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Protein Binding
Protein Binding: Protein binding can enhance or detract from a drug's performance. As a general rule, agents that are minimally protein bound penetrate tissue better than those that are highly bound, but they are excreted much faster. Among drugs that are less than 80-85 percent protein bound, differences appear to be of slight clinical importance. Agents that are highly protein bound may, however, differ markedly from those that are minimally bound in terms of tissue penetration and half-life. Drugs may bind to a wide variety of plasma proteins, including albumin. If the percentage of protein-bound drug is greater when measured in human blood than in a simple albumin solution, the clinician should suspect that the agent may be bound in vivo to one of these "minority" plasma proteins. The concentration of several plasma proteins can be altered by many factors, including stress, surgery, liver or kidney dysfunction, and pregnancy. In such circumstances, free drug concentrations are a more accurate index of clinical effect than are total concentrations. Formulary committees must grasp the clinical significance of qualitative and quantitative differences in protein binding when evaluating competing agents.
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AUG 16, 2022
Immunology
SARS-CoV-2, which causes COVID-19, has mutated many times into new variants, some that we don't hear about, while others
...
Written By:
Carmen Leitch
AUG 12, 2022
Immunology
Our immune cells can target cancer, but T cells can become worn out and exhausted during lengthy battles, and they
...
Written By:
Carmen Leitch
AUG 11, 2022
Drug Discovery & Development
In a recent study published in Nature Medicine, a team of researchers from the Korea Advanced Institute of Science and T
...
Written By:
Laurence Tognetti, MSc
AUG 09, 2022
Immunology
Scientists have been trying to stimulate the immune system to fight cancer for decades, and recent years have brought ma
...
Written By:
Carmen Leitch
JUL 21, 2022
Clinical & Molecular DX
In our best practices blog, we explore how lateral flow assay design affects test performance. Read on to gain a deeper
...
JUL 21, 2022
Immunology
Using cryo-electron microscopy, researchers captured images of a molecule called an autoantibody as it attached to a rec
...
Written By:
Carmen Leitch
JUL 20, 2022
Microbiology
The paramyxovirus includes serious pathogens that can cause pandemics, including ones that lead primarily to mild. Illne
...
Written By:
Carmen Leitch
JUL 19, 2022
Immunology
The immune system relies on signals, which may be activated by the presence of a pathogen, for example. Chemokines are c
...
Written By:
Carmen Leitch
JUL 14, 2022
Clinical & Molecular DX
Magnetic beads (or superparamagnetic particles) can be used for the isolation and purification of cells, nucleic acids,
...
JUL 07, 2022
Clinical & Molecular DX
Enjoy the benefits of working with a single supplier for DNA isolation, protein purification, research, and diagnostics
...
JUL 01, 2022
Health & Medicine
Immune reactive molecules called nanobodies, which are based on molecules found in llamas could offer robust protection
...
Written By:
Carmen Leitch
JUN 23, 2022
Clinical & Molecular DX
Diagnostic assays like the one you’re developing are in demand. But your task isn’t simple. Set yourself up
...
JUN 09, 2022
Cancer
Pancreatic ductal adenocarcinoma (PDAC) is a very aggressive pancreatic cancer with limited treatment options. PDA
...
Written By:
Katie Kokolus
JUN 06, 2022
Immunology
Cancer can arise from a variety of aberrations that cause cells to divide uncontrollably, and form a tumor. The causes o
...
Written By:
Carmen Leitch
JUN 01, 2022
Clinical & Molecular DX
Cancer vaccines have been around for decades, but a unique neoantigen vaccine called NeoVax is making researchers hopefu
...
Written By:
Zoe Michaud
MAY 25, 2022
Cancer
In 2006, the National Cancer Institute (NCI) and the National Human Genome Research Institute (NHGRI) began a cancer gen
...
Written By:
Katie Kokolus
APR 28, 2022
Genetics & Genomics
Lupus is an autoimmune disease that can impact anyone, but tends to affects women between the ages of 15 and 45. The dis
...
Written By:
Carmen Leitch
APR 26, 2022
Immunology
The immune system can get tired when it has to fight against a chronic infection or a disease like cancer. Exhausted T c
...
Written By:
Carmen Leitch
APR 20, 2022
Drug Discovery & Development
Dendritic cells play an important role in the immune system. Specifically, they help gather up antigen-presenting cells
...
Written By:
Ryan Vingum
APR 13, 2022
Immunology
The immune system must be able to swing into action to overcome pathogenic invaders. But the inflammation that accompani
...
Written By:
Carmen Leitch
APR 12, 2022
Cell & Molecular Biology
Obesity is considered a public health problem in many parts of the world, and the rates of obesity are rising
Written By:
Carmen Leitch
APR 11, 2022
Genetics & Genomics
Transcription factors are genes that, once expressed, can influence the activity of other genes, sometimes many other ge
...
Written By:
Carmen Leitch
MAR 29, 2022
Genetics & Genomics
Cells have to express the right genes to carry out the essential functions of life. When genes are expressed, they are t
...
Written By:
Carmen Leitch
MAR 23, 2022
Cell & Molecular Biology
Organisms from plants to fungi to animals also need copper for normal health. Copper is involved in several basic biolog
...
Written By:
Carmen Leitch