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    Drug Discovery

    Drug Discovery: drug discovery is the process by which new candidate medications are discovered. Historically, drugs were discovered through identifying the active ingredient from traditional remedies or by serendipitous discovery. Modern drug discovery involves the identification of screening hits, medicinal chemistry and optimization of those hits to increase the affinity, selectivity (to reduce the potential of side effects), efficacy/potency, metabolic stability (to increase the half-life), and oral bioavailability.

    Trending News

    • FEB 08, 2019
      Drug Discovery & Development
      Drug Combination Generates New Neurons from Neighboring Cells
      Drug Combination Generates New Neurons from Neighboring Cells
      In a study published in Stem Cell Reports, scientists at Penn State University have developed a drug cocktail that conve ...
      Written By: Nouran Amin
      2
      FEB 05, 2019
      Neuroscience
      Proposed New Criteria For Diagnosing Parkinson's
      Proposed New Criteria For Diagnosing Parkinson's
      A new review published in the Journal of Parkinson’s Disease suggests that our previous diagnostic criteria f ...
      Written By: Amy Loriaux
      1
      FEB 04, 2019
      Cancer
      Can Chemotherapy Be Improved?
      Can Chemotherapy Be Improved?
      With all of these "new and improved" methods to treat cancer, such as immuno-based, using nanotechnology, to g ...
      Written By: Amy Loriaux
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      FEB 04, 2019
      Microbiology
      Potential New Antibiotic is Made by an Insect-linked Microbe
      Potential New Antibiotic is Made by an Insect-linked Microbe
      Like many other organisms, bacteria have to compete for resources and have developed a wide array of strategies to use, ...
      Written By: Carmen Leitch
      2
      FEB 03, 2019
      Cell & Molecular Biology
      Hyperactive Neurons May Interfere with the Efficacy of Antidepressants
      Hyperactive Neurons May Interfere with the Efficacy of Antidepressants
      About 6.7 percent of Americans had a major depressive episode in 2016. SSRIs are often prescribed as a treatment, but do ...
      Written By: Carmen Leitch
      1
      FEB 01, 2019
      Drug Discovery & Development
      Re-purposing Anti-rejection Drug for Liver Cancers
      Re-purposing Anti-rejection Drug for Liver Cancers
      Scientists at the University of Pittsburgh School of Medicine have identified a molecular pathway in liver that can allo ...
      Written By: Nouran Amin
      1
      FEB 01, 2019
      Drug Discovery & Development
      Statin Therapy Reduces Risk of Cardiovascular Complications Regardless of Age
      Statin Therapy Reduces Risk of Cardiovascular Complications Regardless of Age
      A meta-analysis study, from randomized clinical trials, found that regardless of age, statin therapy is effective in dec ...
      Written By: Nouran Amin
      2
      FEB 01, 2019
      Cancer
      Can Israeli Company Keep its Promise for a Cure For Cancer?
      Can Israeli Company Keep its Promise for a Cure For Cancer?
      Accelerated Evolution Biotechnology, Ltd. (AEBI), an Israeli company led by CEO Dr. Ilan Morad, made some bold clai ...
      Written By: Amy Loriaux
      1
      FEB 01, 2019
      Cardiology
      Parents Prefer Opioids For Their Children Despite Risks
      Parents Prefer Opioids For Their Children Despite Risks
      Opioid abuse has become an epidemic in the United States. It is estimated that 72,000 deaths were the result of opioid a ...
      Written By: Abbie Arce
      1
      JAN 30, 2019
      Genetics & Genomics
      Hens Engineered to Generate Human Proteins in Their Eggs
      Hens Engineered to Generate Human Proteins in Their Eggs
      Chicken eggs have been used for over 70 years to produce vaccines. Now they could be used to reduce the cost of making c ...
      Written By: Carmen Leitch
      1
      JAN 27, 2019
      Microbiology
      Alzheimer's Linked to a Gum Disease-associated Bacterium
      Alzheimer's Linked to a Gum Disease-associated Bacterium
      Alzheimer's is more likely in the aged, but the exact causes were unclear. New work shows that it may stem from a brain ...
      Written By: Carmen Leitch
      2
      JAN 26, 2019
      Cell & Molecular Biology
      Researchers ID Protein That's Critical to Insulin Production
      Researchers ID Protein That's Critical to Insulin Production
      Insulin is critical to the control of the amount of glucose in the blood. Problems with insulin levels cause diseases li ...
      Written By: Carmen Leitch
      1
      JAN 24, 2019
      Drug Discovery & Development
      Why Do Promising Cancer Drugs Fail?
      Why Do Promising Cancer Drugs Fail?
      After almost 20 years of a once-promising cancer drugs known as MMP inhibitors suddenly failed in clinical trials, scien ...
      Written By: Nouran Amin
      1
      JAN 24, 2019
      Drug Discovery & Development
      Drug Blocks Toxic-Protein Production in ALS
      Drug Blocks Toxic-Protein Production in ALS
      Individuals with ALS, frontotemporal dementia, carry a mutation in the gene C9orf72—resulting in repeated DNA sequ ...
      Written By: Nouran Amin
      1
      JAN 24, 2019
      Drug Discovery & Development
      Drug Slows Cancer's Circadian Clock
      Drug Slows Cancer's Circadian Clock
      According to a study done on human kidney cancer cells and acute myeloid leukemia cells in mice, a compound was examined ...
      Written By: Nouran Amin
      1
      JAN 23, 2019
      Cardiology
      New Discoveries Bring Us Closer To Eliminating Heart Attacks
      New Discoveries Bring Us Closer To Eliminating Heart Attacks
      A host of new discoveries bring medicine closer to the goal of ending heart attacks. These include new protective method ...
      Written By: Abbie Arce
      1
      JAN 23, 2019
      Drug Discovery & Development
      Frequent Aspirin Use Can Lead to Increased Bleeding
      Frequent Aspirin Use Can Lead to Increased Bleeding
      According to a systemic study published in the Journal of the American Medical Association (JAMA), taking aspirin regula ...
      Written By: Nouran Amin
      1
      JAN 23, 2019
      Immunology
      Unleashing the Immune System on Cancer
      Unleashing the Immune System on Cancer
      A team of international researchers has discovered that there may me a more from the immune system to aid in the battle ...
      Written By: Nicholas Breehl
      2
      JAN 23, 2019
      Drug Discovery & Development
      Stroke Drug May Prevent Alzheimer
      Stroke Drug May Prevent Alzheimer
      According to a study published in the Journal of Experimental Medicine, scientists at the University of Southern Califor ...
      Written By: Nouran Amin
      1
      JAN 23, 2019
      Health & Medicine
      Leprosy: An Ancient Disease in Modern Medicine
      Leprosy: An Ancient Disease in Modern Medicine
      People who have leprosy, an infectious disease that has been described in ancient civilizations, have consistently been ...
      Written By: Dena Aruta
      1 2
      JAN 21, 2019
      Genetics & Genomics
      Genetic Connections to Osteoarthritis and Potential Treatments
      Genetic Connections to Osteoarthritis and Potential Treatments
      Scientists are learning more about how small genetic changes can lead to an increased risk of disease.
      Written By: Carmen Leitch
      1 1
      JAN 20, 2019
      Drug Discovery & Development
      Combination Therapeutic Effective for Leishmaniasis and HIV Patients
      Combination Therapeutic Effective for Leishmaniasis and HIV Patients
      In a study published in PLOS Neglected Diseases, a special combination therapy has been proven for efficacy in cases of ...
      Written By: Nouran Amin
      2 1
      JAN 20, 2019
      Drug Discovery & Development
      Multiple sclerosis treatments hold long-term benefits
      Multiple sclerosis treatments hold long-term benefits
      An international study, led by the Clinical Outcomes Research unit (CORe) at Royal Melbourne Hospital and University of ...
      Written By: Nouran Amin
      3
      JAN 19, 2019
      Drug Discovery & Development
      Therapeutic Avenues in Chronic Liver Disease
      Therapeutic Avenues in Chronic Liver Disease
      Known as being a silent killer, diagnosing chronic liver disease in its early stages remains a clinical challenge becaus ...
      Written By: Nouran Amin
      3
    FEB 08, 2019
    Drug Discovery & Development
    Drug Combination Generates New Neurons from Neighboring Cells
    Drug Combination Generates New Neurons from Neighboring Cells
    In a study published in Stem Cell Reports, scientists at Penn State University have developed a drug cocktail that conve ...
    Written By: Nouran Amin
    2
    FEB 05, 2019
    Neuroscience
    Proposed New Criteria For Diagnosing Parkinson's
    Proposed New Criteria For Diagnosing Parkinson's
    A new review published in the Journal of Parkinson’s Disease suggests that our previous diagnostic criteria f ...
    Written By: Amy Loriaux
    1
    FEB 04, 2019
    Cancer
    Can Chemotherapy Be Improved?
    Can Chemotherapy Be Improved?
    With all of these "new and improved" methods to treat cancer, such as immuno-based, using nanotechnology, to g ...
    Written By: Amy Loriaux
    1 1
    FEB 04, 2019
    Microbiology
    Potential New Antibiotic is Made by an Insect-linked Microbe
    Potential New Antibiotic is Made by an Insect-linked Microbe
    Like many other organisms, bacteria have to compete for resources and have developed a wide array of strategies to use, ...
    Written By: Carmen Leitch
    2
    FEB 03, 2019
    Cell & Molecular Biology
    Hyperactive Neurons May Interfere with the Efficacy of Antidepressants
    Hyperactive Neurons May Interfere with the Efficacy of Antidepressants
    About 6.7 percent of Americans had a major depressive episode in 2016. SSRIs are often prescribed as a treatment, but do ...
    Written By: Carmen Leitch
    1
     
     
  • FEB 01, 2019
    Drug Discovery & Development
    Re-purposing Anti-rejection Drug for Liver Cancers
    Re-purposing Anti-rejection Drug for Liver Cancers
    Scientists at the University of Pittsburgh School of Medicine have identified a molecular pathway in liver that can allo ...
    Written By: Nouran Amin
    1
    FEB 01, 2019
    Drug Discovery & Development
    Statin Therapy Reduces Risk of Cardiovascular Complications Regardless of Age
    Statin Therapy Reduces Risk of Cardiovascular Complications Regardless of Age
    A meta-analysis study, from randomized clinical trials, found that regardless of age, statin therapy is effective in dec ...
    Written By: Nouran Amin
    2
    FEB 01, 2019
    Cancer
    Can Israeli Company Keep its Promise for a Cure For Cancer?
    Can Israeli Company Keep its Promise for a Cure For Cancer?
    Accelerated Evolution Biotechnology, Ltd. (AEBI), an Israeli company led by CEO Dr. Ilan Morad, made some bold clai ...
    Written By: Amy Loriaux
    1
    FEB 01, 2019
    Cardiology
    Parents Prefer Opioids For Their Children Despite Risks
    Parents Prefer Opioids For Their Children Despite Risks
    Opioid abuse has become an epidemic in the United States. It is estimated that 72,000 deaths were the result of opioid a ...
    Written By: Abbie Arce
    1
    JAN 30, 2019
    Genetics & Genomics
    Hens Engineered to Generate Human Proteins in Their Eggs
    Hens Engineered to Generate Human Proteins in Their Eggs
    Chicken eggs have been used for over 70 years to produce vaccines. Now they could be used to reduce the cost of making c ...
    Written By: Carmen Leitch
    1
     
     
  • JAN 27, 2019
    Microbiology
    Alzheimer's Linked to a Gum Disease-associated Bacterium
    Alzheimer's Linked to a Gum Disease-associated Bacterium
    Alzheimer's is more likely in the aged, but the exact causes were unclear. New work shows that it may stem from a brain ...
    Written By: Carmen Leitch
    2
    JAN 26, 2019
    Cell & Molecular Biology
    Researchers ID Protein That's Critical to Insulin Production
    Researchers ID Protein That's Critical to Insulin Production
    Insulin is critical to the control of the amount of glucose in the blood. Problems with insulin levels cause diseases li ...
    Written By: Carmen Leitch
    1
    JAN 24, 2019
    Drug Discovery & Development
    Why Do Promising Cancer Drugs Fail?
    Why Do Promising Cancer Drugs Fail?
    After almost 20 years of a once-promising cancer drugs known as MMP inhibitors suddenly failed in clinical trials, scien ...
    Written By: Nouran Amin
    1
    JAN 24, 2019
    Drug Discovery & Development
    Drug Blocks Toxic-Protein Production in ALS
    Drug Blocks Toxic-Protein Production in ALS
    Individuals with ALS, frontotemporal dementia, carry a mutation in the gene C9orf72—resulting in repeated DNA sequ ...
    Written By: Nouran Amin
    1
    JAN 24, 2019
    Drug Discovery & Development
    Drug Slows Cancer's Circadian Clock
    Drug Slows Cancer's Circadian Clock
    According to a study done on human kidney cancer cells and acute myeloid leukemia cells in mice, a compound was examined ...
    Written By: Nouran Amin
    1
     
     
  • JAN 23, 2019
    Cardiology
    New Discoveries Bring Us Closer To Eliminating Heart Attacks
    New Discoveries Bring Us Closer To Eliminating Heart Attacks
    A host of new discoveries bring medicine closer to the goal of ending heart attacks. These include new protective method ...
    Written By: Abbie Arce
    1
    JAN 23, 2019
    Drug Discovery & Development
    Frequent Aspirin Use Can Lead to Increased Bleeding
    Frequent Aspirin Use Can Lead to Increased Bleeding
    According to a systemic study published in the Journal of the American Medical Association (JAMA), taking aspirin regula ...
    Written By: Nouran Amin
    1
    JAN 23, 2019
    Immunology
    Unleashing the Immune System on Cancer
    Unleashing the Immune System on Cancer
    A team of international researchers has discovered that there may me a more from the immune system to aid in the battle ...
    Written By: Nicholas Breehl
    2
    JAN 23, 2019
    Drug Discovery & Development
    Stroke Drug May Prevent Alzheimer
    Stroke Drug May Prevent Alzheimer
    According to a study published in the Journal of Experimental Medicine, scientists at the University of Southern Califor ...
    Written By: Nouran Amin
    1
    JAN 23, 2019
    Health & Medicine
    Leprosy: An Ancient Disease in Modern Medicine
    Leprosy: An Ancient Disease in Modern Medicine
    People who have leprosy, an infectious disease that has been described in ancient civilizations, have consistently been ...
    Written By: Dena Aruta
    1 2
     
     
  • JAN 21, 2019
    Genetics & Genomics
    Genetic Connections to Osteoarthritis and Potential Treatments
    Genetic Connections to Osteoarthritis and Potential Treatments
    Scientists are learning more about how small genetic changes can lead to an increased risk of disease.
    Written By: Carmen Leitch
    1 1
    JAN 20, 2019
    Drug Discovery & Development
    Combination Therapeutic Effective for Leishmaniasis and HIV Patients
    Combination Therapeutic Effective for Leishmaniasis and HIV Patients
    In a study published in PLOS Neglected Diseases, a special combination therapy has been proven for efficacy in cases of ...
    Written By: Nouran Amin
    2 1
    JAN 20, 2019
    Drug Discovery & Development
    Multiple sclerosis treatments hold long-term benefits
    Multiple sclerosis treatments hold long-term benefits
    An international study, led by the Clinical Outcomes Research unit (CORe) at Royal Melbourne Hospital and University of ...
    Written By: Nouran Amin
    3
    JAN 19, 2019
    Drug Discovery & Development
    Therapeutic Avenues in Chronic Liver Disease
    Therapeutic Avenues in Chronic Liver Disease
    Known as being a silent killer, diagnosing chronic liver disease in its early stages remains a clinical challenge becaus ...
    Written By: Nouran Amin
    3
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