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    Molecular Diagnostics

    Molecular Diagnostics: Molecular diagnostic tests detect specific sequences in DNA or RNA that may or may not be associated with disease, including single nucleotide polymorphism (SNP), deletions, rearrangements, insertions and others. By analysing the specifics of the patient and their disease, molecular diagnostics offers the prospect of personalized medicine. These tests are useful in a range of medical specialisms, including infectious disease, oncology, human leucocyte antigen typing, coagulation, and pharmacogenomics-the genetic prediction of which drugs will work best.

    Webinars

    • APR 06, 2022 | 9:00 AM
      Applications of multiplex digital PCR: Monitoring wastewater for SARS-CoV-2 and measuring Bacterial Gene Expression
      Applications of multiplex digital PCR: Monitoring wastewater for...
      Date: April 06, 2022 Time: 9:00am (PDT), 12:00pm (EDT), 6:00pm (CEDT) Digital PCR is a specialized tool for nucleic acid quantification which has applications in many research areas includin...
      Speaker: Joan Slonczewski
      Sponsored By: Thermo Fisher Scientific
      21
      MAR 30, 2022 | 6:00 AM
      Announcing the launch of the Genexus Dx Integrated Sequencer (CE-IVD) - nucleic acid to NGS report in as little as 24 hours
      Announcing the launch of the Genexus Dx Integrated Sequencer (CE-IVD)...
      Targeted NGS has been instrumental in helping the healthcare community deliver on the promise of precision medicine. The Ion Torrent Genexus Integrated Sequencer has enabled targeted genomic...
      Speaker: Andy Felton, Ph.D. , Dr. Luca Quagliata, PhD, BCMAS , Kathy Davy
      Sponsored By: Thermo Fisher Scientific
      14
      MAR 29, 2022 | 9:00 AM
      Accelerating commercialization with custom OEM solutions and GMP
      Accelerating commercialization with custom OEM solutions and GMP
      Date: March 29, 2022 Time: 09:00am (PDT), 12:00pm (EDT), 17:00 (GMT) Advances in molecular and immunodiagnostics are enabling a personalized, high-precision approach to health in many clin...
      Speaker: Matthew Davies , Amy Webster , Mitch Gore , Renee Rathjen
      Sponsored By: Cytiva, IDT
      5
      MAR 24, 2022 | 8:00 AM
      COSMIC: Combining expert-curation with scientific innovation in a gold-standard database for precision oncology
      COSMIC: Combining expert-curation with scientific innovation in...
      Date: March 24, 2022 Time: 8:00am (PST), 11:00am (EST), 4:00pm (GMT) Key to precision oncology is the development of expert databases that organize and standardize information on cancer-rel...
      Speaker: Rebecca White , Dr. Zbyslaw Sondka
      Sponsored By: QIAGEN
      6
      MAR 16, 2022 | 7:00 AM
      Optimize Sepsis Testing with Culture-Independent Diagnostics
      Optimize Sepsis Testing with Culture-Independent Diagnostics
      Date: March 16, 2022 Time: 07:00am (PDT), 10:00am (EDT), 4:00pm (CEDT) During this webinar, we will provide an overview of the current landscape of sepsis management and the impact of rapid...
      Speaker: Dr. James Snyder , Aparna Ahuja, MD , Denise Uettwiller-Geiger, PhD, DLM (ASCP)
      Sponsored By: T2 Biosystems, Inc.
      10
      MAR 10, 2022 | 7:30 AM
      Spatial Transcriptomic Profiling of Spiny Projection Neurons in the Mouse Striatum
      Spatial Transcriptomic Profiling of Spiny Projection Neurons in...
      NanoString has started an ambitious project called the "Spatial Organ Atlas." The goal of this initiative is to map the architecture of tissues with spatially resolved whole transc...
      Speaker: Alison VanSchoiack, PhD
      Presented at: Neuroscience Virtual Event Series 2022
      Sponsored By: NanoString Technologies
      3
      MAR 08, 2022 | 9:00 AM
      COVID-19 Pandemic: Emerging Testing Solutions
      COVID-19 Pandemic: Emerging Testing Solutions
      Date: March 08, 2022 Time: 9:00am (PST), 12:00pm (EST), 6:00pm (CEST) SARS-CoV-2 causes COVID-19, a potentially lethal viral infection that can cause sever...
      Speaker: David M. Engman, MD, PhD
      Sponsored By: Diasorin
      16
      MAR 01, 2022 | 10:00 AM
      Impaired Dendritic Cell Homing in COVID-19
      Impaired Dendritic Cell Homing in COVID-19
      Date: March 01, 2022 Time: 10:00am (PST), 1:00pm (EST), 7:00pm (CEST) The high mortality of COVID-19 is mostly attributed to acute respiratory distress syndrome (ARDS), whose histopathologic...
      Speaker: Lukas Borcherding , Ralf Huss, MD, PhD
      Sponsored By: Visiopharm®
      10
      FEB 24, 2022 | 10:00 AM
      Applying Whole Genome Sequencing to Define and Predict Antimicrobial Resistance
      Applying Whole Genome Sequencing to Define and Predict Antimicrobial...
      Date: February 24, 2021 Time: 10:00am (PST), 1:00pm (EST) One of the largest global public health crises is the rise of antimicrobial-resistant infections. Globally, over 700,000 people die...
      Speaker: Trish Simner
      Sponsored By: OpGen
      18 1
      FEB 23, 2022 | 1:30 PM
      Innovative Approaches to Biomarker Discovery in the Drug Development Process
      Innovative Approaches to Biomarker Discovery in the Drug Development...
      High-throughput sequencing technology such as RNASeq and whole genome sequencing has enabled deep characterization of health and disease states. Biomarker discovery by these means has only h...
      Speaker: Esperanza Anguiano, PhD, MS-MBA
      Presented at: Drug Discovery & Development Virtual Event Series 2022
      Sponsored By: NanoString Technologies
      2
      JAN 25, 2022 | 9:00 AM
      HIV-1 Genotyping Targeting Integrase - Perspectives on Surveillance of Antiretroviral Drug Resistance
      HIV-1 Genotyping Targeting Integrase - Perspectives on Surveillance...
      Date: January 25, 2022 Time: 8:00am (CET) 9:00AM (SAST) Globally, in 2020, 38 million people were living with HIV with an additional 1.5 million newly i...
      Speaker: Kim Steegen, PhD, MSc , Natasha Wood, PhD , Steve Williams, PhD
      Sponsored By: Thermo Fisher Scientific
      26
      JAN 20, 2022 | 11:00 AM
      How to streamline your variant classification workflow with HGMD
      How to streamline your variant classification workflow with HGMD
      Date: January 20, 2022 Time: 11:00am (PST), 2:00pm (EST), 8:00pm (CEST) The Human Gene Mutation Database (HGMD) is a one-of-a-kind resource containing data for hundreds of thousands of varia...
      Speaker: Malaina Gaddis, PhD
      Sponsored By: QIAGEN
      14
      JAN 20, 2022 | 8:00 AM
      Modernization of tissue-based, biomarker-led clinical research
      Modernization of tissue-based, biomarker-led clinical research
      Date: January 20, 2021 Time: 08:00am (PST), 11:00am (EST) Automated staining platforms and digital slide scanners have revolutionized tissue-based biomarker research by providing a powerful...
      Speaker: Dr Stephanie Craig
      Sponsored By: Leica Biosystems
      15 1
      JAN 20, 2022 | 6:00 AM
      Optimizing Patient Blood Management: The Role of the Laboratory
      Optimizing Patient Blood Management: The Role of the Laboratory
      Date: January 20, 2022 Time: 16:00am (PST), 9:00pm (EST) Patient Blood Management (PBM) as defined by the Society for the Advancement of Blood Management refers to “the timely applicat...
      Speaker: Cecilia Scarponi
      Sponsored By: Ortho Clinical Diagnostics
      34 1
      JAN 13, 2022 | 9:00 AM
      Discovering the FDA-cleared Acuitas AMR Gene Panel: Building a Case for Clinical Utility
      Discovering the FDA-cleared Acuitas AMR Gene Panel: Building a...
      Date: January 13, 2022 Time: 09:00am (PST), 12:00pm (EST) Recently, the Infectious Disease Society of America released guidance on how to approach treatment of infections caused by multidrug...
      Speaker: Trish Simner , Dr. Stefan Riedel, MD, PhD
      Sponsored By: OpGen
      13 1
      DEC 09, 2021 | 11:00 AM
      Surveillance and AI-Powered Prediction of AMR to Inform Antibiotic Therapy
      Surveillance and AI-Powered Prediction of AMR to Inform Antibiotic...
      Date: December 09, 2021 Time: 11:00am (PDT), 2:00pm (EDT) The burden of antimicrobial resistance (AMR) has been acknowledged worldwide by leading health institutes. Besides the need for new...
      Speaker: Dr. Arne Materna
      Sponsored By: OpGen
      7
      DEC 08, 2021 | 10:00 AM
      Candida auris: PCR Screening for Infection Prevention
      Candida auris: PCR Screening for Infection Prevention
      Date: December 08, 2021 Time: 10:00am (PST), 1:00pm (EST) In an effort to contain the spread of multidrug resistant nosocomial infections with Candida auris ( C. auris ), the BayCare Laborat...
      Speaker: Maura Pieretti, PhD, HCLD(ABB)
      Sponsored By: Diasorin
      17
      DEC 07, 2021 | 10:00 AM
      An overview of a novel RNAscopeâ„¢ in situ hybridization technology, and applications in pathology of animal models
      An overview of a novel RNAscopeâ„¢ in situ hybridization technology,...
      Date: December 07, 2021 Time: 10:00am (PST) The RNAscope™ technology allows high sensitivity and spatial resolution providing pivotal single-cell information to gain better insights in...
      Speaker: Anushka Dikshit, PhD , Sebastien Monette
      Sponsored By: ACD, a Bio-Techne brand
      1
      DEC 01, 2021 | 12:00 PM
      Viral Evolution and Implications on HIV and SARS-CoV-2
      Viral Evolution and Implications on HIV and SARS-CoV-2
      Date: December 1, 2021 Time: 12:00pm (PST), 3:00pm (EST) Explore the adaptability of your KingFisher instrument. Discover all the ways your Thermo Scientific™ KingFisher™ system...
      Speaker: Mary Rodgers, PhD
      Sponsored By: Abbott
      8
      NOV 30, 2021 | 7:00 AM
      A Fast and Reliable Method for SARS-CoV-2 Wastewater Surveillance
      A Fast and Reliable Method for SARS-CoV-2 Wastewater Surveillance
      Date: November 30, 2021 Time: 7:00am (PDT), 10:00am (EDT) Wastewater Surveillance programs for SARS-CoV-2 are being implemented by health authorities globally. Many laboratories are currentl...
      Speaker: Subhanjan Mondal , Carlotta Olivero
      Sponsored By: Promega
      8 1
      NOV 17, 2021 | 8:00 AM
      Exosomes: From pure isolation to standardized analysis by flow cytometry
      Exosomes: From pure isolation to standardized analysis by flow...
      Date: November 17, 2021 Time: 8:00am (PDT), 11:00am (EDT) From waste disposal to promising biomarkers and therapeutic agents, exosomes and other extracellular vesicles are valuable in resear...
      Speaker: Ariadna Pascual Velazquez , Laura Müller , Stefan Wild, PhD
      Sponsored By: Miltenyi Biotec
      9
      NOV 16, 2021 | 11:00 AM
      The revival of saliva testing: advancing SARS-CoV-2 detection worldwide
      The revival of saliva testing: advancing SARS-CoV-2 detection...
      Date: November 16, 2021 Time: 11:00am (PDT), 2:00pm (EDT) In this 15-minute podcast, Dr. Anne Wyllie, Research Scientist in Epidemiology at Yale School of Public Health, discusses saliva tes...
      Speaker: Anne Wyllie, PhD
      Sponsored By: Thermo Fisher Scientific
      8 1
      NOV 15, 2021 | 6:00 AM
      Fully automated RNA library preparation for sequencing respiratory viruses
      Fully automated RNA library preparation for sequencing respiratory...
      Date: November 15, 2021 Time: 6:00am (PDT), 9:00am (EDT) Targeted sequencing of respiratory viruses’ genomes is important to identify novel viral variants. Compared to amplicon sequenc...
      Speaker: Dr. Tomasz Zemojtel , Randy Pares
      Sponsored By: Beckman Coulter Life Sciences
      6
      NOV 10, 2021 | 10:00 AM
      Latest technologies in antibody and protein labeling
      Latest technologies in antibody and protein labeling
      Date: November 10, 2021 Time: 10:00am PST Conjugated antibodies and proteins are some of the most powerful and commonly used probes currently used in life sciences research. Understanding th...
      Speaker: Douglas Anderson
      Sponsored By: Thermo Fisher Scientific
      11
    APR 06, 2022 | 9:00 AM
    Applications of multiplex digital PCR: Monitoring wastewater for SARS-CoV-2 and measuring Bacterial Gene Expression
    Applications of multiplex digital PCR: Monitoring wastewater for...
    Date: April 06, 2022 Time: 9:00am (PDT), 12:00pm (EDT), 6:00pm (CEDT) Digital PCR is a specialized tool for nucleic acid quantification which has applications in many research areas includin...
    Speaker: Joan Slonczewski
    Sponsored By: Thermo Fisher Scientific
    21
    MAR 30, 2022 | 6:00 AM
    Announcing the launch of the Genexus Dx Integrated Sequencer (CE-IVD) - nucleic acid to NGS report in as little as 24 hours
    Announcing the launch of the Genexus Dx Integrated Sequencer (CE-IVD)...
    Targeted NGS has been instrumental in helping the healthcare community deliver on the promise of precision medicine. The Ion Torrent Genexus Integrated Sequencer has enabled targeted genomic...
    Speaker: Andy Felton, Ph.D. , Dr. Luca Quagliata, PhD, BCMAS , Kathy Davy
    Sponsored By: Thermo Fisher Scientific
    14
    MAR 29, 2022 | 9:00 AM
    Accelerating commercialization with custom OEM solutions and GMP
    Accelerating commercialization with custom OEM solutions and GMP
    Date: March 29, 2022 Time: 09:00am (PDT), 12:00pm (EDT), 17:00 (GMT) Advances in molecular and immunodiagnostics are enabling a personalized, high-precision approach to health in many clin...
    Speaker: Matthew Davies , Amy Webster , Mitch Gore , Renee Rathjen
    Sponsored By: Cytiva, IDT
    5
    MAR 24, 2022 | 8:00 AM
    COSMIC: Combining expert-curation with scientific innovation in a gold-standard database for precision oncology
    COSMIC: Combining expert-curation with scientific innovation in...
    Date: March 24, 2022 Time: 8:00am (PST), 11:00am (EST), 4:00pm (GMT) Key to precision oncology is the development of expert databases that organize and standardize information on cancer-rel...
    Speaker: Rebecca White , Dr. Zbyslaw Sondka
    Sponsored By: QIAGEN
    6
    MAR 16, 2022 | 7:00 AM
    Optimize Sepsis Testing with Culture-Independent Diagnostics
    Optimize Sepsis Testing with Culture-Independent Diagnostics
    Date: March 16, 2022 Time: 07:00am (PDT), 10:00am (EDT), 4:00pm (CEDT) During this webinar, we will provide an overview of the current landscape of sepsis management and the impact of rapid...
    Speaker: Dr. James Snyder , Aparna Ahuja, MD , Denise Uettwiller-Geiger, PhD, DLM (ASCP)
    Sponsored By: T2 Biosystems, Inc.
    10
     
     
  • MAR 10, 2022 | 7:30 AM
    Spatial Transcriptomic Profiling of Spiny Projection Neurons in the Mouse Striatum
    Spatial Transcriptomic Profiling of Spiny Projection Neurons in...
    NanoString has started an ambitious project called the "Spatial Organ Atlas." The goal of this initiative is to map the architecture of tissues with spatially resolved whole transc...
    Speaker: Alison VanSchoiack, PhD
    Presented at: Neuroscience Virtual Event Series 2022
    Sponsored By: NanoString Technologies
    3
    MAR 08, 2022 | 9:00 AM
    COVID-19 Pandemic: Emerging Testing Solutions
    COVID-19 Pandemic: Emerging Testing Solutions
    Date: March 08, 2022 Time: 9:00am (PST), 12:00pm (EST), 6:00pm (CEST) SARS-CoV-2 causes COVID-19, a potentially lethal viral infection that can cause sever...
    Speaker: David M. Engman, MD, PhD
    Sponsored By: Diasorin
    16
    MAR 01, 2022 | 10:00 AM
    Impaired Dendritic Cell Homing in COVID-19
    Impaired Dendritic Cell Homing in COVID-19
    Date: March 01, 2022 Time: 10:00am (PST), 1:00pm (EST), 7:00pm (CEST) The high mortality of COVID-19 is mostly attributed to acute respiratory distress syndrome (ARDS), whose histopathologic...
    Speaker: Lukas Borcherding , Ralf Huss, MD, PhD
    Sponsored By: Visiopharm®
    10
    FEB 24, 2022 | 10:00 AM
    Applying Whole Genome Sequencing to Define and Predict Antimicrobial Resistance
    Applying Whole Genome Sequencing to Define and Predict Antimicrobial...
    Date: February 24, 2021 Time: 10:00am (PST), 1:00pm (EST) One of the largest global public health crises is the rise of antimicrobial-resistant infections. Globally, over 700,000 people die...
    Speaker: Trish Simner
    Sponsored By: OpGen
    18 1
    FEB 23, 2022 | 1:30 PM
    Innovative Approaches to Biomarker Discovery in the Drug Development Process
    Innovative Approaches to Biomarker Discovery in the Drug Development...
    High-throughput sequencing technology such as RNASeq and whole genome sequencing has enabled deep characterization of health and disease states. Biomarker discovery by these means has only h...
    Speaker: Esperanza Anguiano, PhD, MS-MBA
    Presented at: Drug Discovery & Development Virtual Event Series 2022
    Sponsored By: NanoString Technologies
    2
     
     
  • JAN 25, 2022 | 9:00 AM
    HIV-1 Genotyping Targeting Integrase - Perspectives on Surveillance of Antiretroviral Drug Resistance
    HIV-1 Genotyping Targeting Integrase - Perspectives on Surveillance...
    Date: January 25, 2022 Time: 8:00am (CET) 9:00AM (SAST) Globally, in 2020, 38 million people were living with HIV with an additional 1.5 million newly i...
    Speaker: Kim Steegen, PhD, MSc , Natasha Wood, PhD , Steve Williams, PhD
    Sponsored By: Thermo Fisher Scientific
    26
    JAN 20, 2022 | 11:00 AM
    How to streamline your variant classification workflow with HGMD
    How to streamline your variant classification workflow with HGMD
    Date: January 20, 2022 Time: 11:00am (PST), 2:00pm (EST), 8:00pm (CEST) The Human Gene Mutation Database (HGMD) is a one-of-a-kind resource containing data for hundreds of thousands of varia...
    Speaker: Malaina Gaddis, PhD
    Sponsored By: QIAGEN
    14
    JAN 20, 2022 | 8:00 AM
    Modernization of tissue-based, biomarker-led clinical research
    Modernization of tissue-based, biomarker-led clinical research
    Date: January 20, 2021 Time: 08:00am (PST), 11:00am (EST) Automated staining platforms and digital slide scanners have revolutionized tissue-based biomarker research by providing a powerful...
    Speaker: Dr Stephanie Craig
    Sponsored By: Leica Biosystems
    15 1
    JAN 20, 2022 | 6:00 AM
    Optimizing Patient Blood Management: The Role of the Laboratory
    Optimizing Patient Blood Management: The Role of the Laboratory
    Date: January 20, 2022 Time: 16:00am (PST), 9:00pm (EST) Patient Blood Management (PBM) as defined by the Society for the Advancement of Blood Management refers to “the timely applicat...
    Speaker: Cecilia Scarponi
    Sponsored By: Ortho Clinical Diagnostics
    34 1
    JAN 13, 2022 | 9:00 AM
    Discovering the FDA-cleared Acuitas AMR Gene Panel: Building a Case for Clinical Utility
    Discovering the FDA-cleared Acuitas AMR Gene Panel: Building a...
    Date: January 13, 2022 Time: 09:00am (PST), 12:00pm (EST) Recently, the Infectious Disease Society of America released guidance on how to approach treatment of infections caused by multidrug...
    Speaker: Trish Simner , Dr. Stefan Riedel, MD, PhD
    Sponsored By: OpGen
    13 1
     
     
  • DEC 09, 2021 | 11:00 AM
    Surveillance and AI-Powered Prediction of AMR to Inform Antibiotic Therapy
    Surveillance and AI-Powered Prediction of AMR to Inform Antibiotic...
    Date: December 09, 2021 Time: 11:00am (PDT), 2:00pm (EDT) The burden of antimicrobial resistance (AMR) has been acknowledged worldwide by leading health institutes. Besides the need for new...
    Speaker: Dr. Arne Materna
    Sponsored By: OpGen
    7
    DEC 08, 2021 | 10:00 AM
    Candida auris: PCR Screening for Infection Prevention
    Candida auris: PCR Screening for Infection Prevention
    Date: December 08, 2021 Time: 10:00am (PST), 1:00pm (EST) In an effort to contain the spread of multidrug resistant nosocomial infections with Candida auris ( C. auris ), the BayCare Laborat...
    Speaker: Maura Pieretti, PhD, HCLD(ABB)
    Sponsored By: Diasorin
    17
    DEC 07, 2021 | 10:00 AM
    An overview of a novel RNAscopeâ„¢ in situ hybridization technology, and applications in pathology of animal models
    An overview of a novel RNAscopeâ„¢ in situ hybridization technology,...
    Date: December 07, 2021 Time: 10:00am (PST) The RNAscope™ technology allows high sensitivity and spatial resolution providing pivotal single-cell information to gain better insights in...
    Speaker: Anushka Dikshit, PhD , Sebastien Monette
    Sponsored By: ACD, a Bio-Techne brand
    1
    DEC 01, 2021 | 12:00 PM
    Viral Evolution and Implications on HIV and SARS-CoV-2
    Viral Evolution and Implications on HIV and SARS-CoV-2
    Date: December 1, 2021 Time: 12:00pm (PST), 3:00pm (EST) Explore the adaptability of your KingFisher instrument. Discover all the ways your Thermo Scientific™ KingFisher™ system...
    Speaker: Mary Rodgers, PhD
    Sponsored By: Abbott
    8
    NOV 30, 2021 | 7:00 AM
    A Fast and Reliable Method for SARS-CoV-2 Wastewater Surveillance
    A Fast and Reliable Method for SARS-CoV-2 Wastewater Surveillance
    Date: November 30, 2021 Time: 7:00am (PDT), 10:00am (EDT) Wastewater Surveillance programs for SARS-CoV-2 are being implemented by health authorities globally. Many laboratories are currentl...
    Speaker: Subhanjan Mondal , Carlotta Olivero
    Sponsored By: Promega
    8 1
     
     
  • NOV 17, 2021 | 8:00 AM
    Exosomes: From pure isolation to standardized analysis by flow cytometry
    Exosomes: From pure isolation to standardized analysis by flow...
    Date: November 17, 2021 Time: 8:00am (PDT), 11:00am (EDT) From waste disposal to promising biomarkers and therapeutic agents, exosomes and other extracellular vesicles are valuable in resear...
    Speaker: Ariadna Pascual Velazquez , Laura Müller , Stefan Wild, PhD
    Sponsored By: Miltenyi Biotec
    9
    NOV 16, 2021 | 11:00 AM
    The revival of saliva testing: advancing SARS-CoV-2 detection worldwide
    The revival of saliva testing: advancing SARS-CoV-2 detection...
    Date: November 16, 2021 Time: 11:00am (PDT), 2:00pm (EDT) In this 15-minute podcast, Dr. Anne Wyllie, Research Scientist in Epidemiology at Yale School of Public Health, discusses saliva tes...
    Speaker: Anne Wyllie, PhD
    Sponsored By: Thermo Fisher Scientific
    8 1
    NOV 15, 2021 | 6:00 AM
    Fully automated RNA library preparation for sequencing respiratory viruses
    Fully automated RNA library preparation for sequencing respiratory...
    Date: November 15, 2021 Time: 6:00am (PDT), 9:00am (EDT) Targeted sequencing of respiratory viruses’ genomes is important to identify novel viral variants. Compared to amplicon sequenc...
    Speaker: Dr. Tomasz Zemojtel , Randy Pares
    Sponsored By: Beckman Coulter Life Sciences
    6
    NOV 10, 2021 | 10:00 AM
    Latest technologies in antibody and protein labeling
    Latest technologies in antibody and protein labeling
    Date: November 10, 2021 Time: 10:00am PST Conjugated antibodies and proteins are some of the most powerful and commonly used probes currently used in life sciences research. Understanding th...
    Speaker: Douglas Anderson
    Sponsored By: Thermo Fisher Scientific
    11
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