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    Tumor Microenvironment

    Tumor Microenvironment: is the cellular environment in which non-cancerous cells are present in the tumor. This environment including surrounding blood vessels, immune cells, fibroblasts, bone marrow-derived inflammatory cells, lymphocytes, signaling molecules and the extracellular matrix .

    Webinars

    • JUN 03, 2020 | 4:00 PM
      Microfluidic precision autostainer for fast multiplexed TSA-based immunofluorescence
      Microfluidic precision autostainer for fast multiplexed TSA-based...
      Multiplex immunofluorescence IHC is a powerful technique to address the increasing research needs in immuno-oncology to better understand the tumor microenvironment. In this webinar, we will...
      Speaker: Alexandre Kehren, M.Sc.
      Presented at: Immuno-Oncology Virtual Event Series 2020
      Sponsored By: Lunaphore
      2
      JUN 03, 2020 | 4:00 PM
      Spatial Mapping of Gene Expression in Tumors using the RNAscopeâ„¢ Technology
      Spatial Mapping of Gene Expression in Tumors using the RNAscopeâ„¢...
      The RNAscope in situ hybridization technology allows high sensitivity, specificity and spatial resolution providing pivotal single-cell gene expression information to gain better insights in...
      Speaker: Anushka Dikshit, PhD
      Presented at: Immuno-Oncology Virtual Event Series 2020
      Sponsored By: Advanced Cell Diagnostics
      0
      JUN 03, 2020 | 2:00 PM
      Dynamic Live Cell Imaging of Adherent and Immune Cells using CellASIC® ONIX2 Microfluidic Platform
      Dynamic Live Cell Imaging of Adherent and Immune Cells using CellASIC®...
      While providing indispensable insight into immune processes, the live cell imaging of immune cells poses unique challenges due to their non-adherent nature. Suspension cells such as immune c...
      Speaker: Jun Park, PhD
      Presented at: Immuno-Oncology Virtual Event Series 2020
      Sponsored By: MilliporeSigma
      1
      JUN 03, 2020 | 12:00 PM
      How multiplexed imaging reveals key insights into the tumor microenvironment to inform treatment and improve outcomes
      How multiplexed imaging reveals key insights into the tumor microenvironment...
      Multiplexed immunofluorescent imaging sheds new light on cancer and other complex conditions. This imaging technique offers a deeper understanding of cells and their surroundings by providin...
      Speaker: Paul Goodwin , Fiona Ginty , Prachi Bogetto
      Presented at: Immuno-Oncology Virtual Event Series 2020
      Sponsored By: Cytiva
      0
      JUN 03, 2020 | 11:00 AM
      Keynote Presentation: Combinatorial Approaches to Immunotherapy: Melanoma as the Example
      Keynote Presentation: Combinatorial Approaches to Immunotherapy:...
      Immune checkpoint blockade has revolutionized the treatment for patients with cancer. Great efforts remain to better understand resistant mechanisms to treatment as well as means to improve...
      Speaker: Stephen Hodi, MD
      Presented at: Immuno-Oncology Virtual Event Series 2020
      1
      JUN 03, 2020 | 8:00 AM
      Keynote Presentation: It is Time for TIME (Tumor Immune Microenvironment) in Experimental and Diagnostic Pathology
      Keynote Presentation: It is Time for TIME (Tumor Immune Microenvironment)...
      Cancer initiation and virulence depends on mechanisms to evade host immunosurveillance and suppression of early invasion and growth. Distinct phenotypes of the immune infiltrates in and arou...
      Speaker: Alexander David Borowsky, MD
      Presented at: Immuno-Oncology Virtual Event Series 2020
      Sponsored By: Leica Biosystems
      1
      JUN 03, 2020 | 6:00 AM
      Keynote Presentation: Development of Rational Immunotherapy Combinations to Overcome the Immunosuppressive Prostate Tumor Microenvironment
      Keynote Presentation: Development of Rational Immunotherapy Combinations...
      Immune checkpoint therapies targeting the CTLA-4 and PD-(L)1 pathways have been largely clinically disappointing for patients with prostate cancer. This can be attributed to the highly immun...
      Speaker: Sumit K. Subudhi, MD, PhD
      Presented at: Immuno-Oncology Virtual Event Series 2020
      1
      JUN 03, 2020 | 12:00 AM
      Deciphering the function of B cells in human cancer
      Deciphering the function of B cells in human cancer
      B cells have recently come into vogue as important contributors to the anti-tumor immune response in cancer patients. Specifically, B cells and the immune structures in which they reside (te...
      Speaker: Tullia C. Bruno, PhD
      Presented at: Immuno-Oncology Virtual Event Series 2020
      3
      JUN 03, 2020 | 12:00 AM
      Overcoming cell therapy barriers in the suppressive tumor microenvironment with engineered proteins
      Overcoming cell therapy barriers in the suppressive tumor microenvironment...
      1. Identify 3 barriers to immune cell response to cancer 2. List 3 approaches to overcome immunosuppressive barriers to bolster the immune response to cancer 3. Explain how fusion proteins c...
      Speaker: Shannon K. Oda, PhD
      Presented at: Immuno-Oncology Virtual Event Series 2020
      1
      JUN 03, 2020 | 12:00 AM
      Define challenges of tissue-based biomarker development for Immuno-Oncology Therapy
      Define challenges of tissue-based biomarker development for Immuno-Oncology...
      Learning Objectives: 1. Define applications of approved and experimental (multiplexing IF) biomarker assessment in Immuno-Oncology 2. Define bottlenecks and areas of improvement to current t...
      Speaker: Houssein Sater, MD
      Presented at: Immuno-Oncology Virtual Event Series 2020
      1
      MAY 27, 2020 | 8:00 AM
      How multiplexed imaging reveals key insights into the tumor microenvironment to inform treatment and improve outcomes
      How multiplexed imaging reveals key insights into the tumor microenvironment...
      DATE: May 27, 2020 TIME: 8:00am PT, 11:00am ET Multiplexed immunofluorescent imaging sheds new light on cancer and other complex conditions. This imaging technique offers a deeper understand...
      Speaker: Paul Goodwin , Fiona Ginty , Prachi Bogetto
      Sponsored By: Cytiva
      18 2
      MAY 20, 2020 | 1:15 PM
      Flotetuzumab, an Investigational CD123 x CD3 Bispecific Dart® Protein-Induced Clustering of CD3+ T Cells & CD123+ AML Cells in Bone Marrow Biopsies Is Associated with Response to Treatment...
      Flotetuzumab, an Investigational CD123 x CD3 Bispecific Dart®...
      Background: Acute myeloid leukemia (AML) is a molecularly and clinically heterogeneous hematological malignancy. Despite recent advancements in the treatment of AML, approximately 50% of pat...
      Speaker: Jan Davidson, MD, PhD
      Presented at: Advancing Science - A Virtual Oncology Conference
      1
      MAY 20, 2020 | 11:15 AM
      Spatial Landscape of the Immune Microenvironment in Metastatic Prostate Cancer using GeoMxâ„¢ Digital Spatial Profiler
      Spatial Landscape of the Immune Microenvironment in Metastatic...
      Metastatic prostate cancer (mPC) is a phenotypically diverse disease with poor responses to immune based therapeutics. Development of immunotherapeutic strategies for mPC is hampered by the...
      Speaker: Peter Nelson, MD
      Presented at: Advancing Science - A Virtual Oncology Conference
      1
      MAY 19, 2020 | 1:45 PM
      Tumor Signaling 360 Panel: A 360° View of Altered Signaling Pathways in Cancer
      Tumor Signaling 360 Panel: A 360° View of Altered Signaling Pathways...
      Targeted therapies for cancer are increasingly being developed as an alternative for, and in addition to, immunotherapy. Altered tumor signaling can be exploited to single-out cancer cells f...
      Speaker: Erin Piazza, PhD
      Presented at: Advancing Science - A Virtual Oncology Conference
      3
      MAY 19, 2020 | 1:15 PM
      Immune Infiltration Influences the Survival of Pancreatic Cancer Patients
      Immune Infiltration Influences the Survival of Pancreatic Cancer...
      Pancreatic Ductal Adenocarcinoma (PDAC) is a highly aggressive disease associated with poor outcome. It is expected to be the leading cause of cancer-related death in 2030. The unique microe...
      Speaker: Dana Mustafa, Ph.D.
      Presented at: Advancing Science - A Virtual Oncology Conference
      1
      MAY 19, 2020 | 1:15 PM
      Spatial Mapping of Gene Expression in Tumors using the RNAscopeâ„¢ Technology
      Spatial Mapping of Gene Expression in Tumors using the RNAscopeâ„¢...
      The RNAscope in situ hybridization technology allows high sensitivity, specificity and spatial resolution providing pivotal single-cell gene expression information to gain better insights in...
      Speaker: Anushka Dikshit, PhD
      Presented at: Advancing Science - A Virtual Oncology Conference
      3
      MAY 19, 2020 | 12:45 PM
      Highly Multiplexed Digital Spatial Profiling of the Tumor Microenvironment of Head and Neck Squamous Cell Carcinoma Patients Treated with Immune Checkpoint Therapy
      Highly Multiplexed Digital Spatial Profiling of the Tumor Microenvironment...
      Immune checkpoint inhibitors (ICI) have shown durable and long-term benefits in a subset of head and neck squamous cell carcinoma (HNSCC) patients. To identify patient-responders from non-re...
      Speaker: Arutha Kulasinghe, PhD
      Presented at: Advancing Science - A Virtual Oncology Conference
      2
      MAY 12, 2020 | 9:00 AM
      Analytical Quality Control for the Pharmaceutical Industry
      Analytical Quality Control for the Pharmaceutical Industry
      NEW DATE: Date: May 12, 2020 Time: 9:00am PDT, 12:00pm EDT...
      Speaker: Joy McElroy
      Sponsored By: Sartorius
      29 9
      APR 29, 2020 | 8:00 AM
      Realize better NGS results through gentle cell sorting
      Realize better NGS results through gentle cell sorting
      Date: April 29, 2020 Time: 8:00AM PDT, 11:00AM EDT Single cell genomics and other next generation sequencing applications depend strongly on adequate upstream sample preparation. Results can...
      Speaker: Quy Nguyen , Felix Eppler, PhD
      Sponsored By: Miltenyi Biotec
      5 1
      APR 23, 2020 | 10:30 AM
      Keynote Presentation: Systematic identification of therapeutic strategies that leverage tumor evolution
      Keynote Presentation: Systematic identification of therapeutic...
      Our laboratory uses tools from pharmacology, genomics, and cell signaling to identify new precision anticancer therapeutic strategies. Under this broad heading, our work involves three key a...
      Speaker: Kris C. Wood, PhD
      Presented at: Genetics Week Virtual Event Series 2020
      1
      APR 21, 2020 | 1:30 PM
      Spatially Resolved Molecular Investigation of Triple Negative Breast Cancer
      Spatially Resolved Molecular Investigation of Triple Negative...
      Triple-negative breast cancer (TNBC) is an aggressive disease that accounts for 10-20% of all breast cancer cases diagnosed annually in the U.S.1. Despite its prevalence, TNBC remains resist...
      Speaker: Dina Finan, PhD , Stephen Williams, PhD
      Presented at: Genetics Week Virtual Event Series 2020
      1
      APR 16, 2020 | 9:00 AM
      Visualize more biomarkers and extract more insights: Moving from single marker IHC to multiplex IF
      Visualize more biomarkers and extract more insights: Moving from...
      DATE: April 16, 2020 TIME: 9:00am PT, 12:00pm ET There is an increasing need to evaluate and understand unique phenotypes and mechanisms of action within the tumor microenvironment. Existing...
      Speaker: Scott Lawrence (M.S., HT(ASCP)) [C] , Katir Patel, PhD
      Sponsored By: Ultivue
      5
      FEB 26, 2020 | 1:30 PM
      Automated cell separation for drug discovery assays
      Automated cell separation for drug discovery assays
      Whether you are performing killing assays, characterizing the tumor microenvironment, or investigating immunogenicity, primary cells are essential for the discovery of new therapeutics. Conc...
      Speaker: Josh Mahlios, PhD
      Presented at: Drug Discovery & Development Virtual Event Series 2020
      Sponsored By: Miltenyi Biotec
      1
      JAN 01, 2020 | 6:00 AM
      Organoids: A Revolutionary New Tool for Drug Screening
      Organoids: A Revolutionary New Tool for Drug Screening
      “The poor translatability of early-stage preclinical models is a major setback in oncology drug development. Immortalized cell lines, that are extensively used in drug screens, undergo...
      Speaker: Rekha Pal, PhD
      Presented at: Drug Discovery & Development Virtual Event Series 2020
      1
    JUN 03, 2020 | 4:00 PM
    Microfluidic precision autostainer for fast multiplexed TSA-based immunofluorescence
    Microfluidic precision autostainer for fast multiplexed TSA-based...
    Multiplex immunofluorescence IHC is a powerful technique to address the increasing research needs in immuno-oncology to better understand the tumor microenvironment. In this webinar, we will...
    Speaker: Alexandre Kehren, M.Sc.
    Presented at: Immuno-Oncology Virtual Event Series 2020
    Sponsored By: Lunaphore
    2
    JUN 03, 2020 | 4:00 PM
    Spatial Mapping of Gene Expression in Tumors using the RNAscopeâ„¢ Technology
    Spatial Mapping of Gene Expression in Tumors using the RNAscopeâ„¢...
    The RNAscope in situ hybridization technology allows high sensitivity, specificity and spatial resolution providing pivotal single-cell gene expression information to gain better insights in...
    Speaker: Anushka Dikshit, PhD
    Presented at: Immuno-Oncology Virtual Event Series 2020
    Sponsored By: Advanced Cell Diagnostics
    0
    JUN 03, 2020 | 2:00 PM
    Dynamic Live Cell Imaging of Adherent and Immune Cells using CellASIC® ONIX2 Microfluidic Platform
    Dynamic Live Cell Imaging of Adherent and Immune Cells using CellASIC®...
    While providing indispensable insight into immune processes, the live cell imaging of immune cells poses unique challenges due to their non-adherent nature. Suspension cells such as immune c...
    Speaker: Jun Park, PhD
    Presented at: Immuno-Oncology Virtual Event Series 2020
    Sponsored By: MilliporeSigma
    1
    JUN 03, 2020 | 12:00 PM
    How multiplexed imaging reveals key insights into the tumor microenvironment to inform treatment and improve outcomes
    How multiplexed imaging reveals key insights into the tumor microenvironment...
    Multiplexed immunofluorescent imaging sheds new light on cancer and other complex conditions. This imaging technique offers a deeper understanding of cells and their surroundings by providin...
    Speaker: Paul Goodwin , Fiona Ginty , Prachi Bogetto
    Presented at: Immuno-Oncology Virtual Event Series 2020
    Sponsored By: Cytiva
    0
    JUN 03, 2020 | 11:00 AM
    Keynote Presentation: Combinatorial Approaches to Immunotherapy: Melanoma as the Example
    Keynote Presentation: Combinatorial Approaches to Immunotherapy:...
    Immune checkpoint blockade has revolutionized the treatment for patients with cancer. Great efforts remain to better understand resistant mechanisms to treatment as well as means to improve...
    Speaker: Stephen Hodi, MD
    Presented at: Immuno-Oncology Virtual Event Series 2020
    1
     
     
  • JUN 03, 2020 | 8:00 AM
    Keynote Presentation: It is Time for TIME (Tumor Immune Microenvironment) in Experimental and Diagnostic Pathology
    Keynote Presentation: It is Time for TIME (Tumor Immune Microenvironment)...
    Cancer initiation and virulence depends on mechanisms to evade host immunosurveillance and suppression of early invasion and growth. Distinct phenotypes of the immune infiltrates in and arou...
    Speaker: Alexander David Borowsky, MD
    Presented at: Immuno-Oncology Virtual Event Series 2020
    Sponsored By: Leica Biosystems
    1
    JUN 03, 2020 | 6:00 AM
    Keynote Presentation: Development of Rational Immunotherapy Combinations to Overcome the Immunosuppressive Prostate Tumor Microenvironment
    Keynote Presentation: Development of Rational Immunotherapy Combinations...
    Immune checkpoint therapies targeting the CTLA-4 and PD-(L)1 pathways have been largely clinically disappointing for patients with prostate cancer. This can be attributed to the highly immun...
    Speaker: Sumit K. Subudhi, MD, PhD
    Presented at: Immuno-Oncology Virtual Event Series 2020
    1
    JUN 03, 2020 | 12:00 AM
    Deciphering the function of B cells in human cancer
    Deciphering the function of B cells in human cancer
    B cells have recently come into vogue as important contributors to the anti-tumor immune response in cancer patients. Specifically, B cells and the immune structures in which they reside (te...
    Speaker: Tullia C. Bruno, PhD
    Presented at: Immuno-Oncology Virtual Event Series 2020
    3
    JUN 03, 2020 | 12:00 AM
    Overcoming cell therapy barriers in the suppressive tumor microenvironment with engineered proteins
    Overcoming cell therapy barriers in the suppressive tumor microenvironment...
    1. Identify 3 barriers to immune cell response to cancer 2. List 3 approaches to overcome immunosuppressive barriers to bolster the immune response to cancer 3. Explain how fusion proteins c...
    Speaker: Shannon K. Oda, PhD
    Presented at: Immuno-Oncology Virtual Event Series 2020
    1
    JUN 03, 2020 | 12:00 AM
    Define challenges of tissue-based biomarker development for Immuno-Oncology Therapy
    Define challenges of tissue-based biomarker development for Immuno-Oncology...
    Learning Objectives: 1. Define applications of approved and experimental (multiplexing IF) biomarker assessment in Immuno-Oncology 2. Define bottlenecks and areas of improvement to current t...
    Speaker: Houssein Sater, MD
    Presented at: Immuno-Oncology Virtual Event Series 2020
    1
     
     
  • MAY 27, 2020 | 8:00 AM
    How multiplexed imaging reveals key insights into the tumor microenvironment to inform treatment and improve outcomes
    How multiplexed imaging reveals key insights into the tumor microenvironment...
    DATE: May 27, 2020 TIME: 8:00am PT, 11:00am ET Multiplexed immunofluorescent imaging sheds new light on cancer and other complex conditions. This imaging technique offers a deeper understand...
    Speaker: Paul Goodwin , Fiona Ginty , Prachi Bogetto
    Sponsored By: Cytiva
    18 2
    MAY 20, 2020 | 1:15 PM
    Flotetuzumab, an Investigational CD123 x CD3 Bispecific Dart® Protein-Induced Clustering of CD3+ T Cells & CD123+ AML Cells in Bone Marrow Biopsies Is Associated with Response to Treatment...
    Flotetuzumab, an Investigational CD123 x CD3 Bispecific Dart®...
    Background: Acute myeloid leukemia (AML) is a molecularly and clinically heterogeneous hematological malignancy. Despite recent advancements in the treatment of AML, approximately 50% of pat...
    Speaker: Jan Davidson, MD, PhD
    Presented at: Advancing Science - A Virtual Oncology Conference
    1
    MAY 20, 2020 | 11:15 AM
    Spatial Landscape of the Immune Microenvironment in Metastatic Prostate Cancer using GeoMxâ„¢ Digital Spatial Profiler
    Spatial Landscape of the Immune Microenvironment in Metastatic...
    Metastatic prostate cancer (mPC) is a phenotypically diverse disease with poor responses to immune based therapeutics. Development of immunotherapeutic strategies for mPC is hampered by the...
    Speaker: Peter Nelson, MD
    Presented at: Advancing Science - A Virtual Oncology Conference
    1
    MAY 19, 2020 | 1:45 PM
    Tumor Signaling 360 Panel: A 360° View of Altered Signaling Pathways in Cancer
    Tumor Signaling 360 Panel: A 360° View of Altered Signaling Pathways...
    Targeted therapies for cancer are increasingly being developed as an alternative for, and in addition to, immunotherapy. Altered tumor signaling can be exploited to single-out cancer cells f...
    Speaker: Erin Piazza, PhD
    Presented at: Advancing Science - A Virtual Oncology Conference
    3
    MAY 19, 2020 | 1:15 PM
    Immune Infiltration Influences the Survival of Pancreatic Cancer Patients
    Immune Infiltration Influences the Survival of Pancreatic Cancer...
    Pancreatic Ductal Adenocarcinoma (PDAC) is a highly aggressive disease associated with poor outcome. It is expected to be the leading cause of cancer-related death in 2030. The unique microe...
    Speaker: Dana Mustafa, Ph.D.
    Presented at: Advancing Science - A Virtual Oncology Conference
    1
     
     
  • MAY 19, 2020 | 1:15 PM
    Spatial Mapping of Gene Expression in Tumors using the RNAscopeâ„¢ Technology
    Spatial Mapping of Gene Expression in Tumors using the RNAscopeâ„¢...
    The RNAscope in situ hybridization technology allows high sensitivity, specificity and spatial resolution providing pivotal single-cell gene expression information to gain better insights in...
    Speaker: Anushka Dikshit, PhD
    Presented at: Advancing Science - A Virtual Oncology Conference
    3
    MAY 19, 2020 | 12:45 PM
    Highly Multiplexed Digital Spatial Profiling of the Tumor Microenvironment of Head and Neck Squamous Cell Carcinoma Patients Treated with Immune Checkpoint Therapy
    Highly Multiplexed Digital Spatial Profiling of the Tumor Microenvironment...
    Immune checkpoint inhibitors (ICI) have shown durable and long-term benefits in a subset of head and neck squamous cell carcinoma (HNSCC) patients. To identify patient-responders from non-re...
    Speaker: Arutha Kulasinghe, PhD
    Presented at: Advancing Science - A Virtual Oncology Conference
    2
    MAY 12, 2020 | 9:00 AM
    Analytical Quality Control for the Pharmaceutical Industry
    Analytical Quality Control for the Pharmaceutical Industry
    NEW DATE: Date: May 12, 2020 Time: 9:00am PDT, 12:00pm EDT...
    Speaker: Joy McElroy
    Sponsored By: Sartorius
    29 9
    APR 29, 2020 | 8:00 AM
    Realize better NGS results through gentle cell sorting
    Realize better NGS results through gentle cell sorting
    Date: April 29, 2020 Time: 8:00AM PDT, 11:00AM EDT Single cell genomics and other next generation sequencing applications depend strongly on adequate upstream sample preparation. Results can...
    Speaker: Quy Nguyen , Felix Eppler, PhD
    Sponsored By: Miltenyi Biotec
    5 1
    APR 23, 2020 | 10:30 AM
    Keynote Presentation: Systematic identification of therapeutic strategies that leverage tumor evolution
    Keynote Presentation: Systematic identification of therapeutic...
    Our laboratory uses tools from pharmacology, genomics, and cell signaling to identify new precision anticancer therapeutic strategies. Under this broad heading, our work involves three key a...
    Speaker: Kris C. Wood, PhD
    Presented at: Genetics Week Virtual Event Series 2020
    1
     
     
  • APR 21, 2020 | 1:30 PM
    Spatially Resolved Molecular Investigation of Triple Negative Breast Cancer
    Spatially Resolved Molecular Investigation of Triple Negative...
    Triple-negative breast cancer (TNBC) is an aggressive disease that accounts for 10-20% of all breast cancer cases diagnosed annually in the U.S.1. Despite its prevalence, TNBC remains resist...
    Speaker: Dina Finan, PhD , Stephen Williams, PhD
    Presented at: Genetics Week Virtual Event Series 2020
    1
    APR 16, 2020 | 9:00 AM
    Visualize more biomarkers and extract more insights: Moving from single marker IHC to multiplex IF
    Visualize more biomarkers and extract more insights: Moving from...
    DATE: April 16, 2020 TIME: 9:00am PT, 12:00pm ET There is an increasing need to evaluate and understand unique phenotypes and mechanisms of action within the tumor microenvironment. Existing...
    Speaker: Scott Lawrence (M.S., HT(ASCP)) [C] , Katir Patel, PhD
    Sponsored By: Ultivue
    5
    FEB 26, 2020 | 1:30 PM
    Automated cell separation for drug discovery assays
    Automated cell separation for drug discovery assays
    Whether you are performing killing assays, characterizing the tumor microenvironment, or investigating immunogenicity, primary cells are essential for the discovery of new therapeutics. Conc...
    Speaker: Josh Mahlios, PhD
    Presented at: Drug Discovery & Development Virtual Event Series 2020
    Sponsored By: Miltenyi Biotec
    1
    JAN 01, 2020 | 6:00 AM
    Organoids: A Revolutionary New Tool for Drug Screening
    Organoids: A Revolutionary New Tool for Drug Screening
    “The poor translatability of early-stage preclinical models is a major setback in oncology drug development. Immortalized cell lines, that are extensively used in drug screens, undergo...
    Speaker: Rekha Pal, PhD
    Presented at: Drug Discovery & Development Virtual Event Series 2020
    1
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