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    Cancer Molecular Biology

    Molecular biology plays an important role in the diagnosis and treatment of cancer. On a biological level, the development of cancer is characterized by the acquisition of genetic mutations which cause abnormal cell growth, eventually resulting in malignant disease. Understanding how molecular damage can cause these cancer-driving mutations can help design optimal treatment regimens

    Webinars

    • FEB 27, 2019 | 7:30 AM
      Keynote Presentation: Second Harmonic Generation Detection of Ras Conformational Changes and Discovery of a Novel Small-Molecule Binder
      Keynote Presentation: Second Harmonic Generation Detection of...
      Second harmonic generation (SHG) is a biophysical method that sensitively measures real-time conformational change of biomolecules attached to membranes. SHG has recently been applied to dete...
      Speaker: Frank McCormick, PhD
      Presented at: Drug Discovery Virtual Event Series 2019
      1
      FEB 14, 2019 | 7:30 AM
      Keynote Presentation: A Comparative Approach to Oncology Drug Development: Integrating Canine Models
      Keynote Presentation: A Comparative Approach to Oncology Drug...
      Comparative oncology is the study of naturally-occurring cancers in pet animals (mainly dogs) to broaden and deepen our collective understanding of cancers in both companion species and human...
      Speaker: Amy LeBlanc, DVM DACVIM
      Presented at: Laboratory Animal Sciences Virtual Event Series 2019
      2
      FEB 14, 2019 | 6:00 AM
      The NIH Microphysiological Systems Program
      The NIH Microphysiological Systems Program
      Approximately 30% of drugs have failed in human clinical trials due to adverse reactions despite promising pre-clinical studies, and another 60% fail due to lack of efficacy. The NIH Tissue C...
      Speaker: Danilo Tagle, PhD, M.S.
      Presented at: Laboratory Animal Sciences Virtual Event Series 2019
      2
      FEB 05, 2019 | 9:00 AM
      Complimentary Webinar: Data Privacy and Other Clinical Data Management Challenges
      Complimentary Webinar: Data Privacy and Other Clinical Data Management...
      DATE:  February 5, 2019TIME:  9:00am PST, 12:00pm EST CloudLIMS.com is pleased to invite you to attend a complimentary webinar. The webinar focuses on the importa...
      Speaker: Marianne Henderson
      Sponsored By: CloudLIMS
      9
      DEC 10, 2018 | 10:00 PM
      Better Data, Fewer Mice: micro-CT Imaging Breathes New Life into your Lung Research
      Better Data, Fewer Mice: micro-CT Imaging Breathes New Life into...
      DATE: December 11, 2018TIME: 06:00 PSTIt’s understood and accepted that animal disease models generally offer great value for pre-clinical research and efficient drug screeni...
      Speaker: Dr. Christian Dullin , Dr. Sasha (Alexandre) Belenkov , Dr. Francesca Ruscitti
      Sponsored By: Revvity
      4 1
      NOV 28, 2018 | 7:00 AM
      Discover how single-cell RNA sequencing provides deeper insights into lung cancer biology
      Discover how single-cell RNA sequencing provides deeper insights...
      DATE: November 28, 2018TIME:  7:00AM PSTSingle-cell genomics enables a deep dive into the mechanisms responsible for health and disease, in areas from cancer biology to neurob...
      Speaker: Bernard Thienpont , Annika Branting , Pawel Zajac, Ph.D.
      Sponsored By: Illumina, 10x Genomics
      5
      NOV 20, 2018 | 7:00 AM
      COLD-PCR technology: current status and application in liquid biopsies for cancer and prenatal diagnosis
      COLD-PCR technology: current status and application in liquid...
      DATE: November 20, 2018TIME: 07:00 PSTSince its original development (2008) COLD-PCR has been used by several groups for increasing the sensitivity of mutation detection in di...
      Speaker: Mike Makrigiorgos, PhD
      Sponsored By: Revvity
      5
      NOV 15, 2018 | 12:00 PM
      Better Knowledge, Better Care: Precision Medicine for Any Cancer, Any Assay, on Your Platform
      Better Knowledge, Better Care: Precision Medicine for Any Cancer,...
      QIAGEN helps your team focus on the opportunities, not the obstacles, with an end-to-end clinical testing solution. During this talk, we will present a lung cancer case study to show how QIAG...
      Speaker: Raed Samara, PhD , Dan Richards, PhD
      Presented at: Clinical Diagnostics & Research Virtual Event Series 2018
      Sponsored By: QIAGEN
      2
      NOV 15, 2018 | 10:30 AM
      Cervical Cancer: Everlasting World Health Challenge
      Cervical Cancer: Everlasting World Health Challenge
      The main problem for insufficient cervical cancer screening globally (less than 20% women at risk) is outreach failure. Enabling POCs with modern IT/mobile technology and connecting them with...
      Speaker: Olivera Markovic, MD, PhD
      Presented at: Clinical Diagnostics & Research Virtual Event Series 2018
      1
      NOV 15, 2018 | 10:00 AM
      Multiplex fluorescence immunohistochemistry using the Ultivue InSituPlex platform on the Leica Biosystems BOND RX
      Multiplex fluorescence immunohistochemistry using the Ultivue...
      DATE:  November 15, 2018TIME:  10:00am PT, 1:00pm ET Multiplex fluorescence immunohistochemistry offers a window into the biology of human disease, enabling the ana...
      Speaker: Traci DeGeer, BS, HT (ASCP) HTL, QIHC , Alexander Klimowicz
      Sponsored By: Leica Biosystems
      6 1
      NOV 15, 2018 | 7:00 AM
      Use of stem-cell derived endothelial cells for disease relevant cell modeling and drug discovery
      Use of stem-cell derived endothelial cells for disease relevant...
      The use of human pluripotent stem cells (hPSCs) for in vitro disease-modeling is limited by the lack of robust and efficient protocols for the differentiation of relevant adult cell types. Pr...
      Speaker: Filip Roudnicky
      Presented at: 6th annual 24 Hours of Stem Cellsâ„¢ virtual event
      8
      NOV 14, 2018 | 9:00 AM
      Accelerating Cancer Research and Clinical Innovations Using OncoLand
      Accelerating Cancer Research and Clinical Innovations Using OncoLand
      With significant decrease in the cost of sequencing in numerous commercial as well as cancer center–driven initiatives, genomic profiling is increasingly becoming routine across multipl...
      Speaker: Bing Zhou, PhD
      Presented at: Clinical Diagnostics & Research Virtual Event Series 2018
      Sponsored By: QIAGEN
      1
      OCT 30, 2018 | 10:00 AM
      Post-translational Modifications and Data-Independent Acquisitions - Challenges and Opportunities
      Post-translational Modifications and Data-Independent Acquisitions...
      DATE: October 30, 2018TIME: 10:00am PT, 1:00pm ET Identification and quantification of post-translational modifications (PTM) presents a unique challenge to proteomic studies...
      Speaker: Birgit Schilling, PhD , Matthew Stokes, PhD
      Sponsored By: Cell Signaling Technology
      5
      OCT 30, 2018 | 9:00 AM
      Practical Considerations in the Design of Bottom-Up Mass Spectrometry Based Proteomics Methods
      Practical Considerations in the Design of Bottom-Up Mass Spectrometry...
      DATE: October 30, 2018TIME:  9:00AM PSTMass spectrometry-based proteomics is a rapidly growing area of research that provides useful information for many fields including basi...
      Speaker: Sandra Spencer - Ph.D. Analytical Chemistry, BS Chemistry, minor Mathematics, BS Biochemistry, minor Spanish
      3
      OCT 23, 2018 | 9:00 AM
      Chicago® and Dovetail™ Hi-C yield chromosome length scaffolds of the Ixodes scapularis genome
      Chicago® and Dovetail™ Hi-C yield chromosome length scaffolds...
      DATE: October 23, 2018TIME: 9:00AM PDTIxodes scapularis is the principal vector of the Lyme disease spirochete, Borrelia burgdorferi. I. scapularis genome was the first and only...
      Speaker: Monika Gulia-Nuss
      Sponsored By: Dovetail Genomics
      5
      OCT 23, 2018 | 7:00 AM
      FLIPR 1536-well application in high throughput screening
      FLIPR 1536-well application in high throughput screening
      DATE: October 23, 2018TIME: 7:00AM PDTHigh Throughput Screening for the European Lead Factory (ELF) has been performed at Pivot Park Screening Centre (PPSC). 72 HTS campaigns have...
      Speaker: Helma Van Den Hurk, PhD , Tsang Wai Lam, BSc
      Sponsored By: Molecular Devices
      4
      OCT 11, 2018 | 1:30 PM
      Exploiting Cis-Regulatory Enhancers as Therapeutic Targets in Cancer
      Exploiting Cis-Regulatory Enhancers as Therapeutic Targets in...
      Recent work has identified epigenomic features of distal regulatory elements to be dynamic and defining indicators of cellular specification and transformation. Of particular relevance is our...
      Speaker: Martin Hirst, PhD
      Presented at: Cancer Research & Oncology Week Virtual Event Series 2018
      1
      OCT 11, 2018 | 1:30 PM
      Breast Cancer as a Global Disease: Are We Up to The Challenge?
      Breast Cancer as a Global Disease: Are We Up to The Challenge?
      As the most common female malignancy, breast cancer is the most likely reason that a woman will die of cancer around the world. Breast cancer mortality has dropped in the U.S. by 35% since 19...
      Speaker: Benjamin Anderson, MD
      Presented at: Cancer Research & Oncology Week Virtual Event Series 2018
      3
      OCT 11, 2018 | 12:00 PM
      Lung Cancer Evolution and Immune Escape
      Lung Cancer Evolution and Immune Escape
      Lung cancer is the leading cause of cancer-related mortality worldwide. Large-scale sequencing studies have revealed the complex genomic landscape of NSCLC and genomic differences between lun...
      Speaker: Nicholas McGranahan, PhD
      Presented at: Cancer Research & Oncology Week Virtual Event Series 2018
      1
      OCT 11, 2018 | 12:00 PM
      Aurora Kinase A Drives The Evolution of Resistance to Third Generation EGFR Inhibitors in Lung Cancer
      Aurora Kinase A Drives The Evolution of Resistance to Third Generation...
      Although targeted therapies often elicit profound initial patient responses, these effects are transient due to residual disease leading to acquired resistance. How tumors transition between...
      Speaker: Khyati Shah, PhD
      Presented at: Cancer Research & Oncology Week Virtual Event Series 2018
      1
      OCT 11, 2018 | 10:30 AM
      Drug Targeting for Inflammatory Breast Cancer
      Drug Targeting for Inflammatory Breast Cancer
      Two projects looking at novel approaches to targeting inflammatory breast cancer will be presented. Inflammatory breast cancer (IBC) is a unique, understudied, and most lethal subtype account...
      Speaker: Kevin Williams, PhD
      Presented at: Cancer Research & Oncology Week Virtual Event Series 2018
      2
      OCT 11, 2018 | 10:30 AM
      Validating and Publishing with Antibodies- How to Avoid Reviewer's Challenges
      Validating and Publishing with Antibodies- How to Avoid Reviewer's...
      Antibodies are extremely valuable and ubiquitous tools in life science research, but in spite of their widespread use in immunoassays over the past several decades, there is still a lack of u...
      Speaker: Chandra Mohan, PhD
      Presented at: Cancer Research & Oncology Week Virtual Event Series 2018
      Sponsored By: MilliporeSigma
      1
      OCT 11, 2018 | 9:00 AM
      Discovering Cellular Mechanisms and Markers in Anti-PD1 Non-Responders Through Ingenuity Pathway Analysis and Oncoland
      Discovering Cellular Mechanisms and Markers in Anti-PD1 Non-Responders...
      In the last two decades, large amount of next-generation sequencing (NGS) and -omics data has been generated in the field of immuno-oncology. Generating hypotheses by analyzing hundreds if no...
      Speaker: Devendra Mistry, PhD
      Presented at: Cancer Research & Oncology Week Virtual Event Series 2018
      Sponsored By: QIAGEN
      1
      OCT 11, 2018 | 9:00 AM
      Destabilization and Degradation of MYC: More Ways Than One
      Destabilization and Degradation of MYC: More Ways Than One
      The oncogenic transcription factor c-MYC (MYC) is deregulated, and often overexpressed, in more than 50% of cancers. MYC deregulation is associated with poor prognosis and aggressive disease,...
      Speaker: Jason De Melo, PhD
      Presented at: Cancer Research & Oncology Week Virtual Event Series 2018
      1
    FEB 27, 2019 | 7:30 AM
    Keynote Presentation: Second Harmonic Generation Detection of Ras Conformational Changes and Discovery of a Novel Small-Molecule Binder
    Keynote Presentation: Second Harmonic Generation Detection of...
    Second harmonic generation (SHG) is a biophysical method that sensitively measures real-time conformational change of biomolecules attached to membranes. SHG has recently been applied to dete...
    Speaker: Frank McCormick, PhD
    Presented at: Drug Discovery Virtual Event Series 2019
    1
    FEB 14, 2019 | 7:30 AM
    Keynote Presentation: A Comparative Approach to Oncology Drug Development: Integrating Canine Models
    Keynote Presentation: A Comparative Approach to Oncology Drug...
    Comparative oncology is the study of naturally-occurring cancers in pet animals (mainly dogs) to broaden and deepen our collective understanding of cancers in both companion species and human...
    Speaker: Amy LeBlanc, DVM DACVIM
    Presented at: Laboratory Animal Sciences Virtual Event Series 2019
    2
    FEB 14, 2019 | 6:00 AM
    The NIH Microphysiological Systems Program
    The NIH Microphysiological Systems Program
    Approximately 30% of drugs have failed in human clinical trials due to adverse reactions despite promising pre-clinical studies, and another 60% fail due to lack of efficacy. The NIH Tissue C...
    Speaker: Danilo Tagle, PhD, M.S.
    Presented at: Laboratory Animal Sciences Virtual Event Series 2019
    2
    FEB 05, 2019 | 9:00 AM
    Complimentary Webinar: Data Privacy and Other Clinical Data Management Challenges
    Complimentary Webinar: Data Privacy and Other Clinical Data Management...
    DATE:  February 5, 2019TIME:  9:00am PST, 12:00pm EST CloudLIMS.com is pleased to invite you to attend a complimentary webinar. The webinar focuses on the importa...
    Speaker: Marianne Henderson
    Sponsored By: CloudLIMS
    9
    DEC 10, 2018 | 10:00 PM
    Better Data, Fewer Mice: micro-CT Imaging Breathes New Life into your Lung Research
    Better Data, Fewer Mice: micro-CT Imaging Breathes New Life into...
    DATE: December 11, 2018TIME: 06:00 PSTIt’s understood and accepted that animal disease models generally offer great value for pre-clinical research and efficient drug screeni...
    Speaker: Dr. Christian Dullin , Dr. Sasha (Alexandre) Belenkov , Dr. Francesca Ruscitti
    Sponsored By: Revvity
    4 1
     
     
  • NOV 28, 2018 | 7:00 AM
    Discover how single-cell RNA sequencing provides deeper insights into lung cancer biology
    Discover how single-cell RNA sequencing provides deeper insights...
    DATE: November 28, 2018TIME:  7:00AM PSTSingle-cell genomics enables a deep dive into the mechanisms responsible for health and disease, in areas from cancer biology to neurob...
    Speaker: Bernard Thienpont , Annika Branting , Pawel Zajac, Ph.D.
    Sponsored By: Illumina, 10x Genomics
    5
    NOV 20, 2018 | 7:00 AM
    COLD-PCR technology: current status and application in liquid biopsies for cancer and prenatal diagnosis
    COLD-PCR technology: current status and application in liquid...
    DATE: November 20, 2018TIME: 07:00 PSTSince its original development (2008) COLD-PCR has been used by several groups for increasing the sensitivity of mutation detection in di...
    Speaker: Mike Makrigiorgos, PhD
    Sponsored By: Revvity
    5
    NOV 15, 2018 | 12:00 PM
    Better Knowledge, Better Care: Precision Medicine for Any Cancer, Any Assay, on Your Platform
    Better Knowledge, Better Care: Precision Medicine for Any Cancer,...
    QIAGEN helps your team focus on the opportunities, not the obstacles, with an end-to-end clinical testing solution. During this talk, we will present a lung cancer case study to show how QIAG...
    Speaker: Raed Samara, PhD , Dan Richards, PhD
    Presented at: Clinical Diagnostics & Research Virtual Event Series 2018
    Sponsored By: QIAGEN
    2
    NOV 15, 2018 | 10:30 AM
    Cervical Cancer: Everlasting World Health Challenge
    Cervical Cancer: Everlasting World Health Challenge
    The main problem for insufficient cervical cancer screening globally (less than 20% women at risk) is outreach failure. Enabling POCs with modern IT/mobile technology and connecting them with...
    Speaker: Olivera Markovic, MD, PhD
    Presented at: Clinical Diagnostics & Research Virtual Event Series 2018
    1
    NOV 15, 2018 | 10:00 AM
    Multiplex fluorescence immunohistochemistry using the Ultivue InSituPlex platform on the Leica Biosystems BOND RX
    Multiplex fluorescence immunohistochemistry using the Ultivue...
    DATE:  November 15, 2018TIME:  10:00am PT, 1:00pm ET Multiplex fluorescence immunohistochemistry offers a window into the biology of human disease, enabling the ana...
    Speaker: Traci DeGeer, BS, HT (ASCP) HTL, QIHC , Alexander Klimowicz
    Sponsored By: Leica Biosystems
    6 1
     
     
  • NOV 15, 2018 | 7:00 AM
    Use of stem-cell derived endothelial cells for disease relevant cell modeling and drug discovery
    Use of stem-cell derived endothelial cells for disease relevant...
    The use of human pluripotent stem cells (hPSCs) for in vitro disease-modeling is limited by the lack of robust and efficient protocols for the differentiation of relevant adult cell types. Pr...
    Speaker: Filip Roudnicky
    Presented at: 6th annual 24 Hours of Stem Cellsâ„¢ virtual event
    8
    NOV 14, 2018 | 9:00 AM
    Accelerating Cancer Research and Clinical Innovations Using OncoLand
    Accelerating Cancer Research and Clinical Innovations Using OncoLand
    With significant decrease in the cost of sequencing in numerous commercial as well as cancer center–driven initiatives, genomic profiling is increasingly becoming routine across multipl...
    Speaker: Bing Zhou, PhD
    Presented at: Clinical Diagnostics & Research Virtual Event Series 2018
    Sponsored By: QIAGEN
    1
    OCT 30, 2018 | 10:00 AM
    Post-translational Modifications and Data-Independent Acquisitions - Challenges and Opportunities
    Post-translational Modifications and Data-Independent Acquisitions...
    DATE: October 30, 2018TIME: 10:00am PT, 1:00pm ET Identification and quantification of post-translational modifications (PTM) presents a unique challenge to proteomic studies...
    Speaker: Birgit Schilling, PhD , Matthew Stokes, PhD
    Sponsored By: Cell Signaling Technology
    5
    OCT 30, 2018 | 9:00 AM
    Practical Considerations in the Design of Bottom-Up Mass Spectrometry Based Proteomics Methods
    Practical Considerations in the Design of Bottom-Up Mass Spectrometry...
    DATE: October 30, 2018TIME:  9:00AM PSTMass spectrometry-based proteomics is a rapidly growing area of research that provides useful information for many fields including basi...
    Speaker: Sandra Spencer - Ph.D. Analytical Chemistry, BS Chemistry, minor Mathematics, BS Biochemistry, minor Spanish
    3
    OCT 23, 2018 | 9:00 AM
    Chicago® and Dovetail™ Hi-C yield chromosome length scaffolds of the Ixodes scapularis genome
    Chicago® and Dovetail™ Hi-C yield chromosome length scaffolds...
    DATE: October 23, 2018TIME: 9:00AM PDTIxodes scapularis is the principal vector of the Lyme disease spirochete, Borrelia burgdorferi. I. scapularis genome was the first and only...
    Speaker: Monika Gulia-Nuss
    Sponsored By: Dovetail Genomics
    5
     
     
  • OCT 23, 2018 | 7:00 AM
    FLIPR 1536-well application in high throughput screening
    FLIPR 1536-well application in high throughput screening
    DATE: October 23, 2018TIME: 7:00AM PDTHigh Throughput Screening for the European Lead Factory (ELF) has been performed at Pivot Park Screening Centre (PPSC). 72 HTS campaigns have...
    Speaker: Helma Van Den Hurk, PhD , Tsang Wai Lam, BSc
    Sponsored By: Molecular Devices
    4
    OCT 11, 2018 | 1:30 PM
    Exploiting Cis-Regulatory Enhancers as Therapeutic Targets in Cancer
    Exploiting Cis-Regulatory Enhancers as Therapeutic Targets in...
    Recent work has identified epigenomic features of distal regulatory elements to be dynamic and defining indicators of cellular specification and transformation. Of particular relevance is our...
    Speaker: Martin Hirst, PhD
    Presented at: Cancer Research & Oncology Week Virtual Event Series 2018
    1
    OCT 11, 2018 | 1:30 PM
    Breast Cancer as a Global Disease: Are We Up to The Challenge?
    Breast Cancer as a Global Disease: Are We Up to The Challenge?
    As the most common female malignancy, breast cancer is the most likely reason that a woman will die of cancer around the world. Breast cancer mortality has dropped in the U.S. by 35% since 19...
    Speaker: Benjamin Anderson, MD
    Presented at: Cancer Research & Oncology Week Virtual Event Series 2018
    3
    OCT 11, 2018 | 12:00 PM
    Lung Cancer Evolution and Immune Escape
    Lung Cancer Evolution and Immune Escape
    Lung cancer is the leading cause of cancer-related mortality worldwide. Large-scale sequencing studies have revealed the complex genomic landscape of NSCLC and genomic differences between lun...
    Speaker: Nicholas McGranahan, PhD
    Presented at: Cancer Research & Oncology Week Virtual Event Series 2018
    1
    OCT 11, 2018 | 12:00 PM
    Aurora Kinase A Drives The Evolution of Resistance to Third Generation EGFR Inhibitors in Lung Cancer
    Aurora Kinase A Drives The Evolution of Resistance to Third Generation...
    Although targeted therapies often elicit profound initial patient responses, these effects are transient due to residual disease leading to acquired resistance. How tumors transition between...
    Speaker: Khyati Shah, PhD
    Presented at: Cancer Research & Oncology Week Virtual Event Series 2018
    1
     
     
  • OCT 11, 2018 | 10:30 AM
    Drug Targeting for Inflammatory Breast Cancer
    Drug Targeting for Inflammatory Breast Cancer
    Two projects looking at novel approaches to targeting inflammatory breast cancer will be presented. Inflammatory breast cancer (IBC) is a unique, understudied, and most lethal subtype account...
    Speaker: Kevin Williams, PhD
    Presented at: Cancer Research & Oncology Week Virtual Event Series 2018
    2
    OCT 11, 2018 | 10:30 AM
    Validating and Publishing with Antibodies- How to Avoid Reviewer's Challenges
    Validating and Publishing with Antibodies- How to Avoid Reviewer's...
    Antibodies are extremely valuable and ubiquitous tools in life science research, but in spite of their widespread use in immunoassays over the past several decades, there is still a lack of u...
    Speaker: Chandra Mohan, PhD
    Presented at: Cancer Research & Oncology Week Virtual Event Series 2018
    Sponsored By: MilliporeSigma
    1
    OCT 11, 2018 | 9:00 AM
    Discovering Cellular Mechanisms and Markers in Anti-PD1 Non-Responders Through Ingenuity Pathway Analysis and Oncoland
    Discovering Cellular Mechanisms and Markers in Anti-PD1 Non-Responders...
    In the last two decades, large amount of next-generation sequencing (NGS) and -omics data has been generated in the field of immuno-oncology. Generating hypotheses by analyzing hundreds if no...
    Speaker: Devendra Mistry, PhD
    Presented at: Cancer Research & Oncology Week Virtual Event Series 2018
    Sponsored By: QIAGEN
    1
    OCT 11, 2018 | 9:00 AM
    Destabilization and Degradation of MYC: More Ways Than One
    Destabilization and Degradation of MYC: More Ways Than One
    The oncogenic transcription factor c-MYC (MYC) is deregulated, and often overexpressed, in more than 50% of cancers. MYC deregulation is associated with poor prognosis and aggressive disease,...
    Speaker: Jason De Melo, PhD
    Presented at: Cancer Research & Oncology Week Virtual Event Series 2018
    1
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