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    Germline Biology

    Gernline biology describes the sex cells generated within organisms that undergo sexual reproduction. Germ cells include the egg and sperm cells produced by female and male organisms, respectively. Germ cells are designed with half the chromosomes as other cells allowing them to pass their genome from parent to offspring.

    Webinars

    • DEC 12, 2023 | 7:00 AM
      Roundtable: Non-invasive vs Invasive Preimplantation Genetic Testing (PGT)
      Roundtable: Non-invasive vs Invasive Preimplantation Genetic Testing...
      An estimated 48.5 million couples suffer from infertility worldwide, driving up usage of assisted reproductive technologies around the globe. As a result, preimplantation genetic testing (PG...
      Speaker: Anil Biricik, PhD , Sandrine Chamayou, PhD , Prof. Volkan Baltaci, MD, PhD , Alok Tomar, PhD
      Sponsored By: Thermo Fisher Scientific
      34
      JUN 15, 2023 | 7:00 AM
      Early ctDNA Molecular Response Enhanced Through Integrated Analyses of Cell-Free DNA and Matched White Blood Cells
      Early ctDNA Molecular Response Enhanced Through Integrated Analyses...
      Liquid biopsies represent a transformation in the management of cancer as they have the potential to detect, characterize, and monitor cancers earlier than can be achieved with conventional...
      Speaker: Mark Sausen, PhD , Valsamo Anagnostou, MD, PhD
      Sponsored By: Labcorp Oncology
      11
      NOV 10, 2021 | 4:30 PM
      Putting the Pieces Together, from Variant Calling to Biological Insights - A Lynch Syndrome Case Study
      Putting the Pieces Together, from Variant Calling to Biological...
      In this webinar, we present a case study on Lynch syndrome (LS), a hereditary condition characterized by a high risk of colorectal cancer, endometrial cancer, and other neoplasia that typica...
      Speaker: Eric Seiser, PhD
      Presented at: Clinical Diagnostics & Research Virtual Event Series 2021
      Sponsored By: QIAGEN
      1
      OCT 13, 2021 | 10:00 AM
      Overcoming sequence artifacts to fuel clinically relevant NGS applications
      Overcoming sequence artifacts to fuel clinically relevant NGS...
      Date: October 13, 2021 Time: 10:00am (PDT), 01:00pm (EDT) Clinically-relevant applications, such as somatic variant detection, continue to push the bounds...
      Speaker: Zane Jaafar, Ph.D
      Sponsored By: Watchmaker Genomics
      27
      OCT 06, 2021 | 1:30 PM
      Putting the Pieces Together, from Variant Calling to Biological Insights - A Lynch Syndrome Case Study
      Putting the Pieces Together, from Variant Calling to Biological...
      In this webinar, we present a case study on Lynch syndrome (LS), a hereditary condition characterized by a high risk of colorectal cancer, endometrial cancer, and other neoplasia that typica...
      Speaker: Eric Seiser, PhD
      Presented at: Cancer Research & Oncology Week Virtual Event Series 2021
      Sponsored By: QIAGEN
      2
      OCT 08, 2020 | 10:00 AM
      The importance of liquid biopsy MSI for studying tumors and immunotherapy applications
      The importance of liquid biopsy MSI for studying tumors and immunotherapy...
      DATE: October 8, 2020 TIME: 1:00pm PDT Microsatellite instability (MSI) has evolved as a marker of potential hereditary cancer risk and is now a tissue agnostic immune biomarker with a broad...
      Speaker: Paul Walker, MD, FACP
      Sponsored By: Thermo Fisher Scientific - Applied Biosystems
      9
      OCT 08, 2020 | 12:00 AM
      The biology of cancer disparities: an innate immunity story
      The biology of cancer disparities: an innate immunity story
      Cancer disparities among persons of African descent are driven by both biological and nonbiological factors. There is evidence in breast cancer that psychosocial factors (environment, socioe...
      Speaker: K. Sean Kimbro, PhD
      Presented at: Cancer Research & Oncology Week Virtual Event Series 2020
      1
      APR 02, 2020 | 2:30 PM
      Opportunities for using PacBio Long-read Sequencing for COVID-19 Research
      Opportunities for using PacBio Long-read Sequencing for COVID-19...
      Scientists worldwide are actively working to tame the COVID-19 pandemic by developing therapies for patients with severe disease and a vaccine to stem transmission. Accomplishing these two g...
      Speaker: Meredith Ashby, PhD
      Presented at: Coronavirus Series
      Sponsored By: PacBio
      1
      MAR 11, 2020 | 7:30 AM
      PANEL: Neuronal Circuit Resilience - How the Brain Manages to Maintain Reliable Behaviors with Unreliable Neurons
      PANEL: Neuronal Circuit Resilience - How the Brain Manages to...
      Brain function is remarkably reliable despite the imprecise performance of neurons, and the continuous perturbations caused by aging, disease or injury. How does the brain succeed in produci...
      Speaker: Adrienne Fairhall, PhD , Tim Gardner , Carlos Lois, MD, PhD
      Presented at: Neuroscience Virtual Event Series 2020
      1
      NOV 12, 2019 | 10:00 AM
      Leveraging single cell copy number to resolve tumor clonality
      Leveraging single cell copy number to resolve tumor clonality
      DATE: November 12, 2019TIME: 10:00am PSTDirect measurement of copy number by droplet-based shallow sequencing of genomic DNA has the potential to provide new insights into tumor heterog...
      Speaker: Dr. David Craig
      Sponsored By: 10x Genomics
      9 1
      OCT 10, 2019 | 10:30 AM
      Whole genome imaging for sensitive and accurate analysis of structural variations in cancer
      Whole genome imaging for sensitive and accurate analysis of structural...
      Accumulation of structural variations (SVs) across the genome is a known trigger factor for oncogenesis. Structural mutations have been clearly implicated in a number of cancers, most notably...
      Speaker: Sven Bocklandt, PhD
      Presented at: Cancer Research & Oncology Week Virtual Event Series 2019
      Sponsored By: Bionano
      1
      SEP 26, 2019 | 9:00 AM
      Identification of Novel Biomarker Candidates for Early Detection of Melanoma
      Identification of Novel Biomarker Candidates for Early Detection...
      Early detection is critical for improved survival in melanoma. Melanocytic nevi are extremely common benign tumors that mimic melanoma and are therefore commonly biopsied. Currently, the dete...
      Speaker: Margaret Hoang, PhD , Maija Kiuru, PhD
      Presented at: Cell Biology Virtual Event Series 2019
      1
      JUL 23, 2019 | 10:00 AM
      Molecularly Guided High Plex Spatial Profiling in the Tumor Microenvironment
      Molecularly Guided High Plex Spatial Profiling in the Tumor Microenvironment
      DATE: July 23, 2019TIME: 10:00am PDTThe tumor microenvironment is a complex network of different cell types and states that imparts distinct properties to the tumor and plays a signif...
      Speaker: Doug Hinerfeld, PhD , Chris Merritt, PhD , Anushka Dikshit, PhD
      Sponsored By: Advanced Cell Diagnostics
      5
      MAY 09, 2019 | 10:30 AM
      Somatic Gene Recombination in the Brain
      Somatic Gene Recombination in the Brain
      Speculations that some form DNA alteration might be utilized by the brain date to the 1960s [1] wherein hypotheses for genomic alterations of germline DNA were proposed for immunoglobulins an...
      Speaker: Jerold Chun, MD, PhD
      Presented at: Genetics and Genomics Virtual Event Series 2019
      2
      APR 10, 2019 | 10:30 AM
      A Sample to Insight Solution for Detection and Classification of Challenging Pathogenic BRCA Mutations
      A Sample to Insight Solution for Detection and Classification...
      The BRCA1 and BRCA2 genes represent the best examples of the modern understanding of cancer molecular genetics. Testing for germline and somatic mutations in BRCA 1/2 has gradually become com...
      Speaker: Anika Joecker, PhD , Jennifer Poitras, PhD
      Presented at: Molecular Diagnostics Virtual Event Series 2019
      Sponsored By: QIAGEN
      5
      JUN 20, 2018 | 7:30 AM
      Keynote Presentation: Supporting Precision Medicine and Clinical Research at Scale - Challenges and Opportunities
      Keynote Presentation: Supporting Precision Medicine and Clinical...
      Precision medicine based on molecular profiling is moving from the realm of clinical utility studies towards standard of care. There remain, however, significant technological and implementat...
      Speaker: Niall Lennon, PhD
      Presented at: Precision Medicine Virtual Event Series 2018
      1
      MAY 10, 2018 | 10:30 AM
      Cost Effective, Robust Digital Gene Expression Profiling of Up to 96 Targets in 96 Samples for Cell Line Screening with nCounter® PlexSet™ Reagents
      Cost Effective, Robust Digital Gene Expression Profiling of Up...
      Cell line screening studies require highly efficient protocols for studying many samples in parallel.  We have developed a lyse-and-go protocol for digital gene expression profiling of u...
      Speaker: Chris Merritt, PhD
      Presented at: Genetics and Genomics Virtual Event Series 2018
      Sponsored By: NanoString Technologies
      1
      NOV 02, 2017 | 10:00 AM
      WEBINAR: A CRISPR Way of Making Mice
      WEBINAR: A CRISPR Way of Making Mice
      DATE: November 2, 2017TIME: 10:00am PDT, 1:00pm EDTA CRISPR Way of Making MiceThe bulk of genetic variation associated with human disease exists in the noncoding genome, much of whi...
      Speaker: Joe Miano, PhD
      Sponsored By: Synthego
      12 1
      OCT 12, 2017 | 12:00 PM
      Comprehensive genomic and transcriptomic analysis of acral melanoma: A path towards therapeutic development
      Comprehensive genomic and transcriptomic analysis of acral melanoma:...
      Acral lentiginous melanoma (ALM) is a rare sun-shielded melanoma subtype associated with worse survival than cutaneous melanoma (CM), a more common form of skin cancer linked to exposure to u...
      Speaker: Winnie Liang, PhD
      Presented at: Cancer Research & Oncology Week Virtual Event Series 2017
      1
      MAY 24, 2017 | 9:00 AM
      Strand NGS Server: or, why clinical bioinformaticians love Strand
      Strand NGS Server: or, why clinical bioinformaticians love Strand
      I’ll talk about Strand NGS Server, our server-client NGS offering. Strand NGS server is geared towards small-to-medium scale clinical labs with high-volume sequencing throughputs and lo...
      Speaker: Radhakrishna Bettadapura (RK), PhD
      Presented at: Lab Automation Virtual Event Series 2017
      Sponsored By: Strand
      3
      AUG 30, 2016 | 8:00 AM
      Transplanted human stem cell-derived interneuron precursors mitigate mouse bladder dysfunction and central neuropathic pain after spinal cord injury
      Transplanted human stem cell-derived interneuron precursors mitigate...
      Neuropathic pain and bladder dysfunction represent significant quality of life issues for many spinal cord injury patients. Loss of GABAergic tone in the injured spinal cord may contribute to...
      Speaker: Cory Nicholas, PhD
      Presented at: 4th Annual 24 Hours of Stem Cells™ virtual event
      1
      MAY 26, 2016 | 8:00 AM
      Linking T Cell Clonotype to Phenotype with TCR Single-Cell RNA Seq
      Linking T Cell Clonotype to Phenotype with TCR Single-Cell RNA...
      DATE:  May 26, 2016TIME:  8am pacific time, 11am eastern timeJoin us live and learn about a breakthrough in TCR sequencing using single-cell analysis.T cells recognize spe...
      Speaker: Mike Stubbington, PhD , Tapio Lonnberg, PhD
      Sponsored By: Standard BioTools, Standard BioTools
      8
      OCT 16, 2013 | 1:00 PM
      C.E. CREDITS
      Investigating tissue specificity of cancer-causing germline mutations
      Investigating tissue specificity of cancer-causing germline mutations
      The remarkable diversity we see between different cell types in the human body is governed by the specificity attained through transcriptional and epigenetic regulatory programs. Cancer is a...
      Speaker: Jessica C. Mar, PhD
      Presented at: Cancer: Research, Discovery and Therapeutics Virtual Event Series 2013
      68
      AUG 21, 2013 | 3:00 PM
      C.E. CREDITS
      Investigating tissue specificity of cancer-causing germline mutations
      Investigating tissue specificity of cancer-causing germline mutations
      The remarkable diversity we see between different cell types in the human body is governed by the specificity attained through transcriptional and epigenetic regulatory programs. Cancer is a...
      Speaker: Jessica C. Mar, PhD
      Presented at: Genetics and Genomics Virtual Event Series 2013
      70
    DEC 12, 2023 | 7:00 AM
    Roundtable: Non-invasive vs Invasive Preimplantation Genetic Testing (PGT)
    Roundtable: Non-invasive vs Invasive Preimplantation Genetic Testing...
    An estimated 48.5 million couples suffer from infertility worldwide, driving up usage of assisted reproductive technologies around the globe. As a result, preimplantation genetic testing (PG...
    Speaker: Anil Biricik, PhD , Sandrine Chamayou, PhD , Prof. Volkan Baltaci, MD, PhD , Alok Tomar, PhD
    Sponsored By: Thermo Fisher Scientific
    34
    JUN 15, 2023 | 7:00 AM
    Early ctDNA Molecular Response Enhanced Through Integrated Analyses of Cell-Free DNA and Matched White Blood Cells
    Early ctDNA Molecular Response Enhanced Through Integrated Analyses...
    Liquid biopsies represent a transformation in the management of cancer as they have the potential to detect, characterize, and monitor cancers earlier than can be achieved with conventional...
    Speaker: Mark Sausen, PhD , Valsamo Anagnostou, MD, PhD
    Sponsored By: Labcorp Oncology
    11
    NOV 10, 2021 | 4:30 PM
    Putting the Pieces Together, from Variant Calling to Biological Insights - A Lynch Syndrome Case Study
    Putting the Pieces Together, from Variant Calling to Biological...
    In this webinar, we present a case study on Lynch syndrome (LS), a hereditary condition characterized by a high risk of colorectal cancer, endometrial cancer, and other neoplasia that typica...
    Speaker: Eric Seiser, PhD
    Presented at: Clinical Diagnostics & Research Virtual Event Series 2021
    Sponsored By: QIAGEN
    1
    OCT 13, 2021 | 10:00 AM
    Overcoming sequence artifacts to fuel clinically relevant NGS applications
    Overcoming sequence artifacts to fuel clinically relevant NGS...
    Date: October 13, 2021 Time: 10:00am (PDT), 01:00pm (EDT) Clinically-relevant applications, such as somatic variant detection, continue to push the bounds...
    Speaker: Zane Jaafar, Ph.D
    Sponsored By: Watchmaker Genomics
    27
    OCT 06, 2021 | 1:30 PM
    Putting the Pieces Together, from Variant Calling to Biological Insights - A Lynch Syndrome Case Study
    Putting the Pieces Together, from Variant Calling to Biological...
    In this webinar, we present a case study on Lynch syndrome (LS), a hereditary condition characterized by a high risk of colorectal cancer, endometrial cancer, and other neoplasia that typica...
    Speaker: Eric Seiser, PhD
    Presented at: Cancer Research & Oncology Week Virtual Event Series 2021
    Sponsored By: QIAGEN
    2
     
     
  • OCT 08, 2020 | 10:00 AM
    The importance of liquid biopsy MSI for studying tumors and immunotherapy applications
    The importance of liquid biopsy MSI for studying tumors and immunotherapy...
    DATE: October 8, 2020 TIME: 1:00pm PDT Microsatellite instability (MSI) has evolved as a marker of potential hereditary cancer risk and is now a tissue agnostic immune biomarker with a broad...
    Speaker: Paul Walker, MD, FACP
    Sponsored By: Thermo Fisher Scientific - Applied Biosystems
    9
    OCT 08, 2020 | 12:00 AM
    The biology of cancer disparities: an innate immunity story
    The biology of cancer disparities: an innate immunity story
    Cancer disparities among persons of African descent are driven by both biological and nonbiological factors. There is evidence in breast cancer that psychosocial factors (environment, socioe...
    Speaker: K. Sean Kimbro, PhD
    Presented at: Cancer Research & Oncology Week Virtual Event Series 2020
    1
    APR 02, 2020 | 2:30 PM
    Opportunities for using PacBio Long-read Sequencing for COVID-19 Research
    Opportunities for using PacBio Long-read Sequencing for COVID-19...
    Scientists worldwide are actively working to tame the COVID-19 pandemic by developing therapies for patients with severe disease and a vaccine to stem transmission. Accomplishing these two g...
    Speaker: Meredith Ashby, PhD
    Presented at: Coronavirus Series
    Sponsored By: PacBio
    1
    MAR 11, 2020 | 7:30 AM
    PANEL: Neuronal Circuit Resilience - How the Brain Manages to Maintain Reliable Behaviors with Unreliable Neurons
    PANEL: Neuronal Circuit Resilience - How the Brain Manages to...
    Brain function is remarkably reliable despite the imprecise performance of neurons, and the continuous perturbations caused by aging, disease or injury. How does the brain succeed in produci...
    Speaker: Adrienne Fairhall, PhD , Tim Gardner , Carlos Lois, MD, PhD
    Presented at: Neuroscience Virtual Event Series 2020
    1
    NOV 12, 2019 | 10:00 AM
    Leveraging single cell copy number to resolve tumor clonality
    Leveraging single cell copy number to resolve tumor clonality
    DATE: November 12, 2019TIME: 10:00am PSTDirect measurement of copy number by droplet-based shallow sequencing of genomic DNA has the potential to provide new insights into tumor heterog...
    Speaker: Dr. David Craig
    Sponsored By: 10x Genomics
    9 1
     
     
  • OCT 10, 2019 | 10:30 AM
    Whole genome imaging for sensitive and accurate analysis of structural variations in cancer
    Whole genome imaging for sensitive and accurate analysis of structural...
    Accumulation of structural variations (SVs) across the genome is a known trigger factor for oncogenesis. Structural mutations have been clearly implicated in a number of cancers, most notably...
    Speaker: Sven Bocklandt, PhD
    Presented at: Cancer Research & Oncology Week Virtual Event Series 2019
    Sponsored By: Bionano
    1
    SEP 26, 2019 | 9:00 AM
    Identification of Novel Biomarker Candidates for Early Detection of Melanoma
    Identification of Novel Biomarker Candidates for Early Detection...
    Early detection is critical for improved survival in melanoma. Melanocytic nevi are extremely common benign tumors that mimic melanoma and are therefore commonly biopsied. Currently, the dete...
    Speaker: Margaret Hoang, PhD , Maija Kiuru, PhD
    Presented at: Cell Biology Virtual Event Series 2019
    1
    JUL 23, 2019 | 10:00 AM
    Molecularly Guided High Plex Spatial Profiling in the Tumor Microenvironment
    Molecularly Guided High Plex Spatial Profiling in the Tumor Microenvironment
    DATE: July 23, 2019TIME: 10:00am PDTThe tumor microenvironment is a complex network of different cell types and states that imparts distinct properties to the tumor and plays a signif...
    Speaker: Doug Hinerfeld, PhD , Chris Merritt, PhD , Anushka Dikshit, PhD
    Sponsored By: Advanced Cell Diagnostics
    5
    MAY 09, 2019 | 10:30 AM
    Somatic Gene Recombination in the Brain
    Somatic Gene Recombination in the Brain
    Speculations that some form DNA alteration might be utilized by the brain date to the 1960s [1] wherein hypotheses for genomic alterations of germline DNA were proposed for immunoglobulins an...
    Speaker: Jerold Chun, MD, PhD
    Presented at: Genetics and Genomics Virtual Event Series 2019
    2
    APR 10, 2019 | 10:30 AM
    A Sample to Insight Solution for Detection and Classification of Challenging Pathogenic BRCA Mutations
    A Sample to Insight Solution for Detection and Classification...
    The BRCA1 and BRCA2 genes represent the best examples of the modern understanding of cancer molecular genetics. Testing for germline and somatic mutations in BRCA 1/2 has gradually become com...
    Speaker: Anika Joecker, PhD , Jennifer Poitras, PhD
    Presented at: Molecular Diagnostics Virtual Event Series 2019
    Sponsored By: QIAGEN
    5
     
     
  • JUN 20, 2018 | 7:30 AM
    Keynote Presentation: Supporting Precision Medicine and Clinical Research at Scale - Challenges and Opportunities
    Keynote Presentation: Supporting Precision Medicine and Clinical...
    Precision medicine based on molecular profiling is moving from the realm of clinical utility studies towards standard of care. There remain, however, significant technological and implementat...
    Speaker: Niall Lennon, PhD
    Presented at: Precision Medicine Virtual Event Series 2018
    1
    MAY 10, 2018 | 10:30 AM
    Cost Effective, Robust Digital Gene Expression Profiling of Up to 96 Targets in 96 Samples for Cell Line Screening with nCounter® PlexSet™ Reagents
    Cost Effective, Robust Digital Gene Expression Profiling of Up...
    Cell line screening studies require highly efficient protocols for studying many samples in parallel.  We have developed a lyse-and-go protocol for digital gene expression profiling of u...
    Speaker: Chris Merritt, PhD
    Presented at: Genetics and Genomics Virtual Event Series 2018
    Sponsored By: NanoString Technologies
    1
    NOV 02, 2017 | 10:00 AM
    WEBINAR: A CRISPR Way of Making Mice
    WEBINAR: A CRISPR Way of Making Mice
    DATE: November 2, 2017TIME: 10:00am PDT, 1:00pm EDTA CRISPR Way of Making MiceThe bulk of genetic variation associated with human disease exists in the noncoding genome, much of whi...
    Speaker: Joe Miano, PhD
    Sponsored By: Synthego
    12 1
    OCT 12, 2017 | 12:00 PM
    Comprehensive genomic and transcriptomic analysis of acral melanoma: A path towards therapeutic development
    Comprehensive genomic and transcriptomic analysis of acral melanoma:...
    Acral lentiginous melanoma (ALM) is a rare sun-shielded melanoma subtype associated with worse survival than cutaneous melanoma (CM), a more common form of skin cancer linked to exposure to u...
    Speaker: Winnie Liang, PhD
    Presented at: Cancer Research & Oncology Week Virtual Event Series 2017
    1
    MAY 24, 2017 | 9:00 AM
    Strand NGS Server: or, why clinical bioinformaticians love Strand
    Strand NGS Server: or, why clinical bioinformaticians love Strand
    I’ll talk about Strand NGS Server, our server-client NGS offering. Strand NGS server is geared towards small-to-medium scale clinical labs with high-volume sequencing throughputs and lo...
    Speaker: Radhakrishna Bettadapura (RK), PhD
    Presented at: Lab Automation Virtual Event Series 2017
    Sponsored By: Strand
    3
     
     
  • AUG 30, 2016 | 8:00 AM
    Transplanted human stem cell-derived interneuron precursors mitigate mouse bladder dysfunction and central neuropathic pain after spinal cord injury
    Transplanted human stem cell-derived interneuron precursors mitigate...
    Neuropathic pain and bladder dysfunction represent significant quality of life issues for many spinal cord injury patients. Loss of GABAergic tone in the injured spinal cord may contribute to...
    Speaker: Cory Nicholas, PhD
    Presented at: 4th Annual 24 Hours of Stem Cells™ virtual event
    1
    MAY 26, 2016 | 8:00 AM
    Linking T Cell Clonotype to Phenotype with TCR Single-Cell RNA Seq
    Linking T Cell Clonotype to Phenotype with TCR Single-Cell RNA...
    DATE:  May 26, 2016TIME:  8am pacific time, 11am eastern timeJoin us live and learn about a breakthrough in TCR sequencing using single-cell analysis.T cells recognize spe...
    Speaker: Mike Stubbington, PhD , Tapio Lonnberg, PhD
    Sponsored By: Standard BioTools, Standard BioTools
    8
    OCT 16, 2013 | 1:00 PM
    C.E. CREDITS
    Investigating tissue specificity of cancer-causing germline mutations
    Investigating tissue specificity of cancer-causing germline mutations
    The remarkable diversity we see between different cell types in the human body is governed by the specificity attained through transcriptional and epigenetic regulatory programs. Cancer is a...
    Speaker: Jessica C. Mar, PhD
    Presented at: Cancer: Research, Discovery and Therapeutics Virtual Event Series 2013
    68
    AUG 21, 2013 | 3:00 PM
    C.E. CREDITS
    Investigating tissue specificity of cancer-causing germline mutations
    Investigating tissue specificity of cancer-causing germline mutations
    The remarkable diversity we see between different cell types in the human body is governed by the specificity attained through transcriptional and epigenetic regulatory programs. Cancer is a...
    Speaker: Jessica C. Mar, PhD
    Presented at: Genetics and Genomics Virtual Event Series 2013
    70
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