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    Hepatic models

    Hepatic models are pre-clinical systems used to research diseases involving the liver. Examples of hepatic models include "liver-on-a-chip", a microfluidic replica or the liver microenvironment, and liver organoids, a collection of various cells that display liver-specific functions and structural organization. Hepatic models have been used for disease modeling, drug development, and clinical application.

    Webinars

    • DEC 01, 2023 | 6:00 AM
      C.E. CREDITS
      JOIN US ON WORLD AIDS DAY
      JOIN US ON WORLD AIDS DAY
      In recognition of World AIDS Day, we invite you to discover the innovative work being done to help end the HIV epidemic in some of the hardest hit areas in India. A diagnosis is the first st...
      Speaker: Dr. Gavin Cloherty , Dr. Sunil Solomon
      Sponsored By: Abbott
      22
      NOV 17, 2022 | 8:00 AM
      Getting started in Cryo-EM: Virtual Workshop
      Getting started in Cryo-EM: Virtual Workshop
      Date: November 17, 2022 Time: 8:00am PST, 11:00am EST Genome editing is—or will soon be—in the clinic for several diseases and more applications are currently under development....
      Speaker: Natalia de Val , Zuben Brown , Veer Bhatt
      Presented at: Thermo Fisher Scientific - Electron Microscopy Webinars
      Sponsored By: Thermo Fisher Scientific
      11
      JUL 28, 2022 | 6:00 AM
      Take action against viral HCV by leveraging screening programs and HCV Ag
      Take action against viral HCV by leveraging screening programs...
      Date: July 28, 2022 Time: 6:00am (PDT), 9:00am (EDT) Hepatitis B and C continues to be a leading cause of global morbidity and mortality, resulting in 1.1 million deaths and 3 million new in...
      Speaker: Dr. Mia Biondi
      Sponsored By: Abbott Diagnostics
      18
      SEP 17, 2021 | 12:00 PM
      Developing better techniques for 3D culture and analysis.
      Developing better techniques for 3D culture and analysis.
      Date: September 16, 2021 Time: 9:00pm (PDT), 12:00am (EDT) 3D cellular models like organoids and spheroids offer an opportunity to better understand complex biology in a physiologically rele...
      Speaker: Edwin Golez, M.S. , Bhaskar Mandavilli
      Sponsored By: Thermo Fisher Scientific/Gibco
      10 2
      SEP 08, 2021 | 12:00 AM
      Translating Pharmacomicrobiomics: From Microbiome Cloud Uncertainty to Pharmaceutical and Clinical Application(s)
      Translating Pharmacomicrobiomics: From Microbiome Cloud Uncertainty...
      The Human Microbiome Project was conceived almost 15 years ago, as an extension of the Human Genome Project, to explore the diversity of human-associated microorganisms at multiple body site...
      Speaker: Ramy K. Aziz, PhD
      Presented at: Microbiology Week Virtual Event Series 2021
      1
      NOV 18, 2020 | 11:00 AM
      Basic Concepts in Imaging-based High-Throughput Screening and High-Throughput Profiling Assay Development
      Basic Concepts in Imaging-based High-Throughput Screening and...
      This session introduces basic concepts of imaging-based high-throughput screening (HTS) and high-throughput profiling assay development. Imaging-based HTS assays are designed to evaluate a d...
      Speaker: Joshua Harrill, PhD
      Presented at: 7th Annual Conference: SBI2 High Content
      1
      SEP 23, 2020 | 8:00 AM
      Uncovering immunological mechanisms of protection from infection and vaccination in humans
      Uncovering immunological mechanisms of protection from infection...
      Vaccines are among the most effective medical interventions available. The development of vaccines is a complex undertaking, involving many steps, that typically unfolds over a period of sev...
      Speaker: Keynote: Marcelo B. Sztein, MD
      Presented at: 9th Annual Fluidigm Mass Cytometry Virtual Summit
      2
      FEB 26, 2020 | 9:00 AM
      The use of 3D Models in Hepatic Biology
      The use of 3D Models in Hepatic Biology
      DATE: February 26, 2020 TIME: 9:00am PST 3D cell culture and analysis and the study of organoids and spheroids are becoming more prevalent as a research method in publications as traditional...
      Speaker: Julia Tritapoe , David Kuninger, PhD
      Sponsored By: Thermo Fisher Scientific
      12 1
      JAN 01, 2020 | 6:00 AM
      Microphysiological Systems for Human Focused Drug Discovery
      Microphysiological Systems for Human Focused Drug Discovery
      Microphysiological systems (MPS), also known as organ-on-chips, are small scale in vitro cell cultures which mimic facets of tissue or organ level function. MPS frequently utilise primary hu...
      Speaker: Tomasz Kostrzewski, PhD
      Presented at: Drug Discovery & Development Virtual Event Series 2020
      3
      NOV 19, 2019 | 10:00 AM
      LC3-associated endocytosis: guarding against neuroinflammation & neurodegeneration
      LC3-associated endocytosis: guarding against neuroinflammation...
      DATE: November 19, 2019TIME: 10:00am PSTMicroglial cells are the resident innate immune cells of the central nervous system (CNS) and are responsible for regulating inflammatory activati...
      Speaker: Bradlee L. Heckmann, Ph.D.
      Sponsored By: Miltenyi Biotec
      6
      AUG 22, 2019 | 6:00 AM
      In Vitro Screening Approaches to Estimate Human Hepatic Responses to Xenobiotic Exposures
      In Vitro Screening Approaches to Estimate Human Hepatic Responses...
      Prediction of human response to chemical exposures is the primary challenge of pharmaceutical and environmental toxicology research. The complexity of human responses to xenobiotic exposures...
      Speaker: Stephen Ferguson, PhD
      Presented at: Forensics & Toxicology 2019
      1
      JUN 19, 2019 | 10:00 AM
      Getting started in 3D:  Ask an Expert
      Getting started in 3D: Ask an Expert
      DATE: June 19, 2019TIME: 10:00am PDT, 1:00pm EDT As we develop new methods to create more biologically relevant models for research in understanding disease etiology and in...
      Speaker: Mark Kennedy, Ph.D. , Richard Josephson, PhD
      Sponsored By: Thermo Fisher Scientific
      6
      APR 25, 2019 | 1:30 PM
      In Vivo Models for Infectious Disease Research Through the Years
      In Vivo Models for Infectious Disease Research Through the Years
      Over the past 25 years many advances in techniques have been incorporated into infectious disease research. From genetically modified animals to advances in basic techniques that improve res...
      Speaker: Matthew Flegal, BS, SRS
      Presented at: Infectious Disease Virtual Event Series 2019
      4 1
      APR 25, 2019 | 12:00 PM
      Diagnosis and Treatment of Tuberculosis, a Case Study in Challenges and Threats Posed by Infectious Diseases
      Diagnosis and Treatment of Tuberculosis, a Case Study in Challenges...
      Tuberculosis has killed more than one billion people in the last 200 years. It is the oldest and the deadliest human pathogen, recently surpassing HIV. Its adaptation to host and drug pressur...
      Speaker: Faramarz Valafar, PhD
      Presented at: Infectious Disease Virtual Event Series 2019
      2
      APR 25, 2019 | 10:30 AM
      Overcoming Complexity to Elucidate the Role of Immunoglobulin Polymorphism in the Functional Antibody Response
      Overcoming Complexity to Elucidate the Role of Immunoglobulin...
      Recent evidence indicates that the immunoglobulin (IG) gene loci reside within the most complex and variable regions of the human genome, characterized by elevated levels of single nucleotide...
      Speaker: Corey Watson, PhD
      Presented at: Infectious Disease Virtual Event Series 2019
      1
      APR 25, 2019 | 10:30 AM
      Advances in Point-Of-Care Testing for Infectious Diseases
      Advances in Point-Of-Care Testing for Infectious Diseases
      Point-of-care testing (POCT) is diagnostic testing at the time and place of patient care in a physician’s office, an ambulance, a mobile clinic, at home or in hospital. Rapid POC testi...
      Speaker: Krishnan Allampallam, PhD , Paul Lambotte, PhD
      Presented at: Infectious Disease Virtual Event Series 2019
      Sponsored By: Chembio
      4 1
      APR 25, 2019 | 9:00 AM
      Keynote Presentation: The Next Pandemic
      Keynote Presentation: The Next Pandemic
      “Emerging infections” are those that appear suddenly or are rapidly increasing in incidence or geographic range (e.g., HIV/AIDS, Ebola, SARS, Middle East Respiratory Syndrome [MER...
      Speaker: Stephen S. Morse, PhD, FAAM, F.A.C.E.
      Presented at: Infectious Disease Virtual Event Series 2019
      6
      APR 25, 2019 | 7:30 AM
      Keynote Presentation: Ebola Virus Disease - 2019 and Beyond
      Keynote Presentation: Ebola Virus Disease - 2019 and Beyond
      The Ebola virus disease outbreak in West Africa in 2014-2016 was the largest of its kind in history. This was the first outbreak that involved a randomized clinical trial for therapeutics, a...
      Speaker: Colleen Kraft, MD, MSc
      Presented at: Infectious Disease Virtual Event Series 2019
      5
      FEB 27, 2019 | 1:30 PM
      Advanced Liver Tissue Model for Improved in Vitro Prediction
      Advanced Liver Tissue Model for Improved in Vitro Prediction
      Isolated hepatocytes or their enzymes comprise the basis of most in vitro DMPK and toxicity assays used to predict human hepatic outcomes. Because hepato-specific functions are typically lost...
      Speaker: Matthew Shipton, MS
      Presented at: Drug Discovery Virtual Event Series 2019
      1
      FEB 20, 2019 | 9:00 AM
      Choosing the best system to answer your question - What question are you looking to answer?
      Choosing the best system to answer your question - What question...
      DATE:  February 20, 2019TIME:  9:00am PST  ...
      Speaker: David Kuninger, PhD
      Sponsored By: Thermo Fisher Scientific
      15 1
      NOV 14, 2018 | 3:00 PM
      Modeling Inflammation and Fibrosis in Humans with PSC-derived Steatohepatitis Liver Organoids
      Modeling Inflammation and Fibrosis in Humans with PSC-derived...
      Neuronal migration defects, including pachygyria, are among the most severe developmental brain defects in humans. Using human genetics approaches, we recently identified bi-allelic truncatin...
      Speaker: Takanori Takebe
      Presented at: 6th annual 24 Hours of Stem Cells™ virtual event
      8
      MAR 28, 2018 | 10:00 AM
      Primary Cell Systems:  Offerings and Applications from basic biology and tissue modeling to compound screening
      Primary Cell Systems: Offerings and Applications from basic biology...
      DATE: March 28, 2018TIME: 10:00am PDT, 01:00pm EDTPrimary cells are derived from various tissues typically via dissection, enzymatic dissociation, and subsequent culture in media specif...
      Speaker: David Kuninger, PhD , Rhonda Newman, PhD
      Sponsored By: Thermo Fisher Scientific
      7 3
      FEB 28, 2018 | 12:00 AM
      Improved Neuronal Performance with the Gibco B-27 Plus Culture System
      Improved Neuronal Performance with the Gibco B-27 Plus Culture...
      TBD...
      Speaker: David Kuninger, PhD
      Presented at: 6th annual 24 Hours of Stem Cells™ virtual event
      2
      JUL 20, 2017 | 10:00 AM
      WEBINAR: Innovative quantitative imaging techniques and their utility in advancing neurobiology research
      WEBINAR: Innovative quantitative imaging techniques and their...
      DATE: July 20, 2017TIME: 10:00am PT, 1:00pm ETPart 1 - Daniel Beacham: Case study showing how CyQUANT Direct Cell Proliferation and Fluo-4 calcium imaging assays were us...
      Speaker: Dan Beacham, Ph.D. , Nicholas Radio Ph.D. , Michael Derr, M.S.
      Sponsored By: Thermo Fisher Scientific/Gibco
      3
    DEC 01, 2023 | 6:00 AM
    C.E. CREDITS
    JOIN US ON WORLD AIDS DAY
    JOIN US ON WORLD AIDS DAY
    In recognition of World AIDS Day, we invite you to discover the innovative work being done to help end the HIV epidemic in some of the hardest hit areas in India. A diagnosis is the first st...
    Speaker: Dr. Gavin Cloherty , Dr. Sunil Solomon
    Sponsored By: Abbott
    22
    NOV 17, 2022 | 8:00 AM
    Getting started in Cryo-EM: Virtual Workshop
    Getting started in Cryo-EM: Virtual Workshop
    Date: November 17, 2022 Time: 8:00am PST, 11:00am EST Genome editing is—or will soon be—in the clinic for several diseases and more applications are currently under development....
    Speaker: Natalia de Val , Zuben Brown , Veer Bhatt
    Presented at: Thermo Fisher Scientific - Electron Microscopy Webinars
    Sponsored By: Thermo Fisher Scientific
    11
    JUL 28, 2022 | 6:00 AM
    Take action against viral HCV by leveraging screening programs and HCV Ag
    Take action against viral HCV by leveraging screening programs...
    Date: July 28, 2022 Time: 6:00am (PDT), 9:00am (EDT) Hepatitis B and C continues to be a leading cause of global morbidity and mortality, resulting in 1.1 million deaths and 3 million new in...
    Speaker: Dr. Mia Biondi
    Sponsored By: Abbott Diagnostics
    18
    SEP 17, 2021 | 12:00 PM
    Developing better techniques for 3D culture and analysis.
    Developing better techniques for 3D culture and analysis.
    Date: September 16, 2021 Time: 9:00pm (PDT), 12:00am (EDT) 3D cellular models like organoids and spheroids offer an opportunity to better understand complex biology in a physiologically rele...
    Speaker: Edwin Golez, M.S. , Bhaskar Mandavilli
    Sponsored By: Thermo Fisher Scientific/Gibco
    10 2
    SEP 08, 2021 | 12:00 AM
    Translating Pharmacomicrobiomics: From Microbiome Cloud Uncertainty to Pharmaceutical and Clinical Application(s)
    Translating Pharmacomicrobiomics: From Microbiome Cloud Uncertainty...
    The Human Microbiome Project was conceived almost 15 years ago, as an extension of the Human Genome Project, to explore the diversity of human-associated microorganisms at multiple body site...
    Speaker: Ramy K. Aziz, PhD
    Presented at: Microbiology Week Virtual Event Series 2021
    1
     
     
  • NOV 18, 2020 | 11:00 AM
    Basic Concepts in Imaging-based High-Throughput Screening and High-Throughput Profiling Assay Development
    Basic Concepts in Imaging-based High-Throughput Screening and...
    This session introduces basic concepts of imaging-based high-throughput screening (HTS) and high-throughput profiling assay development. Imaging-based HTS assays are designed to evaluate a d...
    Speaker: Joshua Harrill, PhD
    Presented at: 7th Annual Conference: SBI2 High Content
    1
    SEP 23, 2020 | 8:00 AM
    Uncovering immunological mechanisms of protection from infection and vaccination in humans
    Uncovering immunological mechanisms of protection from infection...
    Vaccines are among the most effective medical interventions available. The development of vaccines is a complex undertaking, involving many steps, that typically unfolds over a period of sev...
    Speaker: Keynote: Marcelo B. Sztein, MD
    Presented at: 9th Annual Fluidigm Mass Cytometry Virtual Summit
    2
    FEB 26, 2020 | 9:00 AM
    The use of 3D Models in Hepatic Biology
    The use of 3D Models in Hepatic Biology
    DATE: February 26, 2020 TIME: 9:00am PST 3D cell culture and analysis and the study of organoids and spheroids are becoming more prevalent as a research method in publications as traditional...
    Speaker: Julia Tritapoe , David Kuninger, PhD
    Sponsored By: Thermo Fisher Scientific
    12 1
    JAN 01, 2020 | 6:00 AM
    Microphysiological Systems for Human Focused Drug Discovery
    Microphysiological Systems for Human Focused Drug Discovery
    Microphysiological systems (MPS), also known as organ-on-chips, are small scale in vitro cell cultures which mimic facets of tissue or organ level function. MPS frequently utilise primary hu...
    Speaker: Tomasz Kostrzewski, PhD
    Presented at: Drug Discovery & Development Virtual Event Series 2020
    3
    NOV 19, 2019 | 10:00 AM
    LC3-associated endocytosis: guarding against neuroinflammation & neurodegeneration
    LC3-associated endocytosis: guarding against neuroinflammation...
    DATE: November 19, 2019TIME: 10:00am PSTMicroglial cells are the resident innate immune cells of the central nervous system (CNS) and are responsible for regulating inflammatory activati...
    Speaker: Bradlee L. Heckmann, Ph.D.
    Sponsored By: Miltenyi Biotec
    6
     
     
  • AUG 22, 2019 | 6:00 AM
    In Vitro Screening Approaches to Estimate Human Hepatic Responses to Xenobiotic Exposures
    In Vitro Screening Approaches to Estimate Human Hepatic Responses...
    Prediction of human response to chemical exposures is the primary challenge of pharmaceutical and environmental toxicology research. The complexity of human responses to xenobiotic exposures...
    Speaker: Stephen Ferguson, PhD
    Presented at: Forensics & Toxicology 2019
    1
    JUN 19, 2019 | 10:00 AM
    Getting started in 3D:  Ask an Expert
    Getting started in 3D: Ask an Expert
    DATE: June 19, 2019TIME: 10:00am PDT, 1:00pm EDT As we develop new methods to create more biologically relevant models for research in understanding disease etiology and in...
    Speaker: Mark Kennedy, Ph.D. , Richard Josephson, PhD
    Sponsored By: Thermo Fisher Scientific
    6
    APR 25, 2019 | 1:30 PM
    In Vivo Models for Infectious Disease Research Through the Years
    In Vivo Models for Infectious Disease Research Through the Years
    Over the past 25 years many advances in techniques have been incorporated into infectious disease research. From genetically modified animals to advances in basic techniques that improve res...
    Speaker: Matthew Flegal, BS, SRS
    Presented at: Infectious Disease Virtual Event Series 2019
    4 1
    APR 25, 2019 | 12:00 PM
    Diagnosis and Treatment of Tuberculosis, a Case Study in Challenges and Threats Posed by Infectious Diseases
    Diagnosis and Treatment of Tuberculosis, a Case Study in Challenges...
    Tuberculosis has killed more than one billion people in the last 200 years. It is the oldest and the deadliest human pathogen, recently surpassing HIV. Its adaptation to host and drug pressur...
    Speaker: Faramarz Valafar, PhD
    Presented at: Infectious Disease Virtual Event Series 2019
    2
    APR 25, 2019 | 10:30 AM
    Overcoming Complexity to Elucidate the Role of Immunoglobulin Polymorphism in the Functional Antibody Response
    Overcoming Complexity to Elucidate the Role of Immunoglobulin...
    Recent evidence indicates that the immunoglobulin (IG) gene loci reside within the most complex and variable regions of the human genome, characterized by elevated levels of single nucleotide...
    Speaker: Corey Watson, PhD
    Presented at: Infectious Disease Virtual Event Series 2019
    1
     
     
  • APR 25, 2019 | 10:30 AM
    Advances in Point-Of-Care Testing for Infectious Diseases
    Advances in Point-Of-Care Testing for Infectious Diseases
    Point-of-care testing (POCT) is diagnostic testing at the time and place of patient care in a physician’s office, an ambulance, a mobile clinic, at home or in hospital. Rapid POC testi...
    Speaker: Krishnan Allampallam, PhD , Paul Lambotte, PhD
    Presented at: Infectious Disease Virtual Event Series 2019
    Sponsored By: Chembio
    4 1
    APR 25, 2019 | 9:00 AM
    Keynote Presentation: The Next Pandemic
    Keynote Presentation: The Next Pandemic
    “Emerging infections” are those that appear suddenly or are rapidly increasing in incidence or geographic range (e.g., HIV/AIDS, Ebola, SARS, Middle East Respiratory Syndrome [MER...
    Speaker: Stephen S. Morse, PhD, FAAM, F.A.C.E.
    Presented at: Infectious Disease Virtual Event Series 2019
    6
    APR 25, 2019 | 7:30 AM
    Keynote Presentation: Ebola Virus Disease - 2019 and Beyond
    Keynote Presentation: Ebola Virus Disease - 2019 and Beyond
    The Ebola virus disease outbreak in West Africa in 2014-2016 was the largest of its kind in history. This was the first outbreak that involved a randomized clinical trial for therapeutics, a...
    Speaker: Colleen Kraft, MD, MSc
    Presented at: Infectious Disease Virtual Event Series 2019
    5
    FEB 27, 2019 | 1:30 PM
    Advanced Liver Tissue Model for Improved in Vitro Prediction
    Advanced Liver Tissue Model for Improved in Vitro Prediction
    Isolated hepatocytes or their enzymes comprise the basis of most in vitro DMPK and toxicity assays used to predict human hepatic outcomes. Because hepato-specific functions are typically lost...
    Speaker: Matthew Shipton, MS
    Presented at: Drug Discovery Virtual Event Series 2019
    1
    FEB 20, 2019 | 9:00 AM
    Choosing the best system to answer your question - What question are you looking to answer?
    Choosing the best system to answer your question - What question...
    DATE:  February 20, 2019TIME:  9:00am PST  ...
    Speaker: David Kuninger, PhD
    Sponsored By: Thermo Fisher Scientific
    15 1
     
     
  • NOV 14, 2018 | 3:00 PM
    Modeling Inflammation and Fibrosis in Humans with PSC-derived Steatohepatitis Liver Organoids
    Modeling Inflammation and Fibrosis in Humans with PSC-derived...
    Neuronal migration defects, including pachygyria, are among the most severe developmental brain defects in humans. Using human genetics approaches, we recently identified bi-allelic truncatin...
    Speaker: Takanori Takebe
    Presented at: 6th annual 24 Hours of Stem Cells™ virtual event
    8
    MAR 28, 2018 | 10:00 AM
    Primary Cell Systems:  Offerings and Applications from basic biology and tissue modeling to compound screening
    Primary Cell Systems: Offerings and Applications from basic biology...
    DATE: March 28, 2018TIME: 10:00am PDT, 01:00pm EDTPrimary cells are derived from various tissues typically via dissection, enzymatic dissociation, and subsequent culture in media specif...
    Speaker: David Kuninger, PhD , Rhonda Newman, PhD
    Sponsored By: Thermo Fisher Scientific
    7 3
    FEB 28, 2018 | 12:00 AM
    Improved Neuronal Performance with the Gibco B-27 Plus Culture System
    Improved Neuronal Performance with the Gibco B-27 Plus Culture...
    TBD...
    Speaker: David Kuninger, PhD
    Presented at: 6th annual 24 Hours of Stem Cells™ virtual event
    2
    JUL 20, 2017 | 10:00 AM
    WEBINAR: Innovative quantitative imaging techniques and their utility in advancing neurobiology research
    WEBINAR: Innovative quantitative imaging techniques and their...
    DATE: July 20, 2017TIME: 10:00am PT, 1:00pm ETPart 1 - Daniel Beacham: Case study showing how CyQUANT Direct Cell Proliferation and Fluo-4 calcium imaging assays were us...
    Speaker: Dan Beacham, Ph.D. , Nicholas Radio Ph.D. , Michael Derr, M.S.
    Sponsored By: Thermo Fisher Scientific/Gibco
    3
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