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    High Throughput Screening

    High Throughput Screening: a method for scientific experimentation especially used in drug discovery and relevant to the fields of biology and chemistry[1][2]. Using robotics, data processing/control software, liquid handling devices, and sensitive detectors, high-throughput screening allows a researcher to quickly conduct millions of chemical, genetic, or pharmacological tests. Through this process one can rapidly identify active compounds, antibodies, or genes that modulate a particular biomolecular pathway.

    Webinars

    • NOV 16, 2020 | 8:00 AM
      Targeted single-cell RNA sequencing enables genome-scale CRISPR screens
      Targeted single-cell RNA sequencing enables genome-scale CRISPR...
      Date: November 16, 2020 Time: 8:00am (PST), 11:00am (EST) CRISPR screening has become the prime discovery tool in modern biomedical research and drug discovery. At the same time, most screen...
      Speaker: Wieland Keilholz, Ph.D. , Pawel Zajac, Ph.D. , Dr. Tilmann Buerckstuemmer
      Sponsored By: Illumina
      11
      NOV 05, 2020 | 11:00 AM
      Image and Data Processing for HCS toxicology
      Image and Data Processing for HCS toxicology
      The pharmaceuticals and biotechnology industries have made substantial progress in reducing the number of drugs that fail in clinical trials due to safety. This has been due, in part, to an...
      Speaker: David Egan, PhD
      Presented at: 7th Annual Conference: SBI2 High Content
      4
      NOV 04, 2020 | 8:00 AM
      Overcoming barriers to productivity in HCS - An image-to-answer solution for biologists
      Overcoming barriers to productivity in HCS - An image-to-answer...
      Date: November 4, 2020 Time: 8:00am (PDT), 11:00am (EDT) High-content screening (HCS) is widely used for research in quantitative cellular biology and has proven to be a valuable tool in dru...
      Speaker: William Marshall , David Egan, PhD
      Sponsored By: Cytiva
      2
      OCT 26, 2020 | 11:00 AM
      Introduction to FLIM-FRET techniques
      Introduction to FLIM-FRET techniques
      This session introduces basic concepts of imaging-based high-throughput screening (HTS) and high-throughput profiling assay development. Imaging-based HTS assays are designed to evaluate a d...
      Speaker: David Andrews, PhD
      Presented at: 7th Annual Conference: SBI2 High Content
      1
      OCT 21, 2020 | 10:30 AM
      Introduction to Supel(TM) Swift HLB: Sample Prep and Applications
      Introduction to Supel(TM) Swift HLB: Sample Prep and Applications
      Solid phase extraction has become a preferable technique for reducing matrix effects for sample preparation due to its ease of use and limited time requirements. MilliporeSigma has launched...
      Speaker: M. James Ross, PhD
      Presented at: Analytical Chemistry & Separation Sciences Virtual Event Series 2020
      Sponsored By: MilliporeSigma
      3
      OCT 21, 2020 | 9:00 AM
      Keynote Presentation: Functional properties and digestibility of starch and flour under high-temperature cooking conditions
      Keynote Presentation: Functional properties and digestibility...
      Learning Objectives: 1. Understand the functionality and digestibility of starches at high heating temperatures as measured jointly by RVA 4800 and DSC 2. Acquire new knowledge on the behavi...
      Speaker: Dr. Yongfeng Ai
      Presented at: Analytical Chemistry & Separation Sciences Virtual Event Series 2020
      1
      OCT 21, 2020 | 7:30 AM
      The Use of Dispersive Solid Phase Extraction in the Analysis of Pesticides in Cannabis Matrix
      The Use of Dispersive Solid Phase Extraction in the Analysis of...
      Cannabis is a complex and difficult matrix to work with and the analysis of pesticides in cannabis is a notoriously problematic task. There is major ion suppression present from the signific...
      Speaker: Adam Floyd
      Presented at: Analytical Chemistry & Separation Sciences Virtual Event Series 2020
      Sponsored By: JEOL
      2
      OCT 21, 2020 | 12:00 AM
      Overcoming the challenges of pesticide detection in food: Integrated workflow solutions to screen and confirm multi-residue contaminants
      Overcoming the challenges of pesticide detection in food: Integrated...
      Pesticides are routinely applied to crops to prevent or control pests and are therefore routinely tested for the presence of pesticide residues and to check for compliance with permitted Max...
      Speaker: Scott M. Peterman, PhD
      Presented at: Analytical Chemistry & Separation Sciences Virtual Event Series 2020
      1
      OCT 21, 2020 | 12:00 AM
      Cannabis Testing labs; Quality Control and Standardization
      Cannabis Testing labs; Quality Control and Standardization
      Cannabis testing laboratories play a pivotal role in the multidimensional cannabis industry. Production companies to the consumers, whole cannabis community rely on the analytical results pr...
      Speaker: Niranjan Aryal, PhD
      Presented at: Analytical Chemistry & Separation Sciences Virtual Event Series 2020
      1
      OCT 21, 2020 | 12:00 AM
      Overcoming Challenges Analyzing Heavy Metals in Cannabis by ICP-MS
      Overcoming Challenges Analyzing Heavy Metals in Cannabis by ICP-MS
      There are many obstacles to overcome when analyzing Heavy Metals in Cannabis by ICPMS. Cannabis matrices can be difficult to prepare and analyze due to the complex components of products tha...
      Speaker: Shianna Hines
      Presented at: Analytical Chemistry & Separation Sciences Virtual Event Series 2020
      1
      OCT 21, 2020 | 12:00 AM
      Automated consistency analysis of metabolomic and proteomic data in interlaboratory studies
      Automated consistency analysis of metabolomic and proteomic data...
      As ‘omics research advances, separations data such as chromatograms and nuclear magnetic resonance (NMR) spectra are being used as direct inputs to machine-learning algorithms ranging...
      Speaker: Dr. David A. Sheen
      Presented at: Analytical Chemistry & Separation Sciences Virtual Event Series 2020
      1
      OCT 21, 2020 | 12:00 AM
      Developing a Complete Workflow Including N-Linked Glycans Analysis for Monoclonal Antibodies with High Resolution Mass Spectrometry and Fluorescence Detection
      Developing a Complete Workflow Including N-Linked Glycans Analysis...
      Accurate characterization of monoclonal antibodies is essential to development of biotherapeutics. Thorough understanding of biotherapeutic properties aids in the optimization of bioprocess...
      Speaker: Brian Domanski
      Presented at: Analytical Chemistry & Separation Sciences Virtual Event Series 2020
      1
      SEP 30, 2020 | 10:30 AM
      Straightforward CRISPR knockout: Leveraging predesigned synthetic sgRNAs for highly functional and specific gene knockout
      Straightforward CRISPR knockout: Leveraging predesigned synthetic...
      CRISPR-based genome editing has accelerated biological research and holds great potential for studying and treating human diseases. The CRISPR-Cas9 system requires a Cas9 nuclease and a guid...
      Speaker: James Goldmeyer, PhD
      Presented at: CRISPR Virtual Event Series 2020
      Sponsored By: Horizon Discovery
      3 1
      SEP 30, 2020 | 12:00 AM
      CRISPR/Cas9 as a tool to model and study cancer - insights and lessons learned
      CRISPR/Cas9 as a tool to model and study cancer - insights and...
      Combinatorial inhibition of effector and feedback pathways is a promising treatment strategy for KRAS mutant cancers. However, the particular pathways that should be targeted to optimize the...
      Speaker: Grace R. Anderson, PhD
      Presented at: CRISPR Virtual Event Series 2020
      2
      SEP 30, 2020 | 12:00 AM
      Elucidation of remdesivir cytotoxicity pathways through genome-wide CRISPR-Cas9 screening and transcriptomics
      Elucidation of remdesivir cytotoxicity pathways through genome-wide...
      The adenosine analogue remdesivir has emerged as a front-line antiviral treatment for SARS-CoV-2, with preliminary evidence that it reduces the duration and severity of illness. Prior clinic...
      Speaker: Minja Velimirovic, MSc, PhD Candidate
      Presented at: CRISPR Virtual Event Series 2020
      1
      SEP 23, 2020 | 8:00 AM
      CAR T-Cell Immunotherapy of Solid Tumors - Learning from the Clinic and Lab in Parallel
      CAR T-Cell Immunotherapy of Solid Tumors - Learning from the Clinic...
      Date: Time: Over the last couple of years, it has become apparent that affinity-tuned CAR T cells display enhanced expansion and prolonged persistence in patients and that this strategy can...
      Speaker: John Maher, PhD , Rogier Reijmers, PhD
      LUMICKS
      9 1
      SEP 22, 2020 | 11:45 AM
      Automated Sample Preparation for Biopharmaceutical Analysis: Removing Inefficiencies and Variability
      Automated Sample Preparation for Biopharmaceutical Analysis: Removing...
      ...
      Speaker: Kenda Evans, PhD
      Presented at: Agilent Biopharma Workflow Solutions Virtual Symposium: Advances in Glycan and Sialic Acid Analysis
      2
      SEP 17, 2020 | 3:30 PM
      Repurposing in COVID-19: Can we identify new antivirals
      Repurposing in COVID-19: Can we identify new antivirals
      There are an urgent need for antivirals to treat the newly emerged SARS-CoV-2. We set out to develop cell-based screens to repurpose existing drugs for use against SARS-CoV-2. Our goal was t...
      Speaker: Sara Cherry, PhD
      Presented at: Coronavirus Series
      2
      SEP 17, 2020 | 3:30 PM
      SARS-CoV-2 Testing Today and a New Serology Approach For High Throughput Screening
      SARS-CoV-2 Testing Today and a New Serology Approach For High...
      Richard Hughes: New immunogenicity strategies to meet the needs of a developing pandemic Shortly after the COVID-19 pandemic began, the subject of serological testing for anti-viral antibodi...
      Speaker: Russell Garlick, PhD , Richard Hughes , Joel Lefferts, PhD, HCLD, DABCC
      Presented at: Coronavirus Series
      Sponsored By: LGC Seracare
      1
      SEP 16, 2020 | 12:15 PM
      High-resolution HCA-based phenotypic profiling of tumor spheroids and organoids
      High-resolution HCA-based phenotypic profiling of tumor spheroids...
      Image-based high-content screening (HCS) involving cancer cell lines grown in conventional two-dimensional (2D) cell culture, has provided a cornerstone assay for searching new agents to tre...
      Speaker: Meritxell B. Cutrona, PhD
      Presented at: 7th Annual Conference: SBI2 High Content
      2
      SEP 16, 2020 | 11:00 AM
      Keynote Presentation: Putting Machine Learning Models into Large Scale Production for Drug Discovery
      Keynote Presentation: Putting Machine Learning Models into Large...
      This talk will peek under the hood to show how we combine deep learning models with biology lab automation at Recursion Pharmaceuticals. Every week, we generate millions of microscopy images...
      Speaker: Lina Nilsson, PhD
      Presented at: 7th Annual Conference: SBI2 High Content
      1
      SEP 03, 2020 | 9:00 AM
      The Complexities of SV Analytical Ultracentrifugation: AAVs are not Simple, Binary Systems
      The Complexities of SV Analytical Ultracentrifugation: AAVs are...
      DATE: September 3, 2020 TIME: 09:00am PT, 12:00pm ET xxx Learning Objectives: xxx Webinars will be available for unlimited on-demand viewing after live event. LabRoots is approved as a provi...
      Speaker: Dr. Lake Paul
      Sponsored By: Beckman Coulter Life Sciences
      12
      SEP 02, 2020 | 7:00 AM
      Whole transcriptome in situ cell atlas reveals cellular composition and interactions in the developing human brain
      Whole transcriptome in situ cell atlas reveals cellular composition...
      DATE: September 2, 2020 TIME: 03:00pm PDT, 6:00pm EDT Spatial omics is an expanding collection of methods to examine biological molecules in their geographical context. By retaining the prec...
      Speaker: Dr. Omer Bayraktar , Pawel Zajac, Ph.D. , Dr. Rudy Van Eijsden
      Sponsored By: Illumina, NanoString Technologies
      19 3
      AUG 27, 2020 | 7:00 AM
      SARS-CoV-2 Quality Control for Molecular and Serology assays
      SARS-CoV-2 Quality Control for Molecular and Serology assays
      SARS-CoV-2 has created significant challenges for laboratories, requiring the development, validation, and scale up of testing in a very short time period--often this was done for multiple m...
      Speaker: Duane Newton, PhD, D(ABMM), FIDSA , Elitza S. Theel, PhD, D(ABMM)
      Presented at: A Bio-Rad Quality Control Virtual Conference
      Sponsored By: Bio-Rad Laboratories
      20 2
    NOV 16, 2020 | 8:00 AM
    Targeted single-cell RNA sequencing enables genome-scale CRISPR screens
    Targeted single-cell RNA sequencing enables genome-scale CRISPR...
    Date: November 16, 2020 Time: 8:00am (PST), 11:00am (EST) CRISPR screening has become the prime discovery tool in modern biomedical research and drug discovery. At the same time, most screen...
    Speaker: Wieland Keilholz, Ph.D. , Pawel Zajac, Ph.D. , Dr. Tilmann Buerckstuemmer
    Sponsored By: Illumina
    11
    NOV 05, 2020 | 11:00 AM
    Image and Data Processing for HCS toxicology
    Image and Data Processing for HCS toxicology
    The pharmaceuticals and biotechnology industries have made substantial progress in reducing the number of drugs that fail in clinical trials due to safety. This has been due, in part, to an...
    Speaker: David Egan, PhD
    Presented at: 7th Annual Conference: SBI2 High Content
    4
    NOV 04, 2020 | 8:00 AM
    Overcoming barriers to productivity in HCS - An image-to-answer solution for biologists
    Overcoming barriers to productivity in HCS - An image-to-answer...
    Date: November 4, 2020 Time: 8:00am (PDT), 11:00am (EDT) High-content screening (HCS) is widely used for research in quantitative cellular biology and has proven to be a valuable tool in dru...
    Speaker: William Marshall , David Egan, PhD
    Sponsored By: Cytiva
    2
    OCT 26, 2020 | 11:00 AM
    Introduction to FLIM-FRET techniques
    Introduction to FLIM-FRET techniques
    This session introduces basic concepts of imaging-based high-throughput screening (HTS) and high-throughput profiling assay development. Imaging-based HTS assays are designed to evaluate a d...
    Speaker: David Andrews, PhD
    Presented at: 7th Annual Conference: SBI2 High Content
    1
    OCT 21, 2020 | 10:30 AM
    Introduction to Supel(TM) Swift HLB: Sample Prep and Applications
    Introduction to Supel(TM) Swift HLB: Sample Prep and Applications
    Solid phase extraction has become a preferable technique for reducing matrix effects for sample preparation due to its ease of use and limited time requirements. MilliporeSigma has launched...
    Speaker: M. James Ross, PhD
    Presented at: Analytical Chemistry & Separation Sciences Virtual Event Series 2020
    Sponsored By: MilliporeSigma
    3
     
     
  • OCT 21, 2020 | 9:00 AM
    Keynote Presentation: Functional properties and digestibility of starch and flour under high-temperature cooking conditions
    Keynote Presentation: Functional properties and digestibility...
    Learning Objectives: 1. Understand the functionality and digestibility of starches at high heating temperatures as measured jointly by RVA 4800 and DSC 2. Acquire new knowledge on the behavi...
    Speaker: Dr. Yongfeng Ai
    Presented at: Analytical Chemistry & Separation Sciences Virtual Event Series 2020
    1
    OCT 21, 2020 | 7:30 AM
    The Use of Dispersive Solid Phase Extraction in the Analysis of Pesticides in Cannabis Matrix
    The Use of Dispersive Solid Phase Extraction in the Analysis of...
    Cannabis is a complex and difficult matrix to work with and the analysis of pesticides in cannabis is a notoriously problematic task. There is major ion suppression present from the signific...
    Speaker: Adam Floyd
    Presented at: Analytical Chemistry & Separation Sciences Virtual Event Series 2020
    Sponsored By: JEOL
    2
    OCT 21, 2020 | 12:00 AM
    Overcoming the challenges of pesticide detection in food: Integrated workflow solutions to screen and confirm multi-residue contaminants
    Overcoming the challenges of pesticide detection in food: Integrated...
    Pesticides are routinely applied to crops to prevent or control pests and are therefore routinely tested for the presence of pesticide residues and to check for compliance with permitted Max...
    Speaker: Scott M. Peterman, PhD
    Presented at: Analytical Chemistry & Separation Sciences Virtual Event Series 2020
    1
    OCT 21, 2020 | 12:00 AM
    Cannabis Testing labs; Quality Control and Standardization
    Cannabis Testing labs; Quality Control and Standardization
    Cannabis testing laboratories play a pivotal role in the multidimensional cannabis industry. Production companies to the consumers, whole cannabis community rely on the analytical results pr...
    Speaker: Niranjan Aryal, PhD
    Presented at: Analytical Chemistry & Separation Sciences Virtual Event Series 2020
    1
    OCT 21, 2020 | 12:00 AM
    Overcoming Challenges Analyzing Heavy Metals in Cannabis by ICP-MS
    Overcoming Challenges Analyzing Heavy Metals in Cannabis by ICP-MS
    There are many obstacles to overcome when analyzing Heavy Metals in Cannabis by ICPMS. Cannabis matrices can be difficult to prepare and analyze due to the complex components of products tha...
    Speaker: Shianna Hines
    Presented at: Analytical Chemistry & Separation Sciences Virtual Event Series 2020
    1
     
     
  • OCT 21, 2020 | 12:00 AM
    Automated consistency analysis of metabolomic and proteomic data in interlaboratory studies
    Automated consistency analysis of metabolomic and proteomic data...
    As ‘omics research advances, separations data such as chromatograms and nuclear magnetic resonance (NMR) spectra are being used as direct inputs to machine-learning algorithms ranging...
    Speaker: Dr. David A. Sheen
    Presented at: Analytical Chemistry & Separation Sciences Virtual Event Series 2020
    1
    OCT 21, 2020 | 12:00 AM
    Developing a Complete Workflow Including N-Linked Glycans Analysis for Monoclonal Antibodies with High Resolution Mass Spectrometry and Fluorescence Detection
    Developing a Complete Workflow Including N-Linked Glycans Analysis...
    Accurate characterization of monoclonal antibodies is essential to development of biotherapeutics. Thorough understanding of biotherapeutic properties aids in the optimization of bioprocess...
    Speaker: Brian Domanski
    Presented at: Analytical Chemistry & Separation Sciences Virtual Event Series 2020
    1
    SEP 30, 2020 | 10:30 AM
    Straightforward CRISPR knockout: Leveraging predesigned synthetic sgRNAs for highly functional and specific gene knockout
    Straightforward CRISPR knockout: Leveraging predesigned synthetic...
    CRISPR-based genome editing has accelerated biological research and holds great potential for studying and treating human diseases. The CRISPR-Cas9 system requires a Cas9 nuclease and a guid...
    Speaker: James Goldmeyer, PhD
    Presented at: CRISPR Virtual Event Series 2020
    Sponsored By: Horizon Discovery
    3 1
    SEP 30, 2020 | 12:00 AM
    CRISPR/Cas9 as a tool to model and study cancer - insights and lessons learned
    CRISPR/Cas9 as a tool to model and study cancer - insights and...
    Combinatorial inhibition of effector and feedback pathways is a promising treatment strategy for KRAS mutant cancers. However, the particular pathways that should be targeted to optimize the...
    Speaker: Grace R. Anderson, PhD
    Presented at: CRISPR Virtual Event Series 2020
    2
    SEP 30, 2020 | 12:00 AM
    Elucidation of remdesivir cytotoxicity pathways through genome-wide CRISPR-Cas9 screening and transcriptomics
    Elucidation of remdesivir cytotoxicity pathways through genome-wide...
    The adenosine analogue remdesivir has emerged as a front-line antiviral treatment for SARS-CoV-2, with preliminary evidence that it reduces the duration and severity of illness. Prior clinic...
    Speaker: Minja Velimirovic, MSc, PhD Candidate
    Presented at: CRISPR Virtual Event Series 2020
    1
     
     
  • SEP 23, 2020 | 8:00 AM
    CAR T-Cell Immunotherapy of Solid Tumors - Learning from the Clinic and Lab in Parallel
    CAR T-Cell Immunotherapy of Solid Tumors - Learning from the Clinic...
    Date: Time: Over the last couple of years, it has become apparent that affinity-tuned CAR T cells display enhanced expansion and prolonged persistence in patients and that this strategy can...
    Speaker: John Maher, PhD , Rogier Reijmers, PhD
    LUMICKS
    9 1
    SEP 22, 2020 | 11:45 AM
    Automated Sample Preparation for Biopharmaceutical Analysis: Removing Inefficiencies and Variability
    Automated Sample Preparation for Biopharmaceutical Analysis: Removing...
    ...
    Speaker: Kenda Evans, PhD
    Presented at: Agilent Biopharma Workflow Solutions Virtual Symposium: Advances in Glycan and Sialic Acid Analysis
    2
    SEP 17, 2020 | 3:30 PM
    Repurposing in COVID-19: Can we identify new antivirals
    Repurposing in COVID-19: Can we identify new antivirals
    There are an urgent need for antivirals to treat the newly emerged SARS-CoV-2. We set out to develop cell-based screens to repurpose existing drugs for use against SARS-CoV-2. Our goal was t...
    Speaker: Sara Cherry, PhD
    Presented at: Coronavirus Series
    2
    SEP 17, 2020 | 3:30 PM
    SARS-CoV-2 Testing Today and a New Serology Approach For High Throughput Screening
    SARS-CoV-2 Testing Today and a New Serology Approach For High...
    Richard Hughes: New immunogenicity strategies to meet the needs of a developing pandemic Shortly after the COVID-19 pandemic began, the subject of serological testing for anti-viral antibodi...
    Speaker: Russell Garlick, PhD , Richard Hughes , Joel Lefferts, PhD, HCLD, DABCC
    Presented at: Coronavirus Series
    Sponsored By: LGC Seracare
    1
    SEP 16, 2020 | 12:15 PM
    High-resolution HCA-based phenotypic profiling of tumor spheroids and organoids
    High-resolution HCA-based phenotypic profiling of tumor spheroids...
    Image-based high-content screening (HCS) involving cancer cell lines grown in conventional two-dimensional (2D) cell culture, has provided a cornerstone assay for searching new agents to tre...
    Speaker: Meritxell B. Cutrona, PhD
    Presented at: 7th Annual Conference: SBI2 High Content
    2
     
     
  • SEP 16, 2020 | 11:00 AM
    Keynote Presentation: Putting Machine Learning Models into Large Scale Production for Drug Discovery
    Keynote Presentation: Putting Machine Learning Models into Large...
    This talk will peek under the hood to show how we combine deep learning models with biology lab automation at Recursion Pharmaceuticals. Every week, we generate millions of microscopy images...
    Speaker: Lina Nilsson, PhD
    Presented at: 7th Annual Conference: SBI2 High Content
    1
    SEP 03, 2020 | 9:00 AM
    The Complexities of SV Analytical Ultracentrifugation: AAVs are not Simple, Binary Systems
    The Complexities of SV Analytical Ultracentrifugation: AAVs are...
    DATE: September 3, 2020 TIME: 09:00am PT, 12:00pm ET xxx Learning Objectives: xxx Webinars will be available for unlimited on-demand viewing after live event. LabRoots is approved as a provi...
    Speaker: Dr. Lake Paul
    Sponsored By: Beckman Coulter Life Sciences
    12
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    Speaker: Dr. Omer Bayraktar , Pawel Zajac, Ph.D. , Dr. Rudy Van Eijsden
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    AUG 27, 2020 | 7:00 AM
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