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    Diagnostics

    Diagnostics: diagnosis based on information from sources such as findings from a physical examination, interview with the patient or family or both, medical history of the patient and family, and clinical findings as reported by laboratory tests and radiologic studies. Differential diagnosis involves the process of weighing the probability of one disease versus that of other diseases possibly accounting for a patient's illness. The differential diagnosis of rhinitis (a runny nose) includes allergic rhinitis (hayfever), the abuse of nasal decongestants and, of course, the common cold.

    Webinars

    • DEC 09, 2020 | 9:00 AM
      Human hematopoietic stem cell research made smart and easy
      Human hematopoietic stem cell research made smart and easy
      DATE: December 09, 2020 TIME: 09:00am PST Hematopoietic stem cells (HSCs) ensure homeostasis of blood throughout life. In this webinar, we share insights into the smart and easy isolation, c...
      Speaker: Antje Kremer
      Sponsored By: Miltenyi Biotec
      15 1
      DEC 08, 2020 | 5:00 AM
      Benefits of Automation in Medical Laboratories
      Benefits of Automation in Medical Laboratories
      DATE: December 8, 2020 TIME: 5am PST, 8am EST The Aberdeen Royal Infirmary is one of the earliest adopters of automation solutions worldwide. Already in 2008 the first track was installed an...
      Speaker: Ann Milne, Master in Biomedical Science , Paul Drew, ONC and HC in Medical Laboratory Science, W. H. Carnie Award for his achievements in the Fellowship of Hematology
      Sponsored By: Abbott Diagnostics
      20
      DEC 04, 2020 | 9:00 AM
      IOTest Myeloid Activation CD169-PE/HLA-DR-APC/CD64-PB Antibody Cocktail - Visualizing immune response during infections
      IOTest Myeloid Activation CD169-PE/HLA-DR-APC/CD64-PB Antibody...
      Date: December 4, 2020 Time: 9:00am PST, 12:00pm EST Activation of Myeloid cells and interferon release is an early response to infection. The 3-marker combination (CD169/CD64/HLA-DR) gives...
      Speaker: Shankar Pattabhiraman
      Sponsored By: Beckman Coulter Life Sciences
      5
      DEC 04, 2020 | 5:00 AM
      Hemoglobin A1c: standardization, analytical performance and interference of Hb-variants.
      Hemoglobin A1c: standardization, analytical performance and interference...
      Date: December 04, 2020 Time: 5:00am PDT, 2:00pm CET Diabetes Mellitus has become a worldwide epidemic, affecting approximately 425 million people. Unfortunately, one in two patients remain...
      Speaker: Dr. Erna Lenters-Westra
      Sponsored By: Abbott Diagnostics
      17
      DEC 03, 2020 | 4:30 PM
      An Iterative Approach to Structure-based in silico to in vivo Development of Combinatorial Anti-SARS-CoV-2 Therapy
      An Iterative Approach to Structure-based in silico to in vivo...
      This drug development program is designed to create a family of broad-spectrum, pan-coronaviral drugs that respectively inhibit multiple key enzymes required for viral replication. By target...
      Speaker: Garth Ehrlich, PhD, FAAAS
      Presented at: Coronavirus Series
      5
      DEC 03, 2020 | 1:30 PM
      Using an ARIES® Laboratory Developed Test for SARS-CoV-2 to Respond to the COVID-19 Pandemic in Louisville, KY
      Using an ARIES® Laboratory Developed Test for SARS-CoV-2 to Respond...
      The University of Louisville Infectious Diseases Laboratory (IDL) is a high-complexity, CLIA-certified laboratory in Louisville, KY. The IDL adopted the Luminex ARIES® platform in 2016 f...
      Speaker: Leslie A. Wolf, PhD, HCLD (ABB)
      Presented at: Coronavirus Series
      Sponsored By: Luminex - A DiaSorin Company
      2
      DEC 03, 2020 | 9:00 AM
      New! PerkinElmer® RT-PCR SARS-CoV-2 Solution Updates
      New! PerkinElmer® RT-PCR SARS-CoV-2 Solution Updates
      To execute COVID-19 testing strategies effectively, labs need to procure reliable components of the workflow without interruption – from reagents to equipment and consumables at the sc...
      Speaker: Arvind Kothandaraman
      Presented at: Coronavirus Series
      Sponsored By: PerkinElmer
      3
      DEC 03, 2020 | 12:00 AM
      Development, assessment and commercialization of serological SARS CoV-2 tests - an interdisciplinary success story
      Development, assessment and commercialization of serological SARS...
      Antibody tests are important tools to assess the efficacy of vaccine candidates and to derive suitable vaccination modalities. High specificity and sensitivity are of great importance for th...
      Speaker: Mark Dürkop, PhD
      Presented at: Coronavirus Series
      3
      NOV 20, 2020 | 12:00 PM
      The Expanding Role of Microbiology in Antimicrobial Stewardship
      The Expanding Role of Microbiology in Antimicrobial Stewardship
      Date: September 30, 2020 Time: 9:00am (PDT), 12:00pm (EDT) Learning Objectives Why is Stewardship important? What are the core elements of stewardship and microbiology's role Importance...
      Speaker: Margie Morgan, PhD, D(ABMM), MT(ASCP) , Toni Beavers, PhD
      Sponsored By: BD
      14
      NOV 20, 2020 | 10:00 AM
      Companion Diagnostic and Biomarker Assay Development for Interrogation of Liquid and Solid Tumor Biopsies - From RNAscope to Exosomes
      Companion Diagnostic and Biomarker Assay Development for Interrogation...
      Date: November 20, 2020 Time: 10:00am (PST), 1:00pm (EST) This webinar will provide an overview of the Bio-Techne technologies being used by Biopharma for the development of biomarkers and c...
      Speaker: Robert Monroe, MD, Ph.D , Christopher Bunker, Ph.D., MBA , Michael Valentino, Ph.D.
      Sponsored By: ACD, a Bio-Techne brand
      5
      NOV 20, 2020 | 9:30 AM
      Advances and Challenges in Glycomics and Glycoproteomics (글리이코믹스와 글라이코프로테오믹스의 발전과 도전)
      Advances and Challenges in Glycomics and Glycoproteomics (글리이코믹스와...
      ...
      Speaker: Hyun Joo An
      Presented at: 행사명: Agilent Science and Technology Virtual Symposium 2020
      1
      NOV 20, 2020 | 8:00 AM
      Efficiency to Confidence with High Resolution Accurate Mass Spectrometers: Analyzing IGF-1
      Efficiency to Confidence with High Resolution Accurate Mass Spectrometers:...
      DATE: November 20, 2020 TIME: 8am PDT, 11am EDT Insulin-like growth factor-1 (IGF-1) measurement by high-resolution accurate mass-mass spectrometry (HRAM) is replacing IGF-1 immunoassays and...
      Speaker: Tony Maus
      Sponsored By: Thermo Fisher Scientific
      7 1
      NOV 19, 2020 | 10:00 AM
      Maximizing capacity: the impact of technology innovations and change management on microbiology labs
      Maximizing capacity: the impact of technology innovations and...
      Date: November 19, 2020 Time: 10:00am (PST), 1:00pm (EST) 98% of in-patients will undergo a diagnostic test during a hospital stay.[1] With the increased focus on the accuracy of diagnostic...
      Speaker: Erin McElvania, Ph.D. , Dr. Patrick Murray, Ph.D. , Krešimir Renić, P.Eng. MBB
      Sponsored By: BD
      10
      NOV 19, 2020 | 7:00 AM
      Congenital Cytomegalovirus: Updates on Screening and Diagnostic Algorithm
      Congenital Cytomegalovirus: Updates on Screening and Diagnostic...
      DATE: November 19, 2020 TIME: 7am PST Congenital CMV is the most frequent infectious cause of neonatal malformation in developed nations. Yet, this disease is largely under-recognized by hea...
      Speaker: Dr. Marianne Leruez-Ville , Professor Tiziana Lazzarotto
      Sponsored By: Diasorin
      8
      NOV 19, 2020 | 9:00 AM
      Highly specific multiplexed RNA imaging in tissues with split-FISH
      Highly specific multiplexed RNA imaging in tissues with split-FISH
      Date: November 19, 2020 Time: 12:00am (PDT), 9:00am (CET), 4:00pm (SGT) We present split-FISH, a multiplexed fluorescence in situ hybridization method that leverages a split-probe design to...
      Speaker: Kok Hao Chen , Alan Mullan, PhD
      Sponsored By: Andor
      6 2
      NOV 18, 2020 | 8:00 AM
      Whole-organ mapping using AI and light sheet microscopy
      Whole-organ mapping using AI and light sheet microscopy
      DATE: November 18, 2020 TIME: 08:00am PDT We develop and implement technologies to solve some of the major bottlenecks in biomedical research. In particular, we establish new imaging approac...
      Speaker: Ali Ertürk
      Sponsored By: Miltenyi Biotec
      14
      NOV 17, 2020 | 5:00 AM
      Utilizing rapid diagnostics and new methods to quickly diagnose sepsis
      Utilizing rapid diagnostics and new methods to quickly diagnose...
      Date: November 17, 2020 Time: 5:00am (PST), 8:00am (EST), 2:00pm (CET) Septicemia is a serious clinical condition with roundabout 123,000 cases of sepsis a year in England. In recent years t...
      Speaker: Francis Yongblah
      Sponsored By: Bruker Microbiology & Infection Diagnostics
      7
      NOV 16, 2020 | 7:00 AM
      Hepatitis B. The added value of an accurate diagnosis for the optimization of the patients clinical management
      Hepatitis B. The added value of an accurate diagnosis for the...
      Date: November 16, 2020 Time: 7:00am PDT So far, it has been estimated that 2 billion individuals have been infected by hepatitis B virus (HBV). Among them, 250 million have developed a chro...
      Speaker: Valentina Svicher, PhD
      Sponsored By: Diasorin
      9
      NOV 16, 2020 | 5:00 AM
      Diabetes and the Clinical Laboratory
      Diabetes and the Clinical Laboratory
      DATE: November 16, 2020 TIME: 05:00am PST, 2:00pm CET It may be impossible to stop the inexorable move towards pandemic levels of diabetes, but we can improve the glycaemic control in our pa...
      Speaker: Professor Garry John, PhD, FRCPath
      Sponsored By: Abbott Diagnostics
      11 1
      November 13, 2020 6:00 PM PST | November 14, 2020 10:00 AM SGT
      Q&A Session (In the RoundTable Room)
      Q&A Session (In the RoundTable Room)
      Visit the RoundTable Room to participate in live Q&A with all the speakers!...
      Speaker: Charalambos C. Solomides, MD , Sara Eglitis, MS, QIHC , Faruk Erdem Kombak, MD , Srabani Bhaumik, PhD , Nelson Alexander, PhD
      Presented at: DISCOVERY Global User Symposium
      0
      November 13, 2020 5:00 PM PST | November 14, 2020 9:00 AM SGT
      Representative sampling to address tumor heterogeneity
      Representative sampling to address tumor heterogeneity
      Ensuring that clinical tests are not affected by tumor heterogeneity requires a sampling methodology that captures the genomic, proteomic, and cellular diversity of entire solid tumors. Howe...
      Speaker: Nelson Alexander, PhD
      Presented at: DISCOVERY Global User Symposium
      2
      November 13, 2020 4:00 PM PST | November 14, 2020 8:00 AM SGT
      Fluorescent multiplexing of 3D spheroid FFPE with Roche automated stainer and reagents: assay optimization, imaging and future implications
      Fluorescent multiplexing of 3D spheroid FFPE with Roche automated...
      Three-dimensional (3D) cell culture spheroids and aggregates are preferred over monolayer cell culture due to their architectural and functional similarity to solid tumors. To study expressi...
      Speaker: Srabani Bhaumik, PhD
      Presented at: DISCOVERY Global User Symposium
      1
      November 13, 2020 1:00 PM PST | November 14, 2020 5:00 AM SGT
      Chromogenic multiplex IHC; the future of immunohistochemistry for the practicing pathologist and for research
      Chromogenic multiplex IHC; the future of immunohistochemistry...
      The development of many different chromogens for light microscopy gives us the opportunity to explore different usage of multiplex immunohistochemistry (IHC) for clinical diagnostic purposes...
      Speaker: Charalambos C. Solomides, MD
      Presented at: DISCOVERY Global User Symposium
      0
      NOV 12, 2020 | 4:30 PM
      Extend your clinical reporting capabilities with QCI services
      Extend your clinical reporting capabilities with QCI services
      With QCI services your clinical lab can enable a seamless fastq to clinical report workflow. We provide services such as cloud based variant calling and automated upload of the data to the Q...
      Speaker: Ajay Athavale
      Presented at: Clinical Diagnostics & Research Virtual Event Series 2020
      Sponsored By: QIAGEN
      1
    DEC 09, 2020 | 9:00 AM
    Human hematopoietic stem cell research made smart and easy
    Human hematopoietic stem cell research made smart and easy
    DATE: December 09, 2020 TIME: 09:00am PST Hematopoietic stem cells (HSCs) ensure homeostasis of blood throughout life. In this webinar, we share insights into the smart and easy isolation, c...
    Speaker: Antje Kremer
    Sponsored By: Miltenyi Biotec
    15 1
    DEC 08, 2020 | 5:00 AM
    Benefits of Automation in Medical Laboratories
    Benefits of Automation in Medical Laboratories
    DATE: December 8, 2020 TIME: 5am PST, 8am EST The Aberdeen Royal Infirmary is one of the earliest adopters of automation solutions worldwide. Already in 2008 the first track was installed an...
    Speaker: Ann Milne, Master in Biomedical Science , Paul Drew, ONC and HC in Medical Laboratory Science, W. H. Carnie Award for his achievements in the Fellowship of Hematology
    Sponsored By: Abbott Diagnostics
    20
    DEC 04, 2020 | 9:00 AM
    IOTest Myeloid Activation CD169-PE/HLA-DR-APC/CD64-PB Antibody Cocktail - Visualizing immune response during infections
    IOTest Myeloid Activation CD169-PE/HLA-DR-APC/CD64-PB Antibody...
    Date: December 4, 2020 Time: 9:00am PST, 12:00pm EST Activation of Myeloid cells and interferon release is an early response to infection. The 3-marker combination (CD169/CD64/HLA-DR) gives...
    Speaker: Shankar Pattabhiraman
    Sponsored By: Beckman Coulter Life Sciences
    5
    DEC 04, 2020 | 5:00 AM
    Hemoglobin A1c: standardization, analytical performance and interference of Hb-variants.
    Hemoglobin A1c: standardization, analytical performance and interference...
    Date: December 04, 2020 Time: 5:00am PDT, 2:00pm CET Diabetes Mellitus has become a worldwide epidemic, affecting approximately 425 million people. Unfortunately, one in two patients remain...
    Speaker: Dr. Erna Lenters-Westra
    Sponsored By: Abbott Diagnostics
    17
    DEC 03, 2020 | 4:30 PM
    An Iterative Approach to Structure-based in silico to in vivo Development of Combinatorial Anti-SARS-CoV-2 Therapy
    An Iterative Approach to Structure-based in silico to in vivo...
    This drug development program is designed to create a family of broad-spectrum, pan-coronaviral drugs that respectively inhibit multiple key enzymes required for viral replication. By target...
    Speaker: Garth Ehrlich, PhD, FAAAS
    Presented at: Coronavirus Series
    5
     
     
  • DEC 03, 2020 | 1:30 PM
    Using an ARIES® Laboratory Developed Test for SARS-CoV-2 to Respond to the COVID-19 Pandemic in Louisville, KY
    Using an ARIES® Laboratory Developed Test for SARS-CoV-2 to Respond...
    The University of Louisville Infectious Diseases Laboratory (IDL) is a high-complexity, CLIA-certified laboratory in Louisville, KY. The IDL adopted the Luminex ARIES® platform in 2016 f...
    Speaker: Leslie A. Wolf, PhD, HCLD (ABB)
    Presented at: Coronavirus Series
    Sponsored By: Luminex - A DiaSorin Company
    2
    DEC 03, 2020 | 9:00 AM
    New! PerkinElmer® RT-PCR SARS-CoV-2 Solution Updates
    New! PerkinElmer® RT-PCR SARS-CoV-2 Solution Updates
    To execute COVID-19 testing strategies effectively, labs need to procure reliable components of the workflow without interruption – from reagents to equipment and consumables at the sc...
    Speaker: Arvind Kothandaraman
    Presented at: Coronavirus Series
    Sponsored By: PerkinElmer
    3
    DEC 03, 2020 | 12:00 AM
    Development, assessment and commercialization of serological SARS CoV-2 tests - an interdisciplinary success story
    Development, assessment and commercialization of serological SARS...
    Antibody tests are important tools to assess the efficacy of vaccine candidates and to derive suitable vaccination modalities. High specificity and sensitivity are of great importance for th...
    Speaker: Mark Dürkop, PhD
    Presented at: Coronavirus Series
    3
    NOV 20, 2020 | 12:00 PM
    The Expanding Role of Microbiology in Antimicrobial Stewardship
    The Expanding Role of Microbiology in Antimicrobial Stewardship
    Date: September 30, 2020 Time: 9:00am (PDT), 12:00pm (EDT) Learning Objectives Why is Stewardship important? What are the core elements of stewardship and microbiology's role Importance...
    Speaker: Margie Morgan, PhD, D(ABMM), MT(ASCP) , Toni Beavers, PhD
    Sponsored By: BD
    14
    NOV 20, 2020 | 10:00 AM
    Companion Diagnostic and Biomarker Assay Development for Interrogation of Liquid and Solid Tumor Biopsies - From RNAscope to Exosomes
    Companion Diagnostic and Biomarker Assay Development for Interrogation...
    Date: November 20, 2020 Time: 10:00am (PST), 1:00pm (EST) This webinar will provide an overview of the Bio-Techne technologies being used by Biopharma for the development of biomarkers and c...
    Speaker: Robert Monroe, MD, Ph.D , Christopher Bunker, Ph.D., MBA , Michael Valentino, Ph.D.
    Sponsored By: ACD, a Bio-Techne brand
    5
     
     
  • NOV 20, 2020 | 9:30 AM
    Advances and Challenges in Glycomics and Glycoproteomics (글리이코믹스와 글라이코프로테오믹스의 발전과 도전)
    Advances and Challenges in Glycomics and Glycoproteomics (글리이코믹스와...
    ...
    Speaker: Hyun Joo An
    Presented at: 행사명: Agilent Science and Technology Virtual Symposium 2020
    1
    NOV 20, 2020 | 8:00 AM
    Efficiency to Confidence with High Resolution Accurate Mass Spectrometers: Analyzing IGF-1
    Efficiency to Confidence with High Resolution Accurate Mass Spectrometers:...
    DATE: November 20, 2020 TIME: 8am PDT, 11am EDT Insulin-like growth factor-1 (IGF-1) measurement by high-resolution accurate mass-mass spectrometry (HRAM) is replacing IGF-1 immunoassays and...
    Speaker: Tony Maus
    Sponsored By: Thermo Fisher Scientific
    7 1
    NOV 19, 2020 | 10:00 AM
    Maximizing capacity: the impact of technology innovations and change management on microbiology labs
    Maximizing capacity: the impact of technology innovations and...
    Date: November 19, 2020 Time: 10:00am (PST), 1:00pm (EST) 98% of in-patients will undergo a diagnostic test during a hospital stay.[1] With the increased focus on the accuracy of diagnostic...
    Speaker: Erin McElvania, Ph.D. , Dr. Patrick Murray, Ph.D. , Krešimir Renić, P.Eng. MBB
    Sponsored By: BD
    10
    NOV 19, 2020 | 7:00 AM
    Congenital Cytomegalovirus: Updates on Screening and Diagnostic Algorithm
    Congenital Cytomegalovirus: Updates on Screening and Diagnostic...
    DATE: November 19, 2020 TIME: 7am PST Congenital CMV is the most frequent infectious cause of neonatal malformation in developed nations. Yet, this disease is largely under-recognized by hea...
    Speaker: Dr. Marianne Leruez-Ville , Professor Tiziana Lazzarotto
    Sponsored By: Diasorin
    8
    NOV 19, 2020 | 9:00 AM
    Highly specific multiplexed RNA imaging in tissues with split-FISH
    Highly specific multiplexed RNA imaging in tissues with split-FISH
    Date: November 19, 2020 Time: 12:00am (PDT), 9:00am (CET), 4:00pm (SGT) We present split-FISH, a multiplexed fluorescence in situ hybridization method that leverages a split-probe design to...
    Speaker: Kok Hao Chen , Alan Mullan, PhD
    Sponsored By: Andor
    6 2
     
     
  • NOV 18, 2020 | 8:00 AM
    Whole-organ mapping using AI and light sheet microscopy
    Whole-organ mapping using AI and light sheet microscopy
    DATE: November 18, 2020 TIME: 08:00am PDT We develop and implement technologies to solve some of the major bottlenecks in biomedical research. In particular, we establish new imaging approac...
    Speaker: Ali Ertürk
    Sponsored By: Miltenyi Biotec
    14
    NOV 17, 2020 | 5:00 AM
    Utilizing rapid diagnostics and new methods to quickly diagnose sepsis
    Utilizing rapid diagnostics and new methods to quickly diagnose...
    Date: November 17, 2020 Time: 5:00am (PST), 8:00am (EST), 2:00pm (CET) Septicemia is a serious clinical condition with roundabout 123,000 cases of sepsis a year in England. In recent years t...
    Speaker: Francis Yongblah
    Sponsored By: Bruker Microbiology & Infection Diagnostics
    7
    NOV 16, 2020 | 7:00 AM
    Hepatitis B. The added value of an accurate diagnosis for the optimization of the patients clinical management
    Hepatitis B. The added value of an accurate diagnosis for the...
    Date: November 16, 2020 Time: 7:00am PDT So far, it has been estimated that 2 billion individuals have been infected by hepatitis B virus (HBV). Among them, 250 million have developed a chro...
    Speaker: Valentina Svicher, PhD
    Sponsored By: Diasorin
    9
    NOV 16, 2020 | 5:00 AM
    Diabetes and the Clinical Laboratory
    Diabetes and the Clinical Laboratory
    DATE: November 16, 2020 TIME: 05:00am PST, 2:00pm CET It may be impossible to stop the inexorable move towards pandemic levels of diabetes, but we can improve the glycaemic control in our pa...
    Speaker: Professor Garry John, PhD, FRCPath
    Sponsored By: Abbott Diagnostics
    11 1
    November 13, 2020 6:00 PM PST | November 14, 2020 10:00 AM SGT
    Q&A Session (In the RoundTable Room)
    Q&A Session (In the RoundTable Room)
    Visit the RoundTable Room to participate in live Q&A with all the speakers!...
    Speaker: Charalambos C. Solomides, MD , Sara Eglitis, MS, QIHC , Faruk Erdem Kombak, MD , Srabani Bhaumik, PhD , Nelson Alexander, PhD
    Presented at: DISCOVERY Global User Symposium
    0
     
     
  • November 13, 2020 5:00 PM PST | November 14, 2020 9:00 AM SGT
    Representative sampling to address tumor heterogeneity
    Representative sampling to address tumor heterogeneity
    Ensuring that clinical tests are not affected by tumor heterogeneity requires a sampling methodology that captures the genomic, proteomic, and cellular diversity of entire solid tumors. Howe...
    Speaker: Nelson Alexander, PhD
    Presented at: DISCOVERY Global User Symposium
    2
    November 13, 2020 4:00 PM PST | November 14, 2020 8:00 AM SGT
    Fluorescent multiplexing of 3D spheroid FFPE with Roche automated stainer and reagents: assay optimization, imaging and future implications
    Fluorescent multiplexing of 3D spheroid FFPE with Roche automated...
    Three-dimensional (3D) cell culture spheroids and aggregates are preferred over monolayer cell culture due to their architectural and functional similarity to solid tumors. To study expressi...
    Speaker: Srabani Bhaumik, PhD
    Presented at: DISCOVERY Global User Symposium
    1
    November 13, 2020 1:00 PM PST | November 14, 2020 5:00 AM SGT
    Chromogenic multiplex IHC; the future of immunohistochemistry for the practicing pathologist and for research
    Chromogenic multiplex IHC; the future of immunohistochemistry...
    The development of many different chromogens for light microscopy gives us the opportunity to explore different usage of multiplex immunohistochemistry (IHC) for clinical diagnostic purposes...
    Speaker: Charalambos C. Solomides, MD
    Presented at: DISCOVERY Global User Symposium
    0
    NOV 12, 2020 | 4:30 PM
    Extend your clinical reporting capabilities with QCI services
    Extend your clinical reporting capabilities with QCI services
    With QCI services your clinical lab can enable a seamless fastq to clinical report workflow. We provide services such as cloud based variant calling and automated upload of the data to the Q...
    Speaker: Ajay Athavale
    Presented at: Clinical Diagnostics & Research Virtual Event Series 2020
    Sponsored By: QIAGEN
    1
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