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Drug Discovery
Drug Discovery: drug discovery is the process by which new candidate medications are discovered. Historically, drugs were discovered through identifying the active ingredient from traditional remedies or by serendipitous discovery. Modern drug discovery involves the identification of screening hits, medicinal chemistry and optimization of those hits to increase the affinity, selectivity (to reduce the potential of side effects), efficacy/potency, metabolic stability (to increase the half-life), and oral bioavailability.
MAY 26, 2015 | 6:00 AM
Sign up here to watch this Webinar On DemandCytotoxicity remains one of the major causes of drug withdrawal and there is an urgent need for reliable and time-saving assay workflows. Cells exp...
MAY 14, 2015 | 7:30 AM
I will discuss the use of genomic technologies - mostly ultrahigh-throughput DNA sequencing - to study normal human biology and to determine what goes wrong when we have disease. First I wil...
APR 07, 2015 | 8:30 AM
Date: Tuesday, April 7th, 2015Time: 8:30AM PST, 11:30AM EST, 5:30PM CETThe development of new medicines for Diabetes Type 2 complications has proven to be challenging due to the use of cell...
FEB 05, 2015 | 3:00 PM
C.E. CREDITS
As evidenced by the changes in the new Guide for the Care and Use of Laboratory animals and the latest AVMA Panel on Euthanasia, it is clear that there is growing concern about the care and w...
FEB 05, 2015 | 1:30 PM
C.E. CREDITS
The management of animal research programs has evolved into a complex and multifaceted endeavor. Scientific discovery moves at a fast pace and our knowledge of animal science is continually...
FEB 05, 2015 | 12:00 PM
C.E. CREDITS
The pre-operative assessment and post-operative is critical for successful surgical procedures which will in turn lead to high quality outcomes in research studies. The care of the animals go...
FEB 05, 2015 | 10:30 AM
C.E. CREDITS
In the context of an experimental project requiring surgical preparation of animals, training is not only required for technicians lacking a strong surgical background but also for more exper...
FEB 05, 2015 | 10:30 AM
C.E. CREDITS
Effective workplace training in a research facility is an important key in ensuring smooth operations and high standards of animal care. Today's diverse workforce offers many benefits such a...
FEB 05, 2015 | 9:00 AM
C.E. CREDITS
Recent advances in anesthesia, monitoring, pain assessment and analgesia provide many opportunities for improving the quality of our in vivo scientific data, and promoting high standards of a...
FEB 05, 2015 | 7:30 AM
C.E. CREDITS
An anesthesia system designed to accommodate the physiological characteristics of small animals, including rats and mice, has the potential to provide great practical value to the life scienc...
FEB 05, 2015 | 7:30 AM
C.E. CREDITS
Fish are vertebrates but they are physiologically and psychologically different from mammals. This presentation will try to explain their differences from mammals and the different aspects t...
FEB 05, 2015 | 6:00 AM
C.E. CREDITS
Laboratory animal surgical models are instrumental in biomedical research; therefore establishing healthy defined animal models is crucial to this research. Surgical procedures produce metab...
FEB 05, 2015 | 6:00 AM
C.E. CREDITS
Many researchers are not aware of the critical importance of genetic background of mice, including the concept of inbred substrains, and how the genetic background of substrains can impact th...
FEB 04, 2015 | 1:30 PM
C.E. CREDITS
The field of surgical research has been growing rapidly with the development of new surgical and disease models. An extremely important and often overlooked aspect of creating these models is...
