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Drug Discovery
Drug Discovery: drug discovery is the process by which new candidate medications are discovered. Historically, drugs were discovered through identifying the active ingredient from traditional remedies or by serendipitous discovery. Modern drug discovery involves the identification of screening hits, medicinal chemistry and optimization of those hits to increase the affinity, selectivity (to reduce the potential of side effects), efficacy/potency, metabolic stability (to increase the half-life), and oral bioavailability.
FEB 04, 2015 | 12:00 PM
C.E. CREDITS
In Chile, the regulatory context regarding animal use in research is very poor. A legal framework for Animal Care and Use Committees is practically nonexistent. Also, the chilean culture play...
FEB 04, 2015 | 10:30 AM
C.E. CREDITS
It is the often-ignored simple tips in rodent surgery that make the difference and help minimize postoperative complications and mortality. The presenter will use his years of experience to...
FEB 04, 2015 | 9:00 AM
C.E. CREDITS
Some commonly accepted principles of biosafety include the strict adherence to standard laboratory practices and techniques, the use of safety equipment such as primary barriers and personal...
FEB 04, 2015 | 7:30 AM
C.E. CREDITS
During my presentation, we will discuss:- Normal patterns of behavior (repertoire): social, food intake, territorial, agonistic, anti-predation, sleep and rest, play behavior, grooming, sex...
FEB 04, 2015 | 7:30 AM
C.E. CREDITS
The transportation of laboratory animals is a critical step in obtaining the proper strain of animal that best fits the researchers needs. Animal Extremist groups have made this transportati...
FEB 04, 2015 | 6:00 AM
C.E. CREDITS
Soiled-bedding sentinels are not always efficient in detecting pathogens in rodent colonies. In this context, PCR-based testing can be more sensitive and is being advocated as adjunct to trad...
FEB 04, 2015 | 6:00 AM
C.E. CREDITS
Adherence to strict aseptic technique is vital to all types of animal models requiring surgical intervention from both scientific and welfare perspectives. Training of both new and experience...
DEC 09, 2014 | 7:00 AM
 Statins are among the most commonly prescribed medications that significantly reduce cardiovascular risk in selected individuals. However, these drugs can also be associated with muscle symp...
OCT 30, 2014 | 3:00 PM
Mass spectrometry (MS)-based profiling of clinical specimens has been increasingly used in cancer research to characterize changes in protein expression between tumor and healthy tissue or be...
OCT 30, 2014 | 1:30 PM
Advances in genomic research have led to identification of the majority of the drivers of tumor progression. However, our understanding of the molecular mechanisms propelling tumor growth is...
OCT 29, 2014 | 3:00 PM
Over the last decade we have witnessed tremendous advances in our understanding of the underlying molecular alterations in human cancer. This has stimulated excitement for our ability to deve...
OCT 29, 2014 | 9:00 AM
Although robust and clinically meaningful biomarkers are key to achieving the current vision for precision (molecularly based), cancer medicine (patient stratification, early diagnosis, drug...
OCT 29, 2014 | 6:00 AM
As next-generation sequencing (NGS) platforms advance in their speed, ease-of-use, and cost-effectiveness, many translational researchers are transitioning from microarrays to RNA sequencing...
