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Protein Binding
Protein Binding: Protein binding can enhance or detract from a drug's performance. As a general rule, agents that are minimally protein bound penetrate tissue better than those that are highly bound, but they are excreted much faster. Among drugs that are less than 80-85 percent protein bound, differences appear to be of slight clinical importance. Agents that are highly protein bound may, however, differ markedly from those that are minimally bound in terms of tissue penetration and half-life. Drugs may bind to a wide variety of plasma proteins, including albumin. If the percentage of protein-bound drug is greater when measured in human blood than in a simple albumin solution, the clinician should suspect that the agent may be bound in vivo to one of these "minority" plasma proteins. The concentration of several plasma proteins can be altered by many factors, including stress, surgery, liver or kidney dysfunction, and pregnancy. In such circumstances, free drug concentrations are a more accurate index of clinical effect than are total concentrations. Formulary committees must grasp the clinical significance of qualitative and quantitative differences in protein binding when evaluating competing agents.
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The virus that causes COVID-19 uses the upper airways as a "launchpad" to infect others, said the researchers.Written By: Carmen LeitchJAN 13, 2023Drug Discovery & Development
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JAN 14, 2023
Cell & Molecular Biology
The virus that causes COVID-19 uses the upper airways as a "launchpad" to infect others, said the researchers.
Written By:
Carmen Leitch
JAN 13, 2023
Drug Discovery & Development
In a wrinkle-reduction market run by AbbVie’s Botox™ (active ingredient onabotulinumtoxinA), Revance was jus
...
Written By:
Greta Anne
JAN 12, 2023
Cell & Molecular Biology
The nucleotide bases of our DNA are read in triplets, and three nucleotides together, called a codon, represents an amin
...
Written By:
Carmen Leitch
JAN 04, 2023
Neuroscience
Right now, there are no blood tests that can reliably diagnose Alzheimer's disease on their own. Most people only get di
...
Written By:
Carmen Leitch
JAN 03, 2023
Genetics & Genomics
Researchers can easily assess what genes are being expressed in a tissue by using a method like RT-PCR that precisely an
...
Written By:
Carmen Leitch
DEC 28, 2022
Immunology
Scientists have discovered that an inflammatory cytokine known as LIGHT is a major factor in the deadly airway damage th
...
Written By:
Carmen Leitch
DEC 26, 2022
Immunology
Almost every patient who gets myeloma and is treated with a standard therapy also experiences relapse. But researchers h
...
Written By:
Carmen Leitch
DEC 20, 2022
Clinical & Molecular DX
Immune checkpoints are a part of the immune system that prevents the body’s immune response from destroying health
...
Written By:
Zoe Michaud
DEC 14, 2022
Cell & Molecular Biology
Humans beings carry a lot of fluid in our bodies, and we need strong connections between structures and cells to hold ev
...
Written By:
Carmen Leitch
DEC 13, 2022
Plants & Animals
Scientists believe COVID-19 is still highly transmissible between species based on computer simulations of mammalian cro
...
Written By:
Kerry Charron
DEC 08, 2022
Cancer
Chemotherapies, drugs used to fight cancer by killing tumor cells or preventing them from growing and dividing, remain s
...
Written By:
Katie Kokolus
DEC 03, 2022
Drug Discovery & Development
Every day, we come closer to finding a cure for Alzheimer's. Recently, the New England Journal of Medicine published
...
Written By:
Greta Anne
DEC 01, 2022
Genetics & Genomics
The CRISPR/Cas9 gene editing tool has changed biomedical research, and has even been used in the clinic in a few cases t
...
Written By:
Carmen Leitch
NOV 29, 2022
Genetics & Genomics
Researchers have developed a way to target RNA molecules that can have a harmful result. Instead of targeting the genome
...
Written By:
Carmen Leitch
NOV 29, 2022
Cell & Molecular Biology
Scientists have now discovered yet another way that MYC proteins can promote cancer. MYC has been called a master regula
...
Written By:
Carmen Leitch
NOV 28, 2022
Immunology
Immunity is closely linked to metabolism, and in recent years, scientists have found that fat molecules, or lipids, can
...
Written By:
Carmen Leitch
NOV 23, 2022
Genetics & Genomics
Mitochondria are very special organelles. These cellular powerhouses do more than generate energy. They are known to car
...
Written By:
Carmen Leitch
NOV 21, 2022
Immunology
Zika virus is transmitted by the Aedes aegypti mosquito and can cause a mild illness in otherwise healthy adults. But wh
...
Written By:
Carmen Leitch
NOV 21, 2022
Cell & Molecular Biology
Over six million people have Parkinson's disease, and more are diagnosed every day. The neurodegenerative disease is cha
...
Written By:
Carmen Leitch
NOV 18, 2022
Cell & Molecular Biology
Mitochondria are little organelles that have long been known as the powerhouses of the cell. But in recent years, scient
...
Written By:
Carmen Leitch
NOV 15, 2022
Genetics & Genomics
Telomeres cap the ends of chromosomes, preventing breakage. Some cancer cells can use those protective caps to their adv
...
Written By:
Carmen Leitch
NOV 14, 2022
Cancer
About 20% of breast cancers exhibit elevated levels of a protein known as HER2. You may have heard the classifier
...
Written By:
Katie Kokolus
NOV 13, 2022
Cell & Molecular Biology
When certain things in the cellular environment change, such as a dramatic increase in salt or sugar levels, it can caus
...
Written By:
Carmen Leitch
NOV 10, 2022
Neuroscience
The HUSH (human silencing hub) protein complex is known to silence genes, and researchers have thought that it could be
...
Written By:
Carmen Leitch