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    Drug Discovery

    Drug Discovery: drug discovery is the process by which new candidate medications are discovered. Historically, drugs were discovered through identifying the active ingredient from traditional remedies or by serendipitous discovery. Modern drug discovery involves the identification of screening hits, medicinal chemistry and optimization of those hits to increase the affinity, selectivity (to reduce the potential of side effects), efficacy/potency, metabolic stability (to increase the half-life), and oral bioavailability.

    Webinars

    • FEB 03, 2021 | 12:30 PM
      Optimizing High-Content Imaging of 3D Models for Drug Discovery
      Optimizing High-Content Imaging of 3D Models for Drug Discovery
      In vitro spheroid models are fast becoming the de facto standard for drug discovery applications, largely due to their human-like physiological and morphological characteristics, tissue-like...
      Speaker: Arvonn Tully , Judi Wardwell-Swanson
      Presented at: 7th Annual Conference: SBI2 High Content
      Sponsored By: SBI2, InSphero , Yokogawa
      11 10
      FEB 03, 2021 | 8:00 AM
      An introduction to immuno-oncology at Miltenyi Biotec
      An introduction to immuno-oncology at Miltenyi Biotec
      Date: February 3, 2021 Time: 8:00am (PST), 11:00am (EST) This introduction webinar will provide you with an overview of the general immuno-oncology (IO) research field...
      Speaker: Dr. Marcello Stein
      Sponsored By: Miltenyi Biotec
      19 2
      JAN 21, 2021 | 8:00 AM
      Critical reagent characterization for regulated bioassays accelerated by Uncle
      Critical reagent characterization for regulated bioassays accelerated...
      Date: January 21, 2021 Time: 8:00am (PST), 11:00am (EST) Today, critical reagent characterization is a key component in the overall workflow to establish robust ligand binding assays (e.g.,...
      Speaker: Ron Bowsher , Adam Kinne , Kevin Lance, Ph.D.
      Sponsored By: Unchained Labs
      6
      JAN 12, 2021 | 8:00 AM
      Storage and Logistics of Vaccines at Ultra Low Temperatures
      Storage and Logistics of Vaccines at Ultra Low Temperatures
      DATE: January 12, 2021 TIME: 8:00 am PST, 11:00 am EST, 5:00pm CET Transferring a biologic candidate from the research and development phase to commercial production usually requires increas...
      Speaker: Dr. Alex Esmon
      Sponsored By: Thermo Fisher Scientific
      9
      DEC 17, 2020 | 9:00 AM
      Advancing Cell Biology with Cryo-Correlative Microscopy
      Advancing Cell Biology with Cryo-Correlative Microscopy
      Date: December 17, 2020 Time: 9:00am (PST), 12:00pm (EST) Correlative light and electron microscopy (CLEM) advances biological discoveries by merging different microscopes and imaging moda...
      Speaker: Elizabeth Wright, Ph.D. , Jae Yang, Ph.D. , Bryan Sibert, Ph.D. , Joseph Kim
      Sponsored By: Leica Microsystems, Alveole
      13 2
      DEC 10, 2020 | 8:00 AM
      Simple and Fast Charge Variants Analysis of mAbs by CZE
      Simple and Fast Charge Variants Analysis of mAbs by CZE
      Date: December 10, 2020 Time: 8:00am (PST), 11:00am (EST) As you face increasingly shortened timelines to bring new drugs to market, you find yourself strained to finalize analytical methods...
      Speaker: Yan He, Ph.D.
      Sponsored By: SCIEX
      4 1
      DEC 08, 2020 | 7:00 AM
      Best TLC & HPTLC practices in pharmaceutical separations
      Best TLC & HPTLC practices in pharmaceutical separations
      Thin-Layer Chromatography (TLC) and High-Performance Thin-Layer Chromatography (HPTLC) are convenient, fast, and efficient separation techniques for analytical methods without demanding comp...
      Speaker: Monika Bäeumle , Michaela Oberle , Melanie Broszat
      Sponsored By: MilliporeSigma
      14 1
      DEC 07, 2020 | 9:00 AM
      Rapid hyper-plex staining and simultaneous imaging for immunophenotyping of tissue sections.
      Rapid hyper-plex staining and simultaneous imaging for immunophenotyping...
      Date: December 7, 2020 Time: 9:00am (PST), 12:00pm (EST) The simultaneous detection of biomarkers on tissue samples plays a fundamental role in the study of the tumor microenvironment. Multi...
      Speaker: Diego Dupouy, Ph.D.
      Sponsored By: Lunaphore
      7
      DEC 02, 2020 | 8:00 AM
      Optimize your bioprocess - From shaker to bioreactor
      Optimize your bioprocess - From shaker to bioreactor
      DATE: December 2nd, 2020 TIME: 08:00am PDT, 11:00pm EDT Bioreactors and shakers are used to cultivate microorganisms, plant, insect, and mammalian cells in different volumes. Upscaling of pr...
      Speaker: Ines Hartmann , David Solbach
      Sponsored By: Eppendorf
      11
      NOV 19, 2020 | 9:00 AM
      From Protein Structures to Drug Discovery: Novel therapeutic opportunities.
      From Protein Structures to Drug Discovery: Novel therapeutic opportunities.
      DATE: November 19, 2020 TIME: 9:00am PT, 12am ET Knowledge of the three-dimensional structure of therapeutically relevant targets has become an essential step in the pipeline of drug discove...
      Speaker: Amal Hassan Ali
      Sponsored By: Thermo Fisher Scientific
      16 1
      NOV 19, 2020 | 8:00 AM
      From discovery to functional assays: therapeutic antibody research by Miltenyi Biotec
      From discovery to functional assays: therapeutic antibody research...
      Date: November 19, 2020 Time: 8:00am PST, 11:00am EST Monoclonal antibody-based drugs have shown great potential as a treatment for several cancers. At Miltenyi Biotec, we offer a complete wo...
      Speaker: Dr. Susanne Bethke
      Sponsored By: Miltenyi Biotec
      9
      NOV 18, 2020 | 8:00 AM
      Whole-organ mapping using AI and light sheet microscopy
      Whole-organ mapping using AI and light sheet microscopy
      DATE: November 18, 2020 TIME: 08:00am PDT We develop and implement technologies to solve some of the major bottlenecks in biomedical research. In particular, we establish new imaging approac...
      Speaker: Ali Ertürk
      Sponsored By: Miltenyi Biotec
      14
      NOV 16, 2020 | 8:00 AM
      Targeted single-cell RNA sequencing enables genome-scale CRISPR screens
      Targeted single-cell RNA sequencing enables genome-scale CRISPR...
      Date: November 16, 2020 Time: 8:00am (PST), 11:00am (EST) CRISPR screening has become the prime discovery tool in modern biomedical research and drug discovery. At the same time, most screen...
      Speaker: Wieland Keilholz, Ph.D. , Pawel Zajac, Ph.D. , Dr. Tilmann Buerckstuemmer
      Sponsored By: Illumina
      11
      NOV 12, 2020 | 10:00 AM
      FcRn Affinity Column Chromatography for Therapeutic mAb Characterization
      FcRn Affinity Column Chromatography for Therapeutic mAb Characterization
      Date: November 12, 2020 Time: 10:00am (PST), 1:00pm (EST) Fc receptor based affinity chromatography is a new emerging field of Fc functionality analytics. FcRn affinity columns separate anti...
      Speaker: Tilman Schlothauer, Ph.D
      Sponsored By: Roche CustomBiotech
      3
      NOV 12, 2020 | 12:00 AM
      Fully Automated IHC Multiplexing: Techniques and Assay Development
      Fully Automated IHC Multiplexing: Techniques and Assay Development
      Multiplexing IHC is a technique that is increasing in demand as more and more researchers and physicians are being tasked with doing more with less. With multiplexing, you have the advantage...
      Speaker: Mark Hellewell, PhD
      Presented at: DISCOVERY Global User Symposium
      1
      NOV 10, 2020 | 7:00 AM
      Move Forward with Automation
      Move Forward with Automation
      DATE: November 10, 2020 TIME: 7:00am PDT, 10:00am EDT Automation can provide tremendous benefits such as increased pipetting precision and accuracy, productivity, and throughput. Numerous wo...
      Speaker: Paulina Kocjan , Kirk Mantione, PhD
      Sponsored By: Eppendorf
      15
      NOV 05, 2020 | 11:00 AM
      Image and Data Processing for HCS toxicology
      Image and Data Processing for HCS toxicology
      The pharmaceuticals and biotechnology industries have made substantial progress in reducing the number of drugs that fail in clinical trials due to safety. This has been due, in part, to an...
      Speaker: David Egan, PhD
      Presented at: 7th Annual Conference: SBI2 High Content
      4
      NOV 05, 2020 | 7:30 AM
      Keynote Presentation: The Opioid Crisis: Made in America...Fade in America
      Keynote Presentation: The Opioid Crisis: Made in America...Fade...
      The opioid crisis is a uniquely American challenge. Many factors catalyzed this national nightmare and others continue to fuel it. This presentation delves into some of the major contributor...
      Speaker: Professor Bertha Madras (the Honorable)
      Presented at: Opioid Crisis Virtual Event Series 2020
      1
      NOV 05, 2020 | 7:00 AM
      Stem cell derived exosome production in stirred-tank bioreactors
      Stem cell derived exosome production in stirred-tank bioreactors
      DATE: Date needed, 2020 TIME: Time needed Exosomes are a population of naturally occurring mobile, membrane-limited, 30 – 100 nm in diameter, extracellular vesicles containing a large...
      Speaker: Jorge Escobar , Aurélie Tacheny
      Presented at: Eppendorf Planet of Knowledge - A New Dimension
      Sponsored By: Eppendorf
      12
      NOV 04, 2020 | 8:00 AM
      Overcoming barriers to productivity in HCS - An image-to-answer solution for biologists
      Overcoming barriers to productivity in HCS - An image-to-answer...
      Date: November 4, 2020 Time: 8:00am (PDT), 11:00am (EDT) High-content screening (HCS) is widely used for research in quantitative cellular biology and has proven to be a valuable tool in dru...
      Speaker: William Marshall , David Egan, PhD
      Sponsored By: Cytiva
      2
      OCT 29, 2020 | 8:00 AM
      Cell types to targets: Single cell RNA-sequencing for drug discovery
      Cell types to targets: Single cell RNA-sequencing for drug discovery
      Date: October 29, 2020 Time: 8:00am (PDT), 11:00am (EDT) What cell types cause and perpetuate disease? For many diseases, scientists only have guesses to this critical question. Single cell...
      Speaker: Sarah Middleton, PhD
      Sponsored By: 10x Genomics
      10 2
      OCT 29, 2020 | 6:00 AM
      Single-cell sequencing to investigate epigenetic mechanisms in inflammatory lymphocytes
      Single-cell sequencing to investigate epigenetic mechanisms in...
      Date: October 29, 2020 Time: 6:00am (PDT), 9:00am (EDT), Chronic inflammation can occur as a result of a combination of genetic predispositions and environmental factors. Epigenetic modifica...
      Speaker: Thomas Ayers, Ph.D. , Pawel Zajac, Ph.D. , Dr. Adam Cribbs
      Sponsored By: Illumina, Dolomite Bio
      15
      OCT 28, 2020 | 7:00 AM
      Guiding pancreatic cancer therapy by individualized epigenetics
      Guiding pancreatic cancer therapy by individualized epigenetics
      Date: October 28, 2020 Time: 7:00am (PDT), 10:00am (EDT) Although chemotherapy remains the mainstay of systemic therapy, a large number of cancer patients fail to respond to it. About half o...
      Speaker: Surajit Dhara, Ph.D. , Valentina Maran, Ph.D.
      Sponsored By: Agilent
      12
      OCT 21, 2020 | 9:05 PM
      Incorporating NGS in an Asian non-small cell lung cancer (NSCLC) population - a cost-effectiveness analysis
      Incorporating NGS in an Asian non-small cell lung cancer (NSCLC)...
      There is an expanding list of therapeutically relevant biomarkers for non-small cell lung cancer (NSCLC), and molecular profiling at diagnosis is paramount. Tissue attrition in scaling tradi...
      Speaker: Aaron Tan, PhD
      Presented at: OncomineWorld Autumn: A virtual NGS education meeting
      1
    FEB 03, 2021 | 12:30 PM
    Optimizing High-Content Imaging of 3D Models for Drug Discovery
    Optimizing High-Content Imaging of 3D Models for Drug Discovery
    In vitro spheroid models are fast becoming the de facto standard for drug discovery applications, largely due to their human-like physiological and morphological characteristics, tissue-like...
    Speaker: Arvonn Tully , Judi Wardwell-Swanson
    Presented at: 7th Annual Conference: SBI2 High Content
    Sponsored By: SBI2, InSphero , Yokogawa
    11 10
    FEB 03, 2021 | 8:00 AM
    An introduction to immuno-oncology at Miltenyi Biotec
    An introduction to immuno-oncology at Miltenyi Biotec
    Date: February 3, 2021 Time: 8:00am (PST), 11:00am (EST) This introduction webinar will provide you with an overview of the general immuno-oncology (IO) research field...
    Speaker: Dr. Marcello Stein
    Sponsored By: Miltenyi Biotec
    19 2
    JAN 21, 2021 | 8:00 AM
    Critical reagent characterization for regulated bioassays accelerated by Uncle
    Critical reagent characterization for regulated bioassays accelerated...
    Date: January 21, 2021 Time: 8:00am (PST), 11:00am (EST) Today, critical reagent characterization is a key component in the overall workflow to establish robust ligand binding assays (e.g.,...
    Speaker: Ron Bowsher , Adam Kinne , Kevin Lance, Ph.D.
    Sponsored By: Unchained Labs
    6
    JAN 12, 2021 | 8:00 AM
    Storage and Logistics of Vaccines at Ultra Low Temperatures
    Storage and Logistics of Vaccines at Ultra Low Temperatures
    DATE: January 12, 2021 TIME: 8:00 am PST, 11:00 am EST, 5:00pm CET Transferring a biologic candidate from the research and development phase to commercial production usually requires increas...
    Speaker: Dr. Alex Esmon
    Sponsored By: Thermo Fisher Scientific
    9
    DEC 17, 2020 | 9:00 AM
    Advancing Cell Biology with Cryo-Correlative Microscopy
    Advancing Cell Biology with Cryo-Correlative Microscopy
    Date: December 17, 2020 Time: 9:00am (PST), 12:00pm (EST) Correlative light and electron microscopy (CLEM) advances biological discoveries by merging different microscopes and imaging moda...
    Speaker: Elizabeth Wright, Ph.D. , Jae Yang, Ph.D. , Bryan Sibert, Ph.D. , Joseph Kim
    Sponsored By: Leica Microsystems, Alveole
    13 2
     
     
  • DEC 10, 2020 | 8:00 AM
    Simple and Fast Charge Variants Analysis of mAbs by CZE
    Simple and Fast Charge Variants Analysis of mAbs by CZE
    Date: December 10, 2020 Time: 8:00am (PST), 11:00am (EST) As you face increasingly shortened timelines to bring new drugs to market, you find yourself strained to finalize analytical methods...
    Speaker: Yan He, Ph.D.
    Sponsored By: SCIEX
    4 1
    DEC 08, 2020 | 7:00 AM
    Best TLC & HPTLC practices in pharmaceutical separations
    Best TLC & HPTLC practices in pharmaceutical separations
    Thin-Layer Chromatography (TLC) and High-Performance Thin-Layer Chromatography (HPTLC) are convenient, fast, and efficient separation techniques for analytical methods without demanding comp...
    Speaker: Monika Bäeumle , Michaela Oberle , Melanie Broszat
    Sponsored By: MilliporeSigma
    14 1
    DEC 07, 2020 | 9:00 AM
    Rapid hyper-plex staining and simultaneous imaging for immunophenotyping of tissue sections.
    Rapid hyper-plex staining and simultaneous imaging for immunophenotyping...
    Date: December 7, 2020 Time: 9:00am (PST), 12:00pm (EST) The simultaneous detection of biomarkers on tissue samples plays a fundamental role in the study of the tumor microenvironment. Multi...
    Speaker: Diego Dupouy, Ph.D.
    Sponsored By: Lunaphore
    7
    DEC 02, 2020 | 8:00 AM
    Optimize your bioprocess - From shaker to bioreactor
    Optimize your bioprocess - From shaker to bioreactor
    DATE: December 2nd, 2020 TIME: 08:00am PDT, 11:00pm EDT Bioreactors and shakers are used to cultivate microorganisms, plant, insect, and mammalian cells in different volumes. Upscaling of pr...
    Speaker: Ines Hartmann , David Solbach
    Sponsored By: Eppendorf
    11
    NOV 19, 2020 | 9:00 AM
    From Protein Structures to Drug Discovery: Novel therapeutic opportunities.
    From Protein Structures to Drug Discovery: Novel therapeutic opportunities.
    DATE: November 19, 2020 TIME: 9:00am PT, 12am ET Knowledge of the three-dimensional structure of therapeutically relevant targets has become an essential step in the pipeline of drug discove...
    Speaker: Amal Hassan Ali
    Sponsored By: Thermo Fisher Scientific
    16 1
     
     
  • NOV 19, 2020 | 8:00 AM
    From discovery to functional assays: therapeutic antibody research by Miltenyi Biotec
    From discovery to functional assays: therapeutic antibody research...
    Date: November 19, 2020 Time: 8:00am PST, 11:00am EST Monoclonal antibody-based drugs have shown great potential as a treatment for several cancers. At Miltenyi Biotec, we offer a complete wo...
    Speaker: Dr. Susanne Bethke
    Sponsored By: Miltenyi Biotec
    9
    NOV 18, 2020 | 8:00 AM
    Whole-organ mapping using AI and light sheet microscopy
    Whole-organ mapping using AI and light sheet microscopy
    DATE: November 18, 2020 TIME: 08:00am PDT We develop and implement technologies to solve some of the major bottlenecks in biomedical research. In particular, we establish new imaging approac...
    Speaker: Ali Ertürk
    Sponsored By: Miltenyi Biotec
    14
    NOV 16, 2020 | 8:00 AM
    Targeted single-cell RNA sequencing enables genome-scale CRISPR screens
    Targeted single-cell RNA sequencing enables genome-scale CRISPR...
    Date: November 16, 2020 Time: 8:00am (PST), 11:00am (EST) CRISPR screening has become the prime discovery tool in modern biomedical research and drug discovery. At the same time, most screen...
    Speaker: Wieland Keilholz, Ph.D. , Pawel Zajac, Ph.D. , Dr. Tilmann Buerckstuemmer
    Sponsored By: Illumina
    11
    NOV 12, 2020 | 10:00 AM
    FcRn Affinity Column Chromatography for Therapeutic mAb Characterization
    FcRn Affinity Column Chromatography for Therapeutic mAb Characterization
    Date: November 12, 2020 Time: 10:00am (PST), 1:00pm (EST) Fc receptor based affinity chromatography is a new emerging field of Fc functionality analytics. FcRn affinity columns separate anti...
    Speaker: Tilman Schlothauer, Ph.D
    Sponsored By: Roche CustomBiotech
    3
    NOV 12, 2020 | 12:00 AM
    Fully Automated IHC Multiplexing: Techniques and Assay Development
    Fully Automated IHC Multiplexing: Techniques and Assay Development
    Multiplexing IHC is a technique that is increasing in demand as more and more researchers and physicians are being tasked with doing more with less. With multiplexing, you have the advantage...
    Speaker: Mark Hellewell, PhD
    Presented at: DISCOVERY Global User Symposium
    1
     
     
  • NOV 10, 2020 | 7:00 AM
    Move Forward with Automation
    Move Forward with Automation
    DATE: November 10, 2020 TIME: 7:00am PDT, 10:00am EDT Automation can provide tremendous benefits such as increased pipetting precision and accuracy, productivity, and throughput. Numerous wo...
    Speaker: Paulina Kocjan , Kirk Mantione, PhD
    Sponsored By: Eppendorf
    15
    NOV 05, 2020 | 11:00 AM
    Image and Data Processing for HCS toxicology
    Image and Data Processing for HCS toxicology
    The pharmaceuticals and biotechnology industries have made substantial progress in reducing the number of drugs that fail in clinical trials due to safety. This has been due, in part, to an...
    Speaker: David Egan, PhD
    Presented at: 7th Annual Conference: SBI2 High Content
    4
    NOV 05, 2020 | 7:30 AM
    Keynote Presentation: The Opioid Crisis: Made in America...Fade in America
    Keynote Presentation: The Opioid Crisis: Made in America...Fade...
    The opioid crisis is a uniquely American challenge. Many factors catalyzed this national nightmare and others continue to fuel it. This presentation delves into some of the major contributor...
    Speaker: Professor Bertha Madras (the Honorable)
    Presented at: Opioid Crisis Virtual Event Series 2020
    1
    NOV 05, 2020 | 7:00 AM
    Stem cell derived exosome production in stirred-tank bioreactors
    Stem cell derived exosome production in stirred-tank bioreactors
    DATE: Date needed, 2020 TIME: Time needed Exosomes are a population of naturally occurring mobile, membrane-limited, 30 – 100 nm in diameter, extracellular vesicles containing a large...
    Speaker: Jorge Escobar , Aurélie Tacheny
    Presented at: Eppendorf Planet of Knowledge - A New Dimension
    Sponsored By: Eppendorf
    12
    NOV 04, 2020 | 8:00 AM
    Overcoming barriers to productivity in HCS - An image-to-answer solution for biologists
    Overcoming barriers to productivity in HCS - An image-to-answer...
    Date: November 4, 2020 Time: 8:00am (PDT), 11:00am (EDT) High-content screening (HCS) is widely used for research in quantitative cellular biology and has proven to be a valuable tool in dru...
    Speaker: William Marshall , David Egan, PhD
    Sponsored By: Cytiva
    2
     
     
  • OCT 29, 2020 | 8:00 AM
    Cell types to targets: Single cell RNA-sequencing for drug discovery
    Cell types to targets: Single cell RNA-sequencing for drug discovery
    Date: October 29, 2020 Time: 8:00am (PDT), 11:00am (EDT) What cell types cause and perpetuate disease? For many diseases, scientists only have guesses to this critical question. Single cell...
    Speaker: Sarah Middleton, PhD
    Sponsored By: 10x Genomics
    10 2
    OCT 29, 2020 | 6:00 AM
    Single-cell sequencing to investigate epigenetic mechanisms in inflammatory lymphocytes
    Single-cell sequencing to investigate epigenetic mechanisms in...
    Date: October 29, 2020 Time: 6:00am (PDT), 9:00am (EDT), Chronic inflammation can occur as a result of a combination of genetic predispositions and environmental factors. Epigenetic modifica...
    Speaker: Thomas Ayers, Ph.D. , Pawel Zajac, Ph.D. , Dr. Adam Cribbs
    Sponsored By: Illumina, Dolomite Bio
    15
    OCT 28, 2020 | 7:00 AM
    Guiding pancreatic cancer therapy by individualized epigenetics
    Guiding pancreatic cancer therapy by individualized epigenetics
    Date: October 28, 2020 Time: 7:00am (PDT), 10:00am (EDT) Although chemotherapy remains the mainstay of systemic therapy, a large number of cancer patients fail to respond to it. About half o...
    Speaker: Surajit Dhara, Ph.D. , Valentina Maran, Ph.D.
    Sponsored By: Agilent
    12
    OCT 21, 2020 | 9:05 PM
    Incorporating NGS in an Asian non-small cell lung cancer (NSCLC) population - a cost-effectiveness analysis
    Incorporating NGS in an Asian non-small cell lung cancer (NSCLC)...
    There is an expanding list of therapeutically relevant biomarkers for non-small cell lung cancer (NSCLC), and molecular profiling at diagnosis is paramount. Tissue attrition in scaling tradi...
    Speaker: Aaron Tan, PhD
    Presented at: OncomineWorld Autumn: A virtual NGS education meeting
    1
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