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    Next-Generation Sequencing

    Next-Generation Sequencing: A high-throughput method used to determine a portion of the nucleotide sequence of an individual's genome. This technique utilizes DNA sequencing technologies that are capable of processing multiple DNA sequences in parallel. Also called massively parallel sequencing and NGS.

    Webinars

    • MAR 19, 2014 | 10:00 AM
      MS Bioscreen: From the Bedside to the Bench and Back
      MS Bioscreen: From the Bedside to the Bench and Back
      We present a personalized medicine suite of software applications developed at UCSF for multiple sclerosis (MS): the MS Bioscreen. This new tool addresses the challenges of the dynamic manage...
      Speaker: Pierre-Antoine Gourraud, PhD, MPH
      Presented at: Neuroscience Virtual Event Series 2014
      25
      FEB 19, 2014 | 10:00 AM
      Next-generation sequencing applications in advanced cancer samples: Experience with Ion AmpliSeq custom panels
      Next-generation sequencing applications in advanced cancer samples:...
      Making precision cancer care a future reality requires novel approachesto finding treatment targets in cancers. Single-gene assays currently performed in clinical research laboratories are in...
      Speaker: Christopher Corless, MD, PhD
      Presented at: Advanced Genomics in Clinical and Translational Research - Winter
      122
      FEB 19, 2014 | 9:00 AM
      Next-generation RNA-Seq and Exome-Seq using Ion Proton Sequencer for translational oncology research
      Next-generation RNA-Seq and Exome-Seq using Ion Proton Sequencer...
      Genome sequencing technologies have enabled a rapid expansion into understanding cancer biology, drug development, and treatment resistance. Research in our laboratory has focused on the app...
      Speaker: Milan Radovich, PhD
      Presented at: Advanced Genomics in Clinical and Translational Research - Winter
      106
      FEB 05, 2014 | 11:00 AM
      C.E. CREDITS
      The Future of Mouse Embryo Transfer: Achieving the 3Rs with the NSET Device
      The Future of Mouse Embryo Transfer: Achieving the 3Rs with the...
      Non-surgical transfer techniques for mouse embryos and sperm provide animal welfare benefits for assisted reproduction of mice. While surgical embryo transfer (ET) is an effective method for...
      Speaker: Barbara Stone, PhD
      Presented at: Laboratory Animal Sciences Virtual Event Series 2014
      39
      NOV 20, 2013 | 11:00 AM
      Tools to accelerate biomarker screening for CDx
      Tools to accelerate biomarker screening for CDx
      ...
      Speaker: Dan Rhodes, PhD
      Presented at: Advanced Genomics in Clinical and Translational Research - Fall
      199
      NOV 20, 2013 | 10:00 AM
      Navigating the Evolving Molecular Diagnostic Reimbursement Landscape to Optimize Coverage and Payment and Identify Opportunities
      Navigating the Evolving Molecular Diagnostic Reimbursement Landscape...
      2013 has proven to be a year of paradigmatic shifts in molecular diagnostics reimbursement policy. In this session, we will review and analyze these key policy and payment developments and di...
      Speaker: Nicole Littmann
      Presented at: Advanced Genomics in Clinical and Translational Research - Fall
      50
      NOV 08, 2013 | 12:00 PM
      Childhood cancer with various genomic assay including whole genome sequencing
      Childhood cancer with various genomic assay including whole genome...
      The NCI's Therapeutically Applicable Research to Generate Effective Treatments (TARGET) is a comprehensive genomic characterization initiative to determine the molecular changes that drive th...
      Speaker: Jaime Guidry Auvil, PhD
      Presented at: Cancer: Research, Discovery and Therapeutics Virtual Event Series 2013
      4
      OCT 17, 2013 | 1:00 PM
      C.E. CREDITS
      Transcriptome sequencing in translational oncology research
      Transcriptome sequencing in translational oncology research
      Invading cancer cells leave the tumor to form distant metastases and are ultimately responsible for 90% of deaths in cancer. Reducing the ability of cancer cells to invade and metastasize cou...
      Speaker: Milan Radovich, PhD
      Presented at: Cancer: Research, Discovery and Therapeutics Virtual Event Series 2013
      64
      OCT 17, 2013 | 9:00 AM
      Using DNASTAR Software to Identify Cancer Variations in Targeted Resequencing Data
      Using DNASTAR Software to Identify Cancer Variations in Targeted...
      DNASTAR offers an integrated suite of software for assembling and analyzing data from all major next-generation sequencing platforms. The software supports a variety of reference guided and d...
      Speaker: Matthew Keyser, MS
      Presented at: Cancer: Research, Discovery and Therapeutics Virtual Event Series 2013
      48
      OCT 17, 2013 | 8:00 AM
      C.E. CREDITS
      Next-generation Cancer Care in the Age of Genomics, Precision Medicine, High Throughput Biology
      Next-generation Cancer Care in the Age of Genomics, Precision...
      Developments in DNA sequencing technology have provided a unique opportunity for diagnosis and discovery of genetic alterations for rare diseases. Partnering with 20 academic centers in the U...
      Speaker: C Jimmy Lin, MD, PhD, MHS
      Presented at: Cancer: Research, Discovery and Therapeutics Virtual Event Series 2013
      52
      OCT 17, 2013 | 6:00 AM
      A Bioinformatics Approach to Clinical Sequencing
      A Bioinformatics Approach to Clinical Sequencing
      The widespread adoption of precision medicine in oncology requires: a compendium of therapies targeting the genetic vulnerabilities of cancer; the diagnostic tools capable of generating a pr...
      Speaker: Dan Rhodes, PhD
      Presented at: Cancer: Research, Discovery and Therapeutics Virtual Event Series 2013
      80
      OCT 16, 2013 | 11:00 AM
      C.E. CREDITS
      Embracing Complexity: Drosophila as a Tool to Develop Cancer Therapeutics
      Embracing Complexity: Drosophila as a Tool to Develop Cancer Therapeutics
      Cancer and diabetes are complex diseases that have proven difficult to treat in the clinics. Until recently, most efforts have focused on hitting individual therapeutic targets cleanly. Unfor...
      Speaker: Ross L. Cagan, PhD
      Presented at: Cancer: Research, Discovery and Therapeutics Virtual Event Series 2013
      78
      AUG 22, 2013 | 4:00 PM
      C.E. CREDITS
      Complexity of Mammalian Transcription
      Complexity of Mammalian Transcription
      The next generation sequencing technologies are profoundly influencing our way to study biology. We have previously developed cap-analysis gene expression (CAGE) to simultaneously mRNA/noncod...
      Speaker: Piero Carninci, PhD
      Presented at: Genetics and Genomics Virtual Event Series 2013
      50
      AUG 22, 2013 | 3:00 PM
      Next-generation Cancer Care in the Age of Genomics, Precision Medicine, High Throughput Biology
      Next-generation Cancer Care in the Age of Genomics, Precision...
      Developments in DNA sequencing technology have provided a unique opportunity for diagnosis and discovery of genetic alterations for rare diseases. Partnering with 20 academic centers in the U...
      Speaker: C Jimmy Lin, MD, PhD, MHS
      Presented at: Genetics and Genomics Virtual Event Series 2013
      114
      AUG 22, 2013 | 3:00 PM
      C.E. CREDITS
      Evaluation challenges and regulatory considerations for next-generation sequencing and other high throughput genomic technology based clinical applications
      Evaluation challenges and regulatory considerations for next-generation...
      The use of ultrahigh throughput diagnostic tests that determine genetic sequence variation to guide patient care is rapidly expanding, fueled by the enormous growth in sequencing platform dev...
      Speaker: Živana Težak, PhD
      Presented at: Genetics and Genomics Virtual Event Series 2013
      282
      AUG 22, 2013 | 2:00 PM
      The Road to Genomic Medicine is Paved with Data and Information
      The Road to Genomic Medicine is Paved with Data and Information
      Since the introduction of second-generation DNS sequencing technologies in 2007, the cost of genome sequencing has been consistently by 33% per quarter, with the $1000 genome arriving in 2012...
      Speaker: John Quackenbush, PhD
      Presented at: Genetics and Genomics Virtual Event Series 2013
      110
      AUG 22, 2013 | 1:00 PM
      Dominant regulation of gene expression by microRNAs
      Dominant regulation of gene expression by microRNAs
      MicroRNAs are short non-coding cellular regulators of gene expression. Each microRNA controls the expression of a large set of genes, and microRNAs collectively, may regulate more than half o...
      Speaker: Noam Shomron, PhD
      Presented at: Genetics and Genomics Virtual Event Series 2013
      121
      AUG 22, 2013 | 12:00 PM
      C.E. CREDITS
      Exome Sequencing as a Diagnostic Tool
      Exome Sequencing as a Diagnostic Tool
      It is widely accepted that approximately 85% of known disease-causing DNA variants affect the exons and splice junctions, which is about 1% of the whole genome. As a result, Clinical Exome Se...
      Speaker: Pinar Bayrak-Toydemir, MD, PhD
      Presented at: Genetics and Genomics Virtual Event Series 2013
      66
      AUG 22, 2013 | 10:00 AM
      C.E. CREDITS
      Clinical Interpretation of Sequence Variants
      Clinical Interpretation of Sequence Variants
      The advent of massively parallel sequencing by next generation sequencing platforms now allow genomic approaches for individualizing healthcare. Genomic sequencing data reveals variants in ge...
      Speaker: Elaine Lyon, PhD
      Presented at: Genetics and Genomics Virtual Event Series 2013
      72
      AUG 22, 2013 | 10:00 AM
      C.E. CREDITS
      Using Prostate Cancer Exome Data to Identify Candidate Genes
      Using Prostate Cancer Exome Data to Identify Candidate Genes
      In this presentation, exome data from individuals with prostate cancer will be aligned against an annotated reference human genome and SNPs will be identified using DNASTARs SeqMan NGen softw...
      Speaker: Matthew Keyser, MS
      Presented at: Genetics and Genomics Virtual Event Series 2013
      60
      AUG 22, 2013 | 9:00 AM
      Next-Gen Sequencing: Driving the Transition from Genetics to Genomics
      Next-Gen Sequencing: Driving the Transition from Genetics to Genomics
      The rapid advancements in next generation sequencing have served the research market very well, delivering more and more sequence for less and less money. While these advancements are still b...
      Speaker: Shawn Baker, PhD
      Presented at: Genetics and Genomics Virtual Event Series 2013
      222
      AUG 22, 2013 | 9:00 AM
      C.E. CREDITS
      Management and Analysis of Pre-implantation Genetic Diagnosis Data
      Management and Analysis of Pre-implantation Genetic Diagnosis...
      During IVF procedures pre-implantation genetic diagnosis (PGD) allows for genetic profiling of embryos prior to replacement. Most PGD procedures during IVF are performed to select chromosomal...
      Speaker: Deanne Taylor, MS, PhD
      Presented at: Genetics and Genomics Virtual Event Series 2013
      34
      AUG 21, 2013 | 4:00 PM
      C.E. CREDITS
      Development of Targeted Next Generation Sequencing for Pharmacogenomics
      Development of Targeted Next Generation Sequencing for Pharmacogenomics
      The goal of personalized medicine is to customize healthcare to the individual patient. Pharmacogenomics, the analysis of how a patient's genetic makeup affects the individual's response to c...
      Speaker: Edward Ki Yun Leung, PhD
      Presented at: Genetics and Genomics Virtual Event Series 2013
      42
      AUG 21, 2013 | 2:00 PM
      Claritas Genomics: The Future of Pediatric Diagnostics is Now
      Claritas Genomics: The Future of Pediatric Diagnostics is Now
      Increasingly genome sequence knowledge is unraveling the complexity of rare Mendelian disorders offering hope for our children's medical care through better disease diagnosis and ultimately p...
      Speaker: Patrice Milos, PhD
      Presented at: Genetics and Genomics Virtual Event Series 2013
      96
    MAR 19, 2014 | 10:00 AM
    MS Bioscreen: From the Bedside to the Bench and Back
    MS Bioscreen: From the Bedside to the Bench and Back
    We present a personalized medicine suite of software applications developed at UCSF for multiple sclerosis (MS): the MS Bioscreen. This new tool addresses the challenges of the dynamic manage...
    Speaker: Pierre-Antoine Gourraud, PhD, MPH
    Presented at: Neuroscience Virtual Event Series 2014
    25
    FEB 19, 2014 | 10:00 AM
    Next-generation sequencing applications in advanced cancer samples: Experience with Ion AmpliSeq custom panels
    Next-generation sequencing applications in advanced cancer samples:...
    Making precision cancer care a future reality requires novel approachesto finding treatment targets in cancers. Single-gene assays currently performed in clinical research laboratories are in...
    Speaker: Christopher Corless, MD, PhD
    Presented at: Advanced Genomics in Clinical and Translational Research - Winter
    122
    FEB 19, 2014 | 9:00 AM
    Next-generation RNA-Seq and Exome-Seq using Ion Proton Sequencer for translational oncology research
    Next-generation RNA-Seq and Exome-Seq using Ion Proton Sequencer...
    Genome sequencing technologies have enabled a rapid expansion into understanding cancer biology, drug development, and treatment resistance. Research in our laboratory has focused on the app...
    Speaker: Milan Radovich, PhD
    Presented at: Advanced Genomics in Clinical and Translational Research - Winter
    106
    FEB 05, 2014 | 11:00 AM
    C.E. CREDITS
    The Future of Mouse Embryo Transfer: Achieving the 3Rs with the NSET Device
    The Future of Mouse Embryo Transfer: Achieving the 3Rs with the...
    Non-surgical transfer techniques for mouse embryos and sperm provide animal welfare benefits for assisted reproduction of mice. While surgical embryo transfer (ET) is an effective method for...
    Speaker: Barbara Stone, PhD
    Presented at: Laboratory Animal Sciences Virtual Event Series 2014
    39
    NOV 20, 2013 | 11:00 AM
    Tools to accelerate biomarker screening for CDx
    Tools to accelerate biomarker screening for CDx
    ...
    Speaker: Dan Rhodes, PhD
    Presented at: Advanced Genomics in Clinical and Translational Research - Fall
    199
     
     
  • NOV 20, 2013 | 10:00 AM
    Navigating the Evolving Molecular Diagnostic Reimbursement Landscape to Optimize Coverage and Payment and Identify Opportunities
    Navigating the Evolving Molecular Diagnostic Reimbursement Landscape...
    2013 has proven to be a year of paradigmatic shifts in molecular diagnostics reimbursement policy. In this session, we will review and analyze these key policy and payment developments and di...
    Speaker: Nicole Littmann
    Presented at: Advanced Genomics in Clinical and Translational Research - Fall
    50
    NOV 08, 2013 | 12:00 PM
    Childhood cancer with various genomic assay including whole genome sequencing
    Childhood cancer with various genomic assay including whole genome...
    The NCI's Therapeutically Applicable Research to Generate Effective Treatments (TARGET) is a comprehensive genomic characterization initiative to determine the molecular changes that drive th...
    Speaker: Jaime Guidry Auvil, PhD
    Presented at: Cancer: Research, Discovery and Therapeutics Virtual Event Series 2013
    4
    OCT 17, 2013 | 1:00 PM
    C.E. CREDITS
    Transcriptome sequencing in translational oncology research
    Transcriptome sequencing in translational oncology research
    Invading cancer cells leave the tumor to form distant metastases and are ultimately responsible for 90% of deaths in cancer. Reducing the ability of cancer cells to invade and metastasize cou...
    Speaker: Milan Radovich, PhD
    Presented at: Cancer: Research, Discovery and Therapeutics Virtual Event Series 2013
    64
    OCT 17, 2013 | 9:00 AM
    Using DNASTAR Software to Identify Cancer Variations in Targeted Resequencing Data
    Using DNASTAR Software to Identify Cancer Variations in Targeted...
    DNASTAR offers an integrated suite of software for assembling and analyzing data from all major next-generation sequencing platforms. The software supports a variety of reference guided and d...
    Speaker: Matthew Keyser, MS
    Presented at: Cancer: Research, Discovery and Therapeutics Virtual Event Series 2013
    48
    OCT 17, 2013 | 8:00 AM
    C.E. CREDITS
    Next-generation Cancer Care in the Age of Genomics, Precision Medicine, High Throughput Biology
    Next-generation Cancer Care in the Age of Genomics, Precision...
    Developments in DNA sequencing technology have provided a unique opportunity for diagnosis and discovery of genetic alterations for rare diseases. Partnering with 20 academic centers in the U...
    Speaker: C Jimmy Lin, MD, PhD, MHS
    Presented at: Cancer: Research, Discovery and Therapeutics Virtual Event Series 2013
    52
     
     
  • OCT 17, 2013 | 6:00 AM
    A Bioinformatics Approach to Clinical Sequencing
    A Bioinformatics Approach to Clinical Sequencing
    The widespread adoption of precision medicine in oncology requires: a compendium of therapies targeting the genetic vulnerabilities of cancer; the diagnostic tools capable of generating a pr...
    Speaker: Dan Rhodes, PhD
    Presented at: Cancer: Research, Discovery and Therapeutics Virtual Event Series 2013
    80
    OCT 16, 2013 | 11:00 AM
    C.E. CREDITS
    Embracing Complexity: Drosophila as a Tool to Develop Cancer Therapeutics
    Embracing Complexity: Drosophila as a Tool to Develop Cancer Therapeutics
    Cancer and diabetes are complex diseases that have proven difficult to treat in the clinics. Until recently, most efforts have focused on hitting individual therapeutic targets cleanly. Unfor...
    Speaker: Ross L. Cagan, PhD
    Presented at: Cancer: Research, Discovery and Therapeutics Virtual Event Series 2013
    78
    AUG 22, 2013 | 4:00 PM
    C.E. CREDITS
    Complexity of Mammalian Transcription
    Complexity of Mammalian Transcription
    The next generation sequencing technologies are profoundly influencing our way to study biology. We have previously developed cap-analysis gene expression (CAGE) to simultaneously mRNA/noncod...
    Speaker: Piero Carninci, PhD
    Presented at: Genetics and Genomics Virtual Event Series 2013
    50
    AUG 22, 2013 | 3:00 PM
    Next-generation Cancer Care in the Age of Genomics, Precision Medicine, High Throughput Biology
    Next-generation Cancer Care in the Age of Genomics, Precision...
    Developments in DNA sequencing technology have provided a unique opportunity for diagnosis and discovery of genetic alterations for rare diseases. Partnering with 20 academic centers in the U...
    Speaker: C Jimmy Lin, MD, PhD, MHS
    Presented at: Genetics and Genomics Virtual Event Series 2013
    114
    AUG 22, 2013 | 3:00 PM
    C.E. CREDITS
    Evaluation challenges and regulatory considerations for next-generation sequencing and other high throughput genomic technology based clinical applications
    Evaluation challenges and regulatory considerations for next-generation...
    The use of ultrahigh throughput diagnostic tests that determine genetic sequence variation to guide patient care is rapidly expanding, fueled by the enormous growth in sequencing platform dev...
    Speaker: Živana Težak, PhD
    Presented at: Genetics and Genomics Virtual Event Series 2013
    282
     
     
  • AUG 22, 2013 | 2:00 PM
    The Road to Genomic Medicine is Paved with Data and Information
    The Road to Genomic Medicine is Paved with Data and Information
    Since the introduction of second-generation DNS sequencing technologies in 2007, the cost of genome sequencing has been consistently by 33% per quarter, with the $1000 genome arriving in 2012...
    Speaker: John Quackenbush, PhD
    Presented at: Genetics and Genomics Virtual Event Series 2013
    110
    AUG 22, 2013 | 1:00 PM
    Dominant regulation of gene expression by microRNAs
    Dominant regulation of gene expression by microRNAs
    MicroRNAs are short non-coding cellular regulators of gene expression. Each microRNA controls the expression of a large set of genes, and microRNAs collectively, may regulate more than half o...
    Speaker: Noam Shomron, PhD
    Presented at: Genetics and Genomics Virtual Event Series 2013
    121
    AUG 22, 2013 | 12:00 PM
    C.E. CREDITS
    Exome Sequencing as a Diagnostic Tool
    Exome Sequencing as a Diagnostic Tool
    It is widely accepted that approximately 85% of known disease-causing DNA variants affect the exons and splice junctions, which is about 1% of the whole genome. As a result, Clinical Exome Se...
    Speaker: Pinar Bayrak-Toydemir, MD, PhD
    Presented at: Genetics and Genomics Virtual Event Series 2013
    66
    AUG 22, 2013 | 10:00 AM
    C.E. CREDITS
    Clinical Interpretation of Sequence Variants
    Clinical Interpretation of Sequence Variants
    The advent of massively parallel sequencing by next generation sequencing platforms now allow genomic approaches for individualizing healthcare. Genomic sequencing data reveals variants in ge...
    Speaker: Elaine Lyon, PhD
    Presented at: Genetics and Genomics Virtual Event Series 2013
    72
    AUG 22, 2013 | 10:00 AM
    C.E. CREDITS
    Using Prostate Cancer Exome Data to Identify Candidate Genes
    Using Prostate Cancer Exome Data to Identify Candidate Genes
    In this presentation, exome data from individuals with prostate cancer will be aligned against an annotated reference human genome and SNPs will be identified using DNASTARs SeqMan NGen softw...
    Speaker: Matthew Keyser, MS
    Presented at: Genetics and Genomics Virtual Event Series 2013
    60
     
     
  • AUG 22, 2013 | 9:00 AM
    Next-Gen Sequencing: Driving the Transition from Genetics to Genomics
    Next-Gen Sequencing: Driving the Transition from Genetics to Genomics
    The rapid advancements in next generation sequencing have served the research market very well, delivering more and more sequence for less and less money. While these advancements are still b...
    Speaker: Shawn Baker, PhD
    Presented at: Genetics and Genomics Virtual Event Series 2013
    222
    AUG 22, 2013 | 9:00 AM
    C.E. CREDITS
    Management and Analysis of Pre-implantation Genetic Diagnosis Data
    Management and Analysis of Pre-implantation Genetic Diagnosis...
    During IVF procedures pre-implantation genetic diagnosis (PGD) allows for genetic profiling of embryos prior to replacement. Most PGD procedures during IVF are performed to select chromosomal...
    Speaker: Deanne Taylor, MS, PhD
    Presented at: Genetics and Genomics Virtual Event Series 2013
    34
    AUG 21, 2013 | 4:00 PM
    C.E. CREDITS
    Development of Targeted Next Generation Sequencing for Pharmacogenomics
    Development of Targeted Next Generation Sequencing for Pharmacogenomics
    The goal of personalized medicine is to customize healthcare to the individual patient. Pharmacogenomics, the analysis of how a patient's genetic makeup affects the individual's response to c...
    Speaker: Edward Ki Yun Leung, PhD
    Presented at: Genetics and Genomics Virtual Event Series 2013
    42
    AUG 21, 2013 | 2:00 PM
    Claritas Genomics: The Future of Pediatric Diagnostics is Now
    Claritas Genomics: The Future of Pediatric Diagnostics is Now
    Increasingly genome sequence knowledge is unraveling the complexity of rare Mendelian disorders offering hope for our children's medical care through better disease diagnosis and ultimately p...
    Speaker: Patrice Milos, PhD
    Presented at: Genetics and Genomics Virtual Event Series 2013
    96
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