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Drug Discovery
Drug Discovery: drug discovery is the process by which new candidate medications are discovered. Historically, drugs were discovered through identifying the active ingredient from traditional remedies or by serendipitous discovery. Modern drug discovery involves the identification of screening hits, medicinal chemistry and optimization of those hits to increase the affinity, selectivity (to reduce the potential of side effects), efficacy/potency, metabolic stability (to increase the half-life), and oral bioavailability.
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SEP 19, 2015Neuroscience
The abnormal behavior of two genes (BDNF and DTNBP1) is related to the underlying cause of schizophrenia, providing a ne ...Written By: Ilene SchneiderSEP 18, 2015Cancer
Women successfully treated for breast cancer know that it could return. New research published in the journal Clinical E ...Written By: Ilene SchneiderSEP 18, 2015Neuroscience
When patients begin treatment for dependence on opioids, they are five times as likely to die in the first four weeks wh ...Written By: Ilene SchneiderSEP 18, 2015Cancer
Cells can adapt to overcome cancer drugs designed to interfere with their genetic controls, according to a study by Canc ...Written By: Ilene SchneiderSEP 17, 2015Cancer
The product pipeline for Non-Hodgkin Lymphoma (NHL) exhibits a lower degree of innovation than both the industry and onc ...Written By: Ilene SchneiderSEP 16, 2015Cancer
University of Manchester scientists have identified a gene, FOXC1, that, if turned on, can cause more aggressive cancer ...Written By: Ilene SchneiderSEP 16, 2015Cancer
Pancreatic cancer stem cells (PancSCs) are virtually addicted to oxygen-based metabolism, and could be “suffocated ...Written By: Ilene SchneiderSEP 13, 2015Cancer
Three researchers won prestigious medical awards for a new approach to treating cancer and insights into how creatures d ...Written By: Ilene SchneiderSEP 13, 2015Cancer
A team at the University of Pennsylvania reported that a multiple myeloma patient whose cancer had stopped respondi ...Written By: Ilene SchneiderSEP 11, 2015Cancer
A protein domain may be critical to helping patients fighting acute myeloid leukemia (AML) avoid a relapse. Researchers ...Written By: Ilene SchneiderSEP 11, 2015Cancer
The global market value for Non-Small Cell Lung Cancer (NSCLC) treatment will rise from $6.9 billion in 2014 to $10.9 bi ...Written By: Ilene SchneiderSEP 10, 2015Cancer
A drug-like molecule could prove valuable in cancer research with the potential of developing a new pharmaceutical. ...Written By: Ilene SchneiderSEP 06, 2015Cancer
Immunotherapy is powerful, and British researchers have found a way to make it even more so. By giving cancer patients a ...Written By: Ilene SchneiderSEP 06, 2015Neuroscience
What causes severe early infant epilepsy? Scientists at Karolinska Institutet and Karolinska University Hospital in Swed ...Written By: Ilene SchneiderSEP 06, 2015Neuroscience
Approximately 8 million Americans suffer from nightmares and flashbacks to a traumatic event. While this condition, post ...Written By: Ilene SchneiderSEP 03, 2015Cancer
A genetic test can predict whether some women’s breast cancer will recur, and that could influence how chemotherap ...Written By: Ilene SchneiderSEP 03, 2015Neuroscience
A German-French team has developed a light-sensitive switch to regulate a protein involved in the neurobiology of synapt ...Written By: Ilene SchneiderAUG 30, 2015Cancer
While mathematical models are powerful tools for demonstrating how cancer grows and spreads, they have an either/or prob ...Written By: Ilene SchneiderAUG 30, 2015Neuroscience
Johns Hopkins researchers think that a common gene mutation triggers the brain damage associated with both amyotrophic l ...Written By: Ilene SchneiderAUG 29, 2015Cancer
Viruses can be involved in the development of serious diseases. A case in point is liver cancer, which often develops in ...Written By: Ilene SchneiderAUG 29, 2015Cancer
The adage “you are what you eat” just got a little better, especially for those who like purple potatoes. Co ...Written By: Ilene SchneiderAUG 28, 2015Cancer
Pancreatic cancer, the fourth deadliest cancer in the U.S., is very hard to detect in its early stages. Rarely diagnosed ...Written By: Ilene SchneiderAUG 28, 2015Genetics & Genomics
High blood levels of two very closely related proteins can change the outcome of heart disease, according to a new study ...Written By: Ilene SchneiderAUG 27, 2015Neuroscience
Massachusetts General Hospital has been investigating the neurobiology underlying the effects of general anesthesia. Tho ...Written By: Ilene Schneider
SEP 19, 2015
Neuroscience
The abnormal behavior of two genes (BDNF and DTNBP1) is related to the underlying cause of schizophrenia, providing a ne
...
Written By:
Ilene Schneider
SEP 18, 2015
Cancer
Women successfully treated for breast cancer know that it could return. New research published in the journal Clinical E
...
Written By:
Ilene Schneider
SEP 18, 2015
Neuroscience
When patients begin treatment for dependence on opioids, they are five times as likely to die in the first four weeks wh
...
Written By:
Ilene Schneider
SEP 18, 2015
Cancer
Cells can adapt to overcome cancer drugs designed to interfere with their genetic controls, according to a study by Canc
...
Written By:
Ilene Schneider
SEP 17, 2015
Cancer
The product pipeline for Non-Hodgkin Lymphoma (NHL) exhibits a lower degree of innovation than both the industry and onc
...
Written By:
Ilene Schneider
SEP 16, 2015
Cancer
University of Manchester scientists have identified a gene, FOXC1, that, if turned on, can cause more aggressive cancer
...
Written By:
Ilene Schneider
SEP 16, 2015
Cancer
Pancreatic cancer stem cells (PancSCs) are virtually addicted to oxygen-based metabolism, and could be “suffocated
...
Written By:
Ilene Schneider
SEP 13, 2015
Cancer
Three researchers won prestigious medical awards for a new approach to treating cancer and insights into how creatures d
...
Written By:
Ilene Schneider
SEP 13, 2015
Cancer
A team at the University of Pennsylvania reported that a multiple myeloma patient whose cancer had stopped respondi
...
Written By:
Ilene Schneider
SEP 11, 2015
Cancer
A protein domain may be critical to helping patients fighting acute myeloid leukemia (AML) avoid a relapse. Researchers
...
Written By:
Ilene Schneider
SEP 11, 2015
Cancer
The global market value for Non-Small Cell Lung Cancer (NSCLC) treatment will rise from $6.9 billion in 2014 to $10.9 bi
...
Written By:
Ilene Schneider
SEP 10, 2015
Cancer
A drug-like molecule could prove valuable in cancer research with the potential of developing a new pharmaceutical.
...
Written By:
Ilene Schneider
SEP 06, 2015
Cancer
Immunotherapy is powerful, and British researchers have found a way to make it even more so. By giving cancer patients a
...
Written By:
Ilene Schneider
SEP 06, 2015
Neuroscience
What causes severe early infant epilepsy? Scientists at Karolinska Institutet and Karolinska University Hospital in Swed
...
Written By:
Ilene Schneider
SEP 06, 2015
Neuroscience
Approximately 8 million Americans suffer from nightmares and flashbacks to a traumatic event. While this condition, post
...
Written By:
Ilene Schneider
SEP 03, 2015
Cancer
A genetic test can predict whether some women’s breast cancer will recur, and that could influence how chemotherap
...
Written By:
Ilene Schneider
SEP 03, 2015
Neuroscience
A German-French team has developed a light-sensitive switch to regulate a protein involved in the neurobiology of synapt
...
Written By:
Ilene Schneider
AUG 30, 2015
Cancer
While mathematical models are powerful tools for demonstrating how cancer grows and spreads, they have an either/or prob
...
Written By:
Ilene Schneider
AUG 30, 2015
Neuroscience
Johns Hopkins researchers think that a common gene mutation triggers the brain damage associated with both amyotrophic l
...
Written By:
Ilene Schneider
AUG 29, 2015
Cancer
Viruses can be involved in the development of serious diseases. A case in point is liver cancer, which often develops in
...
Written By:
Ilene Schneider
AUG 29, 2015
Cancer
The adage “you are what you eat” just got a little better, especially for those who like purple potatoes. Co
...
Written By:
Ilene Schneider
AUG 28, 2015
Cancer
Pancreatic cancer, the fourth deadliest cancer in the U.S., is very hard to detect in its early stages. Rarely diagnosed
...
Written By:
Ilene Schneider
AUG 28, 2015
Genetics & Genomics
High blood levels of two very closely related proteins can change the outcome of heart disease, according to a new study
...
Written By:
Ilene Schneider
AUG 27, 2015
Neuroscience
Massachusetts General Hospital has been investigating the neurobiology underlying the effects of general anesthesia. Tho
...
Written By:
Ilene Schneider