Gene Editing: a type of genetic engineering in which DNA is inserted, deleted or replaced in the genome of a living organism using engineered nucleases, or "molecular scissors". These nucleases create site-specific double-strand breaks (DSBs) at desired locations in the genome. The induced double-strand breaks are repaired through nonhomologous end-joining (NHEJ) or homologous recombination (HR), resulting in targeted mutations.
From Discovery to Clinic: Comprehensive CRISPR Solutions for Therapeutic Development CRISPR gene editing has revolutionized the field of molecular biology, offering precise, efficient, and v...
Advanced Gene Therapy Development Solutions: A Comprehensive Platform for Next-Generation Therapeutic Innovation: The landscape of gene therapy has evolved dramatically over the past decade,...
In recent years, non-viral methods for cell engineering have emerged as promising alternatives to viral transduction. Amongst the virus-free technologies, electroporation is considered the g...
The SH800 Cell Sorter by Sony is a versatile solution designed to deliver exceptional sorting performance across a wide array of applications. Tailored to meet diverse user needs, it incorpo...
At Thermo Fisher Scientific, our goal is to bring innovative new products and services that enable the development of more physiologically relevant disease models to help accelerate the drug...
Cimeio Therapeutics is an applied gene editing and immunotherapy company developing a portfolio of Shielded-Cell & Immunotherapy Pairsâ„¢ (SCIP). Gene editing is used to introduce single nucle...
Are low gene editing efficiency or gene expression levels preventing your research from advancing? Is your transfection method killing your cells? Are you struggling to reproduce your initia...
Identifying and verifying low frequencies of genomic alterations resulting from off-target editing, gRNA synthesis errors, cross-contamination, or other unintended gRNA activity is critical...
CRISPR has emerged as a promising alternative to viral-based gene editing by allowing scientists to modify genes with unprecedented ease and flexibility. The discovery and development of a d...
Directing nucleobase deamination or removal can generate precise genomic edits without double-stranded DNA breaks. However, a much broader spectrum of DNA chemical modifications is available...
Originally developed for gene editing, CRISPR-Cas systems have now become powerful molecular diagnostic tools. However, their widespread adoption in diagnostics has relied heavily on traditi...
Gene therapy involves introducing a functional gene into the patient's cells to replace a missing or defective one. It has revolutionized the field of medicine and has the potential to c...
Cell and gene therapy is at the forefront of medical innovation, offering transformative potential for treating complex diseases. However, achieving success in these therapies requires metic...
Abstract: Beginning with a brief historical overview of CRISPR, we will trace its evolution to the current state of gene engineering, highlighting its pivotal role in reshaping the landscape...
Cell and gene therapies are on the brink of transforming the pharmaceutical industry, presenting unique challenges such as ensuring the quality and consistent supply of reagents. Reagents pl...
Gene therapy has revolutionized the field of medicine, and it has the potential to cure a wide variety of genetic disorders. Gene therapy involves the introduction of a functional gene into...
Learning Objevtives: 1. Demonstrate Knowledge with gene editing, microfluidics and non-viral delivery methods. 2. Review the uses of a low-volume high-throughput transfection platform for ge...
Recent advances in gene editing has allowed the generation of advanced rodent research models, mimicking some aspects of human conditions. For neurodegenerative disorders such as Alzheimer&r...
CGX10 Cell Isolation System: Introduction, Utility, and Assessment in a GMP-grade Environment for Multiparametric Cell Sorting A future of long-term, minimally toxic immunotherapy personaliz...
With the fast progress and deeper understanding of CAR-T cell therapy, finding a better solution other than lentivirus transduction is more requested, to overcome the functional limitation o...
Rare diseases pose unique challenges in the medical field, often affecting a small but vulnerable population with limited treatment options. The Rare Disease Challenge (RaDiChal) is a ground...
In the past decade, gene editing has been increasingly emphasized as an essential tool for therapy development. This has led to significant scientific advances in understanding disease mecha...
Rather than being famous in gene editing field only, by revealing the collateral cleavage activity of Cas12a, Cas13a, Cas14 effectors, and more, Clustered Regularly Interspaced Short Palindr...
With the promise of targeted gene editing and CRISPR technologies comes increasing experimental complexity and design challenges. Success in gene editing experiments may depend on many varia...
From Discovery to Clinic: Comprehensive CRISPR Solutions for Therapeutic Development CRISPR gene editing has revolutionized the field of molecular biology, offering precise, efficient, and v...
Advanced Gene Therapy Development Solutions: A Comprehensive Platform for Next-Generation Therapeutic Innovation: The landscape of gene therapy has evolved dramatically over the past decade,...
In recent years, non-viral methods for cell engineering have emerged as promising alternatives to viral transduction. Amongst the virus-free technologies, electroporation is considered the g...
The SH800 Cell Sorter by Sony is a versatile solution designed to deliver exceptional sorting performance across a wide array of applications. Tailored to meet diverse user needs, it incorpo...
At Thermo Fisher Scientific, our goal is to bring innovative new products and services that enable the development of more physiologically relevant disease models to help accelerate the drug...
Cimeio Therapeutics is an applied gene editing and immunotherapy company developing a portfolio of Shielded-Cell & Immunotherapy Pairsâ„¢ (SCIP). Gene editing is used to introduce single nucle...
Are low gene editing efficiency or gene expression levels preventing your research from advancing? Is your transfection method killing your cells? Are you struggling to reproduce your initia...
Identifying and verifying low frequencies of genomic alterations resulting from off-target editing, gRNA synthesis errors, cross-contamination, or other unintended gRNA activity is critical...
CRISPR has emerged as a promising alternative to viral-based gene editing by allowing scientists to modify genes with unprecedented ease and flexibility. The discovery and development of a d...
Directing nucleobase deamination or removal can generate precise genomic edits without double-stranded DNA breaks. However, a much broader spectrum of DNA chemical modifications is available...
Originally developed for gene editing, CRISPR-Cas systems have now become powerful molecular diagnostic tools. However, their widespread adoption in diagnostics has relied heavily on traditi...
Gene therapy involves introducing a functional gene into the patient's cells to replace a missing or defective one. It has revolutionized the field of medicine and has the potential to c...
Cell and gene therapy is at the forefront of medical innovation, offering transformative potential for treating complex diseases. However, achieving success in these therapies requires metic...
Abstract: Beginning with a brief historical overview of CRISPR, we will trace its evolution to the current state of gene engineering, highlighting its pivotal role in reshaping the landscape...
Cell and gene therapies are on the brink of transforming the pharmaceutical industry, presenting unique challenges such as ensuring the quality and consistent supply of reagents. Reagents pl...
Gene therapy has revolutionized the field of medicine, and it has the potential to cure a wide variety of genetic disorders. Gene therapy involves the introduction of a functional gene into...
Learning Objevtives: 1. Demonstrate Knowledge with gene editing, microfluidics and non-viral delivery methods. 2. Review the uses of a low-volume high-throughput transfection platform for ge...
Recent advances in gene editing has allowed the generation of advanced rodent research models, mimicking some aspects of human conditions. For neurodegenerative disorders such as Alzheimer&r...
CGX10 Cell Isolation System: Introduction, Utility, and Assessment in a GMP-grade Environment for Multiparametric Cell Sorting A future of long-term, minimally toxic immunotherapy personaliz...
With the fast progress and deeper understanding of CAR-T cell therapy, finding a better solution other than lentivirus transduction is more requested, to overcome the functional limitation o...
Rare diseases pose unique challenges in the medical field, often affecting a small but vulnerable population with limited treatment options. The Rare Disease Challenge (RaDiChal) is a ground...
In the past decade, gene editing has been increasingly emphasized as an essential tool for therapy development. This has led to significant scientific advances in understanding disease mecha...
Rather than being famous in gene editing field only, by revealing the collateral cleavage activity of Cas12a, Cas13a, Cas14 effectors, and more, Clustered Regularly Interspaced Short Palindr...
With the promise of targeted gene editing and CRISPR technologies comes increasing experimental complexity and design challenges. Success in gene editing experiments may depend on many varia...