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CRISPR
CRISPR is an abbreviation of Clustered Regularly Interspaced Short Palindromic Repeats. The name was minted at a time when the origin and use of the interspacing subsequences were not known. At that time the CRISPRs were described as segments of prokaryotic DNA containing short, repetitive base sequences. In a palindromic repeat, the sequence of nucleotides is the same in both directions. Each repetition is followed by short segments of spacer DNA from previous exposures to foreign DNA (e.g., a virus or plasmid). Small clusters of cas (CRISPR-associated) genes are located next to CRISPR sequences.
JUL 26, 2023 | 4:05 PM
Employing a metagenomic search, we identified a family of miniature CRISPR-Cas type V-L systems capable of RNA-guided dsDNA target cleavage without a tracrRNA. A bacterial depletion screen r...
JUL 26, 2023 | 2:30 PM
Phosphorylation of α-synuclein at the Serine-129 site (α-syn Ser129P) is an established pathologic hallmark of synucleinopathies and a therapeutic target. In physiologic states,...
JUL 26, 2023 | 12:15 PM
Genetically modified cell models accelerate the development of safe and effective therapeutics, making them indispensable in the quest for new drugs. Through manipulation of cell line geneti...
JUL 26, 2023 | 11:20 AM
Chimeric antigen receptor (CAR)-reprogrammed immune cells offer exciting therapeutic potential for addressing oncology, autoimmune diseases, transplant medicine, and infections. However, cur...
MAR 08, 2023 | 9:00 AM
Date: March 08, 2023 Time: 9:00am (PST), 12:00pm (EST), 6:00pm (CET) An unbiased characterization of the human microbiome is crucial to a more complete understanding of microbial effect on h...
MAR 08, 2023 | 8:00 AM
Date: March 08, 2023 Time: 8:00am (PST), 11:00am (EST), 5:00pm (CET) Engineered nucleases like the CRISPR-Cas9 system provide researchers with powerful tools for the manipulation of the geno...
FEB 22, 2023 | 5:30 AM
Many current technologies used in drug discovery and preclinical development programmes typically involve multi-step operations, extensive hands-on time, and lengthy liquid handling processe...
JAN 18, 2023 | 9:00 AM
Date: January 18, 2023 Time: 9:00am (PST), 12:00pm (EST), 6:00pm (CET) CRISPR-Cas systems are widely used in genome engineering applications. They contain RNA-guided ribonucleoprotein (RNP)...
DEC 13, 2022 | 8:00 AM
Date: December 13, 2022 Time: 8:00am (PST), 11:00am (EST), 5:00pm (CET) Understanding the diversity of repair outcomes after introducing a genomic cut is essential for realizing the therapeu...
NOV 02, 2022 | 7:30 AM
Clustered regularly interspaced short palindromic repeats (CRISPR)–CRISPR-associated protein 13 (Cas13) has been rapidly developed for nucleic-acid-based diagnostics by using its chara...
NOV 02, 2022 | 6:00 AM
CRISPR has revolutionized the biosciences over the past decade. The RNA-targeting CRISPR effector protein Cas13, discovered in 2016, opened up a myriad of new applications for CRISPR-based t...
