Understanding mouse behavior is vital for researchers using murine models for scientific analysis. Mice are nocturnal animals, usually preferring to sleep during the day and eat and perform activity at night. Mice are a social species and thus are typically caged in groups or 4 - 5 mice. Male mice behave territorially and thus will not tolerate other males in their cages so male laboratory mice should not be mixed post-weaning. Females tend to be less aggressive than males.
Batten disease or the Neuronal Ceroid Lipofuscinoses (NCLss) are each the result of inherited mutations that result in lysosomal dysfunction. Some of these disorders are due to deficiencies i...
Late-onset Alzheimer’s disease (LOAD) is the most common form of dementia worldwide. To date, animal models of Alzheimer’s have focused on rare familial mutations, due to a lack o...
Comparative oncology is the study of naturally-occurring cancers in pet animals (mainly dogs) to broaden and deepen our collective understanding of cancers in both companion species and human...
Preclinical drug discovery is at the edge of a major transformation that promises to improve translation to the clinic through enhanced acquisition and advanced analysis of data. While an imp...
High-throughput screening is widely useful in identifying genes and pathways that drive changes in cell behavior such as cell cycle regulation, metastasis, and drug resistance. Millipor...
Understanding the immune repertoire is an important aspect of immuno-oncology research, which can be used to gather insights into the function and overall status of the immune system. We have...
Treatments for respiratory diseases represent an enormous, unmet medical need with limited therapies currently approved for use. Despite many compounds demonstrating beneficial effects in ani...
DATE: May 22, 2018TIME: 08:00AM PDT The nuclear receptors pregnane X receptor (PXR) and constitutive androstane receptor (CAR) are closely related transcription factors that...
DATE: May 3, 2018TIME: 11:00AM PDT, 2:00PM EDTWhile stress is one of the leading causes of neuropsychiatric disorders, the molecular underpinnings of how stress induces alterations in b...
Cannabidiol (CBD) has emerged as a promising anti-epileptic drug in otherwise treatment-resistant genetic epileptic disorders. However, the clinical trials have been limited by their use of C...
The study of rare, neurological disorder and the development of effect treatments can pose many unique challenges. A paucity of scientists working on these disorders often limits forward prog...
Clathrin mediated endocytosis (CME) at pre-synaptic terminals is functionally coupled to neuro-transmitter release. Like other cytosolic proteins, clathrin is synthesized in cell-bodies and c...
Since its initial description more than 70 years ago, autism spectrum disorder (ASD) has been diagnosed more frequently in boys. However, we remain unsure of why males are affected in greater...
There is a growing debate about the usefulness of animal studies in biomedical research and drug development. Some of the challenges in translation from animals to human patients may be from...
Conspecific aggression is a common problem amongst laboratory housed male mice. While C57BL/6 are not the most aggressive strain we house, they are exceedingly common, and dealing with...
Studying the genetics of rare congenital disorders disrupting cognitive function has led to the identification of multiple disease genes that helped us better understand the mechanisms underl...
DATE: February 9, 2017TIME: 12:00pm PT, 3:00pm ETThe presentation will develop the FELASA (Federation of the European Laboratory Animal Science Association) views on education and train...
DATE: February 9, 2017TIME: 9:00am PT, 12:00pm ETTraditional models of liver fibrosis in rodents involve many weeks of induction, with frequent injections of a pro-fibrotic agent. The m...
DATE: February 8, 2017TIME: 1:30pm PT, 4:30pm ETThe powerful and expanding use of genetically modified mice introduces important aspects of genetics in managing these strains for breedi...
DATE: February 8, 2017TIME: 1:30pm PT, 4:30pm ETPerlara PBC, is a public benefit company committed to discovering small molecule therapeutics for rare genetic diseases. Our approach con...
DATE: February 8, 2017TIME: 10:30am PT, 1:30pm ETThe utility of animal models in drug development is limited, in part, by the measures available to researchers for monitoring animals. I...
A crucial part of providing animals for research is successful breeding. Still, in many mouse facilities breeding efficiency is complicated by problems with reproduction, such as pre-weaning...
The environment has been found to be a major contributor to data variability and many aspects of the laboratory environment are stressful to rodents and do not accurately reflect the human ex...
Noise and vibration are very effective activators of stress pathways in rodent models that can increase variability in animal models, thereby confounding virtually every area of biomedical an...
Batten disease or the Neuronal Ceroid Lipofuscinoses (NCLss) are each the result of inherited mutations that result in lysosomal dysfunction. Some of these disorders are due to deficiencies i...
Late-onset Alzheimer’s disease (LOAD) is the most common form of dementia worldwide. To date, animal models of Alzheimer’s have focused on rare familial mutations, due to a lack o...
Comparative oncology is the study of naturally-occurring cancers in pet animals (mainly dogs) to broaden and deepen our collective understanding of cancers in both companion species and human...
Preclinical drug discovery is at the edge of a major transformation that promises to improve translation to the clinic through enhanced acquisition and advanced analysis of data. While an imp...
High-throughput screening is widely useful in identifying genes and pathways that drive changes in cell behavior such as cell cycle regulation, metastasis, and drug resistance. Millipor...
Understanding the immune repertoire is an important aspect of immuno-oncology research, which can be used to gather insights into the function and overall status of the immune system. We have...
Treatments for respiratory diseases represent an enormous, unmet medical need with limited therapies currently approved for use. Despite many compounds demonstrating beneficial effects in ani...
DATE: May 22, 2018TIME: 08:00AM PDT The nuclear receptors pregnane X receptor (PXR) and constitutive androstane receptor (CAR) are closely related transcription factors that...
DATE: May 3, 2018TIME: 11:00AM PDT, 2:00PM EDTWhile stress is one of the leading causes of neuropsychiatric disorders, the molecular underpinnings of how stress induces alterations in b...
Cannabidiol (CBD) has emerged as a promising anti-epileptic drug in otherwise treatment-resistant genetic epileptic disorders. However, the clinical trials have been limited by their use of C...
The study of rare, neurological disorder and the development of effect treatments can pose many unique challenges. A paucity of scientists working on these disorders often limits forward prog...
Clathrin mediated endocytosis (CME) at pre-synaptic terminals is functionally coupled to neuro-transmitter release. Like other cytosolic proteins, clathrin is synthesized in cell-bodies and c...
Since its initial description more than 70 years ago, autism spectrum disorder (ASD) has been diagnosed more frequently in boys. However, we remain unsure of why males are affected in greater...
There is a growing debate about the usefulness of animal studies in biomedical research and drug development. Some of the challenges in translation from animals to human patients may be from...
Conspecific aggression is a common problem amongst laboratory housed male mice. While C57BL/6 are not the most aggressive strain we house, they are exceedingly common, and dealing with...
Studying the genetics of rare congenital disorders disrupting cognitive function has led to the identification of multiple disease genes that helped us better understand the mechanisms underl...
DATE: February 9, 2017TIME: 12:00pm PT, 3:00pm ETThe presentation will develop the FELASA (Federation of the European Laboratory Animal Science Association) views on education and train...
DATE: February 9, 2017TIME: 9:00am PT, 12:00pm ETTraditional models of liver fibrosis in rodents involve many weeks of induction, with frequent injections of a pro-fibrotic agent. The m...
DATE: February 8, 2017TIME: 1:30pm PT, 4:30pm ETThe powerful and expanding use of genetically modified mice introduces important aspects of genetics in managing these strains for breedi...
DATE: February 8, 2017TIME: 1:30pm PT, 4:30pm ETPerlara PBC, is a public benefit company committed to discovering small molecule therapeutics for rare genetic diseases. Our approach con...
DATE: February 8, 2017TIME: 10:30am PT, 1:30pm ETThe utility of animal models in drug development is limited, in part, by the measures available to researchers for monitoring animals. I...
A crucial part of providing animals for research is successful breeding. Still, in many mouse facilities breeding efficiency is complicated by problems with reproduction, such as pre-weaning...
The environment has been found to be a major contributor to data variability and many aspects of the laboratory environment are stressful to rodents and do not accurately reflect the human ex...
Noise and vibration are very effective activators of stress pathways in rodent models that can increase variability in animal models, thereby confounding virtually every area of biomedical an...
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