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    Research

    Research: comprises "creative and systematic work undertaken to increase the stock of knowledge, including knowledge of humans, culture and society, and the use of this stock of knowledge to devise new applications."

    Webinars

    • APR 26, 2022 | 11:00 AM
      Stretching the Limits of Microscopy Imaging with Deep Learning
      Stretching the Limits of Microscopy Imaging with Deep Learning
      Date: April 26, 2022 Time: 11:00am (PDT), 2:00pm (EDT), 8:00pm (CEST) Balance between spatial resolution, temporal resolution, and sample viability is key to extracting more data from your i...
      Speaker: Hoyin Lai
      Sponsored By: Leica Microsystems
      6
      APR 26, 2022 | 7:00 AM
      Modelling of cellular interactions in mixed murine organoids
      Modelling of cellular interactions in mixed murine organoids
      Date: April 26, 2022 Time: 7:00am (PDT), 10:00am (EDT), 4:00pm (CET) Cell competition is a mechanism of interaction that dictates cell selection based on differences in cellular fitness. We...
      Speaker: Saskia J.E Suijkerbuijk
      Sponsored By: Andor
      8
      APR 26, 2022 | 7:00 AM
      High-Content Phenotypic Screening - Answering Questions You Haven't Even Asked Yet
      High-Content Phenotypic Screening - Answering Questions You Haven't...
      Date: April 19, 2022 Time: 7:00am (PDT), 10:00am (EDT), 4:00pm (CEST) High-content (HC) phenotypic profiling approaches are a powerful tool to study the effect of biological, genetic, and ch...
      Speaker: Dr. Angeline Lim , Dr. Victor Wong
      Sponsored By: Molecular Devices
      5
      APR 25, 2022 | 12:00 AM
      C.E. CREDITS
      The Patient is Bleeding: Balancing Clinical and Laboratory Needs
      The Patient is Bleeding: Balancing Clinical and Laboratory Needs
      Explore viscoelastic testing (VET) for managing surgical bleeding, guiding transfusions, and improving perioperative patient care....
      Speaker: Oksana Volod, MD
      Presented at: Stago EdVantage Virtual University
      Sponsored By: Diagnostica Stago, Inc.
      11
      APR 21, 2022 | 12:00 PM
      Recent Advances in Lyophilized qPCR Reagents
      Recent Advances in Lyophilized qPCR Reagents
      The global pandemic has increased focus and scrutiny on molecular diagnostic assay development, resulting in a need for assays that provide quick results while delivering expected performanc...
      Speaker: Olivier Bricaud, PhD
      Presented at: Genetics Week Virtual Event Series 2022
      Sponsored By: Thermo Fisher Scientific
      2
      APR 21, 2022 | 8:00 AM
      Upgrade your B cell culture
      Upgrade your B cell culture
      Date: April 21, 2022 Time: 8:00am (PDT), 11:00am (EDT), 6:00pm (CEST) Due to the low frequency of B cells in human peripheral blood, it can be difficult to obtain sufficient numbers of B cel...
      Speaker: Dr. Susanne Bethke , Dr. Henriette Zimmermann
      Sponsored By: Miltenyi Biotec
      8
      APR 21, 2022 | 5:30 AM
      Standardization of the Interpretation and Reporting of Sequence Variants Identified in Neoplasms
      Standardization of the Interpretation and Reporting of Sequence...
      Accurate classification of genetic alterations is important to ensure the provision of high-quality clinical data. For interpretation of germline alterations, there are standardized guidelin...
      Speaker: Nikita Mehta, MS, CGC
      Presented at: Genetics Week Virtual Event Series 2022
      3
      APR 21, 2022 | 5:30 AM
      PTS-ID: Developing Precision Behavioral Health Diagnostics for PTSD
      PTS-ID: Developing Precision Behavioral Health Diagnostics for...
      In 2013, a separate diagnosis of PTSD was introduced into the DSM-V to mitigate the well-known issue of accurately differentiating between PSTD and other psychiatric disorders. In addition t...
      Speaker: Tshaka Cunningham, PhD
      Presented at: Genetics Week Virtual Event Series 2022
      2
      APR 21, 2022 | 5:30 AM
      Hypoxia Biomarkers: Personalizing Cancer Treatments by Targeting Hypoxia
      Hypoxia Biomarkers: Personalizing Cancer Treatments by Targeting...
      A hypoxic tumour microenvironment is a feature of solid tumours. Many tumour types contain high fractions of hypoxic tissue. The relationship between high levels of tumour hypoxia and a poor...
      Speaker: Joely Irlam
      Presented at: Genetics Week Virtual Event Series 2022
      2
      APR 21, 2022 | 5:30 AM
      Advances in Liquid Biopsy Technologies
      Advances in Liquid Biopsy Technologies
      Up until now, Big Data in healthcare has failed to drive any real progress in curing disease. However, we have just now reached a cost and throughput threshold in sequencing and bioinformati...
      Speaker: David Spetzler, MS, MBA, PhD
      Presented at: Genetics Week Virtual Event Series 2022
      2
      APR 20, 2022 | 1:30 PM
      Panel Presentation: Curating the Genome to Drive Precision Diagnosis in Clinical Care
      Panel Presentation: Curating the Genome to Drive Precision Diagnosis...
      The speakers will discuss how to surmount obstacles related to translating sequencing data into actionable results, and propose curated variant content shared with the clinical community as...
      Speaker: Mark Kiel, MD, PhD , Catherine Nester
      Presented at: Genetics Week Virtual Event Series 2022
      2
      APR 20, 2022 | 11:00 AM
      Characterization of lentiviral vectors using capillary electrophoresis platform technology
      Characterization of lentiviral vectors using capillary electrophoresis...
      Date: April 20, 2022 Time: 11:00am (PDT), 2:00pm (EDT), 8:00pm (CEST) As novel therapeutic modalities progress through development, improved analytical techniques are required to overcome co...
      Speaker: Aaron Shafer
      Sponsored By: SCIEX
      7
      APR 20, 2022 | 7:30 AM
      Keynote Presentation: Laboratory Assessment of Covid-19 Immunity in Patients with a Cancer Diagnosis: Alpha to Omicron
      Keynote Presentation: Laboratory Assessment of Covid-19 Immunity...
      The COVID-19 pandemic has taken a dramatic toll worldwide. Its impact possibly has been the most palpable amongst uniquely vulnerable groups of patients, such as patients with a cancer diagn...
      Speaker: Balazs Halmos, MD
      Presented at: Genetics Week Virtual Event Series 2022
      3
      APR 20, 2022 | 5:30 AM
      Improving Fetal Fraction of EDTA-Gel NIPS Samples Using Gel-Based Size-Selection
      Improving Fetal Fraction of EDTA-Gel NIPS Samples Using Gel-Based...
      Objective : Evaluation of EDTA-gel blood collection tubes from remote locations for NIPS (Non-invasive prenatal testing). Design: Paired comparisons Population: 61 pregnant women from Britis...
      Speaker: Dr François Rousseau, MD, MSc, FRCPC, FCAHS
      Presented at: Genetics Week Virtual Event Series 2022
      3
      APR 20, 2022 | 5:30 AM
      Aneuploidy on a Brush - A New Approach to Detecting Cancer and Pre-Cancers of the Esophagus
      Aneuploidy on a Brush - A New Approach to Detecting Cancer and...
      Esophageal adenocarcinoma [EAC] is the fastest growing in incidence cancer in the US over the last 25 years, while also having a 5 year survival of less than 20%. Barrett’s Esophagus [...
      Speaker: Joseph Willis, MD
      Presented at: Genetics Week Virtual Event Series 2022
      2
      APR 19, 2022 | 4:30 PM
      Extracting Novel Hypotheses and Insights from Single Cell Data
      Extracting Novel Hypotheses and Insights from Single Cell Data
      Follow us on a journey of single cell data exploration. See how you can Process, Analyze, Compare, and Contextualize, your results to identify novel biological relationships and drive new hy...
      Speaker: Jean-Noel Billaud, PhD
      Presented at: Genetics Week Virtual Event Series 2022
      Sponsored By: QIAGEN
      2
      APR 19, 2022 | 3:00 PM
      Using NGS for MicroRNA and Gene Expression Analysis with Integrated Bioinformatics for Pathway Discovery and Biomarker Verification
      Using NGS for MicroRNA and Gene Expression Analysis with Integrated...
      MicroRNAs (miRNAs) are small RNAs with an average size of 22 nucleotides that regulate gene expression through various mechanisms. During the last decade, researchers have identified over 26...
      Speaker: Samuel Rulli, PhD
      Presented at: Genetics Week Virtual Event Series 2022
      Sponsored By: QIAGEN
      1
      APR 19, 2022 | 1:30 PM
      C.E. CREDITS
      Boosting Signal-to-Noise in Single Cell RNA-Seq Through Molecular Depletion
      Boosting Signal-to-Noise in Single Cell RNA-Seq Through Molecular...
      Regardless of method, single cell RNA-seq only captures a small fraction of the transcriptome of each cell. Often, this is due to inherent limitations of the methodology as reads ‘drop...
      Speaker: Dante DeAscanis
      Presented at: Genetics Week Virtual Event Series 2022
      Sponsored By: Jumpcode Genomics
      3
      APR 19, 2022 | 12:00 PM
      C.E. CREDITS
      RT-LAMP: Best Practices and Tips to Accelerate Detection of Viral Pathogens, Including SARS-CoV-2
      RT-LAMP: Best Practices and Tips to Accelerate Detection of Viral...
      Loop-mediated isothermal amplification (LAMP) uses a stand-displacing DNA polymerase and four to six primers to rapidly amplify DNA at a single temperature. By eliminating temperature cyclin...
      Speaker: Ingrida VendelÄ—, PhD , Leann Buhrow, PhD
      Presented at: Genetics Week Virtual Event Series 2022
      Sponsored By: Thermo Fisher Scientific
      3
      APR 19, 2022 | 12:00 PM
      Advances in Targeted Sequencing: Accelerate Your NGS Workflows with New QIAseq Chemistry
      Advances in Targeted Sequencing: Accelerate Your NGS Workflows...
      Targeted sequencing has many applications in cancer biomarker research, carrier screening and inherited disorders, drug development, mitochondrial DNA variant detection, human ID and paterni...
      Speaker: Krishna Amin
      Presented at: Genetics Week Virtual Event Series 2022
      Sponsored By: QIAGEN
      1
      APR 19, 2022 | 10:30 AM
      Panel Presentation: Attain Successful Single-cell Sequencing Results with the Latest Cell and Nuclei Isolation Workflows
      Panel Presentation: Attain Successful Single-cell Sequencing Results...
      Revolutionary sequencing technologies are enabling whole transcriptome profiling of tens to hundreds of thousands of single cells in parallel, in a single experiment. This has led to an expl...
      Speaker: Carina Emery , Alina Steinbach
      Presented at: Genetics Week Virtual Event Series 2022
      Sponsored By: Miltenyi Biotec
      1
      APR 19, 2022 | 10:00 AM
      The COVID-19 Public Health Experience: Tales from the Lab
      The COVID-19 Public Health Experience: Tales from the Lab
      Date: April 19, 2022 Time: 10:00am (PDT), 1:00pm (EDT), 7:00pm (CEST) Once upon a time, there were three public health labs. These labs were busy serving their states when, out of nowhere, a...
      Speaker: Alana Sterkel, Ph.D., D(ABMM), SM{ASCP )CM , Wade Aldous, Ph.D. D(ABMM) , Sara Blosser, PhD, D(ABMM)
      Sponsored By: Roche Diagnostics
      7
      APR 19, 2022 | 7:30 AM
      C.E. CREDITS
      Keynote Presentation: Ultra-Rapid Nanopore Whole Genome Sequencing in a Critical Care Setting
      Keynote Presentation: Ultra-Rapid Nanopore Whole Genome Sequencing...
      While early genetic diagnosis can guide critical care management, the turnaround time for whole genome based diagnostic testing is months. Recent programs in neonatal populations have reduce...
      Speaker: John E. Gorzynski, DVM, PhD
      Presented at: Genetics Week Virtual Event Series 2022
      2
      APR 19, 2022 | 6:00 AM
      High-sensitivity, Targeted NGS Variant Detection of Viral and Bacterial Pathogens: A Novel Solution for Healthcare and Environmental Surveillance and Research
      High-sensitivity, Targeted NGS Variant Detection of Viral and...
      Pathogen detection and surveillance have become a high priority in both healthcare and environmental settings for the safety of patients and the general public. The COVID-19 pandemic highlig...
      Speaker: Dylan Barbera
      Presented at: Genetics Week Virtual Event Series 2022
      Sponsored By: QIAGEN
      1
    APR 26, 2022 | 11:00 AM
    Stretching the Limits of Microscopy Imaging with Deep Learning
    Stretching the Limits of Microscopy Imaging with Deep Learning
    Date: April 26, 2022 Time: 11:00am (PDT), 2:00pm (EDT), 8:00pm (CEST) Balance between spatial resolution, temporal resolution, and sample viability is key to extracting more data from your i...
    Speaker: Hoyin Lai
    Sponsored By: Leica Microsystems
    6
    APR 26, 2022 | 7:00 AM
    Modelling of cellular interactions in mixed murine organoids
    Modelling of cellular interactions in mixed murine organoids
    Date: April 26, 2022 Time: 7:00am (PDT), 10:00am (EDT), 4:00pm (CET) Cell competition is a mechanism of interaction that dictates cell selection based on differences in cellular fitness. We...
    Speaker: Saskia J.E Suijkerbuijk
    Sponsored By: Andor
    8
    APR 26, 2022 | 7:00 AM
    High-Content Phenotypic Screening - Answering Questions You Haven't Even Asked Yet
    High-Content Phenotypic Screening - Answering Questions You Haven't...
    Date: April 19, 2022 Time: 7:00am (PDT), 10:00am (EDT), 4:00pm (CEST) High-content (HC) phenotypic profiling approaches are a powerful tool to study the effect of biological, genetic, and ch...
    Speaker: Dr. Angeline Lim , Dr. Victor Wong
    Sponsored By: Molecular Devices
    5
    APR 25, 2022 | 12:00 AM
    C.E. CREDITS
    The Patient is Bleeding: Balancing Clinical and Laboratory Needs
    The Patient is Bleeding: Balancing Clinical and Laboratory Needs
    Explore viscoelastic testing (VET) for managing surgical bleeding, guiding transfusions, and improving perioperative patient care....
    Speaker: Oksana Volod, MD
    Presented at: Stago EdVantage Virtual University
    Sponsored By: Diagnostica Stago, Inc.
    11
    APR 21, 2022 | 12:00 PM
    Recent Advances in Lyophilized qPCR Reagents
    Recent Advances in Lyophilized qPCR Reagents
    The global pandemic has increased focus and scrutiny on molecular diagnostic assay development, resulting in a need for assays that provide quick results while delivering expected performanc...
    Speaker: Olivier Bricaud, PhD
    Presented at: Genetics Week Virtual Event Series 2022
    Sponsored By: Thermo Fisher Scientific
    2
     
     
  • APR 21, 2022 | 8:00 AM
    Upgrade your B cell culture
    Upgrade your B cell culture
    Date: April 21, 2022 Time: 8:00am (PDT), 11:00am (EDT), 6:00pm (CEST) Due to the low frequency of B cells in human peripheral blood, it can be difficult to obtain sufficient numbers of B cel...
    Speaker: Dr. Susanne Bethke , Dr. Henriette Zimmermann
    Sponsored By: Miltenyi Biotec
    8
    APR 21, 2022 | 5:30 AM
    Standardization of the Interpretation and Reporting of Sequence Variants Identified in Neoplasms
    Standardization of the Interpretation and Reporting of Sequence...
    Accurate classification of genetic alterations is important to ensure the provision of high-quality clinical data. For interpretation of germline alterations, there are standardized guidelin...
    Speaker: Nikita Mehta, MS, CGC
    Presented at: Genetics Week Virtual Event Series 2022
    3
    APR 21, 2022 | 5:30 AM
    PTS-ID: Developing Precision Behavioral Health Diagnostics for PTSD
    PTS-ID: Developing Precision Behavioral Health Diagnostics for...
    In 2013, a separate diagnosis of PTSD was introduced into the DSM-V to mitigate the well-known issue of accurately differentiating between PSTD and other psychiatric disorders. In addition t...
    Speaker: Tshaka Cunningham, PhD
    Presented at: Genetics Week Virtual Event Series 2022
    2
    APR 21, 2022 | 5:30 AM
    Hypoxia Biomarkers: Personalizing Cancer Treatments by Targeting Hypoxia
    Hypoxia Biomarkers: Personalizing Cancer Treatments by Targeting...
    A hypoxic tumour microenvironment is a feature of solid tumours. Many tumour types contain high fractions of hypoxic tissue. The relationship between high levels of tumour hypoxia and a poor...
    Speaker: Joely Irlam
    Presented at: Genetics Week Virtual Event Series 2022
    2
    APR 21, 2022 | 5:30 AM
    Advances in Liquid Biopsy Technologies
    Advances in Liquid Biopsy Technologies
    Up until now, Big Data in healthcare has failed to drive any real progress in curing disease. However, we have just now reached a cost and throughput threshold in sequencing and bioinformati...
    Speaker: David Spetzler, MS, MBA, PhD
    Presented at: Genetics Week Virtual Event Series 2022
    2
     
     
  • APR 20, 2022 | 1:30 PM
    Panel Presentation: Curating the Genome to Drive Precision Diagnosis in Clinical Care
    Panel Presentation: Curating the Genome to Drive Precision Diagnosis...
    The speakers will discuss how to surmount obstacles related to translating sequencing data into actionable results, and propose curated variant content shared with the clinical community as...
    Speaker: Mark Kiel, MD, PhD , Catherine Nester
    Presented at: Genetics Week Virtual Event Series 2022
    2
    APR 20, 2022 | 11:00 AM
    Characterization of lentiviral vectors using capillary electrophoresis platform technology
    Characterization of lentiviral vectors using capillary electrophoresis...
    Date: April 20, 2022 Time: 11:00am (PDT), 2:00pm (EDT), 8:00pm (CEST) As novel therapeutic modalities progress through development, improved analytical techniques are required to overcome co...
    Speaker: Aaron Shafer
    Sponsored By: SCIEX
    7
    APR 20, 2022 | 7:30 AM
    Keynote Presentation: Laboratory Assessment of Covid-19 Immunity in Patients with a Cancer Diagnosis: Alpha to Omicron
    Keynote Presentation: Laboratory Assessment of Covid-19 Immunity...
    The COVID-19 pandemic has taken a dramatic toll worldwide. Its impact possibly has been the most palpable amongst uniquely vulnerable groups of patients, such as patients with a cancer diagn...
    Speaker: Balazs Halmos, MD
    Presented at: Genetics Week Virtual Event Series 2022
    3
    APR 20, 2022 | 5:30 AM
    Improving Fetal Fraction of EDTA-Gel NIPS Samples Using Gel-Based Size-Selection
    Improving Fetal Fraction of EDTA-Gel NIPS Samples Using Gel-Based...
    Objective : Evaluation of EDTA-gel blood collection tubes from remote locations for NIPS (Non-invasive prenatal testing). Design: Paired comparisons Population: 61 pregnant women from Britis...
    Speaker: Dr François Rousseau, MD, MSc, FRCPC, FCAHS
    Presented at: Genetics Week Virtual Event Series 2022
    3
    APR 20, 2022 | 5:30 AM
    Aneuploidy on a Brush - A New Approach to Detecting Cancer and Pre-Cancers of the Esophagus
    Aneuploidy on a Brush - A New Approach to Detecting Cancer and...
    Esophageal adenocarcinoma [EAC] is the fastest growing in incidence cancer in the US over the last 25 years, while also having a 5 year survival of less than 20%. Barrett’s Esophagus [...
    Speaker: Joseph Willis, MD
    Presented at: Genetics Week Virtual Event Series 2022
    2
     
     
  • APR 19, 2022 | 4:30 PM
    Extracting Novel Hypotheses and Insights from Single Cell Data
    Extracting Novel Hypotheses and Insights from Single Cell Data
    Follow us on a journey of single cell data exploration. See how you can Process, Analyze, Compare, and Contextualize, your results to identify novel biological relationships and drive new hy...
    Speaker: Jean-Noel Billaud, PhD
    Presented at: Genetics Week Virtual Event Series 2022
    Sponsored By: QIAGEN
    2
    APR 19, 2022 | 3:00 PM
    Using NGS for MicroRNA and Gene Expression Analysis with Integrated Bioinformatics for Pathway Discovery and Biomarker Verification
    Using NGS for MicroRNA and Gene Expression Analysis with Integrated...
    MicroRNAs (miRNAs) are small RNAs with an average size of 22 nucleotides that regulate gene expression through various mechanisms. During the last decade, researchers have identified over 26...
    Speaker: Samuel Rulli, PhD
    Presented at: Genetics Week Virtual Event Series 2022
    Sponsored By: QIAGEN
    1
    APR 19, 2022 | 1:30 PM
    C.E. CREDITS
    Boosting Signal-to-Noise in Single Cell RNA-Seq Through Molecular Depletion
    Boosting Signal-to-Noise in Single Cell RNA-Seq Through Molecular...
    Regardless of method, single cell RNA-seq only captures a small fraction of the transcriptome of each cell. Often, this is due to inherent limitations of the methodology as reads ‘drop...
    Speaker: Dante DeAscanis
    Presented at: Genetics Week Virtual Event Series 2022
    Sponsored By: Jumpcode Genomics
    3
    APR 19, 2022 | 12:00 PM
    C.E. CREDITS
    RT-LAMP: Best Practices and Tips to Accelerate Detection of Viral Pathogens, Including SARS-CoV-2
    RT-LAMP: Best Practices and Tips to Accelerate Detection of Viral...
    Loop-mediated isothermal amplification (LAMP) uses a stand-displacing DNA polymerase and four to six primers to rapidly amplify DNA at a single temperature. By eliminating temperature cyclin...
    Speaker: Ingrida VendelÄ—, PhD , Leann Buhrow, PhD
    Presented at: Genetics Week Virtual Event Series 2022
    Sponsored By: Thermo Fisher Scientific
    3
    APR 19, 2022 | 12:00 PM
    Advances in Targeted Sequencing: Accelerate Your NGS Workflows with New QIAseq Chemistry
    Advances in Targeted Sequencing: Accelerate Your NGS Workflows...
    Targeted sequencing has many applications in cancer biomarker research, carrier screening and inherited disorders, drug development, mitochondrial DNA variant detection, human ID and paterni...
    Speaker: Krishna Amin
    Presented at: Genetics Week Virtual Event Series 2022
    Sponsored By: QIAGEN
    1
     
     
  • APR 19, 2022 | 10:30 AM
    Panel Presentation: Attain Successful Single-cell Sequencing Results with the Latest Cell and Nuclei Isolation Workflows
    Panel Presentation: Attain Successful Single-cell Sequencing Results...
    Revolutionary sequencing technologies are enabling whole transcriptome profiling of tens to hundreds of thousands of single cells in parallel, in a single experiment. This has led to an expl...
    Speaker: Carina Emery , Alina Steinbach
    Presented at: Genetics Week Virtual Event Series 2022
    Sponsored By: Miltenyi Biotec
    1
    APR 19, 2022 | 10:00 AM
    The COVID-19 Public Health Experience: Tales from the Lab
    The COVID-19 Public Health Experience: Tales from the Lab
    Date: April 19, 2022 Time: 10:00am (PDT), 1:00pm (EDT), 7:00pm (CEST) Once upon a time, there were three public health labs. These labs were busy serving their states when, out of nowhere, a...
    Speaker: Alana Sterkel, Ph.D., D(ABMM), SM{ASCP )CM , Wade Aldous, Ph.D. D(ABMM) , Sara Blosser, PhD, D(ABMM)
    Sponsored By: Roche Diagnostics
    7
    APR 19, 2022 | 7:30 AM
    C.E. CREDITS
    Keynote Presentation: Ultra-Rapid Nanopore Whole Genome Sequencing in a Critical Care Setting
    Keynote Presentation: Ultra-Rapid Nanopore Whole Genome Sequencing...
    While early genetic diagnosis can guide critical care management, the turnaround time for whole genome based diagnostic testing is months. Recent programs in neonatal populations have reduce...
    Speaker: John E. Gorzynski, DVM, PhD
    Presented at: Genetics Week Virtual Event Series 2022
    2
    APR 19, 2022 | 6:00 AM
    High-sensitivity, Targeted NGS Variant Detection of Viral and Bacterial Pathogens: A Novel Solution for Healthcare and Environmental Surveillance and Research
    High-sensitivity, Targeted NGS Variant Detection of Viral and...
    Pathogen detection and surveillance have become a high priority in both healthcare and environmental settings for the safety of patients and the general public. The COVID-19 pandemic highlig...
    Speaker: Dylan Barbera
    Presented at: Genetics Week Virtual Event Series 2022
    Sponsored By: QIAGEN
    1
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