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    Monoclonal proteins

    Monoclonal proteins, also called M proteins, are elevated in the blood and urine of patients with multiple myeloma or monoclonal gammopathy of undetermined significance (MGUS), a condition which is highly correlated to bone marrow and blood cancers. Monoclonal proteins are antibodies produced in the bone marrow by the cancerous cells.

    Webinars

    • JUN 17, 2020 | 12:00 PM
      High-Throughput Assay for Monitoring COVID19 Antibodies and Their Isotypes
      High-Throughput Assay for Monitoring COVID19 Antibodies and Their...
      The 2020 pandemic caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) continues to rage. While PCR-based assays are used for viral diagnosis, high through-put, rapid s...
      Speaker: Susan Zolla-Pazner, PhD
      Presented at: Coronavirus Series
      Sponsored By: Luminex - A DiaSorin Company
      1
      JUN 02, 2020 | 9:00 AM
      Osmolality Testing: Providing Unique Process Control for Downstream Operations
      Osmolality Testing: Providing Unique Process Control for Downstream...
      DATE: June 2, 2020 TIME: 9:00am PT, 12:00pm ET Osmolality is a well-established parameter for upstream bioprocessing, formulation, analytical development and QC applications throughout the m...
      Speaker: Alois Jungbauer, PhD , Kristeena Wright, PhD
      Sponsored By: Advanced Instruments
      11 1
      MAY 12, 2020 | 9:00 AM
      Analytical Quality Control for the Pharmaceutical Industry
      Analytical Quality Control for the Pharmaceutical Industry
      NEW DATE: Date: May 12, 2020 Time: 9:00am PDT, 12:00pm EDT...
      Speaker: Joy McElroy
      Sponsored By: Sartorius
      29 9
      MAR 31, 2020 | 9:00 AM
      Impact of liquid biopsy in advanced HER2+ breast cancer tumors: a follow-up study
      Impact of liquid biopsy in advanced HER2+ breast cancer tumors:...
      DATE: March 31, 2020 TIME: 9:00am PT, 12:00pm ET HER2-positive breast cancer is a type of breast cancer caused by over-expression of a protein called human epidermal growth factor receptor 2...
      Speaker: Matteo Allegretti, PhD
      Sponsored By: Thermo Fisher Scientific - Ion Torrent, Thermo Fisher Scientific - Applied Biosystems
      7
      DEC 10, 2019 | 7:00 AM
      Proven Answers for Protein, Vaccine and Gene Therapy Analysis
      Proven Answers for Protein, Vaccine and Gene Therapy Analysis
      DATE: December 11, 2019 TIME: 7:00am PST, 10:00am EST Rapid growth in the cell and gene therapy industry has generated an urgent need for robust analytics around characterization of both vec...
      Speaker: Mukesh Malik, PhD
      Sponsored By: SCIEX
      8 1
      NOV 21, 2019 | 9:00 AM
      The role of immune cells and immune checkpoints in multiple myeloma
      The role of immune cells and immune checkpoints in multiple myeloma
      DATE: November 21, 2019TIME: 9:00am PST, 12:00pm EST Multiple Myeloma is a disease of terminally differentiated plasma cells with the massive production of monoclonal immunoglobu...
      Speaker: Nathalie Heider-Hönatsch, M.Sc.
      Sponsored By: Thermo Fisher Scientific/Gibco
      11
      NOV 07, 2019 | 9:00 AM
      Factor V Expression in ExpiCHO Cells
      Factor V Expression in ExpiCHO Cells
      DATE: November 7, 2019 TIME: 9:00am PST, 12:00pm EST In collaboration with Hematherix and Thermo Fisher, Dr. Laurent Mosnier is investigating a new treatment for acute traumatic bl...
      Speaker: Laurent Mosnier, PhD
      Sponsored By: Thermo Fisher Scientific/Gibco
      5 2
      OCT 24, 2019 | 1:30 PM
      Characterization of Biotherapeutics by Chemometric and Machine Learning Analysis of NMR Spectra
      Characterization of Biotherapeutics by Chemometric and Machine...
      With annual sales exceeding $145 billion, growth of biologic therapeutics is outpacing that of small-molecule drugs, and the development, manufacture, and delivery of biologics presents very...
      Speaker: Frank Delaglio, PhD
      Presented at: Analytical Chemistry Virtual Event Series 2019
      4 1
      OCT 24, 2019 | 9:00 AM
      A Comparison of Established NMR Chemometric Methods in Biopharma
      A Comparison of Established NMR Chemometric Methods in Biopharma
      Therapeutic monoclonal antibodies are a clinically important and life-saving class of biotherapeutics used in the treatment of several previously intractable diseases. However, their developm...
      Speaker: K. Wade Elliott, PhD
      Presented at: Analytical Chemistry Virtual Event Series 2019
      3
      SEP 25, 2019 | 8:00 AM
      Expression, Purification and Characterization of Difficult to Express Membrane Proteins in the Expi293 and ExpiCHO Expression Systems:  Case study of Potassium chloride co-transporter KCC2
      Expression, Purification and Characterization of Difficult to...
      DATE: September 25, 2019TIME: 8:00am PT, 11:00am ET This talk will focus on strategies for optimizing expression levels of membrane proteins using the Gibcoâ„¢ Expi293â„¢ and ExpiCHOâ„¢ Expres...
      Speaker: Anass Jawhari, PhD
      Sponsored By: Thermo Fisher Scientific/Gibco
      4
      AUG 29, 2019 | 9:00 AM
      Enabling Next-Generation Targeted siRNA Therapies with ExpiCHO
      Enabling Next-Generation Targeted siRNA Therapies with ExpiCHO
      DATE: August 29, 2019TIME: 9:00am PT/ 12:00pm ET Monoclonal antibodies (mAbs) are a cornerstone of modern biomedical research and biotherapeutics. Therefore, reproducibly obtai...
      Speaker: Ian Huggins, PhD
      Sponsored By: Thermo Fisher Scientific/Gibco
      6
      MAR 26, 2019 | 2:00 PM
      The Role of Endosomes in Prostate Cancer
      The Role of Endosomes in Prostate Cancer
      DATE:  March 26, 2019TIME:  2:00pm PDT, 5:00pm EDT  Prostate cancer is the second most common form of cancer in males, affecting one in eight men by the time t...
      Speaker: Ian Johnson, BSc., Ph.D
      Sponsored By: Thermo Fisher Scientific/Gibco
      7
      FEB 27, 2019 | 12:00 PM
      Studies on Malignancies With a Novel Proliferation Biomarker
      Studies on Malignancies With a Novel Proliferation Biomarker
      Studies in drug development and on hematological and solid Tumors with a Thymidine Kinase 1 immunoassayThere are many tumor biomarkers but, they mostly reflect tumor mass or past growth,...
      Speaker: Martin Shaw
      Presented at: Drug Discovery Virtual Event Series 2019
      1
      FEB 27, 2019 | 10:30 AM
      Synthetic Antibodies - The Emerging Field of "Aptamers" in Diagnostics and Drug Discovery
      Synthetic Antibodies - The Emerging Field of "Aptamers" in Diagnostics...
      An aptamer (also known as a synthetic antibody) is a stable DNA, RNA, or peptide ligand that binds with high affinity and specificity to targets such as small molecules, peptides, proteins, b...
      Speaker: G. Thomas Caltagirone, PhD
      Presented at: Drug Discovery Virtual Event Series 2019
      1
      JAN 31, 2019 | 6:00 AM
      Overcoming Challenges in EuCODE Cell Culture Platform Development
      Overcoming Challenges in EuCODE Cell Culture Platform Development
      Ambrx’s mammalian expression platform (EuCODE™) enables non-native amino acids (nnAAs) through an expanded genetic code to both generate novel bio-therapeutics and to optimize the...
      Speaker: Weimin Lin, PhD
      Presented at: BioProcessing Virtual Event Series 2019
      3
      NOV 15, 2018 | 10:00 AM
      Multiplex fluorescence immunohistochemistry using the Ultivue InSituPlex platform on the Leica Biosystems BOND RX
      Multiplex fluorescence immunohistochemistry using the Ultivue...
      DATE:  November 15, 2018TIME:  10:00am PT, 1:00pm ET Multiplex fluorescence immunohistochemistry offers a window into the biology of human disease, enabling the ana...
      Speaker: Traci DeGeer, BS, HT (ASCP) HTL, QIHC , Alexander Klimowicz
      Sponsored By: Leica Biosystems
      6 1
      OCT 25, 2018 | 12:00 PM
      Through the Looking Glass, and What Amino Acids Found There
      Through the Looking Glass, and What Amino Acids Found There
      Analytical chemistry can take you to strange places - for me it has been to the bottom of a quarry, being covered in dirt, excavating sesame-seed sized fossils that allow us to work out when...
      Speaker: Kirsty Penkman, PhD
      Presented at: Analytical Chemistry Virtual Event Series 2018
      1
      OCT 25, 2018 | 10:30 AM
      Trash or Treasure: Optimizing Titration Electrodes and Consumables
      Trash or Treasure: Optimizing Titration Electrodes and Consumables
      Everyone that uses titration in their lab knows how simple and fast the technique can be.  However, uncertainty around when to replace electrodes creates confusion. Reagent quality, tubi...
      Speaker: Jessica McVay , Lori Spafford
      Presented at: Analytical Chemistry Virtual Event Series 2018
      Sponsored By: Metrohm USA
      1
      OCT 24, 2018 | 1:30 PM
      Accessories and Techniques for FT-IR Sample Analysis
      Accessories and Techniques for FT-IR Sample Analysis
      This intensive workshop will introduce infrared spectroscopy, outline the various sample handling methods and provide guidance on the numerous transmission and reflectance methods available f...
      Speaker: Richard Larsen, PhD
      Presented at: Analytical Chemistry Virtual Event Series 2018
      1
      OCT 24, 2018 | 12:00 PM
      Ion Mobility-Mass Spectrometry in the -Omics
      Ion Mobility-Mass Spectrometry in the -Omics
      Ion mobility-mass spectrometry (IM-MS) is a rapid, gas-phase separation technique that has become an integral part of the analytical repertoire of techniques for the -omics. This method coupl...
      Speaker: Christopher Chouinard, PhD
      Presented at: Analytical Chemistry Virtual Event Series 2018
      1
      OCT 24, 2018 | 10:30 AM
      Chemometric Methods for Analysis of 2D 1H-13C Methyl NMR Spectra of Monoclonal Antibodies for Higher Order Structure Characterization
      Chemometric Methods for Analysis of 2D 1H-13C Methyl NMR Spectra...
      Two-dimensional (2D) 1H-13C methyl correlated NMR is increasingly being recognized as a powerful tool to characterize the higher order structure (HOS) of monoclonal antibody (mAb) therapeutic...
      Speaker: Luke Arbogast, PhD
      Presented at: Analytical Chemistry Virtual Event Series 2018
      1
      OCT 24, 2018 | 9:00 AM
      Keynote Presentation: Solid Phase Microextraction: New Developments in Bioanalysis and Medical Applications
      Keynote Presentation: Solid Phase Microextraction: New Developments...
      Solid phase microextraction (SPME) is a versatile, non-exhaustive sample preparation tool that has been demonstrated to be well-suited for facile and effective analysis of a broad range of co...
      Speaker: Barbara Bojko, PhD , Janusz Pawliszyn, PhD, FCIC, FRSC
      Presented at: Analytical Chemistry Virtual Event Series 2018
      2
      OCT 24, 2018 | 7:30 AM
      Keynote Presentation: Mass Spectrometry Approaches for the the Single Cell Chemical Characterization of the Brain
      Keynote Presentation: Mass Spectrometry Approaches for the the...
      In the postgenomic era, one expects the suite of chemical players in a brain region to be known and their functions uncovered. Perhaps surprisingly, many neurochemicals remain poorly characte...
      Speaker: Jonathan Sweedler, PhD
      Presented at: Analytical Chemistry Virtual Event Series 2018
      3
      OCT 24, 2018 | 6:00 AM
      Applied Hyperspectral Imaging Fundamentals and Case Studies
      Applied Hyperspectral Imaging Fundamentals and Case Studies
      A fast, reliable and low cost characterization of materials/ products as fed to a process, and/or resulting from different processing actions, represents one of the most challenging targets i...
      Speaker: Giuseppe Bonifazi, PhD
      Presented at: Analytical Chemistry Virtual Event Series 2018
      2
    JUN 17, 2020 | 12:00 PM
    High-Throughput Assay for Monitoring COVID19 Antibodies and Their Isotypes
    High-Throughput Assay for Monitoring COVID19 Antibodies and Their...
    The 2020 pandemic caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) continues to rage. While PCR-based assays are used for viral diagnosis, high through-put, rapid s...
    Speaker: Susan Zolla-Pazner, PhD
    Presented at: Coronavirus Series
    Sponsored By: Luminex - A DiaSorin Company
    1
    JUN 02, 2020 | 9:00 AM
    Osmolality Testing: Providing Unique Process Control for Downstream Operations
    Osmolality Testing: Providing Unique Process Control for Downstream...
    DATE: June 2, 2020 TIME: 9:00am PT, 12:00pm ET Osmolality is a well-established parameter for upstream bioprocessing, formulation, analytical development and QC applications throughout the m...
    Speaker: Alois Jungbauer, PhD , Kristeena Wright, PhD
    Sponsored By: Advanced Instruments
    11 1
    MAY 12, 2020 | 9:00 AM
    Analytical Quality Control for the Pharmaceutical Industry
    Analytical Quality Control for the Pharmaceutical Industry
    NEW DATE: Date: May 12, 2020 Time: 9:00am PDT, 12:00pm EDT...
    Speaker: Joy McElroy
    Sponsored By: Sartorius
    29 9
    MAR 31, 2020 | 9:00 AM
    Impact of liquid biopsy in advanced HER2+ breast cancer tumors: a follow-up study
    Impact of liquid biopsy in advanced HER2+ breast cancer tumors:...
    DATE: March 31, 2020 TIME: 9:00am PT, 12:00pm ET HER2-positive breast cancer is a type of breast cancer caused by over-expression of a protein called human epidermal growth factor receptor 2...
    Speaker: Matteo Allegretti, PhD
    Sponsored By: Thermo Fisher Scientific - Ion Torrent, Thermo Fisher Scientific - Applied Biosystems
    7
    DEC 10, 2019 | 7:00 AM
    Proven Answers for Protein, Vaccine and Gene Therapy Analysis
    Proven Answers for Protein, Vaccine and Gene Therapy Analysis
    DATE: December 11, 2019 TIME: 7:00am PST, 10:00am EST Rapid growth in the cell and gene therapy industry has generated an urgent need for robust analytics around characterization of both vec...
    Speaker: Mukesh Malik, PhD
    Sponsored By: SCIEX
    8 1
     
     
  • NOV 21, 2019 | 9:00 AM
    The role of immune cells and immune checkpoints in multiple myeloma
    The role of immune cells and immune checkpoints in multiple myeloma
    DATE: November 21, 2019TIME: 9:00am PST, 12:00pm EST Multiple Myeloma is a disease of terminally differentiated plasma cells with the massive production of monoclonal immunoglobu...
    Speaker: Nathalie Heider-Hönatsch, M.Sc.
    Sponsored By: Thermo Fisher Scientific/Gibco
    11
    NOV 07, 2019 | 9:00 AM
    Factor V Expression in ExpiCHO Cells
    Factor V Expression in ExpiCHO Cells
    DATE: November 7, 2019 TIME: 9:00am PST, 12:00pm EST In collaboration with Hematherix and Thermo Fisher, Dr. Laurent Mosnier is investigating a new treatment for acute traumatic bl...
    Speaker: Laurent Mosnier, PhD
    Sponsored By: Thermo Fisher Scientific/Gibco
    5 2
    OCT 24, 2019 | 1:30 PM
    Characterization of Biotherapeutics by Chemometric and Machine Learning Analysis of NMR Spectra
    Characterization of Biotherapeutics by Chemometric and Machine...
    With annual sales exceeding $145 billion, growth of biologic therapeutics is outpacing that of small-molecule drugs, and the development, manufacture, and delivery of biologics presents very...
    Speaker: Frank Delaglio, PhD
    Presented at: Analytical Chemistry Virtual Event Series 2019
    4 1
    OCT 24, 2019 | 9:00 AM
    A Comparison of Established NMR Chemometric Methods in Biopharma
    A Comparison of Established NMR Chemometric Methods in Biopharma
    Therapeutic monoclonal antibodies are a clinically important and life-saving class of biotherapeutics used in the treatment of several previously intractable diseases. However, their developm...
    Speaker: K. Wade Elliott, PhD
    Presented at: Analytical Chemistry Virtual Event Series 2019
    3
    SEP 25, 2019 | 8:00 AM
    Expression, Purification and Characterization of Difficult to Express Membrane Proteins in the Expi293 and ExpiCHO Expression Systems:  Case study of Potassium chloride co-transporter KCC2
    Expression, Purification and Characterization of Difficult to...
    DATE: September 25, 2019TIME: 8:00am PT, 11:00am ET This talk will focus on strategies for optimizing expression levels of membrane proteins using the Gibcoâ„¢ Expi293â„¢ and ExpiCHOâ„¢ Expres...
    Speaker: Anass Jawhari, PhD
    Sponsored By: Thermo Fisher Scientific/Gibco
    4
     
     
  • AUG 29, 2019 | 9:00 AM
    Enabling Next-Generation Targeted siRNA Therapies with ExpiCHO
    Enabling Next-Generation Targeted siRNA Therapies with ExpiCHO
    DATE: August 29, 2019TIME: 9:00am PT/ 12:00pm ET Monoclonal antibodies (mAbs) are a cornerstone of modern biomedical research and biotherapeutics. Therefore, reproducibly obtai...
    Speaker: Ian Huggins, PhD
    Sponsored By: Thermo Fisher Scientific/Gibco
    6
    MAR 26, 2019 | 2:00 PM
    The Role of Endosomes in Prostate Cancer
    The Role of Endosomes in Prostate Cancer
    DATE:  March 26, 2019TIME:  2:00pm PDT, 5:00pm EDT  Prostate cancer is the second most common form of cancer in males, affecting one in eight men by the time t...
    Speaker: Ian Johnson, BSc., Ph.D
    Sponsored By: Thermo Fisher Scientific/Gibco
    7
    FEB 27, 2019 | 12:00 PM
    Studies on Malignancies With a Novel Proliferation Biomarker
    Studies on Malignancies With a Novel Proliferation Biomarker
    Studies in drug development and on hematological and solid Tumors with a Thymidine Kinase 1 immunoassayThere are many tumor biomarkers but, they mostly reflect tumor mass or past growth,...
    Speaker: Martin Shaw
    Presented at: Drug Discovery Virtual Event Series 2019
    1
    FEB 27, 2019 | 10:30 AM
    Synthetic Antibodies - The Emerging Field of "Aptamers" in Diagnostics and Drug Discovery
    Synthetic Antibodies - The Emerging Field of "Aptamers" in Diagnostics...
    An aptamer (also known as a synthetic antibody) is a stable DNA, RNA, or peptide ligand that binds with high affinity and specificity to targets such as small molecules, peptides, proteins, b...
    Speaker: G. Thomas Caltagirone, PhD
    Presented at: Drug Discovery Virtual Event Series 2019
    1
    JAN 31, 2019 | 6:00 AM
    Overcoming Challenges in EuCODE Cell Culture Platform Development
    Overcoming Challenges in EuCODE Cell Culture Platform Development
    Ambrx’s mammalian expression platform (EuCODE™) enables non-native amino acids (nnAAs) through an expanded genetic code to both generate novel bio-therapeutics and to optimize the...
    Speaker: Weimin Lin, PhD
    Presented at: BioProcessing Virtual Event Series 2019
    3
     
     
  • NOV 15, 2018 | 10:00 AM
    Multiplex fluorescence immunohistochemistry using the Ultivue InSituPlex platform on the Leica Biosystems BOND RX
    Multiplex fluorescence immunohistochemistry using the Ultivue...
    DATE:  November 15, 2018TIME:  10:00am PT, 1:00pm ET Multiplex fluorescence immunohistochemistry offers a window into the biology of human disease, enabling the ana...
    Speaker: Traci DeGeer, BS, HT (ASCP) HTL, QIHC , Alexander Klimowicz
    Sponsored By: Leica Biosystems
    6 1
    OCT 25, 2018 | 12:00 PM
    Through the Looking Glass, and What Amino Acids Found There
    Through the Looking Glass, and What Amino Acids Found There
    Analytical chemistry can take you to strange places - for me it has been to the bottom of a quarry, being covered in dirt, excavating sesame-seed sized fossils that allow us to work out when...
    Speaker: Kirsty Penkman, PhD
    Presented at: Analytical Chemistry Virtual Event Series 2018
    1
    OCT 25, 2018 | 10:30 AM
    Trash or Treasure: Optimizing Titration Electrodes and Consumables
    Trash or Treasure: Optimizing Titration Electrodes and Consumables
    Everyone that uses titration in their lab knows how simple and fast the technique can be.  However, uncertainty around when to replace electrodes creates confusion. Reagent quality, tubi...
    Speaker: Jessica McVay , Lori Spafford
    Presented at: Analytical Chemistry Virtual Event Series 2018
    Sponsored By: Metrohm USA
    1
    OCT 24, 2018 | 1:30 PM
    Accessories and Techniques for FT-IR Sample Analysis
    Accessories and Techniques for FT-IR Sample Analysis
    This intensive workshop will introduce infrared spectroscopy, outline the various sample handling methods and provide guidance on the numerous transmission and reflectance methods available f...
    Speaker: Richard Larsen, PhD
    Presented at: Analytical Chemistry Virtual Event Series 2018
    1
    OCT 24, 2018 | 12:00 PM
    Ion Mobility-Mass Spectrometry in the -Omics
    Ion Mobility-Mass Spectrometry in the -Omics
    Ion mobility-mass spectrometry (IM-MS) is a rapid, gas-phase separation technique that has become an integral part of the analytical repertoire of techniques for the -omics. This method coupl...
    Speaker: Christopher Chouinard, PhD
    Presented at: Analytical Chemistry Virtual Event Series 2018
    1
     
     
  • OCT 24, 2018 | 10:30 AM
    Chemometric Methods for Analysis of 2D 1H-13C Methyl NMR Spectra of Monoclonal Antibodies for Higher Order Structure Characterization
    Chemometric Methods for Analysis of 2D 1H-13C Methyl NMR Spectra...
    Two-dimensional (2D) 1H-13C methyl correlated NMR is increasingly being recognized as a powerful tool to characterize the higher order structure (HOS) of monoclonal antibody (mAb) therapeutic...
    Speaker: Luke Arbogast, PhD
    Presented at: Analytical Chemistry Virtual Event Series 2018
    1
    OCT 24, 2018 | 9:00 AM
    Keynote Presentation: Solid Phase Microextraction: New Developments in Bioanalysis and Medical Applications
    Keynote Presentation: Solid Phase Microextraction: New Developments...
    Solid phase microextraction (SPME) is a versatile, non-exhaustive sample preparation tool that has been demonstrated to be well-suited for facile and effective analysis of a broad range of co...
    Speaker: Barbara Bojko, PhD , Janusz Pawliszyn, PhD, FCIC, FRSC
    Presented at: Analytical Chemistry Virtual Event Series 2018
    2
    OCT 24, 2018 | 7:30 AM
    Keynote Presentation: Mass Spectrometry Approaches for the the Single Cell Chemical Characterization of the Brain
    Keynote Presentation: Mass Spectrometry Approaches for the the...
    In the postgenomic era, one expects the suite of chemical players in a brain region to be known and their functions uncovered. Perhaps surprisingly, many neurochemicals remain poorly characte...
    Speaker: Jonathan Sweedler, PhD
    Presented at: Analytical Chemistry Virtual Event Series 2018
    3
    OCT 24, 2018 | 6:00 AM
    Applied Hyperspectral Imaging Fundamentals and Case Studies
    Applied Hyperspectral Imaging Fundamentals and Case Studies
    A fast, reliable and low cost characterization of materials/ products as fed to a process, and/or resulting from different processing actions, represents one of the most challenging targets i...
    Speaker: Giuseppe Bonifazi, PhD
    Presented at: Analytical Chemistry Virtual Event Series 2018
    2
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