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    Target Identification

    Target Identification: is the process of identifying the direct molecular target - for example protein or nucleic acid - of a small molecule. In clinical pharmacology, target identification is aimed at finding the efficacy target of a drug/pharmaceutical or other xenobiotic. The techniques used may be based on principles of biochemistry, biophysics, genetics, chemical biology or other disciplines.

    Webinars

    • NOV 16, 2016 | 8:00 AM
      The important role of lncRNAs in breast cancer
      The important role of lncRNAs in breast cancer
      DATE:  November 16, 2016 TIME:  8:00am PT, 11:00am ET  Breast cancer is the most commonly diagnosed cancer in women and is the second leading cause of cancer death among wo...
      Speaker: Rebecca DeVaux, PhD , Alfredo Hidalgo-Miranda, PhD
      Sponsored By: Affymetrix, Affymetrix
      8
      SEP 29, 2016 | 10:00 AM
      Advancing Personalized Medicine through whole-genome profiling
      Advancing Personalized Medicine through whole-genome profiling
      DATE:  September 29, 2016 TIME:  10:00am PT, 1:00pm ET One of the challenges with personalized medicine lies in the identification of robust, clinically relevant biomarkers. Tra...
      Speaker: Stewart Neill, MD
      Sponsored By: Affymetrix, Affymetrix
      10
      JUN 30, 2016 | 7:30 AM
      Proteome centric precision medicine:  embracing pathological diversity
      Proteome centric precision medicine: embracing pathological diversity
      Precision medicine requires success in two intertwined aspects: precision therapy and personalized medicine. Precision therapy is being able to effectively treat the right disease; to have th...
      Speaker: Jennifer Van Eyk, PhD
      Presented at: Beckman Coulter Life Sciences Virtual Trade Show
      Sponsored By: Beckman Coulter Life Sciences, Beckman Coulter Life Sciences
      8
      MAY 12, 2016 | 12:00 PM
      Learning Biology from Networks and their Structure
      Learning Biology from Networks and their Structure
      Network models are an invaluable tool for integrating multiple data types and for modeling interactions between biological elements. One common question that arises, however, is what to do wi...
      Speaker: John Platig, PhD
      Presented at: Genetics and Genomics Virtual Event Series 2016
      2
      APR 06, 2016 | 1:30 PM
      Validation and Implementation of Whole-Exome Sequencing to Guide Precision Cancer Care
      Validation and Implementation of Whole-Exome Sequencing to Guide...
      Cancer remains the second leading cause of death in the United States.  Most tumors arise from a myriad of genetic changes that dysregulate cell growth and prompt survival.  Ident...
      Speaker: Hanna Rennert, PhD, F.A.C.M.G
      Presented at: Molecular Diagnostics Virtual Event Series 2016
      4
      APR 06, 2016 | 6:00 AM
      EFIRM Liquid Biopsy
      EFIRM Liquid Biopsy
      The advent of personalized medicine employing molecular targeted therapies has markedly changed the treatment of cancer in the past 10 years. Although tumor tissue biopsy-based genotyping is...
      Speaker: David Wong DMD, DMSc
      Presented at: Molecular Diagnostics Virtual Event Series 2016
      5 1
      FEB 02, 2016 | 9:00 AM
      Arrays or RNA-Seq? Choosing the right tool for the job
      Arrays or RNA-Seq? Choosing the right tool for the job
      DATE: February 2nd, 2016 TIME:  9am pacific time, 12pm eastern time What is the most appropriate technology to empower your research?   Next generation sequencing (NGS) for RN...
      Speaker: Sridar Chittur, PhD, MBA , Yesim Gökmen-Polar, PhD
      Sponsored By: Affymetrix, Affymetrix
      11 3
      JAN 26, 2016 | 8:00 AM
      WEBINAR: Concordance of PTEN gene status in circulating tumor cells and tumor tissue from mCRPC patients
      WEBINAR: Concordance of PTEN gene status in circulating tumor...
      DATE: January 26th, 2016 TIME: 8am pacific, 11am eastern PTEN gene loss occurs frequently in castration-resistant prostate cancer (CRPC) and may drive progression through activation of th...
      Speaker: Edith Szafer-Glusman, PhD
      Sponsored By: Epic Sciences, Epic Sciences
      9
      JAN 21, 2016 | 8:00 AM
      How to identify key genes with CRISPR-Cas9 and shRNA screens
      How to identify key genes with CRISPR-Cas9 and shRNA screens
      DATE:  January 21, 2016 TIME:   8am Pacific time, 11am Eastern time In this webinar, you will learn:  basics of pooled lentiviral screening workflows implications of ...
      Speaker: Anja Smith, PhD
      Sponsored By: Dharmacon, Dharmacon
      18 1
      DEC 02, 2015 | 8:00 AM
      WEBINAR: Novel Psychoactive Substances: challenges and choices in forensic toxicology
      WEBINAR: Novel Psychoactive Substances: challenges and choices...
      Live Webinar: December 2, 2015 8:00am PST In recent years, there has been a dramatic increase in the number of new designer drugs designed to mimic the effects of controlled substances. &n...
      Speaker: Julia Pearson, PhD, DABFT
      Sponsored By: Thermo Fisher Scientific, Thermo Fisher Scientific
      8
      NOV 12, 2015 | 10:30 AM
      Pharmacogenetics in the Clinical Laboratory: Opportunities and Challenges
      Pharmacogenetics in the Clinical Laboratory: Opportunities and...
      Appropriate dosing of pharmaceuticals is critical to prevent sub-therapeutic efficacy or the occurrence of adverse events. However, genetic variability may significantly influence an individu...
      Speaker: Allison Chambliss, PhD
      Presented at: Clinical Diagnostics & Research Virtual Event Series 2015
      4
      NOV 04, 2015 | 11:00 AM
      Advances in AMPK and Autophagy signaling
      Advances in AMPK and Autophagy signaling
      DATE: November 4th, 2015 TIME: 11:00am Pacific time, 2:00pm Eastern time AMPK, a highly conserved sensor of cellular energy status, is found in all eukaryotic cells and maintains met...
      Speaker: Reuben Shaw, PhD
      Sponsored By: Cell Signaling Technology, Cell Signaling Technology
      14 1
      OCT 28, 2015 | 11:00 AM
      The Hidden Effects of Epigenetic Discoveries
      The Hidden Effects of Epigenetic Discoveries
      DATE: October 28th, 2015TIME: 11am Pacific time, 2pm Eastern timeNew discoveries uncover that exposure to current environmental, dietary, behavioral, and medical conditions can significantly...
      Speaker: Jeffrey Kim, PhD , Christopher Scharer, PhD , Carlos Barrero, MD
      Sponsored By: Rockland
      25
      OCT 01, 2015 | 12:00 PM
      Detection and sequencing of rare mutations using mutation enrichment via COLD-PCR
      Detection and sequencing of rare mutations using mutation enrichment...
      Detection of rare mutations is required for reliable identification of mutations in liquid biopsies and heterogeneous tumors. Yet low-level mutation detection remains a technically challengin...
      Speaker: Mike Makrigiorgos, PhD, DABMP
      Presented at: Cancer Research & Oncology Week Virtual Event Series 2015
      2
      OCT 01, 2015 | 8:00 AM
      WEBINAR: Close your uncertainty gap with High Resolution Mass Spectrometry
      WEBINAR: Close your uncertainty gap with High Resolution Mass...
      Is your lab constantly challenged by case back log while trying to validate new methods to identify designer drugs? Your challenge is common to many forensic toxicology labs around the world....
      Speaker: Maciej Bromirski, MSc , Kristine Van Natta
      Sponsored By: Thermo Fisher Scientific, Thermo Fisher Scientific
      2 1
      SEP 03, 2015 | 3:00 PM
      Next-Generation Sequencing for Diagnosis and Surveillance of Emerging Infections
      Next-Generation Sequencing for Diagnosis and Surveillance of Emerging...
      Next-generation sequencing (NGS) technologies are powerful approaches for diagnosis and surveillance of emerging infections. Unbiased metagenomic NGS can detect the full spectrum of pathogen...
      Speaker: Charles Chiu, MD, PhD
      Presented at: Microbiology Virtual Event Series 2015
      2
      SEP 02, 2015 | 6:00 AM
      Simple, fast and accurate microbial identification by sequencing
      Simple, fast and accurate microbial identification by sequencing
      Managing microbial contaminants is critical during the manufacturing of biologics, food and beverage to ensure that products meet the high quality product standard as well as staying complian...
      Speaker: Jane Luo, PhD
      Presented at: Microbiology Virtual Event Series 2015
      9
      JUN 30, 2015 | 11:00 AM
      Webinar: Simplify Routine Workflows - Using LC-tandem MS for General Clinical Use
      Webinar: Simplify Routine Workflows - Using LC-tandem MS for General...
      Date: Tuesday, June 30th, 2015Time: 11:00AM PDT, 2:00PM EDT There is a growing interest of LC-tandem MS in clinical laboratories because this analytical technique can provide definitive ident...
      Speaker: Joseph Di Bussolo, PhD
      Sponsored By: Thermo Fisher Scientific, Thermo Fisher Scientific
      7
      MAY 14, 2015 | 1:30 PM
      Germline Cancer Genetics in 2015
      Germline Cancer Genetics in 2015
      Germline cancer genetics became a reality with the cloning of the tumor suppressor gene RB1 for hereditary retinoblastoma in 1986 by Friend and Weinberg. The existence of cancer susceptibili...
      Speaker: Judy E Garber, MD, MPH
      Presented at: Genetics and Genomics Virtual Event Series 2015
      4
      MAY 13, 2015 | 3:00 PM
      Using the network architecture of eQTLs to understand complex traits
      Using the network architecture of eQTLs to understand complex...
      Genome Wide Association Studies (GWAS) and eQTL analyses are producing huge numbers of associations and show no signs of slowing. There are now more than 8,500 SNPs associated with more than...
      Speaker: John Platig, PhD
      Presented at: Genetics and Genomics Virtual Event Series 2015
      2
      MAY 13, 2015 | 1:30 PM
      More from Less- High Quality Data from Low Quality Samples
      More from Less- High Quality Data from Low Quality Samples
      The continued growth of DNA sequencing as a fundamental data output has driven the need for the ability to generate high quality data from an increasing breadth of diminishing primary sample...
      Speaker: Andrew Barry
      Presented at: Genetics and Genomics Virtual Event Series 2015
      4
      APR 07, 2015 | 8:30 AM
      Diabetic Cardiomyopathy Modeling & Screening with iPSC Cardiomyocytes
      Diabetic Cardiomyopathy Modeling & Screening with iPSC Cardiomyocytes
      Date: Tuesday, April 7th, 2015Time: 8:30AM PST, 11:30AM EST, 5:30PM CETThe development of new medicines for Diabetes Type 2 complications has proven to be challenging due to the use of cell...
      Speaker: Roberto Iacone, PhD , Brad Swanson, PhD
      Sponsored By: Cellular Dynamics, Cellular Dynamics
      11 2
      OCT 30, 2014 | 1:30 PM
      Dissecting cancer signaling pathways with chemical scalpels
      Dissecting cancer signaling pathways with chemical scalpels
      Advances in genomic research have led to identification of the majority of the drivers of tumor progression. However, our understanding of the molecular mechanisms propelling tumor growth is...
      Speaker: Nadya Tarasova, PhD
      Presented at: Cancer: Research, Discovery and Therapeutics Virtual Event Series 2014
      14
      OCT 30, 2014 | 12:00 PM
      Breast-Predict: Leveraging the Power of Systems Medicine Towards Personalized Cancer Therapy
      Breast-Predict: Leveraging the Power of Systems Medicine Towards...
      Although the incidence of breast cancer is steadily increasing, mortality rates are decreasing. This means that the majority of women with breast cancer now survive, making it even more impor...
      Speaker: William M. Gallagher, BSc PhD CBiol MSB
      Presented at: Cancer: Research, Discovery and Therapeutics Virtual Event Series 2014
      12
    NOV 16, 2016 | 8:00 AM
    The important role of lncRNAs in breast cancer
    The important role of lncRNAs in breast cancer
    DATE:  November 16, 2016 TIME:  8:00am PT, 11:00am ET  Breast cancer is the most commonly diagnosed cancer in women and is the second leading cause of cancer death among wo...
    Speaker: Rebecca DeVaux, PhD , Alfredo Hidalgo-Miranda, PhD
    Sponsored By: Affymetrix, Affymetrix
    8
    SEP 29, 2016 | 10:00 AM
    Advancing Personalized Medicine through whole-genome profiling
    Advancing Personalized Medicine through whole-genome profiling
    DATE:  September 29, 2016 TIME:  10:00am PT, 1:00pm ET One of the challenges with personalized medicine lies in the identification of robust, clinically relevant biomarkers. Tra...
    Speaker: Stewart Neill, MD
    Sponsored By: Affymetrix, Affymetrix
    10
    JUN 30, 2016 | 7:30 AM
    Proteome centric precision medicine:  embracing pathological diversity
    Proteome centric precision medicine: embracing pathological diversity
    Precision medicine requires success in two intertwined aspects: precision therapy and personalized medicine. Precision therapy is being able to effectively treat the right disease; to have th...
    Speaker: Jennifer Van Eyk, PhD
    Presented at: Beckman Coulter Life Sciences Virtual Trade Show
    Sponsored By: Beckman Coulter Life Sciences, Beckman Coulter Life Sciences
    8
    MAY 12, 2016 | 12:00 PM
    Learning Biology from Networks and their Structure
    Learning Biology from Networks and their Structure
    Network models are an invaluable tool for integrating multiple data types and for modeling interactions between biological elements. One common question that arises, however, is what to do wi...
    Speaker: John Platig, PhD
    Presented at: Genetics and Genomics Virtual Event Series 2016
    2
    APR 06, 2016 | 1:30 PM
    Validation and Implementation of Whole-Exome Sequencing to Guide Precision Cancer Care
    Validation and Implementation of Whole-Exome Sequencing to Guide...
    Cancer remains the second leading cause of death in the United States.  Most tumors arise from a myriad of genetic changes that dysregulate cell growth and prompt survival.  Ident...
    Speaker: Hanna Rennert, PhD, F.A.C.M.G
    Presented at: Molecular Diagnostics Virtual Event Series 2016
    4
     
     
  • APR 06, 2016 | 6:00 AM
    EFIRM Liquid Biopsy
    EFIRM Liquid Biopsy
    The advent of personalized medicine employing molecular targeted therapies has markedly changed the treatment of cancer in the past 10 years. Although tumor tissue biopsy-based genotyping is...
    Speaker: David Wong DMD, DMSc
    Presented at: Molecular Diagnostics Virtual Event Series 2016
    5 1
    FEB 02, 2016 | 9:00 AM
    Arrays or RNA-Seq? Choosing the right tool for the job
    Arrays or RNA-Seq? Choosing the right tool for the job
    DATE: February 2nd, 2016 TIME:  9am pacific time, 12pm eastern time What is the most appropriate technology to empower your research?   Next generation sequencing (NGS) for RN...
    Speaker: Sridar Chittur, PhD, MBA , Yesim Gökmen-Polar, PhD
    Sponsored By: Affymetrix, Affymetrix
    11 3
    JAN 26, 2016 | 8:00 AM
    WEBINAR: Concordance of PTEN gene status in circulating tumor cells and tumor tissue from mCRPC patients
    WEBINAR: Concordance of PTEN gene status in circulating tumor...
    DATE: January 26th, 2016 TIME: 8am pacific, 11am eastern PTEN gene loss occurs frequently in castration-resistant prostate cancer (CRPC) and may drive progression through activation of th...
    Speaker: Edith Szafer-Glusman, PhD
    Sponsored By: Epic Sciences, Epic Sciences
    9
    JAN 21, 2016 | 8:00 AM
    How to identify key genes with CRISPR-Cas9 and shRNA screens
    How to identify key genes with CRISPR-Cas9 and shRNA screens
    DATE:  January 21, 2016 TIME:   8am Pacific time, 11am Eastern time In this webinar, you will learn:  basics of pooled lentiviral screening workflows implications of ...
    Speaker: Anja Smith, PhD
    Sponsored By: Dharmacon, Dharmacon
    18 1
    DEC 02, 2015 | 8:00 AM
    WEBINAR: Novel Psychoactive Substances: challenges and choices in forensic toxicology
    WEBINAR: Novel Psychoactive Substances: challenges and choices...
    Live Webinar: December 2, 2015 8:00am PST In recent years, there has been a dramatic increase in the number of new designer drugs designed to mimic the effects of controlled substances. &n...
    Speaker: Julia Pearson, PhD, DABFT
    Sponsored By: Thermo Fisher Scientific, Thermo Fisher Scientific
    8
     
     
  • NOV 12, 2015 | 10:30 AM
    Pharmacogenetics in the Clinical Laboratory: Opportunities and Challenges
    Pharmacogenetics in the Clinical Laboratory: Opportunities and...
    Appropriate dosing of pharmaceuticals is critical to prevent sub-therapeutic efficacy or the occurrence of adverse events. However, genetic variability may significantly influence an individu...
    Speaker: Allison Chambliss, PhD
    Presented at: Clinical Diagnostics & Research Virtual Event Series 2015
    4
    NOV 04, 2015 | 11:00 AM
    Advances in AMPK and Autophagy signaling
    Advances in AMPK and Autophagy signaling
    DATE: November 4th, 2015 TIME: 11:00am Pacific time, 2:00pm Eastern time AMPK, a highly conserved sensor of cellular energy status, is found in all eukaryotic cells and maintains met...
    Speaker: Reuben Shaw, PhD
    Sponsored By: Cell Signaling Technology, Cell Signaling Technology
    14 1
    OCT 28, 2015 | 11:00 AM
    The Hidden Effects of Epigenetic Discoveries
    The Hidden Effects of Epigenetic Discoveries
    DATE: October 28th, 2015TIME: 11am Pacific time, 2pm Eastern timeNew discoveries uncover that exposure to current environmental, dietary, behavioral, and medical conditions can significantly...
    Speaker: Jeffrey Kim, PhD , Christopher Scharer, PhD , Carlos Barrero, MD
    Sponsored By: Rockland
    25
    OCT 01, 2015 | 12:00 PM
    Detection and sequencing of rare mutations using mutation enrichment via COLD-PCR
    Detection and sequencing of rare mutations using mutation enrichment...
    Detection of rare mutations is required for reliable identification of mutations in liquid biopsies and heterogeneous tumors. Yet low-level mutation detection remains a technically challengin...
    Speaker: Mike Makrigiorgos, PhD, DABMP
    Presented at: Cancer Research & Oncology Week Virtual Event Series 2015
    2
    OCT 01, 2015 | 8:00 AM
    WEBINAR: Close your uncertainty gap with High Resolution Mass Spectrometry
    WEBINAR: Close your uncertainty gap with High Resolution Mass...
    Is your lab constantly challenged by case back log while trying to validate new methods to identify designer drugs? Your challenge is common to many forensic toxicology labs around the world....
    Speaker: Maciej Bromirski, MSc , Kristine Van Natta
    Sponsored By: Thermo Fisher Scientific, Thermo Fisher Scientific
    2 1
     
     
  • SEP 03, 2015 | 3:00 PM
    Next-Generation Sequencing for Diagnosis and Surveillance of Emerging Infections
    Next-Generation Sequencing for Diagnosis and Surveillance of Emerging...
    Next-generation sequencing (NGS) technologies are powerful approaches for diagnosis and surveillance of emerging infections. Unbiased metagenomic NGS can detect the full spectrum of pathogen...
    Speaker: Charles Chiu, MD, PhD
    Presented at: Microbiology Virtual Event Series 2015
    2
    SEP 02, 2015 | 6:00 AM
    Simple, fast and accurate microbial identification by sequencing
    Simple, fast and accurate microbial identification by sequencing
    Managing microbial contaminants is critical during the manufacturing of biologics, food and beverage to ensure that products meet the high quality product standard as well as staying complian...
    Speaker: Jane Luo, PhD
    Presented at: Microbiology Virtual Event Series 2015
    9
    JUN 30, 2015 | 11:00 AM
    Webinar: Simplify Routine Workflows - Using LC-tandem MS for General Clinical Use
    Webinar: Simplify Routine Workflows - Using LC-tandem MS for General...
    Date: Tuesday, June 30th, 2015Time: 11:00AM PDT, 2:00PM EDT There is a growing interest of LC-tandem MS in clinical laboratories because this analytical technique can provide definitive ident...
    Speaker: Joseph Di Bussolo, PhD
    Sponsored By: Thermo Fisher Scientific, Thermo Fisher Scientific
    7
    MAY 14, 2015 | 1:30 PM
    Germline Cancer Genetics in 2015
    Germline Cancer Genetics in 2015
    Germline cancer genetics became a reality with the cloning of the tumor suppressor gene RB1 for hereditary retinoblastoma in 1986 by Friend and Weinberg. The existence of cancer susceptibili...
    Speaker: Judy E Garber, MD, MPH
    Presented at: Genetics and Genomics Virtual Event Series 2015
    4
    MAY 13, 2015 | 3:00 PM
    Using the network architecture of eQTLs to understand complex traits
    Using the network architecture of eQTLs to understand complex...
    Genome Wide Association Studies (GWAS) and eQTL analyses are producing huge numbers of associations and show no signs of slowing. There are now more than 8,500 SNPs associated with more than...
    Speaker: John Platig, PhD
    Presented at: Genetics and Genomics Virtual Event Series 2015
    2
     
     
  • MAY 13, 2015 | 1:30 PM
    More from Less- High Quality Data from Low Quality Samples
    More from Less- High Quality Data from Low Quality Samples
    The continued growth of DNA sequencing as a fundamental data output has driven the need for the ability to generate high quality data from an increasing breadth of diminishing primary sample...
    Speaker: Andrew Barry
    Presented at: Genetics and Genomics Virtual Event Series 2015
    4
    APR 07, 2015 | 8:30 AM
    Diabetic Cardiomyopathy Modeling & Screening with iPSC Cardiomyocytes
    Diabetic Cardiomyopathy Modeling & Screening with iPSC Cardiomyocytes
    Date: Tuesday, April 7th, 2015Time: 8:30AM PST, 11:30AM EST, 5:30PM CETThe development of new medicines for Diabetes Type 2 complications has proven to be challenging due to the use of cell...
    Speaker: Roberto Iacone, PhD , Brad Swanson, PhD
    Sponsored By: Cellular Dynamics, Cellular Dynamics
    11 2
    OCT 30, 2014 | 1:30 PM
    Dissecting cancer signaling pathways with chemical scalpels
    Dissecting cancer signaling pathways with chemical scalpels
    Advances in genomic research have led to identification of the majority of the drivers of tumor progression. However, our understanding of the molecular mechanisms propelling tumor growth is...
    Speaker: Nadya Tarasova, PhD
    Presented at: Cancer: Research, Discovery and Therapeutics Virtual Event Series 2014
    14
    OCT 30, 2014 | 12:00 PM
    Breast-Predict: Leveraging the Power of Systems Medicine Towards Personalized Cancer Therapy
    Breast-Predict: Leveraging the Power of Systems Medicine Towards...
    Although the incidence of breast cancer is steadily increasing, mortality rates are decreasing. This means that the majority of women with breast cancer now survive, making it even more impor...
    Speaker: William M. Gallagher, BSc PhD CBiol MSB
    Presented at: Cancer: Research, Discovery and Therapeutics Virtual Event Series 2014
    12
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