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Protein Binding
Protein Binding: Protein binding can enhance or detract from a drug's performance. As a general rule, agents that are minimally protein bound penetrate tissue better than those that are highly bound, but they are excreted much faster. Among drugs that are less than 80-85 percent protein bound, differences appear to be of slight clinical importance. Agents that are highly protein bound may, however, differ markedly from those that are minimally bound in terms of tissue penetration and half-life. Drugs may bind to a wide variety of plasma proteins, including albumin. If the percentage of protein-bound drug is greater when measured in human blood than in a simple albumin solution, the clinician should suspect that the agent may be bound in vivo to one of these "minority" plasma proteins. The concentration of several plasma proteins can be altered by many factors, including stress, surgery, liver or kidney dysfunction, and pregnancy. In such circumstances, free drug concentrations are a more accurate index of clinical effect than are total concentrations. Formulary committees must grasp the clinical significance of qualitative and quantitative differences in protein binding when evaluating competing agents.
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MAR 28, 2023
Drug Discovery & Development
Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease that is also known as Lou Gehrig’s Disease. It
...
Written By:
Greta Anne
MAR 27, 2023
Immunology
In the gut, the immune system has to maintain tissue health and prevent infection, while also tolerating the presence of
...
Written By:
Carmen Leitch
MAR 27, 2023
Cancer
Innate Immunity is a nonspecific host defense mechanism against foreign antigens. It is the first line of defense in a h
...
Sponsored By:
MBL International
MAR 21, 2023
Drug Discovery & Development
Until the incredibly infectious Omicron variant emerged and took over, it seemed like there was a never-ending stream of
...
Written By:
Carmen Leitch
MAR 20, 2023
Cancer
Our body has mechanisms to regulate the immune system. Effective immunity requires the body to know when to ramp u
...
Written By:
Katie Kokolus
MAR 14, 2023
Immunology
It has been thought that the first step in B cell activation, when these immune cells recognize an infectious pathogen,
...
Written By:
Carmen Leitch
MAR 09, 2023
Microbiology
Aspergillus fumigatus is a common fungus that grows in soil, plant matter, and dust around the world. It can also infect
...
Written By:
Carmen Leitch
MAR 07, 2023
Genetics & Genomics
Antibiotics can destroy many types of bacteria, but increasingly, bacterial pathogens are gaining resistance to many com
...
Written By:
Carmen Leitch
FEB 28, 2023
Clinical & Molecular DX
Though the COVID-19 pandemic has waned, SARS-CoV-2 is still with us, and we still need diagnostic tests. Scientists have
...
Written By:
Carmen Leitch
FEB 27, 2023
Drug Discovery & Development
A new drug shows the potential to treat an exceptionally resilient sexual infection. A case study from the
...
Written By:
Amielle Moreno
FEB 24, 2023
Genetics & Genomics
The earth has a magnetic field, and some animals such as monarch butterflies and turtles can use it to navigate during l
...
Written By:
Carmen Leitch
FEB 24, 2023
Drug Discovery & Development
Traditional chemical disinfectants have adverse effects on both human health and global health.1 Disinfectant sprays suc
...
Written By:
Greta Anne
FEB 14, 2023
Health & Medicine
If this proof-of-concept pans out, a single oral or injection of their inhibitor will block sperm mobility for up to 2.5
...
Written By:
Amielle Moreno
FEB 11, 2023
Microbiology
Two natural products can prevent SARS-CoV-2 from binding to the ACE2 receptor and infecting human cells.
Written By:
Carmen Leitch
FEB 08, 2023
Immunology
The immune system can mount crucial defenses when our bodies are threatened by pathogens. But those defenses have to be
...
Written By:
Carmen Leitch
FEB 06, 2023
Health & Medicine
Kidney failure has a significant impact on public health; about 750,000 Americans and 2 million people around the world
...
Written By:
Carmen Leitch
JAN 30, 2023
Cannabis Sciences
Cannabis has a longstanding history and notoriety for its multi-faceted economic and medicinal uses. Hemp has historical
...
Written By:
Mandy Woods
JAN 30, 2023
Neuroscience
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...
Written By:
Carmen Leitch
JAN 29, 2023
Drug Discovery & Development
Albicidin is a peptide antibiotic that works as a DNA gyrase inhibitor with bactericidal activity towards fluoroquinolon
...
Written By:
Greta Anne
JAN 28, 2023
Drug Discovery & Development
Alzheimer's is a disease that impairs the brain's ability to carry out simple tasks and even causes dementia. De
...
Written By:
Greta Anne
JAN 27, 2023
Cancer
With estimates of over 150,000 new cases and over 50,000 deaths in 2022, colorectal cancer (CRC) remains one of the top
...
Written By:
Katie Kokolus
JAN 23, 2023
Neuroscience
By controling the activity of an enzyme called CHIP, three proteins regulate tau. Now the genes for these three trouble
...
Written By:
Amielle Moreno
JAN 16, 2023
Immunology
Our immune system is built to detect foreign invaders, pathogens, and debris, and eliminate them. So how dies it deal wi
...
Written By:
Carmen Leitch
JAN 16, 2023
Cell & Molecular Biology
For the first time, a signaling pathway that links two species has been revealed - molecules generated when bacteria inf
...
Written By:
Carmen Leitch