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    Optogenetics

    Optogenetics: is a method that uses light to modulate molecular events in a targeted manner in living cells or organisms. It relies on the use of genetically-encoded proteins that change conformation in the presence of light to alter cell behaviour, for example, by changing the membrane voltage potential of excitable cells.

    Webinars

    • OCT 31, 2023 | 9:00 AM
      AAV Gene Therapy: A novel approach to AAV biopanning in human brain
      AAV Gene Therapy: A novel approach to AAV biopanning in human...
      Gene therapy holds potential for treating neurological diseases by delivering genetic information into specific cell types. However, selective and efficient targeting of cell types remains c...
      Speaker: Joshua Ortiz-Guzman, Ph.D.
      Sponsored By: Leica Microsystems
      11
      SEP 20, 2023 | 9:00 AM
      Integration of Affinité's SPR technology for quality control in AAV bioproduction
      Integration of Affinité's SPR technology for quality control in...
      Adeno-associated virus (AAV) are increasingly produced as they hold tremendous potential in gene therapy. At research level, small quantities are produced for proof of concept studies. Howev...
      Speaker: Dr. Marie-Eve Paquet , Dr. Shuo Zhao , Dr Alina Venereo Sanchez
      Sponsored By: Affinité Instruments
      10
      JUN 06, 2023 | 9:00 AM
      Time-resolved electron microscopy: synaptic ultrastructure millisecond by millisecond with high-pressure freezing
      Time-resolved electron microscopy: synaptic ultrastructure millisecond...
      Transmission electron microscopy reveals the architecture of cells at nanometer resolution, but chemical fixation severely warps their native structure. The true ultrastructure of cells can...
      Speaker: Shigeki Watanabe, Ph.D , Grant Kusick
      Sponsored By: Leica Microsystems
      8
      MAR 09, 2022 | 10:00 AM
      Time-resolved electron microscopy: synaptic ultrastructure millisecond by millisecond with high-pressure freezing
      Time-resolved electron microscopy: synaptic ultrastructure millisecond...
      Date: March 09, 2022 Time: 10:00am (PST), 1:00pm (EST), 7:00pm (CEST) Transmission electron microscopy reveals the architecture of cells at nanometer resolution, but chemical fixation severe...
      Speaker: Shigeki Watanabe, Ph.D , Grant Kusick
      Sponsored By: Leica Microsystems
      5
      AUG 25, 2021 | 12:00 PM
      Debate Discussion: Can We Generate an Organizing Theory of the Brain?
      Debate Discussion: Can We Generate an Organizing Theory of the...
      ...
      Speaker: David Kleinfeld, PhD , Mohammad M. Ghassemi, PhD , Florian Engert, PhD
      Presented at: Neuroscience Virtual Event Series 2021
      2
      AUG 25, 2021 | 12:00 AM
      Alpha-synuclein Aggregation in Parkinson's Disease - Is it Relevant and How can we Model it?
      Alpha-synuclein Aggregation in Parkinson's Disease - Is it Relevant...
      Parkinson’s disease (PD) is the second most common neurodegenerative disorder with multiple motor and non-motor symptoms. PD is characterized by the presence on proteinaceous neuronal...
      Speaker: Andrii Domanskyi, PhD
      Presented at: Neuroscience Virtual Event Series 2021
      5
      AUG 25, 2021 | 12:00 AM
      A Novel Mouse Model of Ataxia Telangiectasia for Testing Small Molecule Readthrough (SMRT) Compounds
      A Novel Mouse Model of Ataxia Telangiectasia for Testing Small...
      Ataxia Telangiectasia, also known as A-T, is a devastating neuropediatric and genetic disorder for which there is no cure. Patients suffer from immune deficiency, cancer predisposition, and...
      Speaker: Paul Mathews, PhD
      Presented at: Neuroscience Virtual Event Series 2021
      1
      JUN 24, 2021 | 10:00 AM
      Single-Cell, Spatial Phenotyping: Fueling the Next Wave of Discovery Biology
      Single-Cell, Spatial Phenotyping: Fueling the Next Wave of Discovery...
      Date: June 24, 2021 Time: 10:00am PDT The Chan Zuckerberg Initiative (CZI) was founded to help solve some of society’s toughest challenges— from eradicating disease and improving...
      Speaker: Jonah Cool Ph.D. , Oliver Braubach, Ph.D.
      Sponsored By: Akoya Biosciences
      8
      SEP 28, 2020 | 5:00 PM
      Applying a single-cell GPS to discover novel spatial biomarkers in FFPE tissues
      Applying a single-cell GPS to discover novel spatial biomarkers...
      Date: September 28, 2020 Time: 5:00pm (PDT), 8:00am (HKT), 9:00am (JST) Although there have been dramatic advances in the field of single-cell sequencing, current methods cannot be applied t...
      Speaker: Kohta Miyawaki, MD, PhD , Aaron Mayer, PhD , Oliver Braubach, Ph.D.
      Sponsored By: Akoya Biosciences
      12
      AUG 06, 2020 | 10:00 AM
      Part IV: SPARC - A method to genetically manipulate precise proportions of cells
      Part IV: SPARC - A method to genetically manipulate precise proportions...
      Many experimental approaches rely on controlling gene expression in select subsets of cells within an individual animal. However, reproducibly targeting transgene expression to specific frac...
      Speaker: Jesse Isaacman-Beck, PhD
      Presented at: 2020 Beckman Symposium
      2
      AUG 06, 2020 | 12:00 AM
      Nanomaterials Engineering to Probe and Control Living Systems
      Nanomaterials Engineering to Probe and Control Living Systems
      Unique physical, chemical, and optical phenomena arise when materials are confined to the nanoscale. We are accustomed to making observations for the behavior of living systems on a macrosco...
      Speaker: Markita Landry, PhD
      Presented at: 2020 Beckman Symposium
      2
      AUG 06, 2020 | 12:00 AM
      SPARC - A method to genetically manipulate precise proportions of cells
      SPARC - A method to genetically manipulate precise proportions...
      Many experimental approaches rely on controlling gene expression in select subsets of cells within an individual animal. However, reproducibly targeting transgene expression to specific frac...
      Speaker: Jesse Isaacman-Beck, PhD
      Presented at: 2020 Beckman Symposium
      1
      JUL 09, 2020 | 11:00 AM
      Learning to aggress: from complex social behavior to whole brain light sheet microscopy
      Learning to aggress: from complex social behavior to whole brain...
      DATE: July 9, 2020 TIME: 11:00am PT Maladaptive aggression is an immutable force that contributes to the suffering and death of millions of people around the world annually, as well as prese...
      Speaker: Sam Golden, Ph.D
      Sponsored By: Miltenyi Biotec
      10
      JUN 03, 2020 | 12:00 AM
      Local and Acute Optogenetic Control of Microtubule Dynamics in Live Cells
      Local and Acute Optogenetic Control of Microtubule Dynamics in...
      Microtubules (MTs) are dynamic cytoskeleton polymers forming a polarized intracellular network that provides structural support, facilitates intracellular transport and drives chromosome seg...
      Speaker: Torsten Wittmann
      Presented at: Cell & Developmental Biology Virtual Meeting
      2
      APR 30, 2020 | 8:00 AM
      Uncovering the membrane mechanism of cytokinesis using live cell imaging and subcellular optogenetic tools.
      Uncovering the membrane mechanism of cytokinesis using live cell...
      DATE:April 30, 2020 TIME: 8AM PT, 11AM ET, 4PM BST, 5PM CEST Cytokinesis is the physical separation of two cells that occurs after the completion of mitosis. The mechanism underlying it is v...
      Speaker: Alan Mullan, PhD , Jean Castillo-Badillo, PhD , Claudia Florindo, PhD
      Sponsored By: Andor
      7 2
      APR 24, 2020 | 9:00 AM
      Deep Immune Profiling of Peripheral Blood Mononuclear Cells (PBMCs) with the CODEX® Platform
      Deep Immune Profiling of Peripheral Blood Mononuclear Cells (PBMCs)...
      DATE: April 24, 2020 TIME: 9:00am PT, 12:00pm ET Single-cell analysis of cell suspensions is increasingly important in studies of infectious diseases, cancer and autoimmune disorders, given...
      Speaker: Jon Mulholland, MS , Anum Khan, PhD , Oliver Braubach, Ph.D.
      Sponsored By: Akoya Biosciences
      6
      MAR 11, 2020 | 3:00 PM
      PANEL: A Team Multi-Disciplinary Approach to Understanding the Neural Circuit Dynamics Underlying Working Memory and Decision-Making
      PANEL: A Team Multi-Disciplinary Approach to Understanding the...
      Working memory (the ability to hold some information in mind for a few seconds, and to manipulate that information) and decision-making (committing to one out of multiple possible choices) a...
      Speaker: Carlos Brody, PhD , Ben Engelhard, PhD , Stephen Keeley, PhD , Marlies Oostland, PhD , Lucas Pinto, MD, PhD , Adrian Wanner, PhD , Ilana Witten, PhD
      Presented at: Neuroscience Virtual Event Series 2020
      1
      MAR 11, 2020 | 3:00 PM
      PANEL: Anatomical Characterization of Neuron Cell Types in the Mouse Brain
      PANEL: Anatomical Characterization of Neuron Cell Types in the...
      Identifying the diversity of neuronal cell types of the nervous system is one of the main objectives of the BRAIN Initiative, with the vision that distinct neuronal identities will allow for...
      Speaker: Giorgio Ascoli, PhD , Hong-Wei Dong, MD, PhD , Byungkook Lim, PhD
      Presented at: Neuroscience Virtual Event Series 2020
      1
      MAR 11, 2020 | 1:30 PM
      PANEL: Dissecting the circuit logics in the amygdala underlying emotional learning
      PANEL: Dissecting the circuit logics in the amygdala underlying...
      Learning is often an emotional process. Emotional stimuli with different valences, such as threat and reward, can transform an otherwise neutral sensory input into one that can trigger disti...
      Speaker: Bo Li , Tianyi Mao , Haining Zhong
      Presented at: Neuroscience Virtual Event Series 2020
      1
      JAN 01, 2020 | 6:00 AM
      Acoustically Targeted Molecular Neuromodulation
      Acoustically Targeted Molecular Neuromodulation
      The study of biological function in intact organisms and the development of targeted cellular therapeutics necessitate methods to image and control cellular function in vivo. Technologies su...
      Speaker: Mikhail Shapiro, PhD
      Presented at: Neuroscience Virtual Event Series 2020
      2
      MAR 13, 2019 | 6:00 AM
      Keynote Presentation: Updates from the NIH BRAIN Initiative
      Keynote Presentation: Updates from the NIH BRAIN Initiative
      Joshua Gordon, M.D., Ph.D., Director of the National Institute of Mental Health, will provide an overview of challenges and opportunities in mental health research. Dr. Gordon will present em...
      Speaker: Joshua A. Gordon, MD, PhD
      Presented at: Neuroscience Virtual Event Series 2019
      3
      MAR 14, 2018 | 6:00 AM
      Mapping Cerebellum-to-Forebrain Connectivity Using Optogenetics and Functional Magnetic Resonance Imaging
      Mapping Cerebellum-to-Forebrain Connectivity Using Optogenetics...
      Complex animal behavior is produced by dynamic interactions between discrete regions of the brain. As such, defining functional connections between brain regions is critical in gaining a full...
      Speaker: Paul Mathews, PhD
      Presented at: Neuroscience Virtual Event Series 2018
      4 1
      SEP 01, 2017 | 12:00 AM
      A gut feeling about stem cell therapy for enteric neuropathies
      A gut feeling about stem cell therapy for enteric neuropathies
      The enteric nervous system (ENS) plays an essential role in gut motility. Diseases of the ENS result in bowel motility disorders that are some of the most challenging clinical conditions to m...
      Speaker: Lincon Stamp
      Presented at: 6th annual 24 Hours of Stem Cellsâ„¢ virtual event
      1
      MAR 15, 2017 | 1:30 PM
      New generation open source miniaturized microscopes for network dynamic imaging in freely moving mice
      New generation open source miniaturized microscopes for network...
      Miniaturized microscopes in combination with genetically encoded calcium indicators now allow recordings of activity from hundreds of neurons simultaneously in freely moving animals. We are b...
      Speaker: Peyman Golshani, MD, PhD
      Presented at: Neuroscience Virtual Event Series 2017
      2
    OCT 31, 2023 | 9:00 AM
    AAV Gene Therapy: A novel approach to AAV biopanning in human brain
    AAV Gene Therapy: A novel approach to AAV biopanning in human...
    Gene therapy holds potential for treating neurological diseases by delivering genetic information into specific cell types. However, selective and efficient targeting of cell types remains c...
    Speaker: Joshua Ortiz-Guzman, Ph.D.
    Sponsored By: Leica Microsystems
    11
    SEP 20, 2023 | 9:00 AM
    Integration of Affinité's SPR technology for quality control in AAV bioproduction
    Integration of Affinité's SPR technology for quality control in...
    Adeno-associated virus (AAV) are increasingly produced as they hold tremendous potential in gene therapy. At research level, small quantities are produced for proof of concept studies. Howev...
    Speaker: Dr. Marie-Eve Paquet , Dr. Shuo Zhao , Dr Alina Venereo Sanchez
    Sponsored By: Affinité Instruments
    10
    JUN 06, 2023 | 9:00 AM
    Time-resolved electron microscopy: synaptic ultrastructure millisecond by millisecond with high-pressure freezing
    Time-resolved electron microscopy: synaptic ultrastructure millisecond...
    Transmission electron microscopy reveals the architecture of cells at nanometer resolution, but chemical fixation severely warps their native structure. The true ultrastructure of cells can...
    Speaker: Shigeki Watanabe, Ph.D , Grant Kusick
    Sponsored By: Leica Microsystems
    8
    MAR 09, 2022 | 10:00 AM
    Time-resolved electron microscopy: synaptic ultrastructure millisecond by millisecond with high-pressure freezing
    Time-resolved electron microscopy: synaptic ultrastructure millisecond...
    Date: March 09, 2022 Time: 10:00am (PST), 1:00pm (EST), 7:00pm (CEST) Transmission electron microscopy reveals the architecture of cells at nanometer resolution, but chemical fixation severe...
    Speaker: Shigeki Watanabe, Ph.D , Grant Kusick
    Sponsored By: Leica Microsystems
    5
    AUG 25, 2021 | 12:00 PM
    Debate Discussion: Can We Generate an Organizing Theory of the Brain?
    Debate Discussion: Can We Generate an Organizing Theory of the...
    ...
    Speaker: David Kleinfeld, PhD , Mohammad M. Ghassemi, PhD , Florian Engert, PhD
    Presented at: Neuroscience Virtual Event Series 2021
    2
     
     
  • AUG 25, 2021 | 12:00 AM
    Alpha-synuclein Aggregation in Parkinson's Disease - Is it Relevant and How can we Model it?
    Alpha-synuclein Aggregation in Parkinson's Disease - Is it Relevant...
    Parkinson’s disease (PD) is the second most common neurodegenerative disorder with multiple motor and non-motor symptoms. PD is characterized by the presence on proteinaceous neuronal...
    Speaker: Andrii Domanskyi, PhD
    Presented at: Neuroscience Virtual Event Series 2021
    5
    AUG 25, 2021 | 12:00 AM
    A Novel Mouse Model of Ataxia Telangiectasia for Testing Small Molecule Readthrough (SMRT) Compounds
    A Novel Mouse Model of Ataxia Telangiectasia for Testing Small...
    Ataxia Telangiectasia, also known as A-T, is a devastating neuropediatric and genetic disorder for which there is no cure. Patients suffer from immune deficiency, cancer predisposition, and...
    Speaker: Paul Mathews, PhD
    Presented at: Neuroscience Virtual Event Series 2021
    1
    JUN 24, 2021 | 10:00 AM
    Single-Cell, Spatial Phenotyping: Fueling the Next Wave of Discovery Biology
    Single-Cell, Spatial Phenotyping: Fueling the Next Wave of Discovery...
    Date: June 24, 2021 Time: 10:00am PDT The Chan Zuckerberg Initiative (CZI) was founded to help solve some of society’s toughest challenges— from eradicating disease and improving...
    Speaker: Jonah Cool Ph.D. , Oliver Braubach, Ph.D.
    Sponsored By: Akoya Biosciences
    8
    SEP 28, 2020 | 5:00 PM
    Applying a single-cell GPS to discover novel spatial biomarkers in FFPE tissues
    Applying a single-cell GPS to discover novel spatial biomarkers...
    Date: September 28, 2020 Time: 5:00pm (PDT), 8:00am (HKT), 9:00am (JST) Although there have been dramatic advances in the field of single-cell sequencing, current methods cannot be applied t...
    Speaker: Kohta Miyawaki, MD, PhD , Aaron Mayer, PhD , Oliver Braubach, Ph.D.
    Sponsored By: Akoya Biosciences
    12
    AUG 06, 2020 | 10:00 AM
    Part IV: SPARC - A method to genetically manipulate precise proportions of cells
    Part IV: SPARC - A method to genetically manipulate precise proportions...
    Many experimental approaches rely on controlling gene expression in select subsets of cells within an individual animal. However, reproducibly targeting transgene expression to specific frac...
    Speaker: Jesse Isaacman-Beck, PhD
    Presented at: 2020 Beckman Symposium
    2
     
     
  • AUG 06, 2020 | 12:00 AM
    Nanomaterials Engineering to Probe and Control Living Systems
    Nanomaterials Engineering to Probe and Control Living Systems
    Unique physical, chemical, and optical phenomena arise when materials are confined to the nanoscale. We are accustomed to making observations for the behavior of living systems on a macrosco...
    Speaker: Markita Landry, PhD
    Presented at: 2020 Beckman Symposium
    2
    AUG 06, 2020 | 12:00 AM
    SPARC - A method to genetically manipulate precise proportions of cells
    SPARC - A method to genetically manipulate precise proportions...
    Many experimental approaches rely on controlling gene expression in select subsets of cells within an individual animal. However, reproducibly targeting transgene expression to specific frac...
    Speaker: Jesse Isaacman-Beck, PhD
    Presented at: 2020 Beckman Symposium
    1
    JUL 09, 2020 | 11:00 AM
    Learning to aggress: from complex social behavior to whole brain light sheet microscopy
    Learning to aggress: from complex social behavior to whole brain...
    DATE: July 9, 2020 TIME: 11:00am PT Maladaptive aggression is an immutable force that contributes to the suffering and death of millions of people around the world annually, as well as prese...
    Speaker: Sam Golden, Ph.D
    Sponsored By: Miltenyi Biotec
    10
    JUN 03, 2020 | 12:00 AM
    Local and Acute Optogenetic Control of Microtubule Dynamics in Live Cells
    Local and Acute Optogenetic Control of Microtubule Dynamics in...
    Microtubules (MTs) are dynamic cytoskeleton polymers forming a polarized intracellular network that provides structural support, facilitates intracellular transport and drives chromosome seg...
    Speaker: Torsten Wittmann
    Presented at: Cell & Developmental Biology Virtual Meeting
    2
    APR 30, 2020 | 8:00 AM
    Uncovering the membrane mechanism of cytokinesis using live cell imaging and subcellular optogenetic tools.
    Uncovering the membrane mechanism of cytokinesis using live cell...
    DATE:April 30, 2020 TIME: 8AM PT, 11AM ET, 4PM BST, 5PM CEST Cytokinesis is the physical separation of two cells that occurs after the completion of mitosis. The mechanism underlying it is v...
    Speaker: Alan Mullan, PhD , Jean Castillo-Badillo, PhD , Claudia Florindo, PhD
    Sponsored By: Andor
    7 2
     
     
  • APR 24, 2020 | 9:00 AM
    Deep Immune Profiling of Peripheral Blood Mononuclear Cells (PBMCs) with the CODEX® Platform
    Deep Immune Profiling of Peripheral Blood Mononuclear Cells (PBMCs)...
    DATE: April 24, 2020 TIME: 9:00am PT, 12:00pm ET Single-cell analysis of cell suspensions is increasingly important in studies of infectious diseases, cancer and autoimmune disorders, given...
    Speaker: Jon Mulholland, MS , Anum Khan, PhD , Oliver Braubach, Ph.D.
    Sponsored By: Akoya Biosciences
    6
    MAR 11, 2020 | 3:00 PM
    PANEL: A Team Multi-Disciplinary Approach to Understanding the Neural Circuit Dynamics Underlying Working Memory and Decision-Making
    PANEL: A Team Multi-Disciplinary Approach to Understanding the...
    Working memory (the ability to hold some information in mind for a few seconds, and to manipulate that information) and decision-making (committing to one out of multiple possible choices) a...
    Speaker: Carlos Brody, PhD , Ben Engelhard, PhD , Stephen Keeley, PhD , Marlies Oostland, PhD , Lucas Pinto, MD, PhD , Adrian Wanner, PhD , Ilana Witten, PhD
    Presented at: Neuroscience Virtual Event Series 2020
    1
    MAR 11, 2020 | 3:00 PM
    PANEL: Anatomical Characterization of Neuron Cell Types in the Mouse Brain
    PANEL: Anatomical Characterization of Neuron Cell Types in the...
    Identifying the diversity of neuronal cell types of the nervous system is one of the main objectives of the BRAIN Initiative, with the vision that distinct neuronal identities will allow for...
    Speaker: Giorgio Ascoli, PhD , Hong-Wei Dong, MD, PhD , Byungkook Lim, PhD
    Presented at: Neuroscience Virtual Event Series 2020
    1
    MAR 11, 2020 | 1:30 PM
    PANEL: Dissecting the circuit logics in the amygdala underlying emotional learning
    PANEL: Dissecting the circuit logics in the amygdala underlying...
    Learning is often an emotional process. Emotional stimuli with different valences, such as threat and reward, can transform an otherwise neutral sensory input into one that can trigger disti...
    Speaker: Bo Li , Tianyi Mao , Haining Zhong
    Presented at: Neuroscience Virtual Event Series 2020
    1
    JAN 01, 2020 | 6:00 AM
    Acoustically Targeted Molecular Neuromodulation
    Acoustically Targeted Molecular Neuromodulation
    The study of biological function in intact organisms and the development of targeted cellular therapeutics necessitate methods to image and control cellular function in vivo. Technologies su...
    Speaker: Mikhail Shapiro, PhD
    Presented at: Neuroscience Virtual Event Series 2020
    2
     
     
  • MAR 13, 2019 | 6:00 AM
    Keynote Presentation: Updates from the NIH BRAIN Initiative
    Keynote Presentation: Updates from the NIH BRAIN Initiative
    Joshua Gordon, M.D., Ph.D., Director of the National Institute of Mental Health, will provide an overview of challenges and opportunities in mental health research. Dr. Gordon will present em...
    Speaker: Joshua A. Gordon, MD, PhD
    Presented at: Neuroscience Virtual Event Series 2019
    3
    MAR 14, 2018 | 6:00 AM
    Mapping Cerebellum-to-Forebrain Connectivity Using Optogenetics and Functional Magnetic Resonance Imaging
    Mapping Cerebellum-to-Forebrain Connectivity Using Optogenetics...
    Complex animal behavior is produced by dynamic interactions between discrete regions of the brain. As such, defining functional connections between brain regions is critical in gaining a full...
    Speaker: Paul Mathews, PhD
    Presented at: Neuroscience Virtual Event Series 2018
    4 1
    SEP 01, 2017 | 12:00 AM
    A gut feeling about stem cell therapy for enteric neuropathies
    A gut feeling about stem cell therapy for enteric neuropathies
    The enteric nervous system (ENS) plays an essential role in gut motility. Diseases of the ENS result in bowel motility disorders that are some of the most challenging clinical conditions to m...
    Speaker: Lincon Stamp
    Presented at: 6th annual 24 Hours of Stem Cellsâ„¢ virtual event
    1
    MAR 15, 2017 | 1:30 PM
    New generation open source miniaturized microscopes for network dynamic imaging in freely moving mice
    New generation open source miniaturized microscopes for network...
    Miniaturized microscopes in combination with genetically encoded calcium indicators now allow recordings of activity from hundreds of neurons simultaneously in freely moving animals. We are b...
    Speaker: Peyman Golshani, MD, PhD
    Presented at: Neuroscience Virtual Event Series 2017
    2
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