Follow
Protein Binding
Protein Binding: Protein binding can enhance or detract from a drug's performance. As a general rule, agents that are minimally protein bound penetrate tissue better than those that are highly bound, but they are excreted much faster. Among drugs that are less than 80-85 percent protein bound, differences appear to be of slight clinical importance. Agents that are highly protein bound may, however, differ markedly from those that are minimally bound in terms of tissue penetration and half-life. Drugs may bind to a wide variety of plasma proteins, including albumin. If the percentage of protein-bound drug is greater when measured in human blood than in a simple albumin solution, the clinician should suspect that the agent may be bound in vivo to one of these "minority" plasma proteins. The concentration of several plasma proteins can be altered by many factors, including stress, surgery, liver or kidney dysfunction, and pregnancy. In such circumstances, free drug concentrations are a more accurate index of clinical effect than are total concentrations. Formulary committees must grasp the clinical significance of qualitative and quantitative differences in protein binding when evaluating competing agents.
-
JUL 30, 2023Genetics & Genomics
It's estimated that as many as one-third of Americans suffer from chronic pain, and many medications that have been ...Written By: Carmen LeitchJUL 25, 2023Cancer
Steroidogenesis, the biological process by which the body generates steroid hormones, facilitates the production of andr ...Written By: Katie KokolusJUL 21, 2023Cell & Molecular Biology
Human cells are brimming with thousands of proteins, which interact with each other in various ways to impact cell funct ...Written By: Carmen LeitchJUL 17, 2023Drug Discovery & DevelopmentIntroduction Antibodies are the ideal therapeutic biomolecules due to their ability to bind to a variety of targets with ...JUL 05, 2023Cell & Molecular Biology
Some transcription factors are known as master regulators, and they can have an impact on many different biochemical pat ...Written By: Carmen LeitchJUL 04, 2023Cell & Molecular Biology
The human body has many important proteins, and insulin and mucin may be among the most crucial. Researchers have shown ...Written By: Carmen LeitchJUN 28, 2023Immunology
There are multiple types of immune cells in the body which respond to disease and infection. One population of cells inc ...Written By: Brian G. MorrealeJUN 21, 2023Neuroscience
Researchers at Harvard's School of Public Health have uncovered a significant link between omega-3 fatty acids and exten ...Written By: Amielle MorenoJUN 09, 2023Cell & Molecular Biology
New work by Kobayashi, Kawakami, Nureki, and colleagues has revealed a fascinating way to trigger the most common class ...Written By: Carmen LeitchJUN 06, 2023Immunology
Multiple sclerosis (MS) affects roughly 2.5 million people worldwide and is a neurological disease affecting the brain a ...Written By: Brian G. MorrealeMAY 31, 2023Cannabis Sciences
A study published in Neuron reveals a previously unknown way in which cannabidiol (CBD) reduces seizures in many treatme ...Written By: Kerry CharronMAY 25, 2023Immunology
A major research topic in medicine is to improve immune system function. The body responds to disease by activating cell ...Written By: Brian G. MorrealeMAY 22, 2023Cannabis Sciences
Psilocybin is a hallucinogenic compound found in over 200 mushroom species, and the substance has significant therapeuti ...Written By: Kerry CharronMAY 21, 2023Cancer
Inflammation occurs as a natural response to an insult, such as an injury or a bacterial infection. When your body ...Written By: Katie KokolusMAY 17, 2023Microbiology
It's thought that about 90 percent of the world's population has been infected at some point in their early live ...Written By: Carmen LeitchAPR 24, 2023Cell & Molecular Biology
Published by Bindi M. Doshi, PhD on Mar 17, 2023 Organoids are 3D structures made up of cells that replic ...Sponsored By: MBL InternationalAPR 14, 2023Immunology
The immune system has to be ready to identify and react to pathogens, and it also has to be turned off when the job is d ...Written By: Carmen LeitchAPR 14, 2023Microbiology
Epstein-Barr virus can spread so easily, it is thought that over 90% of people in the world have been infected, which us ...Written By: Carmen LeitchAPR 10, 2023Immunology
New research can help explain why people can be easily reinfected with coronavirus after being infected one, two, or eve ...Written By: Carmen LeitchAPR 09, 2023Neuroscience
Researchers at Washington University School of Medicine discovered a biomarker identifying people with a primary tauopat ...Written By: Kerry CharronAPR 05, 2023Neuroscience
There has been a great deal controversy in Alzheimer's research in recent years. Some scientists hypothesize that the di ...Written By: Carmen LeitchAPR 04, 2023Cancer
After years of effort, a game-changing treatment has emerged from outside the Biopharma sector: a cancer drug that only ...Written By: Amielle MorenoAPR 04, 2023Immunology
A case of COVID-19 starts when SARS-CoV-2 infects cells in the nasal passages. Many experts and scientists have therefor ...Written By: Carmen LeitchAPR 02, 2023Microbiology
Nature has designed some spectacular micromachines, such as the flagella that propel bacterial cells, or microbial injec ...Written By: Carmen Leitch
JUL 30, 2023
Genetics & Genomics
It's estimated that as many as one-third of Americans suffer from chronic pain, and many medications that have been
...
Written By:
Carmen Leitch
JUL 25, 2023
Cancer
Steroidogenesis, the biological process by which the body generates steroid hormones, facilitates the production of andr
...
Written By:
Katie Kokolus
JUL 21, 2023
Cell & Molecular Biology
Human cells are brimming with thousands of proteins, which interact with each other in various ways to impact cell funct
...
Written By:
Carmen Leitch
JUL 17, 2023
Drug Discovery & Development
Introduction Antibodies are the ideal therapeutic biomolecules due to their ability to bind to a variety of targets with
...
JUL 05, 2023
Cell & Molecular Biology
Some transcription factors are known as master regulators, and they can have an impact on many different biochemical pat
...
Written By:
Carmen Leitch
JUL 04, 2023
Cell & Molecular Biology
The human body has many important proteins, and insulin and mucin may be among the most crucial. Researchers have shown
...
Written By:
Carmen Leitch
JUN 28, 2023
Immunology
There are multiple types of immune cells in the body which respond to disease and infection. One population of cells inc
...
Written By:
Brian G. Morreale
JUN 21, 2023
Neuroscience
Researchers at Harvard's School of Public Health have uncovered a significant link between omega-3 fatty acids and exten
...
Written By:
Amielle Moreno
JUN 09, 2023
Cell & Molecular Biology
New work by Kobayashi, Kawakami, Nureki, and colleagues has revealed a fascinating way to trigger the most common class
...
Written By:
Carmen Leitch
JUN 06, 2023
Immunology
Multiple sclerosis (MS) affects roughly 2.5 million people worldwide and is a neurological disease affecting the brain a
...
Written By:
Brian G. Morreale
MAY 31, 2023
Cannabis Sciences
A study published in Neuron reveals a previously unknown way in which cannabidiol (CBD) reduces seizures in many treatme
...
Written By:
Kerry Charron
MAY 25, 2023
Immunology
A major research topic in medicine is to improve immune system function. The body responds to disease by activating cell
...
Written By:
Brian G. Morreale
MAY 22, 2023
Cannabis Sciences
Psilocybin is a hallucinogenic compound found in over 200 mushroom species, and the substance has significant therapeuti
...
Written By:
Kerry Charron
MAY 21, 2023
Cancer
Inflammation occurs as a natural response to an insult, such as an injury or a bacterial infection. When your body
...
Written By:
Katie Kokolus
MAY 17, 2023
Microbiology
It's thought that about 90 percent of the world's population has been infected at some point in their early live
...
Written By:
Carmen Leitch
APR 24, 2023
Cell & Molecular Biology
Published by Bindi M. Doshi, PhD on Mar 17, 2023 Organoids are 3D structures made up of cells that replic
...
Sponsored By:
MBL International
APR 14, 2023
Immunology
The immune system has to be ready to identify and react to pathogens, and it also has to be turned off when the job is d
...
Written By:
Carmen Leitch
APR 14, 2023
Microbiology
Epstein-Barr virus can spread so easily, it is thought that over 90% of people in the world have been infected, which us
...
Written By:
Carmen Leitch
APR 10, 2023
Immunology
New research can help explain why people can be easily reinfected with coronavirus after being infected one, two, or eve
...
Written By:
Carmen Leitch
APR 09, 2023
Neuroscience
Researchers at Washington University School of Medicine discovered a biomarker identifying people with a primary tauopat
...
Written By:
Kerry Charron
APR 05, 2023
Neuroscience
There has been a great deal controversy in Alzheimer's research in recent years. Some scientists hypothesize that the di
...
Written By:
Carmen Leitch
APR 04, 2023
Cancer
After years of effort, a game-changing treatment has emerged from outside the Biopharma sector: a cancer drug that only
...
Written By:
Amielle Moreno
APR 04, 2023
Immunology
A case of COVID-19 starts when SARS-CoV-2 infects cells in the nasal passages. Many experts and scientists have therefor
...
Written By:
Carmen Leitch
APR 02, 2023
Microbiology
Nature has designed some spectacular micromachines, such as the flagella that propel bacterial cells, or microbial injec
...
Written By:
Carmen Leitch