining pluripotent stem cells, controlled drug delivery and biomaterial scaffolds. When generating these replacement tissues,...
ATP-binding cassette transporter A1 (ABCA1) mediates cholesterol efflux to lipid-free apolipoproteins such as apolipoprotein A-I (apoA-I) and apolipoprotein E (apoE). ABCA1 is essential regul...
Synaptic dysfunction and loss caused by age-dependent accumulation of synaptotoxic Amyloid beta (Abeta)1-42 oligomers is proposed to underlie cognitive decline in Alzheimers disease (AD). Syn...
Neuron-glial interactions are increasingly recognized as being key for physiological and pathological processes in the central nervous system. Microglia have been found to play a causal role...
Dendritic spine shape enables sequestering of subcellular components needed for synaptic plasticity, including polyribosomes for local protein synthesis, smooth endoplasmic reticulum (SER) to...
The Brain Research through Advancing Innovative Neurotechnologies (BRAIN) Initiative is part of a new Presidential focus aimed at revolutionizing our understanding of the human brain. By...
Down syndrome (DS) is a complex multi-system disorder affecting more than 5.8 million individuals around the world and it causes significant physical, psychological, and cognitive abnormaliti...
Multiple Sclerosis (MS) is an autoimmune disease that leads to widespread pathology within the central nervous system (CNS) and is the most common cause of neurologic disability among young a...
In physical systems built with many components, emergent properties, such as magnetism, are often generated from the interactions among these particles. These emergent properties are often in...
Making precision cancer care a future reality requires novel approachesto finding treatment targets in cancers. Single-gene assays currently performed in clinical research laboratories are in...
Laboratory rats and mice are the most used animal species in scientific research, but still having a lot of information available about them, there are many places in Latin America where ther...