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Viral Vector gene therapy has been the focus of intense research driven by the safety profile and several clinical breakthroughs. As of March 2022, there are two viral vector gene therapies...
Tissues in the body are wonderfully organized, with specific arrangements of cells, extracellular matrix, secreted molecules, and fluid flow that synergize that create emergent functions. How...
Developing new diagnostic and therapeutic tools for brain disorders is an ethical imperative and conducting human research with neural devices is a key step towards achieving that goal. Condu...
A major challenge for the clinical application of pluripotent stem cell therapy for neurodegenerative diseases is large-scale manufacturing and cryopreservation of neurons and glia that can b...
Sanger sequencing and polymerase chain reaction (PCR) methods have been the standard molecular methods in clinical diagnostics for decades. Next-Generation Sequencing (NGS) technology r...
Blockade of CTLA-4 and PD-1, members of the B7/CD28 family, have proven to be the most successful cancer immunotherapies to date. While the current therapeutic focus remains on B7/CD28 family...
To date the anatomic extent of tumor (TNM-classification) has been by far the most important factors to predict the prognosis of cancer patients. However, this classification provides limited...
As you transition your discovery through research and development to commercial production in a GMP setting, your goal is to speed that process by minimizing variables. Laboratory equipment...
Best practices for developing precision medicine diagnostics can include completing a retrospective analysis. Obtaining enough samples to have a statistically significant study typicall...
Cancer cells can acquire immune resistance resulting in a loss of immunosurveillance. Tumor cells can upregulate PDL-1 which binds to PD-1. This complex inhibits CD8 Tumor Infiltrating cells...
The main problem for insufficient cervical cancer screening globally (less than 20% women at risk) is outreach failure. Enabling POCs with modern IT/mobile technology and connecting them with...
In the US, there are about 75 million individuals less than 18 years of age. COVID-19 has had a major impact on the pediatric population, as there have been more than 13.5 million documented...
The WOLF Cell Sorter from NanoCellect Biomedical was designed to provide an affordable microfluidic benchtop solution to sort cell easily, gently using sterile microfluidic cartridges. NanoC...
The study of rare, neurological disorder and the development of effect treatments can pose many unique challenges. A paucity of scientists working on these disorders often limits forward prog...
What if your lab could perform exome sequencing with the same sensitivity and efficiency of targeted sequencing? The new integrated QIAseq Human Exome TR Insights solution from QIAGEN delive...
Phosphorylation of α-synuclein at the Serine-129 site (α-syn Ser129P) is an established pathologic hallmark of synucleinopathies and a therapeutic target. In physiologic states,...
With over 500 million COVID-19 cases and more than 6 million deaths, the COVID-19 pandemic remains a global health threat maintained by the impact of a changing virus. Emerging SARS-CoV-2 va...
We currently do not have effective vaccines or antiviral drugs for most of the viral diseases that afflict humans. Antiviral therapies that enable long-term control over human immunodeficien...
In order to realize the benefits of personalized cancer therapy, increasing demands are placed upon clinical laboratories to provide timely, comprehensive, clinically actionable, and analytic...
Authors: Mark C. Benfield, Elizabeth Marchio, Aimee Thomas, Kyrsten Boswell, and Nicole Nguyen. In August 2020 the MV Bianca lost a shipping container filled with an estimated 750 million ra...
Effective immunotherapy of pancreatic ductal adenocarcinoma (PDAC) is hampered by the lack of suitable tumor-specific antigens. To address this challenge, we have combined high-throughput fl...
Our laboratory uses tools from pharmacology, genomics, and cell signaling to identify new precision anticancer therapeutic strategies. Under this broad heading, our work involves three key a...
Recent advances in DNA sequencing and omics-based capabilities are revealing incredible therapeutic opportunities and quickly transforming drug discovery. Molecularly targeted drugs aim to e...
DNASTAR offers an integrated suite of software for accurate assembly and analysis of sequence data from all major next-generation sequencing platforms supporting key workflows including de no...
The global trend towards industrialization and urbanization has led to ever more people living and working indoors. Some studies estimate that humans in industrialized countries spend as much...
Quinolones are one the most commonly prescribed classes of antibacterials in the world and are used to treat a broad variety of Gram-negative and Gram-positive bacterial infections in humans....
With significant decrease in the cost of sequencing in numerous commercial as well as cancer center–driven initiatives, genomic profiling is increasingly becoming routine across multipl...
Viral Vector gene therapy has been the focus of intense research driven by the safety profile and several clinical breakthroughs. As of March 2022, there are two viral vector gene therapies...
