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    Follow

    Epigenome

    The epigenome is a term used to describe all the molecular modifications on DNA within a single cell. Epigenetic markers vary between cell types. The epigenome does not alter the DNA sequence but influences the way cells use genetic information contained in the DNA.

    Webinars

    • FEB 26, 2020 | 9:00 AM
      CRISPR Based Screening: Advantages of Transcriptional Activators and Inhibitors
      CRISPR Based Screening: Advantages of Transcriptional Activators...
      CRISPR revolutionized gene editing, but multi-target screening remains a complex goal. In addition, the fast pace of CRISPR technology development has brought sophisticated options for libra...
      Speaker: Andrew Ravanelli, PhD
      Presented at: Drug Discovery & Development Virtual Event Series 2020
      Sponsored By: MilliporeSigma
      2 1
      OCT 30, 2019 | 7:00 AM
      A Novel Approach for Single-cell Multi-omic Analysis to Identify Regulatory Signatures in Cancer
      A Novel Approach for Single-cell Multi-omic Analysis to Identify...
      DATE: October 30, 2019TIME: 7:00am PDTJoin us for a webinar to learn how to apply single cell methods to study cancer. Dr. William Greenleaf, Associate Professor from Stanford Universit...
      Speaker: William J. Greenleaf, Ph.D
      Sponsored By: 10x Genomics
      18 1
      OCT 10, 2019 | 6:00 AM
      Highly-efficient and -specific genome editing with Cas9 nickase ribonucleoproteins in Primary T-cells
      Highly-efficient and -specific genome editing with Cas9 nickase...
      In this webinar, we will be discussing some of our most recent testing using our Cas9 proteins, Cas9 RNP nickases in a variety of human cell types, including primary T-cells. Cas nucleases wh...
      Speaker: Jacob Lamberth
      Presented at: Cancer Research & Oncology Week Virtual Event Series 2019
      Sponsored By: MilliporeSigma
      1
      AUG 14, 2019 | 8:00 AM
      The Metagenomics of Dozens of Earth's Cities and One Space Station
      The Metagenomics of Dozens of Earth's Cities and One Space Station
      DATE: August 14, 2019TIME: 8:00am PDT Infectious disease surveillance and monitoring is critical in settings where disease outbreaks and antibiotic resistance can dramatically im...
      Speaker: Dr. Christopher Mason
      Sponsored By: Zymo Research
      2
      JUN 19, 2019 | 8:00 AM
      Exploring the genetic landscape of solid tumors using whole-genome copy number analysis
      Exploring the genetic landscape of solid tumors using whole-genome...
      DATE: June 19, 2019TIME: 8:00am PDT, 11:00am EDT Approximately 80% of all cancers are known to be affected by both somatic mutations and copy number changes. Furthermore, r...
      Speaker: Ravindra Kolhe, MD, PhD , Joanna Przybyl, PhD
      Sponsored By: Thermo Fisher Scientific - Applied Biosystems
      4
      MAY 08, 2019 | 6:00 AM
      C.E. CREDITS
      Novel DNA Methylation in Mammals
      Novel DNA Methylation in Mammals
      Genetic drivers of cancer can be dysregulated through epigenetic modifications of DNA. Although the critical role of DNA 5-methylcytosine (5mC) in the regulation of transcription is recognize...
      Speaker: Tao Wu, PhD
      Presented at: Genetics and Genomics Virtual Event Series 2019
      2
      NOV 28, 2018 | 7:00 AM
      Discover how single-cell RNA sequencing provides deeper insights into lung cancer biology
      Discover how single-cell RNA sequencing provides deeper insights...
      DATE: November 28, 2018TIME:  7:00AM PSTSingle-cell genomics enables a deep dive into the mechanisms responsible for health and disease, in areas from cancer biology to neurob...
      Speaker: Bernard Thienpont , Annika Branting , Pawel Zajac, Ph.D.
      Sponsored By: Illumina, 10x Genomics
      5
      OCT 11, 2018 | 1:30 PM
      Exploiting Cis-Regulatory Enhancers as Therapeutic Targets in Cancer
      Exploiting Cis-Regulatory Enhancers as Therapeutic Targets in...
      Recent work has identified epigenomic features of distal regulatory elements to be dynamic and defining indicators of cellular specification and transformation. Of particular relevance is our...
      Speaker: Martin Hirst, PhD
      Presented at: Cancer Research & Oncology Week Virtual Event Series 2018
      1
      OCT 10, 2018 | 9:00 AM
      Understanding Cancer Through Whole-Genome Screening
      Understanding Cancer Through Whole-Genome Screening
      High-throughput screening is widely useful in identifying genes and pathways that drive changes in cell behavior such as cell cycle regulation, metastasis, and drug resistance.  Millipor...
      Speaker: Andrew Ravanelli, PhD
      Presented at: Cancer Research & Oncology Week Virtual Event Series 2018
      Sponsored By: MilliporeSigma
      5
      SEP 13, 2018 | 1:30 PM
      New PacBio Solutions for High-Resolution Microbiology & Immunology Analysis
      New PacBio Solutions for High-Resolution Microbiology & Immunology...
      PacBio Sequencing has been recognized as the gold standard in microbial sequencing due to simultaneously providing long sequence reads (genome contiguity), high consensus accuracy (genome acc...
      Speaker: Jonas Korlach, PhD
      Presented at: Microbiology & Immunology Virtual Event Series 2018
      Sponsored By: PacBio
      1
      MAY 09, 2018 | 12:00 PM
      Knowledge Portals: Accelerating Action from Genetic Data
      Knowledge Portals: Accelerating Action from Genetic Data
      The Type 2 Diabetes Knowledge Portal is an open-access resource for human genetic information on type 2 diabetes (T2D). It is a central repository for data from large genomic studies that ide...
      Speaker: Noel Burtt
      Presented at: Genetics and Genomics Virtual Event Series 2018
      2
      JAN 30, 2018 | 9:00 AM
      WEBINAR: Metagenomics and base modifications from long, short, and linked-reads
      WEBINAR: Metagenomics and base modifications from long, short,...
      DATE: January 30, 2018TIME: 9:00AM PST, 12:00PM ESTInfectious disease surveillance and monitoring is critical in settings where disease outbreaks and antibiotic resistance can dramatica...
      Speaker: Christopher Mason, PhD , Shuiquan Tang, PhD
      Sponsored By: Zymo Research
      6 1
      OCT 11, 2017 | 12:00 PM
      Examining Cancer with the minION: Methylation and Structural Variation
      Examining Cancer with the minION: Methylation and Structural Variation
      Nanopore sequencing has enormous potential for application to cancer, but specifically offers advantages into two main arenas, epigenetics and structural variation. Methylation is well-known...
      Speaker: Winston Timp, PhD
      Presented at: Cancer Research & Oncology Week Virtual Event Series 2017
      Sponsored By: Oxford Nanopore Technologies
      1
      APR 13, 2017 | 9:00 AM
      Keynote Presentation - DNA Standards and Bioinformatics Benchmarks for Metagenomics
      Keynote Presentation - DNA Standards and Bioinformatics Benchmarks...
      Genomics and metagenomics have become ubiquitous research efforts.  Here we will show details of the development of physical, computational, and even space-based standards for metagenomi...
      Speaker: Christopher Mason, PhD
      Presented at: Molecular Diagnostics Virtual Event Series 2017
      2
      MAY 12, 2016 | 10:30 AM
      DNA methylation analysis by multiplexed reduced representation bisulfite sequencing
      DNA methylation analysis by multiplexed reduced representation...
      DNA methylation is an essential mechanism of epigenetic gene regulation with broad relevance in development and disease. Its localization on genomic DNA and general stability make this epigen...
      Speaker: Paul Datlinger
      Presented at: Genetics and Genomics Virtual Event Series 2016
      2
      APR 11, 2016 | 9:00 AM
      WEBINAR: The epigenome in normal human placental development and its dysregulation in preeclampsia
      WEBINAR: The epigenome in normal human placental development and...
      9:00 AM PT, 11:00 AM CT, 12:00 PM ET Epigenetics defines the set of distinct and heritable molecular mechanisms able to influence gene expression without altering the primary genetic seque...
      Speaker: Peter Jones, Ph.D., D.Sc. , Nandor Than, MD, PhD
      Sponsored By: Zymo Research, Zymo Research
      10 4
      FEB 24, 2016 | 1:00 PM
      From genomics to precision medicine: Uncovering and manipulating the genetic circuits underlying common disease
      From genomics to precision medicine: Uncovering and manipulating...
      Precision medicine requires understanding the mechanistic basis of complex disorders, and to precisely manipulate these mechanisms to better human health. This is partly enabled by the recent...
      Speaker: Manolis Kellis, PhD
      Presented at: Precision Medicine Virtual Event Series 2016
      2
      OCT 28, 2015 | 11:00 AM
      The Hidden Effects of Epigenetic Discoveries
      The Hidden Effects of Epigenetic Discoveries
      DATE: October 28th, 2015TIME: 11am Pacific time, 2pm Eastern timeNew discoveries uncover that exposure to current environmental, dietary, behavioral, and medical conditions can significantly...
      Speaker: Jeffrey Kim, PhD , Christopher Scharer, PhD , Carlos Barrero, MD
      Sponsored By: Rockland
      25
      MAY 14, 2015 | 1:30 PM
      Epigenomic Profiles of Asthma
      Epigenomic Profiles of Asthma
      Asthma is heritable, influenced by the environment, and is modified by in utero exposures and aging; all of these features are also common to epigenetic regulation. Furthermore, genetic varia...
      Speaker: Ivana Yang, PhD
      Presented at: Genetics and Genomics Virtual Event Series 2015
      2
      MAY 13, 2015 | 1:30 PM
      Epigenomics of common, rare, and somatic variants underlying disease and cancer
      Epigenomics of common, rare, and somatic variants underlying disease...
      Perhaps the greatest surprise of genetic studies of human disease is that 90% of top-scoring disease-associated loci lie outside protein-coding regions. This has increased the urgency of mapp...
      Speaker: Manolis Kellis, PhD
      Presented at: Genetics and Genomics Virtual Event Series 2015
      4
      OCT 30, 2014 | 6:00 AM
      Epigenetic Dysregulation in the Pathogenesis of Myeloproliferative Neoplasms
      Epigenetic Dysregulation in the Pathogenesis of Myeloproliferative...
      When the BCR/ABL1 fusion protein was identified in chronic myelogenous leukemia and the JAK2 V617F mutation was identified in patients with other myeloproliferative neoplasms (MPNs) such as p...
      Speaker: Kristin Landis-Piwowar, PhD, MLS
      Presented at: Cancer: Research, Discovery and Therapeutics Virtual Event Series 2014
      8
      SEP 24, 2014 | 2:00 PM
      Targeting Lysine Acetylation in Cancer
      Targeting Lysine Acetylation in Cancer
      Master regulatory transcription factors localize to the genome in a manner influenced by chromatin accessibility and influencing global chromatin structure. With an interest in understanding...
      Speaker: Jay Bradner, MD
      Presented at: Advances in Drug Discovery and Development
      18
      OCT 16, 2013 | 7:00 AM
      Metabolic reprogramming: links to the epigenome
      Metabolic reprogramming: links to the epigenome
      Cancer cells are characterized by major alterations in both cellular metabolism and epigenetic profiles. Current understanding of links between metabolism and chromatin in the context of can...
      Speaker: Kathryn E Wellen, PhD
      Presented at: Cancer: Research, Discovery and Therapeutics Virtual Event Series 2013
      108
      AUG 22, 2013 | 5:00 PM
      Clinical Utility Potential of Epigenetic Aberrations in Human Solid Tumors
      Clinical Utility Potential of Epigenetic Aberrations in Human...
      As Chief of Scientific Intelligence at the John Wayne Cancer Institute, Dr. Hoon interacts with external academic, industry, and government agencies to develop innovative translational rese...
      Speaker: Dave S Hoon, PhD
      Presented at: Genetics and Genomics Virtual Event Series 2013
      104
    FEB 26, 2020 | 9:00 AM
    CRISPR Based Screening: Advantages of Transcriptional Activators and Inhibitors
    CRISPR Based Screening: Advantages of Transcriptional Activators...
    CRISPR revolutionized gene editing, but multi-target screening remains a complex goal. In addition, the fast pace of CRISPR technology development has brought sophisticated options for libra...
    Speaker: Andrew Ravanelli, PhD
    Presented at: Drug Discovery & Development Virtual Event Series 2020
    Sponsored By: MilliporeSigma
    2 1
    OCT 30, 2019 | 7:00 AM
    A Novel Approach for Single-cell Multi-omic Analysis to Identify Regulatory Signatures in Cancer
    A Novel Approach for Single-cell Multi-omic Analysis to Identify...
    DATE: October 30, 2019TIME: 7:00am PDTJoin us for a webinar to learn how to apply single cell methods to study cancer. Dr. William Greenleaf, Associate Professor from Stanford Universit...
    Speaker: William J. Greenleaf, Ph.D
    Sponsored By: 10x Genomics
    18 1
    OCT 10, 2019 | 6:00 AM
    Highly-efficient and -specific genome editing with Cas9 nickase ribonucleoproteins in Primary T-cells
    Highly-efficient and -specific genome editing with Cas9 nickase...
    In this webinar, we will be discussing some of our most recent testing using our Cas9 proteins, Cas9 RNP nickases in a variety of human cell types, including primary T-cells. Cas nucleases wh...
    Speaker: Jacob Lamberth
    Presented at: Cancer Research & Oncology Week Virtual Event Series 2019
    Sponsored By: MilliporeSigma
    1
    AUG 14, 2019 | 8:00 AM
    The Metagenomics of Dozens of Earth's Cities and One Space Station
    The Metagenomics of Dozens of Earth's Cities and One Space Station
    DATE: August 14, 2019TIME: 8:00am PDT Infectious disease surveillance and monitoring is critical in settings where disease outbreaks and antibiotic resistance can dramatically im...
    Speaker: Dr. Christopher Mason
    Sponsored By: Zymo Research
    2
    JUN 19, 2019 | 8:00 AM
    Exploring the genetic landscape of solid tumors using whole-genome copy number analysis
    Exploring the genetic landscape of solid tumors using whole-genome...
    DATE: June 19, 2019TIME: 8:00am PDT, 11:00am EDT Approximately 80% of all cancers are known to be affected by both somatic mutations and copy number changes. Furthermore, r...
    Speaker: Ravindra Kolhe, MD, PhD , Joanna Przybyl, PhD
    Sponsored By: Thermo Fisher Scientific - Applied Biosystems
    4
     
     
  • MAY 08, 2019 | 6:00 AM
    C.E. CREDITS
    Novel DNA Methylation in Mammals
    Novel DNA Methylation in Mammals
    Genetic drivers of cancer can be dysregulated through epigenetic modifications of DNA. Although the critical role of DNA 5-methylcytosine (5mC) in the regulation of transcription is recognize...
    Speaker: Tao Wu, PhD
    Presented at: Genetics and Genomics Virtual Event Series 2019
    2
    NOV 28, 2018 | 7:00 AM
    Discover how single-cell RNA sequencing provides deeper insights into lung cancer biology
    Discover how single-cell RNA sequencing provides deeper insights...
    DATE: November 28, 2018TIME:  7:00AM PSTSingle-cell genomics enables a deep dive into the mechanisms responsible for health and disease, in areas from cancer biology to neurob...
    Speaker: Bernard Thienpont , Annika Branting , Pawel Zajac, Ph.D.
    Sponsored By: Illumina, 10x Genomics
    5
    OCT 11, 2018 | 1:30 PM
    Exploiting Cis-Regulatory Enhancers as Therapeutic Targets in Cancer
    Exploiting Cis-Regulatory Enhancers as Therapeutic Targets in...
    Recent work has identified epigenomic features of distal regulatory elements to be dynamic and defining indicators of cellular specification and transformation. Of particular relevance is our...
    Speaker: Martin Hirst, PhD
    Presented at: Cancer Research & Oncology Week Virtual Event Series 2018
    1
    OCT 10, 2018 | 9:00 AM
    Understanding Cancer Through Whole-Genome Screening
    Understanding Cancer Through Whole-Genome Screening
    High-throughput screening is widely useful in identifying genes and pathways that drive changes in cell behavior such as cell cycle regulation, metastasis, and drug resistance.  Millipor...
    Speaker: Andrew Ravanelli, PhD
    Presented at: Cancer Research & Oncology Week Virtual Event Series 2018
    Sponsored By: MilliporeSigma
    5
    SEP 13, 2018 | 1:30 PM
    New PacBio Solutions for High-Resolution Microbiology & Immunology Analysis
    New PacBio Solutions for High-Resolution Microbiology & Immunology...
    PacBio Sequencing has been recognized as the gold standard in microbial sequencing due to simultaneously providing long sequence reads (genome contiguity), high consensus accuracy (genome acc...
    Speaker: Jonas Korlach, PhD
    Presented at: Microbiology & Immunology Virtual Event Series 2018
    Sponsored By: PacBio
    1
     
     
  • MAY 09, 2018 | 12:00 PM
    Knowledge Portals: Accelerating Action from Genetic Data
    Knowledge Portals: Accelerating Action from Genetic Data
    The Type 2 Diabetes Knowledge Portal is an open-access resource for human genetic information on type 2 diabetes (T2D). It is a central repository for data from large genomic studies that ide...
    Speaker: Noel Burtt
    Presented at: Genetics and Genomics Virtual Event Series 2018
    2
    JAN 30, 2018 | 9:00 AM
    WEBINAR: Metagenomics and base modifications from long, short, and linked-reads
    WEBINAR: Metagenomics and base modifications from long, short,...
    DATE: January 30, 2018TIME: 9:00AM PST, 12:00PM ESTInfectious disease surveillance and monitoring is critical in settings where disease outbreaks and antibiotic resistance can dramatica...
    Speaker: Christopher Mason, PhD , Shuiquan Tang, PhD
    Sponsored By: Zymo Research
    6 1
    OCT 11, 2017 | 12:00 PM
    Examining Cancer with the minION: Methylation and Structural Variation
    Examining Cancer with the minION: Methylation and Structural Variation
    Nanopore sequencing has enormous potential for application to cancer, but specifically offers advantages into two main arenas, epigenetics and structural variation. Methylation is well-known...
    Speaker: Winston Timp, PhD
    Presented at: Cancer Research & Oncology Week Virtual Event Series 2017
    Sponsored By: Oxford Nanopore Technologies
    1
    APR 13, 2017 | 9:00 AM
    Keynote Presentation - DNA Standards and Bioinformatics Benchmarks for Metagenomics
    Keynote Presentation - DNA Standards and Bioinformatics Benchmarks...
    Genomics and metagenomics have become ubiquitous research efforts.  Here we will show details of the development of physical, computational, and even space-based standards for metagenomi...
    Speaker: Christopher Mason, PhD
    Presented at: Molecular Diagnostics Virtual Event Series 2017
    2
    MAY 12, 2016 | 10:30 AM
    DNA methylation analysis by multiplexed reduced representation bisulfite sequencing
    DNA methylation analysis by multiplexed reduced representation...
    DNA methylation is an essential mechanism of epigenetic gene regulation with broad relevance in development and disease. Its localization on genomic DNA and general stability make this epigen...
    Speaker: Paul Datlinger
    Presented at: Genetics and Genomics Virtual Event Series 2016
    2
     
     
  • APR 11, 2016 | 9:00 AM
    WEBINAR: The epigenome in normal human placental development and its dysregulation in preeclampsia
    WEBINAR: The epigenome in normal human placental development and...
    9:00 AM PT, 11:00 AM CT, 12:00 PM ET Epigenetics defines the set of distinct and heritable molecular mechanisms able to influence gene expression without altering the primary genetic seque...
    Speaker: Peter Jones, Ph.D., D.Sc. , Nandor Than, MD, PhD
    Sponsored By: Zymo Research, Zymo Research
    10 4
    FEB 24, 2016 | 1:00 PM
    From genomics to precision medicine: Uncovering and manipulating the genetic circuits underlying common disease
    From genomics to precision medicine: Uncovering and manipulating...
    Precision medicine requires understanding the mechanistic basis of complex disorders, and to precisely manipulate these mechanisms to better human health. This is partly enabled by the recent...
    Speaker: Manolis Kellis, PhD
    Presented at: Precision Medicine Virtual Event Series 2016
    2
    OCT 28, 2015 | 11:00 AM
    The Hidden Effects of Epigenetic Discoveries
    The Hidden Effects of Epigenetic Discoveries
    DATE: October 28th, 2015TIME: 11am Pacific time, 2pm Eastern timeNew discoveries uncover that exposure to current environmental, dietary, behavioral, and medical conditions can significantly...
    Speaker: Jeffrey Kim, PhD , Christopher Scharer, PhD , Carlos Barrero, MD
    Sponsored By: Rockland
    25
    MAY 14, 2015 | 1:30 PM
    Epigenomic Profiles of Asthma
    Epigenomic Profiles of Asthma
    Asthma is heritable, influenced by the environment, and is modified by in utero exposures and aging; all of these features are also common to epigenetic regulation. Furthermore, genetic varia...
    Speaker: Ivana Yang, PhD
    Presented at: Genetics and Genomics Virtual Event Series 2015
    2
    MAY 13, 2015 | 1:30 PM
    Epigenomics of common, rare, and somatic variants underlying disease and cancer
    Epigenomics of common, rare, and somatic variants underlying disease...
    Perhaps the greatest surprise of genetic studies of human disease is that 90% of top-scoring disease-associated loci lie outside protein-coding regions. This has increased the urgency of mapp...
    Speaker: Manolis Kellis, PhD
    Presented at: Genetics and Genomics Virtual Event Series 2015
    4
     
     
  • OCT 30, 2014 | 6:00 AM
    Epigenetic Dysregulation in the Pathogenesis of Myeloproliferative Neoplasms
    Epigenetic Dysregulation in the Pathogenesis of Myeloproliferative...
    When the BCR/ABL1 fusion protein was identified in chronic myelogenous leukemia and the JAK2 V617F mutation was identified in patients with other myeloproliferative neoplasms (MPNs) such as p...
    Speaker: Kristin Landis-Piwowar, PhD, MLS
    Presented at: Cancer: Research, Discovery and Therapeutics Virtual Event Series 2014
    8
    SEP 24, 2014 | 2:00 PM
    Targeting Lysine Acetylation in Cancer
    Targeting Lysine Acetylation in Cancer
    Master regulatory transcription factors localize to the genome in a manner influenced by chromatin accessibility and influencing global chromatin structure. With an interest in understanding...
    Speaker: Jay Bradner, MD
    Presented at: Advances in Drug Discovery and Development
    18
    OCT 16, 2013 | 7:00 AM
    Metabolic reprogramming: links to the epigenome
    Metabolic reprogramming: links to the epigenome
    Cancer cells are characterized by major alterations in both cellular metabolism and epigenetic profiles. Current understanding of links between metabolism and chromatin in the context of can...
    Speaker: Kathryn E Wellen, PhD
    Presented at: Cancer: Research, Discovery and Therapeutics Virtual Event Series 2013
    108
    AUG 22, 2013 | 5:00 PM
    Clinical Utility Potential of Epigenetic Aberrations in Human Solid Tumors
    Clinical Utility Potential of Epigenetic Aberrations in Human...
    As Chief of Scientific Intelligence at the John Wayne Cancer Institute, Dr. Hoon interacts with external academic, industry, and government agencies to develop innovative translational rese...
    Speaker: Dave S Hoon, PhD
    Presented at: Genetics and Genomics Virtual Event Series 2013
    104
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