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Protein Binding
Protein Binding: Protein binding can enhance or detract from a drug's performance. As a general rule, agents that are minimally protein bound penetrate tissue better than those that are highly bound, but they are excreted much faster. Among drugs that are less than 80-85 percent protein bound, differences appear to be of slight clinical importance. Agents that are highly protein bound may, however, differ markedly from those that are minimally bound in terms of tissue penetration and half-life. Drugs may bind to a wide variety of plasma proteins, including albumin. If the percentage of protein-bound drug is greater when measured in human blood than in a simple albumin solution, the clinician should suspect that the agent may be bound in vivo to one of these "minority" plasma proteins. The concentration of several plasma proteins can be altered by many factors, including stress, surgery, liver or kidney dysfunction, and pregnancy. In such circumstances, free drug concentrations are a more accurate index of clinical effect than are total concentrations. Formulary committees must grasp the clinical significance of qualitative and quantitative differences in protein binding when evaluating competing agents.
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OCT 31, 2022
Genetics & Genomics
There is viral DNA in the human genome, and each instance traces back to an ancestor who was infected with a retrovirus.
...
Written By:
Carmen Leitch
OCT 28, 2022
Cell & Molecular Biology
Three Advantages: Reduction in plastic use Time savings Better results Nucleic acids play an essential role in the funct
...
Sponsored By:
MilliporeSigma
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Genetics & Genomics
Hereditary hemochromatosis (HH) is caused by genetic mutations that lead to the abnormal accumulation of iron in differe
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Written By:
Carmen Leitch
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Drug Discovery & Development
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...
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Annie Lennon
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Immunology
Introduction The immune system plays a dual role in inflammation and cancer development. Immune system effector cells ra
...
Sponsored By:
Sino Biological
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Gene sequences are made up of nucleotide bases, which are 'read' by the cell's machinery in triplets; three
...
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Carmen Leitch
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Microbiology
WHO has estimated that there are almost 300 million people with chronic hepatitis B infections, and there are around 1.5
...
Written By:
Carmen Leitch
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Clinical & Molecular DX
A new report published in the Journal Immunity describes an approach to developing an effective vaccine against human im
...
Written By:
Zoe Michaud
OCT 05, 2022
Health & Medicine
Researchers have now published a study that has revealed how SARS-CoV-2, the virus that causes COVID-19, can infect brai
...
Written By:
Carmen Leitch
SEP 30, 2022
Drug Discovery & Development
Scientists are developing a human version of a drug that was highly beneficial to a hamster model of COVID-19. The drug,
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The significance of antibody based in vivo studies For both research and therapeutic purposes, antibodies ca
...
Sponsored By:
MBL International Corporation
SEP 25, 2022
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In cells, active genes are transcribed into mRNA molecules, which can be edited and processed in a variety of ways, to u
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SEP 18, 2022
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...
Sponsored By:
Sino Biological
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...
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...
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...
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Katie Kokolus
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...
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AUG 23, 2022
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...
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Carmen Leitch
AUG 22, 2022
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Many different proteins can bind DNA, and they perform a variety of critical functions in cells. DNA-binding proteins of
...
Written By:
Carmen Leitch
AUG 21, 2022
Microbiology
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...
Written By:
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