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    Mechanism of Action

    Mechanism of action refers to the specific biological process through which the drug treats the underlying cause. It describes the more general response or effect of the drug. It is the interaction that allows a drug substance to produce it pharmacological effect.

    Webinars

    • MAY 29, 2024 | 9:00 AM
      C.E. CREDITS
      HISTOLOGY HACKS FOR CRYOSECTIONING
      HISTOLOGY HACKS FOR CRYOSECTIONING
      Histology laboratorians in the research world move fast, but those who perform cryosectioning know that these particular tissues require lighting speed and precision. Cryosectioning is the a...
      Speaker: Marla Rivera-Oliver, PhD
      Sponsored By: Leica Biosystems
      19 1
      FEB 14, 2024 | 9:00 AM
      C.E. CREDITS
      HISTOLOGY HACKS FOR CRYOSECTIONING
      HISTOLOGY HACKS FOR CRYOSECTIONING
      Learning Objectives Identify three ways automation improves cryosectioning techniques Demonstrate three essential elements to obtaining reproducible, high-quality sections with cryosectionin...
      Speaker: Marla Rivera-Oliver, PhD
      Sponsored By: Leica Biosystems
      30 1
      JAN 23, 2024 | 10:00 AM
      Exploring the Potential of 3D Organoids through Live-Cell Analysis
      Exploring the Potential of 3D Organoids through Live-Cell Analysis
      Organoid technologies are increasingly being used as in vitro models of human development and disease because they exhibit morphogenetic, structural and functional properties that recapitula...
      Speaker: Kalpana Barnes
      Presented at: The Future of Biomedicine: Reproducible Advanced Cell Systems and Translational Insights
      2
      DEC 07, 2023 | 8:00 AM
      Translating COSMIC's gold standard data into actionable insights
      Translating COSMIC's gold standard data into actionable insights
      As the vast landscape of genetic oncology continues to expand, the ability to understand and utilize the full potential of this rich data becomes increasingly challenging. As a result, resea...
      Speaker: Leonie Hodges , Alex Holmes, Ph.D. , Jennifer Wilding, Ph.D.
      Sponsored By: QIAGEN
      15
      JUL 26, 2023 | 12:15 PM
      Advancing Protein Stabilization Therapeutic Development and DUBTAC Drug Discovery through Gene and Cell Engineering
      Advancing Protein Stabilization Therapeutic Development and DUBTAC...
      Genetically modified cell models accelerate the development of safe and effective therapeutics, making them indispensable in the quest for new drugs. Through manipulation of cell line geneti...
      Speaker: Dr. Yongli Shan
      Presented at: GenScript 3rd Annual Gene and Cell Engineering Summit
      4
      JUN 06, 2023 | 9:00 AM
      Time-resolved electron microscopy: synaptic ultrastructure millisecond by millisecond with high-pressure freezing
      Time-resolved electron microscopy: synaptic ultrastructure millisecond...
      Transmission electron microscopy reveals the architecture of cells at nanometer resolution, but chemical fixation severely warps their native structure. The true ultrastructure of cells can...
      Speaker: Shigeki Watanabe, Ph.D , Grant Kusick
      Sponsored By: Leica Microsystems
      8
      APR 05, 2023 | 1:00 PM
      Practical considerations for fluorescent cell staining and microscopy in cancer cell biology research
      Practical considerations for fluorescent cell staining and microscopy...
      Date: April 04, 2023 Time: 10:00pm (PDT), Date: April 05, 2023 Time: 2:00am (EDT), 7:00am (CEST), 1:00pm (SGT) This seminar provides an overview of fluorescence microscopy in cancer research...
      Speaker: Dan Beacham, Ph.D.
      Sponsored By: Thermo Fisher Scientific
      27
      MAR 08, 2023 | 6:00 AM
      Recurrent Neural Networks in Brains and Machines
      Recurrent Neural Networks in Brains and Machines
      Neural networks are a powerful tool for modeling neural activity in the brain. In this talk, I will discuss how these models have helped in my own research and highlight recent work building...
      Speaker: Christopher Cueva, PhD
      Presented at: Neuroscience Virtual Event Series 2023
      2
      FEB 22, 2023 | 5:30 AM
      Bridging the Gap - How Human Microphysiological Systems Improve the Translatability of NASH Drug Discovery
      Bridging the Gap - How Human Microphysiological Systems Improve...
      Non-alcoholic fatty liver disease (NAFLD) is a spectrum of metabolic disorders affecting 25% of our global population. 20% of NAFLD patients go on to develop Non-alcoholic steatohepatitis (N...
      Speaker: Raul Silva
      Presented at: Drug Discovery & Development Virtual Event Series 2023
      2
      FEB 15, 2023 | 7:00 AM
      Scattering Microscopy: Label-Free Imaging Approaches
      Scattering Microscopy: Label-Free Imaging Approaches
      Date: February 15, 2023 Time: 7:00am (PST), 10:00pm (EST), 4:00pm (CET) While not all microscopy samples can fluoresce, all can scatter light, and this scattered light can be imaged. This ha...
      Speaker: Philipp Kukura , Francesco Reina , Matthew Kose-Dunn , Phil Allen
      Sponsored By: Teledyne Photometrics
      28
      APR 19, 2022 | 5:30 AM
      C.E. CREDITS
      Advances in High Throughput Proteomics using Next Generation Sequencing as a Readout
      Advances in High Throughput Proteomics using Next Generation Sequencing...
      The combination of the wealth of genomic and phenotypic datasets to the measurement of the circulating proteome enables a snapshot of real-time biology and important results for determining...
      Speaker: Dale Yuzuki, M.A., M.Ed.
      Presented at: Genetics Week Virtual Event Series 2022
      3
      APR 05, 2022 | 8:00 AM
      Investigating antimicrobial mechanisms-of-action using automated genome-wide and gene-specific editing
      Investigating antimicrobial mechanisms-of-action using automated...
      Date: April 05, 2022 Time: 8:00am (PDT), 11:00am (EDT), 5:00pm (CEDT) Members of the cinnamic acid and stilbenoid chemical families are common intermediates in the production of important bi...
      Speaker: Ali Clark-ElSayed
      Sponsored By: Inscripta
      8
      MAR 23, 2022 | 11:55 PM
      Overcoming Challenges Associated with Analysis of Pesticides Regulated by Colorado State in Hemp Using a Novel LC/MS/MS Method with Dual ESI and APCI Source
      Overcoming Challenges Associated with Analysis of Pesticides Regulated...
      Like any other agricultural crop, pesticides are applied to hemp plants to protect it from pests and improve growth yield. Chronic exposure to pesticides can lead to serious health risks and...
      Speaker: Avinash Dalmia, PhD
      Presented at: Cannabis Sciences Virtual Event Series 2022
      2
      MAR 10, 2022 | 11:55 PM
      The Spatial Reach of Brain Wave Synchronization
      The Spatial Reach of Brain Wave Synchronization
      Brain wave synchronization, also called neuronal coherence, is a fundamental mechanism of communication in the brain, where synchronized field potentials coordinate synaptic and spiking even...
      Speaker: John Myers, PhD
      Presented at: Neuroscience Virtual Event Series 2022
      2
      MAR 09, 2022 | 10:00 AM
      Time-resolved electron microscopy: synaptic ultrastructure millisecond by millisecond with high-pressure freezing
      Time-resolved electron microscopy: synaptic ultrastructure millisecond...
      Date: March 09, 2022 Time: 10:00am (PST), 1:00pm (EST), 7:00pm (CEST) Transmission electron microscopy reveals the architecture of cells at nanometer resolution, but chemical fixation severe...
      Speaker: Shigeki Watanabe, Ph.D , Grant Kusick
      Sponsored By: Leica Microsystems
      5
      MAR 01, 2022 | 8:00 AM
      Histology Hacks For Cryosectioning
      Histology Hacks For Cryosectioning
      Date: March 01, 2022 Time: 08:00am (PST), 11:00am (EST) Histology laboratorians in the research world move fast, but those who perform cryosectioning know that these particular tissues requi...
      Speaker: Marla Rivera-Oliver, PhD
      Sponsored By: Leica Biosystems
      22
      AUG 25, 2021 | 12:00 AM
      The Long Hangover: Adolescent Intermittent Ethanol's Effects on Hippocampal Neuroimmune and Cell Death Markers, Reversal by Donepezil
      The Long Hangover: Adolescent Intermittent Ethanol's Effects on...
      Adolescence is a critical period for the developing brain, and binge drinking during this neuromaturation can result in enduring abnormal brain function and behavior. Repeated adolescent bin...
      Speaker: Kati Healey, MA, PhD
      Presented at: Neuroscience Virtual Event Series 2021
      1
      AUG 24, 2021 | 11:00 AM
      EAD easy as 1-2-3: Making characterization of complex biotherapeutics routine
      EAD easy as 1-2-3: Making characterization of complex biotherapeutics...
      Date: August 24, 2021 Time: 11:00am (PDT), 1:00pm (EDT) Electron-based dissociation mechanisms have shown great promise for advanced characterization of biomolecules. However, routine adopti...
      Speaker: Matt Stone, PhD , Claire Bramwell, PhD
      Sponsored By: Sciex
      9 1
      JUN 29, 2021 | 7:00 AM
      One Academic Medical Center's Experience with the Unyvero Multiplex Platform for Testing Bronchoalveolar Lavage Fluids: Analytical and Clinical Assessment
      One Academic Medical Center's Experience with the Unyvero Multiplex...
      Date: June 29, 2021 Time: 7:00am (PDT), 10:00am (EDT) The Unyvero Lower Respiratory Tract Panel demonstrated reliable concordance with culture based methods for organism identification from...
      Speaker: Dr. James Snyder , Dr. Wes Hoffmann
      Sponsored By: OpGen
      5
      JUN 02, 2021 | 12:00 AM
      Fueling Antitumor Immunity Using Oncolytic Viruses Encoding Metabolic Modulators
      Fueling Antitumor Immunity Using Oncolytic Viruses Encoding Metabolic...
      Despite the promising results with current approved immunotherapies, all patients do not have the same level of response, and recent efforts have focused on understanding and avoiding immuno...
      Speaker: Dayana Rivadeneira, PhD
      Presented at: Immuno-Oncology Virtual Event Series 2021
      2
      AUG 06, 2020 | 12:00 AM
      Causes and consequences of rapid cancer cell adaptation to therapeutic drugs
      Causes and consequences of rapid cancer cell adaptation to therapeutic...
      Despite the increasing number of effective anti-cancer therapies, successful treatment is limited by the development of drug resistance. While the contribution of genetic factors to drug res...
      Speaker: Sabrina Spencer, PhD
      Presented at: 2020 Beckman Symposium
      1
      JUL 29, 2020 | 12:00 AM
      Phenotypic and MoA Analysis of Anti-Metastatic Molecules using 3D Tumoroid Invasion Assays, Kinetic Ligand Binding, and Cellular Microscopy
      Phenotypic and MoA Analysis of Anti-Metastatic Molecules using...
      Metastasis is the main cause of death in cancer patients and one of the most complex biological processes in human diseases (Hanahan et al., 2011). The development of therapies designed to f...
      Speaker: Brad Larson
      Presented at: Immuno-Oncology & Cancer Biology Virtual Conference
      1
      APR 24, 2020 | 8:00 AM
      The International Council for Standardisation in Hematology (ICSH) recommendations for Hemostasis Critical Values, Tests, and Reporting - a stepwise description for the committee's decisions
      The International Council for Standardisation in Hematology (ICSH)...
      The International Council for Standardization in Haematology (ICSH) is a nonprofit organization dedicated to providing open-access guidance documents to enhance the quality of laboratory tes...
      Speaker: Bob Gosselin
      Sponsored By: Diagnostica Stago, Inc.
      10
      APR 22, 2020 | 8:00 AM
      C.E. CREDITS
      The NEW Coag Value Playbook...Embrace the Power of Local Testing
      The NEW Coag Value Playbook...Embrace the Power of Local Testing
      Discover strategies for labs to optimize coagulation testing, improve patient outcomes, and strengthen their role in clinical care teams....
      Speaker: Eleanor Herriman, MD, MBA , Oksana Volod, MD
      Presented at: Stago EdVantage Virtual University
      Sponsored By: Diagnostica Stago, Inc.
      7
    MAY 29, 2024 | 9:00 AM
    C.E. CREDITS
    HISTOLOGY HACKS FOR CRYOSECTIONING
    HISTOLOGY HACKS FOR CRYOSECTIONING
    Histology laboratorians in the research world move fast, but those who perform cryosectioning know that these particular tissues require lighting speed and precision. Cryosectioning is the a...
    Speaker: Marla Rivera-Oliver, PhD
    Sponsored By: Leica Biosystems
    19 1
    FEB 14, 2024 | 9:00 AM
    C.E. CREDITS
    HISTOLOGY HACKS FOR CRYOSECTIONING
    HISTOLOGY HACKS FOR CRYOSECTIONING
    Learning Objectives Identify three ways automation improves cryosectioning techniques Demonstrate three essential elements to obtaining reproducible, high-quality sections with cryosectionin...
    Speaker: Marla Rivera-Oliver, PhD
    Sponsored By: Leica Biosystems
    30 1
    JAN 23, 2024 | 10:00 AM
    Exploring the Potential of 3D Organoids through Live-Cell Analysis
    Exploring the Potential of 3D Organoids through Live-Cell Analysis
    Organoid technologies are increasingly being used as in vitro models of human development and disease because they exhibit morphogenetic, structural and functional properties that recapitula...
    Speaker: Kalpana Barnes
    Presented at: The Future of Biomedicine: Reproducible Advanced Cell Systems and Translational Insights
    2
    DEC 07, 2023 | 8:00 AM
    Translating COSMIC's gold standard data into actionable insights
    Translating COSMIC's gold standard data into actionable insights
    As the vast landscape of genetic oncology continues to expand, the ability to understand and utilize the full potential of this rich data becomes increasingly challenging. As a result, resea...
    Speaker: Leonie Hodges , Alex Holmes, Ph.D. , Jennifer Wilding, Ph.D.
    Sponsored By: QIAGEN
    15
    JUL 26, 2023 | 12:15 PM
    Advancing Protein Stabilization Therapeutic Development and DUBTAC Drug Discovery through Gene and Cell Engineering
    Advancing Protein Stabilization Therapeutic Development and DUBTAC...
    Genetically modified cell models accelerate the development of safe and effective therapeutics, making them indispensable in the quest for new drugs. Through manipulation of cell line geneti...
    Speaker: Dr. Yongli Shan
    Presented at: GenScript 3rd Annual Gene and Cell Engineering Summit
    4
     
     
  • JUN 06, 2023 | 9:00 AM
    Time-resolved electron microscopy: synaptic ultrastructure millisecond by millisecond with high-pressure freezing
    Time-resolved electron microscopy: synaptic ultrastructure millisecond...
    Transmission electron microscopy reveals the architecture of cells at nanometer resolution, but chemical fixation severely warps their native structure. The true ultrastructure of cells can...
    Speaker: Shigeki Watanabe, Ph.D , Grant Kusick
    Sponsored By: Leica Microsystems
    8
    APR 05, 2023 | 1:00 PM
    Practical considerations for fluorescent cell staining and microscopy in cancer cell biology research
    Practical considerations for fluorescent cell staining and microscopy...
    Date: April 04, 2023 Time: 10:00pm (PDT), Date: April 05, 2023 Time: 2:00am (EDT), 7:00am (CEST), 1:00pm (SGT) This seminar provides an overview of fluorescence microscopy in cancer research...
    Speaker: Dan Beacham, Ph.D.
    Sponsored By: Thermo Fisher Scientific
    27
    MAR 08, 2023 | 6:00 AM
    Recurrent Neural Networks in Brains and Machines
    Recurrent Neural Networks in Brains and Machines
    Neural networks are a powerful tool for modeling neural activity in the brain. In this talk, I will discuss how these models have helped in my own research and highlight recent work building...
    Speaker: Christopher Cueva, PhD
    Presented at: Neuroscience Virtual Event Series 2023
    2
    FEB 22, 2023 | 5:30 AM
    Bridging the Gap - How Human Microphysiological Systems Improve the Translatability of NASH Drug Discovery
    Bridging the Gap - How Human Microphysiological Systems Improve...
    Non-alcoholic fatty liver disease (NAFLD) is a spectrum of metabolic disorders affecting 25% of our global population. 20% of NAFLD patients go on to develop Non-alcoholic steatohepatitis (N...
    Speaker: Raul Silva
    Presented at: Drug Discovery & Development Virtual Event Series 2023
    2
    FEB 15, 2023 | 7:00 AM
    Scattering Microscopy: Label-Free Imaging Approaches
    Scattering Microscopy: Label-Free Imaging Approaches
    Date: February 15, 2023 Time: 7:00am (PST), 10:00pm (EST), 4:00pm (CET) While not all microscopy samples can fluoresce, all can scatter light, and this scattered light can be imaged. This ha...
    Speaker: Philipp Kukura , Francesco Reina , Matthew Kose-Dunn , Phil Allen
    Sponsored By: Teledyne Photometrics
    28
     
     
  • APR 19, 2022 | 5:30 AM
    C.E. CREDITS
    Advances in High Throughput Proteomics using Next Generation Sequencing as a Readout
    Advances in High Throughput Proteomics using Next Generation Sequencing...
    The combination of the wealth of genomic and phenotypic datasets to the measurement of the circulating proteome enables a snapshot of real-time biology and important results for determining...
    Speaker: Dale Yuzuki, M.A., M.Ed.
    Presented at: Genetics Week Virtual Event Series 2022
    3
    APR 05, 2022 | 8:00 AM
    Investigating antimicrobial mechanisms-of-action using automated genome-wide and gene-specific editing
    Investigating antimicrobial mechanisms-of-action using automated...
    Date: April 05, 2022 Time: 8:00am (PDT), 11:00am (EDT), 5:00pm (CEDT) Members of the cinnamic acid and stilbenoid chemical families are common intermediates in the production of important bi...
    Speaker: Ali Clark-ElSayed
    Sponsored By: Inscripta
    8
    MAR 23, 2022 | 11:55 PM
    Overcoming Challenges Associated with Analysis of Pesticides Regulated by Colorado State in Hemp Using a Novel LC/MS/MS Method with Dual ESI and APCI Source
    Overcoming Challenges Associated with Analysis of Pesticides Regulated...
    Like any other agricultural crop, pesticides are applied to hemp plants to protect it from pests and improve growth yield. Chronic exposure to pesticides can lead to serious health risks and...
    Speaker: Avinash Dalmia, PhD
    Presented at: Cannabis Sciences Virtual Event Series 2022
    2
    MAR 10, 2022 | 11:55 PM
    The Spatial Reach of Brain Wave Synchronization
    The Spatial Reach of Brain Wave Synchronization
    Brain wave synchronization, also called neuronal coherence, is a fundamental mechanism of communication in the brain, where synchronized field potentials coordinate synaptic and spiking even...
    Speaker: John Myers, PhD
    Presented at: Neuroscience Virtual Event Series 2022
    2
    MAR 09, 2022 | 10:00 AM
    Time-resolved electron microscopy: synaptic ultrastructure millisecond by millisecond with high-pressure freezing
    Time-resolved electron microscopy: synaptic ultrastructure millisecond...
    Date: March 09, 2022 Time: 10:00am (PST), 1:00pm (EST), 7:00pm (CEST) Transmission electron microscopy reveals the architecture of cells at nanometer resolution, but chemical fixation severe...
    Speaker: Shigeki Watanabe, Ph.D , Grant Kusick
    Sponsored By: Leica Microsystems
    5
     
     
  • MAR 01, 2022 | 8:00 AM
    Histology Hacks For Cryosectioning
    Histology Hacks For Cryosectioning
    Date: March 01, 2022 Time: 08:00am (PST), 11:00am (EST) Histology laboratorians in the research world move fast, but those who perform cryosectioning know that these particular tissues requi...
    Speaker: Marla Rivera-Oliver, PhD
    Sponsored By: Leica Biosystems
    22
    AUG 25, 2021 | 12:00 AM
    The Long Hangover: Adolescent Intermittent Ethanol's Effects on Hippocampal Neuroimmune and Cell Death Markers, Reversal by Donepezil
    The Long Hangover: Adolescent Intermittent Ethanol's Effects on...
    Adolescence is a critical period for the developing brain, and binge drinking during this neuromaturation can result in enduring abnormal brain function and behavior. Repeated adolescent bin...
    Speaker: Kati Healey, MA, PhD
    Presented at: Neuroscience Virtual Event Series 2021
    1
    AUG 24, 2021 | 11:00 AM
    EAD easy as 1-2-3: Making characterization of complex biotherapeutics routine
    EAD easy as 1-2-3: Making characterization of complex biotherapeutics...
    Date: August 24, 2021 Time: 11:00am (PDT), 1:00pm (EDT) Electron-based dissociation mechanisms have shown great promise for advanced characterization of biomolecules. However, routine adopti...
    Speaker: Matt Stone, PhD , Claire Bramwell, PhD
    Sponsored By: Sciex
    9 1
    JUN 29, 2021 | 7:00 AM
    One Academic Medical Center's Experience with the Unyvero Multiplex Platform for Testing Bronchoalveolar Lavage Fluids: Analytical and Clinical Assessment
    One Academic Medical Center's Experience with the Unyvero Multiplex...
    Date: June 29, 2021 Time: 7:00am (PDT), 10:00am (EDT) The Unyvero Lower Respiratory Tract Panel demonstrated reliable concordance with culture based methods for organism identification from...
    Speaker: Dr. James Snyder , Dr. Wes Hoffmann
    Sponsored By: OpGen
    5
    JUN 02, 2021 | 12:00 AM
    Fueling Antitumor Immunity Using Oncolytic Viruses Encoding Metabolic Modulators
    Fueling Antitumor Immunity Using Oncolytic Viruses Encoding Metabolic...
    Despite the promising results with current approved immunotherapies, all patients do not have the same level of response, and recent efforts have focused on understanding and avoiding immuno...
    Speaker: Dayana Rivadeneira, PhD
    Presented at: Immuno-Oncology Virtual Event Series 2021
    2
     
     
  • AUG 06, 2020 | 12:00 AM
    Causes and consequences of rapid cancer cell adaptation to therapeutic drugs
    Causes and consequences of rapid cancer cell adaptation to therapeutic...
    Despite the increasing number of effective anti-cancer therapies, successful treatment is limited by the development of drug resistance. While the contribution of genetic factors to drug res...
    Speaker: Sabrina Spencer, PhD
    Presented at: 2020 Beckman Symposium
    1
    JUL 29, 2020 | 12:00 AM
    Phenotypic and MoA Analysis of Anti-Metastatic Molecules using 3D Tumoroid Invasion Assays, Kinetic Ligand Binding, and Cellular Microscopy
    Phenotypic and MoA Analysis of Anti-Metastatic Molecules using...
    Metastasis is the main cause of death in cancer patients and one of the most complex biological processes in human diseases (Hanahan et al., 2011). The development of therapies designed to f...
    Speaker: Brad Larson
    Presented at: Immuno-Oncology & Cancer Biology Virtual Conference
    1
    APR 24, 2020 | 8:00 AM
    The International Council for Standardisation in Hematology (ICSH) recommendations for Hemostasis Critical Values, Tests, and Reporting - a stepwise description for the committee's decisions
    The International Council for Standardisation in Hematology (ICSH)...
    The International Council for Standardization in Haematology (ICSH) is a nonprofit organization dedicated to providing open-access guidance documents to enhance the quality of laboratory tes...
    Speaker: Bob Gosselin
    Sponsored By: Diagnostica Stago, Inc.
    10
    APR 22, 2020 | 8:00 AM
    C.E. CREDITS
    The NEW Coag Value Playbook...Embrace the Power of Local Testing
    The NEW Coag Value Playbook...Embrace the Power of Local Testing
    Discover strategies for labs to optimize coagulation testing, improve patient outcomes, and strengthen their role in clinical care teams....
    Speaker: Eleanor Herriman, MD, MBA , Oksana Volod, MD
    Presented at: Stago EdVantage Virtual University
    Sponsored By: Diagnostica Stago, Inc.
    7
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